Food Bioscience
·
2024
·
IF 4.8
Zenghong Xing,Wenxin Han,Taotao Dai,Deming Gong,Guowen Zhang
In this study, the potato protein (PP)-pectin (PC) nanoparticles were constructed to encapsulate ferulic acid (FA). The effects of FA additive amount, addition order and pH value on the properties of PP-FA-PC/PP-PC-FA nanocomplexes were investigated. It was found that when the mass ratio of PP to FA was 25:1, the PP-FA-PC nanocomplex had the smallest particle size, turbidity and the highest FA encapsulation efficiency. At pH 5.0, the addition order of FA had an effect on the properties of the nanocomplexes, and the formed nanocomplexes had larger particle size, higher turbidity and better encapsulation efficiency than the nanocomplexes formed at pH 7.0. Additionally, the nanocomplexes formed at pH 5.0 also possessed lower ABTS + and DPPH free radical scavenging rates, indicating that FA was successfully encapsulated by PP-PC nanoparticles. The results of Z-average diameter and fourier transform infrared spectra confirmed PP-FA-PC nanocomplex at pH 5.0 encapsulated FA based on hydrogen bonding, hydrophobic and electrostatic interactions. The scanning electron microscopy showed that the PP-FA-PC nanocomplex exhibited irregular and segregated small particles at pH 5.0. Moreover, the PP-FA-PC nanocomplexes at pH 5.0 had the best encapsulation ability and protection effect on FA, and the environmental stability was the best. The release rate of FA loaded by PP-PC nanoparticles was greatly reduced in simulated gastric fluid, while increased in simulated intestinal fluid compared to free FA. This study may provide valuable information for PP-PC nanoparticles as a food-grade delivery system, signifying the potential application in the health food industry.
研究领域:
食品科学
·
纳米技术
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2025
·
IF 3.8
Hui-Ming Xiang,Xiao-Hong Wei,Yi-Ran Li,Bo-Jun Zhang,Min Li,Rui-Yan Ma
BACKGROUND As sex pheromones are environmentally friendly and specific, they are often used to monitor and control oriental fruit moths (OFMs). Currently, non-biodegradable polymers are commonly employed as carriers to prepare controlled sex pheromone release systems for plant protection. Electrospinning is a relatively simple technique for preparing biodegradable nanofibers that allows for the controlled release of sex pheromones. This study aimed to develop a biodegradable controlled release system for the combination of OFM pheromone and codlemone via electrospinning, in which codlemone was used as a synergist for OFM pheromone. RESULTS New systems for the controlled release of combined pheromones from OFM and colding moths were developed using electrospun nanofibers from polycaprolactone (PCL), cellulose acetate (CA), and polylactic acid (PLA). In the indoor experiments, the load ratio and release stability of CA nanofibers loaded with combined pheromones (CA-SP) were superior to those of the other two nanofiber types. In the field experiments, among all the treatments, 10 mg of CA-SP was the most attractive to OFMs, and its effective duration was approximately 6 weeks. The optimum storage temperature for all nanofibers was −20 °C. CONCLUSION Electrospun CA-SP nanofibers were biodegradable and environmentally friendly, with stable release. This study presents a new technique that could be beneficial for the monitoring and control of OFMs. © 2025 Society of Chemical Industry.
研究领域:
昆虫学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jia Xu,Qing Wu,Jing Wang,Yingjie Liu,Ke Liu,Ming Xia,Dong Wang
The development of materials with high lysozyme adsorption is critical for drug delivery and skin wound applications, as it enhances antibacterial properties, stability, and controlled release of therapeutic agents, thereby improving treatment efficacy and safety. Alginate-based nanofiber scaffolds, featuring high surface area and multiple adsorption sites, can efficiently absorb lysozyme and regulate its release through tunable pore channels, offering a promising approach to chronic wound management. In this study, we fabricated poly (vinyl al co hol-co-ethylene) (EVOH) nanofiber-based sodium alginate (ENSA) aerogels using a simple two-step crosslinking procedure. The resulting aerogels, with controllable porosity formed via high-pressure spraying techniques (aerogel film) and molding (aerogel sponge), were evaluated for their high-loading capacity and controllable release of lysozyme. The aerogel film exhibited a remarkable lysozyme adsorption capacity of 1965 ± 36 mg/g, while the aerogel sponge sustained lysozyme release over 14 days. Analysis of the drug-release mechanism through four kinetic models revealed two distinct processes: cation exchange and matrix diffusion. The aerogel's pore structure influenced the diffusion processes, enabling tailored drug release profiles. Additionally, the ENSA aerogels demonstrated good mechanical properties, non-cytotoxicity, and potent antibacterial activity, positioning them as promising materials for skin wound dressings.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaolong Hu,Hongyan Zhang,Zuan-Tao Li,Yu Chen,Hao Cheng,Bi-Huan Zhong,Yong-li Li,Xiao-Ping Liao,Jian Sun,Mei X. Wu,Gang-Biao Jiang
Regarding the several antibacterial hydrogels that have been created thus far, their fixed forms and limited mobility hinder their ability to fully eradicate the germs that are still present deep within the wound and to satisfy the requirements of wound healing. Hence, a remotely triggered phase change hydrogel (CMCS/Gel/OGG/TA/Fe 3+ , CGO-TF) was created for controlled release and promoting healing of infected wounds. The CGO-TF has excellent mechanical, tissue adhesion, injectability, and reactive oxygen species scavenging capabilities (76.08 % ± 3.46 %). Importantly, the hydrogel can remotely trigger morphological phase transition and TA ’on–off’ release when driven by NIR. To be specific, after exposure to NIR for 10 min, the hydrogel can undergo a “solid-liquid” phase transition to fill deep wound tissue gaps or irregular wounds; the controlled release of TA can be remotely triggered to work in tandem with the hydrogel’s photothermal response to create an efficient bacteriostatic effect that can stop the growth of MDRB. For the treatment of infected skin injury in mice, the hydrogel can promote wound healing by removing wound bacteria (99.88 % ± 0.08 %), activating M2-type macrophage polarization, stimulating vascular neogenesis, and accelerating granulation tissue proliferation (928.2 μm ± 74.71 μm). In conclusion, CGO-TF is a promising medical biomaterial.
研究领域:
生物材料
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医学工程
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药剂学
✓ 已验证
产品关联
DOI
高影响因子
Wood Material Science & Engineering
·
2024
·
IF 2.2
Li Jin,Xin Ren,Fei Wang,Zhiwei Fan,Shuaibo Han,Yan Zhang,Hui Wang,Xinxing Wu,Fangli Sun
Disodium octoborate tetrahydrate (DOT) is a well-received and eco-friendly preservative. However, it is prone to leaching from wood in humid conditions or rainy seasons, causing problems such as decreased efficiency in resisting fungi and poor surface performance in surface finishing. To obtain enhanced leaching resistance and simultaneously achieve controlled release of DOT, a pH and temperature dual responsive poly (2-hydroxyethyl methacrylate/2-(Dimethylamino) ethyl methacrylate) (PDH) was prepared and optimized for in situ construction of DOT-loaded PDH (PDHD) in wood. Results showed that PDH displayed obvious pH and temperature-responsive swelling, and when loaded with DOT, the PDHD consequently released DOT in a pH and temperature-responsive way. Fourier transform infrared spectroscopy, Solid-13C NMR analysis and Dynamic mechanical analysis confirmed the copolymerization of 2-Hydroxyethyl methacrylate (HEMA) and 2-(Dimethylamino) ethyl methacrylate (DMAEMA), as well as the presence of crosslinked structure formed from hydrogen bond between the hydroxyl group of HEMA and the N,N-dimethylamino groups of DMAEMA. After that, the PDHD was in situ constructed in wood for controlled release of boron. During the water leaching test, the modified wood exhibited a boron fixation rate of 49.05% compared with 0.72% of the neat DOT-treated wood. Besides, it presented controlled release activity in response to pH and temperature. This work provides new approaches to the fixation of boron preservatives and notably realizes responsive releasing of boron compounds for long-term wood preservation.
研究领域:
材料科学
·
林学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 8
·1041
·
IF 4.7
Teng Sun,Dekang Zhan,Xiangzhu Wang,Qingjie Guo,Mingzhou Wu,Pu Shen,Man Wu
This study aims to improve the slow-release performance of a film material for a controlled-release fertilizer (CRF) while enhancing its biodegradability. A water-based biodegradable polymer material doped with biochar (BC) was prepared from modified polyvinyl alcohol (PVA) with polyvinylpyrrolidone (PVP) and chitosan (CTS), hereinafter referred to as PVA/PVP–CTSaBCb. An environmentally friendly novel controlled-release phosphate fertilizer (CRPF) was developed using PVA/PVP-CTS8%BC7%as the film. The effect of the PVA/PVP-CTS8%BC7%coating on the service life of the CRPF was investigated. The film was characterized via stress–strain testing, SEM, FTIR, XRD, and TGA analyses. The addition of the CTS modifier increased the stress of PVA/PVP-CTS8%by 7.6% compared with that of PVA/PVP owing to the decrease in the crystallinity of PVP/PVP-CTS8%. The hydrophilic –OH groups were reduced due to the mixing of CTS and PVA/PVP. Meanwhile, the water resistance of the PVA/PVP-CTS8%BC7%was improved. And the controlled-release service life of the CRPF was prolonged. Moreover, the addition of BC increased the crystallinity of the PVA/PVP-CTS8%by 10%, reduced the fracture elongation of the material, and further improved the biodegradability of the PVA/PVP-CTS8%BC7%. When the amount of BC added was 7%, the phosphorus release rate of the CRPF was 30% on the 28th day. Moreover, the degradation rate of the PVA/PVP-CTS8%BC7%polymer film was 35% after 120 days. This study provides basic data for applying water-based degradable polymer materials in CRFs.
研究领域:
农业科学
·
材料科学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Xin Ding,Kexin Yang,Xin Yang,Jie Zhou,Miao Wang,Zhihao Lin,Yaowei Zhang,Donghui Xu,Bining Jiao,Ge Chen,Xiaomin Xu,Lin Qin,Guangyang Liu
At present, it is highly important to develop nanopesticide, which can improve the effect of pesticides and reduce the risks of environmental. Zeolitic imidazolate framework (ZIF) is usually used as a nanocarrier of nanopesticide, which has a porous structure and stimuli-responsive properties. However, the drug loading performance and stability of ZIF are poor. To solve these disadvantages, we successfully prepared bimetallic ZIF nanocarriers by hybridizing and structurally regulating ZIF-L with Co. Here, we propose that Zn and Co bimetallic ZIF (ZnCo-ZIF) was used for efficient loading and controlled release of thiamethoxam (THX). Notably, the specific surface area of ZnCo-ZIF with flower-cluster structure was 8.7338 m 2 /g, which could provide a large number of active sites for THX loading. Besides, it was found that the maximum THX loading rate of ZnCo-ZIF was 12.7% by optimizing the load experimental conditions, which was 1.4 times higher than that initial. After that, ZnCo-ZIF@THX was modified by the metal-phenol network (MPN), which formed through the chelation of tannic acid (TA) and iron ions. In the PBS release medium, the cumulative release rate of the ZnCo-ZIF@THX@MPN reaches 100% for 24h. In addition, the photostability of ZnCo-ZIF@THX@MPN had been greatly improved, which the photodegradation half-life of it was 4.17 times that of THX technical drug. After MPN encapsulation, the maximum retention and rainwater resistance of the nanopesticide on vegetable leaves were also improved. The bemisia tabaci was used as the model insect, and the mortality of ZnCo-ZIF@THX@MPN against was increased to 88.15%. Finally, the safety experiment shows ZnCo-ZIF@THX@MPN had no inhibitory effect on pakchoi seed germination and had good biosafety. This work provides a new idea for the development that the facile synthesis of bimetallic flower-cluster nanocarriers and load of thiamethoxam.
研究领域:
农业科学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2026
·
IF 4.4
Zhiping Liu,Jiansheng Li,Yanmin Huang,Weiguo Li,Chunrui Cai,Qiang Hu,Yanlin Chen,Jianguo Cui
Through dual encapsulation of the insecticide lufenuron with β-cyclodextrin octadecanoate and urea-formaldehyde resin, a lufenuron@β-cyclodextrin octadecanoate/urea formaldehyde resin (LF@β-CDs/UF) nanoformulation was prepared. This dual-carrier synergy significantly prolonged the release cycle of lufenuron and enhanced environmental adaptability. Results demonstrated that under 25 °C and pH 7 conditions, its release cycle reached 324 h in 20% methanol–water, representing a 1.5-fold prolongation compared to the single-carrier lufenuron@β-cyclodextrin octadecanoate (LF@β-CDs) nanoformulation, with a pH/temperature-responsive release behavior. The photolysis half-life (t50) was extended by 1.6- and 9.3-fold compared to LF@β-CDs (51 h) and lufenuron (LF) microemulsion (8.9 h), respectively. At a low concentration of 6.25 mg/L, the mortality rate against Spodoptera litura reached 73.33%, significantly outperforming LF@β-CDs (29.33%) and LF microemulsion (5.33%). The LF@β-CDs/UF also substantially prolonged insecticidal duration and enhanced the systemic translocation of lufenuron in plants. Biosafety assessment showed that it significantly reduced ecological toxicity, increasing rice seed germination rates from 40.7% (microemulsion) to 71.3% at 400 mg/L seed-soaking concentration, while elevating the acute toxicity LC50 value in zebrafish by 4.4-fold, demonstrating substantially comparative eco-friendliness compared to conventional formulations. This dual-carrier technology, via structure–function synergy, provides an innovative solution to challenges such as low pesticide utilization efficiency and high environmental risks.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Wenxiu Yang,Kun Zeng,Jiaxin Liu,Lechen Chen,Mozhen Wang,Shengchi Zhuo,Xuewu Ge
The combination of the molecular imprinting technology and porous materials is a promising way to obtain high-efficient selective adsorption and separation materials for bioactive macromolecules . In this work, we developed a novel approach to prepare near-infrared (NIR)-light-response inverse-opal lysozyme (Lyz)-imprinted polydopamine/polypyrrole (IO-PDA/PPy-MIP) composite microspheres using micron-sized SiO 2 colloidal crystal microspheres as the sacrificed template. The pore size of the IO-PDA/PPy-MIP microspheres can be tuned from 200 to 800 nm by the size of silica nanoparticles which self-assemble to form the template SiO 2 colloidal crystal microspheres. The IO-PDA/PPy-MIP microspheres show a rapid selective adsorption ability for Lyz due to the inverse-opal macroporous structure. The adsorption capacity exceeds 800 mg/g within 20 min, and the imprinting factor is as high as 24. The bound Lyz molecules can be released rapidly from IO-PDA/PPy-MIP microspheres triggered by the irradiation of NIR laser and remain enough bioactivity to decompose Escherichia coli efficiently. The prepared IO-PDA/PPy-MIP microspheres also exhibit excellent structure stability and good recyclability. The adsorption capacity can remain up to 90% of the initial value after 5 times recycle. This work provides not only a method to prepare novel NIR-light-response inverse-opal macroporous molecularly imprinted microspheres, but also a new perspective on the design of selectively separation materials for the fast, high-efficient recognition and separation of biomacromolecules.
研究领域:
材料科学
·
生物化学
·
纳米技术
✓ 已验证
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2018
·
IF 7.877
Lei Wang,Yujie Hu,Yongwei Hao,Li Li,Cuixia Zheng,Hongjuan Zhao,Mengya Niu,Yanyan Yin,Zhenzhong Zhang,Yun Zhang
Combination therapy with multiple drugs or/and multiple assistant treatments has become a hot spot in cancer therapy. In this study, a new type of core-shell structured dual-drug delivery system based on poly (lactic- co -glycolic acid) (PLGA, inner cores) and hyaluronic acid (HA, outer shells) was constructed. Firstly, HA was conjugated to PLGA for preparation of HA-PLGA block copolymer . Secondly, 5-amino levulinic acid (ALA) was connected to PLGA through a pH-sensitive hydrazone bond for synthesization of PLGA-HBA-ALA. Finally, the core-shell structured nanoparticles ( [email protected] /ALA NPs) were constructed by self-assembled method for artemisinin (ART) loading in PLGA cores. In this co-delivery system, ALA and ART can be released in a manner of procedural controlled release. ALA was released from the NPs at first though the pH sensitive hydrazone bond cleavage in order to generate protoporphyrin IX (PpIX) for heme formation. And the increase of heme can effectively improve the curative effect of the subsequent released ART. Furthermore, this system has also shown obvious sonodynaimc activity which can be used for cancer sonodynamic combination therapy. The in vitro and in vivo anticancer results demonstrate that [email protected] /ALA delivery system could provide a prospective comprehensive treatment strategy for cancer therapy.
研究领域:
药学
·
纳米技术
·
癌症研究
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
PEST MANAGEMENT SCIENCE
·
2026
·
IF 4.2
Longfei Bian,Ruisi Chen,Rong Zhao,Xiaoyuan Wang,Guiji Yin,Lutao Yang,Wenneng Wu,Yuru Chen,Saijie Song
BACKGROUND Kiwifruit soft rot is a devastating post-harvest disease that leads to significant economic losses in the kiwifruit industry. Although chemical pesticides can effectively inhibit pathogenic fungi, their conventional formulations still have disadvantages such as poor stability, low utilization rate, and high environmental risks. Therefore, developing environmentally friendly and multifunctional smart pesticide delivery system (PDS) is key to achieving sustainable plant disease control. RESULTS In this study, we developed a multifunctional PDS by using β -cyclodextrin ( β -CD)-modified mesoporous silica nanoparticles (MSN) as a nanocarrier for prochloraz (Pro) delivery. The nanopesticide (Pro-MSN- β -CD) exhibited high loading efficiency (68.74%) and demonstrated pH- and α -amylase-responsive controlled release behavior. In addition, it also exhibited enhanced foliar adhesion and rain erosion resistance performance. In vitro antifungal assays showed 100% inhibition of Botryosphaeria dothidea at 1 μg mL −1 . Post-harvest trials on kiwifruit revealed superior protective (67.50%) and curative (58.59%) efficacy against soft rot. Biosafety assessments confirmed minimal phytotoxicity in mung bean germination tests. CONCLUSION The Pro-MSN- β -CD nanopesticide offered an efficient, biosafe, and environmentally friendly solution for controlling kiwifruit soft rot. Its stimuli responsive release and enhanced targeting performance provided a sustainable strategy for post-harvest disease management, contributing to the advancement of precision agriculture. © 2026 Society of Chemical Industry.
✓ 已验证
DOI
PubMed
高影响因子
Energy Sources Part A-Recovery Utilization and Environmental Effects
·
2023
·
IF 2.9
Chaoyu Hao,Le Li,Ruicong Zhai,Yupeng Deng,Yitong Ma,Ao Li
A controlled-release inerting inhibitor (CRII) was prepared by embedding the little inhibiting balls (LIB) into the sodium alginate (SA) hydrogel. The water retention and flowability of the SA hydrogel were studied, and the controlled-release effect of the CRII was analyzed by CO2 production rate and scanning electron microscopy. At last, the inhibiting performance and the long-lasting effect of the CRII were investigated. The experimental results show that the 1.5 wt% SA hydrogel has the best water retention and good flowability. Meanwhile, the SA hydrogel also has a great effect on CO2 retention. During the heating process, 88.86% of CO2 produced by the LIB escaped into the air, while only 42.57% of the CRII did. As the temperature gradually increases, a large number of micropores are formed on the surface of LIB, which achieves the controlled-release of inhibitory components. In comparison to the raw coal, the temperature at which CO enters the exponential growth is delayed by 18.8°C for the CRII-treated coal sample, and the release of CO is reduced by 86.3% at 127.8°C. Comparing the CRII-treated coal samples placed for 1 and 8 days, the average inhibition rate of the latter decreased by 0%, −1.81%, 0.56% and 2.59% in four stages (45 ~ 75°C, 75 ~ 100°C, 100 ~ 160°C and 160 ~ 180°C), respectively. The average inhibition rate of the coal samples treated by CRII did not decrease basically before 160°C, while the coal samples treated by NaCl aqueous solution under the same conditions showed a significant decrease in the early stage. In future studies, it is a worthwhile focus that how to optimize the ratio of each component in the LIB and further study the controlled-release performance.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）