International Journal of Nanomedicine
·
2023
·
IF 8
Ping Sun,Wei Huang,Lin Kang,Mingji Jin,Bo Fan,Hongyan Jin,Qi-Ming Wang,Zhonggao Gao
Sun P, Huang W, Kang L, Jin M, Fan B, Jin H, Wang Q, Gao Z. Int J Nanomedicine. 2017;12:3221–3234At the authors request, the Editor and Publisher of International Journal of Nanomedicine wish to retract the published article. An investigation by the Publisher found overlap in images from Figure 5. Specifically, The image from Figure 5, 0 h, Blank, has been duplicated with the same image for Figure 5, 0 h, H6R6-NP.The image from Figure 5, 0h, Naked siRNA, has been duplicated with the same image for Figure 5, 0 h, H6R6-NP.The image from Figure 5, 24 h, Naked siRNA, has been duplicated with the same image for Figure 5, 24 h, H6R6-NP.The image from Figure 5, 48 h, Naked siRNA, has been duplicated with the image for Figure 5, 48 h, CS-NP.The authors cooperated with the investigation and provided data associated with the study. However, despite the authors’ assistance, they were unable to provide a satisfactory explanation for how the images came to be duplicated, and the validity of the published work could not be verified. The decision was made to retract the article and the authors agreed with this.We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.
✓ 已验证
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Zihan Zhao,Chunfeng Li,Lei Le,Mingli Liu,Zhihao Zhang
The expanding application of corn stalk/polypropylene composites (CPCs) is accompanied by increasingly stringent performance requirements. Consequently, endowing flame retardancy, smoke suppression, and multifunctionality to CPCs while maintaining their mechanical properties is significant. Herein, a biobased flame retardant, arginine/ZIF-67 dual-modified ammonium polyphosphate (APP-Arg-MOF; MOF, metal–organic framework), for CPCs was engineered. APP was first functionalized with Arg via ion exchange to enhance its compatibility and flame retardancy. Subsequently, ZIF-67 was uniformly grown on APP-Arg through coordination-driven assembly using cobalt ions and 2-methylimidazole. The experimental results explained the exceptional multifunctional enhancement. The CPC/APP-Arg-MOF composite achieved a limiting oxygen index of 29.2% and passed the UL-94 V-0 rating. Cone calorimetry revealed significant reductions in the peak heat release rate (63.1%), total heat release (21.9%), and total smoke production (34.7%). Remarkably, the bending and tensile strengths increased by 10.0% and 26.9%, respectively, relative to CPC/APP, attributed to improved interfacial compatibility via Arg and ZIF-67 nanostructures. Furthermore, the CPC/APP-Arg-MOF composite exhibited potent antimicrobial activity, with inhibition rates of 97% against E. coli and 99% against S. aureus, leveraging synergistic effects of Arg and Co2+ release from ZIF-67. Meanwhile, the composite also maintained flame-retardant and antibacterial properties after 200 h of UV aging. Therefore, this work presents a sustainable APP surface modification strategy by utilizing Arg and ZIF-67 to simultaneously enhance fire safety, smoke suppression, and mechanical, antimicrobial, and anti-UV aging performances of CPC, offering significant potential for CPC applications.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Weiqiang Li,Kaisheng Diao,Daoyang Qiu,Yifang Zeng,Kaijie Tang,Yifu Zhu,Yingying Sheng,Yangping Wen,Mingfang Li
A new strategy to mimic antibody for electrochemical recognition and detection of deoxynivalenol (DON) using a highly-sensitive and selective antibody-like sensor based on molecularly imprinted poly( l -arginine) (P-Arg-MIP) on carboxylic acid functionalized carbon nanotubes (COOH-MWCNTs) was proposed. l -arginine as functional monomer was screened to prepare imprinted electrode via its electro-polymerization in the presence of DON onto the surface of COOH-MWCNTs electrode coupled with theoretical calculation. Surface morphology, structural characteristics, and electrochemical properties of P-Arg-MIP/COOH-MWCNTs were characterized by SEM, EDS, FTIR, and CV, respectively. P-Arg-MIP/COOH-MWCNTs displayed relatively high conductivity, high effective surface area, antibody-like molecular recognition and affinity, and a good response towards DON in a linear range from 0.1 to 70 μM with LOD of 0.07 μM in wheat flour samples with satisfactory recovery and feasible practicability in comparison with HPLC. This method provides a promising biomimetic sensing platform for the determination of mycotoxins in food and agro-products.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Tong Shi,Hui Liu,Teng Song,Zhiyu Xiong,Li Yuan,David Julian McClements,Wengang Jin,Quancai Sun,Ruichang Gao
The effects of l -arginine (Arg)-assisted ultrasonic treatment on the molecular and interfacial characteristics of myosin and emulsifying properties of the emulsion were evaluated to ascertain the underlying mechanism in improving the emulsion stability. Ultrasonication induced the exposure of residues of native myosin, which was increased by the addition of Arg (40 mM). Furthermore, in terms of emulsions containing Arg, the higher the ultrasonication intensity was, the greater the increase in adsorbed protein (from 15.43 ± 0.28% to 50.49 ± 1.65%) and π value, and the decrease in droplet sizes (from 4098 nm to 2324 nm) ( P < 0.05). Moreover, the increase in the ordered structures of interfacial myosin induced by Arg and ultrasonication favoured the formation of a protein gelation network. In summary, Arg-assisted ultrasonic treatment improved the stability of the emulsion by inducing the exposure of native myosin and facilitating the formation of ordered structures of interfacial myosin.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2017
·
IF 3.887
Chang Liu,Qi Lan,Wei He,Changlu Nie,Chunjuan Zhang,Tonghua Xu,Tongying Jiang,Siling Wang
The purpose of the study was to design a novel octa-arginine (R8) modified lipid emulsion (LE) system for the ocular delivery of the lipophilic drug disulfiram (DSF). The influence of the particle size of the lipid emulsions and the presence of R8 on corneal permeation was studied. DSF-loaded lipid emulsions with different particle sizes (DSF-LE1, DSF-LE2, DSF-LE3) and DSF-loaded lipid emulsions modified with R8 (DSF-LE1-R8 and DSF-LE2-R8) were prepared. The Zeta potential of the lipid emulsions was changed from negative to a positive value after modification of R8. The mucoadhesion of different preparations was investigated, and DSF-LE1-R8 was found to produce the strongest mucoadhesion. The in vitro corneal penetration study and in vivo ocular distribution study showed that the R8 modified lipid emulsion (DSF-LE1-R8) with a nano particle size, exhibited the highest permeability and the largest amount of DDC distributed in ocular issues. Coumarin-6 labelled LE1-R8 displayed more homogeneous fluorescence with the deeper penetration into the cornea compared with other preparations at various times. Confocal laser scanning microscopy showed that, in addition to paracellular routes, LE-R8 could also transport across the corneal epithelium by transcellular routes as a result of increased uptake due to the R8 modification. Furthermore, the anti-cataract effect was evaluated and it was found that DSF-LE1-R8 exhibited a marked anti-cataract effect. Therefore, the lipid emulsions with nano-sized particles and modification of R8 were proposed as a potential ocular delivery system to improve the corneal penetration and ocular delivery of DSF.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Fungi
·
2024
·Vol. 10
·期 11
·801
·
IF 4.2
Di Wang,Lingkui Meng,Haijue Zhang,Rong Liu,Yuhan Zhu,Xinyu Tan,Yan Wu,Qingchao Gao,Xueyan Ren,Qingjun Kong
Black spot, one of the major diseases of kiwifruit, is caused byAlternaria alternata. A comprehensive investigation into its pathogenicity mechanism is imperative in order to propose a targeted and effective control strategy. The effect of L-arginine on the pathogenicity ofA. alternataand the underlying mechanisms were investigated. The results showed that treatment with 5 mM L−1of L-arginine promoted spore germination and increased the colony diameter and lesion diameter ofA. alternatain vivo and in vitro, which were 23.1% and 9.3% higher than that of the control, respectively. Exogenous L-arginine treatment also induced endogenous L-arginine and nitric oxide (NO) accumulation by activating nitric oxide synthase (NOS), arginine decarboxylase (ADC) and ornithine decarboxylase (ODC). In addition, exogenous L-arginine triggered an increase in reactive oxygen species (ROS) levels by activating the activity and inducing gene expression upregulation of NADPH oxidase. The hydrogen peroxide (H2O2) and superoxide anion (O2.−) levels were 15.9% and 2.2 times higher, respectively, than in the control group on the second day of L-arginine treatment. Meanwhile, antioxidant enzyme activities and gene expression levels were enhanced, including superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), glutathione peroxidase (GPX), and glutathione reductase (GR). In addition, exogenous L-arginine stimulated cell wall-degrading enzymes in vivo and in vitro by activating gene expression. These results suggested that exogenous L-arginine promoted the pathogenicity ofA. alternataby inducing the accumulation of polyamines, NO, and ROS, and by activating systems of antioxidants and cell wall-degrading enzymes. The present study not only revealed the mechanism by which low concentrations of L-arginine increase the pathogenicity ofA. alternata, but also provided a theoretical basis for the exclusive and precise targeting ofA. alternatain kiwifruit.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF VINYL & ADDITIVE TECHNOLOGY
·
2025
·
IF 3.6
Yanqin Shi,Jiachao Mei,Yuchen Yao,Jingzhe Zhang,Si Chen,Meng Ma,Huiwen He,Yulu Zhu,Xu Wang
Zinc arginine [Zn(Arg) 2 ] was a zinc salt stabilizer with excellent initial whiteness and long-term thermal stability for PVC, as reported by our previous work. Clarifying the synergistic thermal stability mechanisms of Zn(Arg) 2 and its auxiliary stabilizers under dynamic and static conditions was an important scientific issue to guide the practical application of Zn(Arg) 2 . In this work, acetylacetone (ATE) was found to be a good auxiliary thermal stabilizer with Zn(Arg) 2 for PVC, especially at the 4:6 ratio of ATE and Zn(Arg) 2 . However, the best ATE derivatives under static and dynamic conditions were not the same, which were ATE and stearoylbenzoylmethane (SBM), dibenzoylmethane (DBM), and benzoylacetone (BZT), respectively. The reasons were that ATE derivatives could react with Zn(Arg) 2 and produce zinc acetylacetonate (Zn-ATE) under the static thermal aging condition. However, under dynamic thermal aging conditions, ATE derivatives replaced unstable chlorine atoms on the PVC chains by the α-C between two carbonyl groups through an alkylation reaction. The conclusions were confirmed by the calculation results of the natural population analysis (NPA) charge. In addition, the compatibility of ATE derivatives and PVC was another reason for the thermal stability and transparency of PVC samples. Highlights The synergistic effect of zinc, arginine, and acetylacetone derivatives was investigated. There are two different synergistic effects under static and dynamic thermal aging conditions. Zinc, arginine, and acetylacetone reacted under static thermal aging conditions. The natural population analysis charge was used to confirm the two mechanisms.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Hepatocellular Carcinoma
·
2025
·
IF 3.4
Jiayuan Zhang,Tian Tian,Shanshan Tian,Jinhai Yao,Yingwan Zhang,Rujia Xie,Ting Yang,Bing Han
Purpose This study aims to investigate the mechanism of action of arsenic-based agents against hepatocellular carcinoma (HCC) and to identify effective drug targets for HCC treatment.Methods Huh7 and HepG2 cells treated with NaAsO2 were assessed for cell viability, pyroptosis, migration, and invasion after undergoing lentiviral transfection. An orthotopic liver tumor model was established and divided into a model group and a treatment group. Proteins associated with QRICH1, PRMT1, cGAS-STING, and the classical pyroptosis pathway were quantified using Western blotting. The intracellular expression and localization of PRMT1 and NLRP3 in HCC were analyzed through cellular immunofluorescence. Co-immunoprecipitation (Co-IP) was performed to examine the protein interactions between PRMT1 and cGAS, as well as between STING and NLRP3. Chromatin immunoprecipitation (ChIP) was used to confirm QRICH1 enrichment in the PRMT1 promoter region.Results NaAsO2 treatment significantly inhibited the proliferation of Huh7 and HepG2 cells and effectively blocked their migration and invasion capabilities, while promoting cellular pyroptosis. Quantitative polymerase chain reaction(QRCR) and ChIP assays confirmed that NaAsO2 regulates PRMT1 expression by down-regulate QRICH1 binding in the PRMT1 promoter region. Additionally, NaAsO2 decreased the expression of the QRICH1-PRMT1 complex and upregulated the cGAS-STING signaling pathway, activating the downstream NLRP3-dependent classical pyroptosis pathway. Overexpression of QRICH1 reversed these effects.Conclusion NaAsO2 inhibits the expression of the QRICH1-PRMT1 axis, activates cGAS-STING signaling pathway transduction, and induces pyroptosis in HCC cells, thereby increasing the infiltration of immune cells in liver cancer tissues.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2019
·
IF 5.839
Tong Shi,Zhiyu Xiong,Wengang Jin,Li Yuan,Quancai Sun,Yuhao Zhang,Xiuting Li,Ruichang Gao
The suppression mechanism of l -arginine (Arg) in fish myosin heat-induced aggregation was investigated in this work. The hydrodynamic radius determined by dynamic light scattering (DLS) and the turbidity of a myosin solution decreased in a dose-dependently manner with Arg after heating, especially in a solution without pH modification ( P < 0.05). The surface hydrophobicity of myosin exhibited the same trend as that for hydrodynamic radius and turbidity ( P < 0.05). The myosin secondary structures clearly changed with Arg concentration during heating ( P < 0.05). These results demonstrate that positively-charged Arg could form ionic interactions with negatively charged myosin, as well as promote repulsion between myosin molecules induced by higher pH values. Furthermore, the resultant hydrogen bonding observed indicated that, in addition to Arg having ionic linkage effects, the specific structure of Arg played an important role in the suppression of myosin aggregation. Essentially, Arg markedly disturbed the hydrogen bonds of the myosin backbone and formed new hydrogen bonds with myosin molecules via two amino groups (-NH 2 ), which are part of the guanidinium moiety of Arg, preferentially hydrogen bonding with the backbone carbonyl oxygen atoms of myosin molecules. This work provides support for using Arg as an additive to modify the texture of fish products to produce liquid and semiliquid food suitable for the elderly consumers in an aging society.
✓ 已验证
产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2018
·
IF 5.089
Xiaoxu Zhu,Linxian Li,Shiyi Li,Cheng Ning,Cunliu Zhou
The effects of l –arginine (Arg) and l –lysine (Lys) on the emulsifying properties of the salt-soluble meat proteins (SSMPs)–soybean oil emulsion (SSOE) and soybean oil–water emulsion (SWE) were evaluated to ascertain their roles in improving the emulsion stability of sausage. The results indicated that Arg/Lys addition or increasing pH increased the emulsifying activity/stability index and the absolute ζ–potential of emulsion droplets but decreased the creaming index, apparent viscosity, and mean particle size of SSOE. Amino acid analysis showed that Arg/Lys accumulated at the interface of the emulsion droplets. Arg/Lys also decreased the surface tension of SWE at 0.002% but increased the stability of SWE at 0.1% – 0.3%. In summary, Arg/Lys improved the stability of emulsified sausage by increasing the electrostatic repulsion of emulsion droplets and decreasing the interfacial tension of soybean oil-water.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Tingting Li,Yuanqing Huo,Huifang Ji,Wenjie Yan,Mengni Jia,Changming Xiong,Yunlan Li,Ruiping Zhang
Liver fibrosis, a pivotal pathological stage in the progression of chronic liver diseases to cirrhosis and hepatocellular carcinoma is characterized by liver sinusoidal endothelial cell (LSEC) capillarization, oxidative stress imbalance, and cell pyroptosis. Current clinical interventions show limited efficacy in reversing fibrosis, highlighting the urgent need for novel therapeutic strategies. In this study, we developed an L-arginine-loaded melanin-like nanozyme (L-Arg@MeNPs) that targets liver fibrosis through a triple-action mechanism: (1) sustained nitric oxiderelease from L-Arg restores LSEC fenestration, improving sinusoidal permeability; (2) the MeNPs exhibit catalase/superoxide dismutase-mimicking activity to scavenge reactive oxygen species, thereby blocking the NOD-like receptor pyrin domain-containing 3/caspase-1-mediated pyroptosis pathway; and (3) intrinsic photoacoustic/magnetic resonance dual-modal imaging enables real-time therapeutic monitoring. Overcoming the biosafety limitations of conventional metal-based nanozymes, this system demonstrates superior pH stability and metabolic degradability. In vivo studies confirm that L-Arg@MeNPs effectively ameliorate the fibrotic microenvironment and reduce excessive extracellular matrixdeposition, offering a targeted, safe, and theranostic solution for clinical liver fibrosis treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Animal Nutrition
·
2025
·
IF 7.5
Jing Zhang,Jiaojiao Lang,Lijun Bu,Yapeng Liu,Wenjie Huo,Caixia Pei,Qiang Liu
Arginine (Arg) can potentially increase milk yields in early lactating dairy cows by stimulating the development of mammary gland and the biosynthesis of milk proteins and fatty acids (FA); however, the underlying mechanism is still unclear. The hypothesis was detected that rumen-protected Arg (RPArg) addition would increase the yields of milk, milk fat, and milk protein and aimed to elucidate the possible mechanism. Forty-eight multiparous Chinese Holstein dairy cows (milk yield 34.9 ± 1.27 kg/d, body weight 658 ± 12.7 kg, and days in lactation [DIL] 16.4 ± 2.56) were selected on the principle of proximity and blocked by DIL and milk yield, and divided into one of four groups in a randomized block design: control (without RPArg), low RPArg (LRPArg, 20 g/d Arg), medium RPArg (MRPArg, 40 g/d Arg), and high RPArg (HRPArg, 60 g/d Arg), 4 replicates per group and 3 cows per replicate the experiment duration was 95 days, including a 10-day covariate period, a 15-day adaptation period, and a 70-day sampling period. The production of actual milk, energy-corrected milk, fat-corrected milk, milk fat, and milk protein linearly increased ( P < 0.05) with RPArg provision. The yields of de novo FA and mixed FA in the milk linearly increased ( P < 0.01), but that of preformed FA linearly decreased ( P = 0.007). Supplementation with RPArg linearly increased the daily production of Arg, Asp, Cys, Glu, His, Met, Phe, Ser, Thr, and Trp ( P < 0.05). With RPArg provision, serum contents of glucose, albumin, total protein, and nitric oxide linearly increased ( P < 0.05); the levels of estradiol, prolactin, and insulin-like growth factor 1 quadratically increased ( P < 0.01); and that of blood urea nitrogen quadratically decreased ( P = 0.023). Furthermore, supplementation with 40 g/d Arg from RPArg promoted the expression of proteins implicated in mammary gland proliferation, FA synthesis, and milk protein synthesis. Thus, RPArg addition enhanced milk production, FA synthesis, and milk protein synthesis by promoting the expression of proteins involved in mammary gland development, FA synthesis, and milk protein synthesis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）