Biomaterials Science
·
2020
·Vol. 8
·期 6
·1649-1657
·
IF 6.183
Bianbian Qiao,Qian Pang,Peiqi Yuan,Yilun Luo,Lie Ma
Wound infection is a major challenge in the clinic that greatly hinders the wound healing process. It is highly important to develop smart wound dressings that can sense bacterial infection at early stages and provide on-demand treatment. In this work, a smart hydrogel-based wound dressing capable of monitoring bacterial infection via a pH-responsive fluorescence resonance energy transfer (FRET) transition of Cyanine3 (Cy3) and Cyanine5 (Cy5) in a bacterial environment and providing on-demand treatment of infection via near infrared (NIR) light-triggered antibiotic release was developed. The smart hydrogel was prepared by physical crosslinking of polyvinyl alcohol (PVA) and an ultraviolet (UV)-cleavable polyprodrug (GS-Linker-MPEG), in which Cy3 and Cy5-modified silica nanoparticles (SNP-Cy3/Cy5) were loaded and acted as a pH-responsive fluorescent probe to detect bacterial infection based on the FRET effect between Cy3 and Cy5. Also, up-conversion nanoparticles (UCNP) were loaded into the hydrogels to cleave the UV-responsive GS-Linker-MPEG and achieve NIR-responsive release of GS in the bacterial environment. The in vitro studies proved that the smart hydrogels present good water absorption ability and excellent mechanical properties as well as good biocompatibility, which are necessary for their application in wound dressings. Moreover, the hydrogels showed obvious FRET transitions in both acidic buffer and bacteria solution. Upon irradiating the hydrogels with NIR light, UCNP were able to convert NIR light to UV light to trigger the release of GS from the hydrogels for antibacterial treatment. This research is expected to provide a new strategy for self-reporting and effective treatment of wound infection.
研究领域:
生物医学工程
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材料科学
·
感染生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Physical Chemistry C
·
2022
·
IF 4.177
Haoqi He,Yumin Zhang,Shuo Zhu,Jian Ye,Li Lin
Surface-enhanced Raman scattering (SERS) nanotags have garnered much attention for in vivo and intraoperative imaging due to their high sensitivity and intrinsic fingerprint spectrum. Recently, in vivo bioimaging at the second biological near-infrared (NIR-II) window has demonstrated significant advances with better spatial resolution and deeper tissue penetration. The development of SERS nanotags at the NIR-II window are therefore highly desired. The resonant strategy, i.e., the use of resonant substrates and resonant molecules, can be helpful in fabricating bright SERS nanotags at the NIR-II window; however, this strategy has not been demonstrated with the lack of quantitative assessments. Here we report a quantitative study on the Raman enhancements of the resonant strategy in preparing NIR-II SERS nanotags. By comparing the resonant and nonresonant plasmonic nanorod substrates, the resonant substrates have been shown to provide an enhancement factor of up to 4 orders of magnitude. When using the resonant Raman reporter molecules, SERS intensities can be further increased by 25–546 times. This work demonstrates the potential of the resonant strategy in fabricating ultrasensitive NIR-II SERS nanotags and provides insights into the design of related plasmonic devices.
研究领域:
生物医学工程
·
纳米技术
·
光谱学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Chenhui Ji,Yao Huang,Leilei Sun,Hongchao Geng,Wensheng Liu,Craig A. Grimes,Miaomiao Luo,Xinxin Feng,Qingyun Cai
The ability to accurately characterize microorganism distribution in the intestinal tract is helpful for understanding intrinsic mechanisms. Within the intestine, traditional optical probes used for microorganism labeling commonly suffer from a low imaging penetration depth and poor resolution. We report a novel observation tool useful for microbial research by labeling near-infrared-IIb (NIR-IIb, 1500–1700 nm) lanthanide nanomaterials NaGdF4:Yb3+,Er3+@NaGdF4,Nd3+ (Er@Nd NPs) onto the surface of Lactobacillus bulgaricus (L. bulgaricus) via EDC-NHS chemistry. We monitor microorganisms in tissue by two-photon excitation (TPE) microscopy and in vivo with NIR-IIb imaging. This dual-technique approach offers great potential for determining the distribution of transplanted bacteria in the intestinal tract with a higher spatiotemporal resolution.
研究领域:
生物医学工程
·
微生物学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 27
·2214497
·
IF 19
Zhichao Liu,Xue Yu,Qingpeng Peng,Xiaodie Zhu,Jianqiang Xiao,Jiangtao Xu,Shouxiang Jiang,Jianbei Qiu,Xuhui Xu
Mechanoluminescence (ML) materials with long-wavelength emission bands are essential for future in vivo bioimaging, non-destructive testing of solids, etc. The lack of a defined mechanism, however, prevents the application of near infrared ML materials above 650 nm in several new fields. Here, the addition of Ga 3+ ions to Y 3 Al 5 O 12 : Cr 3+ manipulates matrix microstructure evolution, boosting near-infrared (NIR) zero-phonon line (ZPL) stress optical output of the Cr 3+ ion at 688 nm. The key factor changing the crystal field intensity D q /B due to the addition of Ga 3+ ions is what causes the luminescence amplification of ZPL. The ML fabricated by composite polydimethylsiloxane and Y 3 Al 4 GaO 12 : Cr 3+ (YAGG: Cr 3+ ) may penetrate chicken feet epidermal tissue and 4 mm pork tissue thanks to the strong NIR ZPL emission of YAGG: Cr 3+ phosphor. This discovery of enhancing near-infrared ZPL intensity by solid solution provides us with a new technique for optimizing NIR ML materials, as well as a new prospect for NIR ML materials in biological applications.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
Materials Today Communications
·
2023
·
IF 3.8
Peng Wang,Shuang Liang,Xiaohua Li,Zhanying Sun,Haoran An,Na Li
High temperature can cause aging of materials , so it is urgent to investigate self-healing materials with low temperature positioning and self-healing ability. In this paper, water-based polyurethane/polypyrrole nanocomposites with NIR-induced self-healing properties (SWPUA/PPy) were prepared by mixing polypyrrole nanoparticles (PPy) as photo-thermal conversion agent with self-healing waterborne polyurethane emulsion (SWPUA). The effects of PPy content on thermal stability, mechanical properties and self-healing effects of SWPUA/PPy nanocomposites were investigated. The results showed that the addition of PPy had little effect on the chemical structure of SWPUA, and a small amount of PPy could make the material have excellent NIR-induced self-healing properties. When PPy content was 0.0125 wt %, the self-healing efficiency of NIR irradiation for 40 min was 89.25 %. Besides, the addition of PPy also improved the thermal stability and tensile strength of SWPUA/PPy samples.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Shunhu Zhang,Chun Tian,Xiaowu Jiang,Xiang Xu,Haitao Zhao,Jiyuan Sun,Lifen Zhang,Zhenping Cheng
To improve the solubility and recyclability of the NIR photocatalyst, two synthetic strategies, namely “living” polymers with permanent NIR photocatalyst by reversible addition-fragmentation chain transfer (RAFT) polymerization and “non-living” polymers with recyclable NIR macro-photocatalyst (macro-PC) by conventional radical polymerization, were developed by copolymerization of hydrophilic and polymerizable zinc phthalocyanine (ZnTAPc-MAm or ZnTAPc-Am) monomers. The resultant macro-PCs from RAFT polymerization were endowed with permanent NIR photocatalysis due to the attachment of zinc phthalocyanine moieties, and the features of both “living” and permanent NIR photocatalyst of the “living” macro-PCs were verified by much simple multiple chain extensions via RAFT polymerization in water (only involved in “living” polymers and fresh monomer) under irradiation with NIR LED light ( λ max = 730 nm) at room temperature. In addition, the resultant water-soluble “non-living” macro-PCs from conventional radical polymerization were endowed with only NIR photocatalysis property but they could be easily recycled just by centrifugation, which facilitates to synthesize tailored polymers by recyclable PCs under NIR irradiation.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2018
·Vol. 24
·期 71
·19060-19065
·
IF 5.16
Chunli Zhu,Haijing Shen,Haoyang Liu,Xiaobo Lv,Zhihao Li,Quan Yuan
Graphical Large-scale 2D α-In 2 Se 3 nanosheets were prepared by a solvent exfoliation technique. The obtained α-In 2 Se 3 nanosheets exhibit excellent near-infrared (NIR) photothermal performance under an 808 nm laser irradiation, which leads to a significant antibacterial effect. The excellent photothermal performance highlights the potential application in chemical and biological fields of α-In 2 Se 3 nanosheets. Two-dimensional (2D) nanoflakes represent an appealing class of materials for optoelectronics applications due to their unique layered structures and excellent electronic properties. However, the lack of easy-to-manipulate and effective methods for large-scale production of these 2D materials limits their potential for applications. Also, few efforts have been made to explore their applications in biological fields. This work reports the preparation of large quantities of 2D In 2 Se 3 nanosheets through a solvent exfoliation technique. Transmission electron microscopy and atomic force microscopy results show that the In 2 Se 3 nanosheets are obtained with lateral sizes of tens of nanometers to hundreds of nanometers and thickness of 2–17 layers. Raman features coupled with the X-ray diffractometry results unequivocally confirm the as-prepared In 2 Se 3 nanosheets to be α phase. Moreover, these α-In 2 Se 3 nanosheets exhibit an excellent near-infrared (NIR) photothermal performance under an 808 nm laser irradiation. NIR photo-excitation of the α-In 2 Se 3 nanosheets in the presence of bacteria leads to a significant antibacterial effect, suggesting that these nanosheets have great potential to be photothermal antibacterial agents. Our work on α-In 2 Se 3 nanosheets presents an available method for exfoliating 2D layered materials, and highlights the potential application in chemical and biological fields of α-In 2 Se 3 nanosheets.
研究领域:
材料科学
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纳米技术
·
生物医学工程
·
光电
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DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-10
·
IF 10.6
Hu Yulin,Xu Baoqi,Li Wei,Liang Lin,Fei Fan,Lin Quankui
The human cannot detect light with a wavelength exceeding 700 nm, primarily due to limitations in the physiological structure of the human eye. However, in certain specific scenarios, the ability to detect near-infrared (NIR) light proves to be extremely valuable. To attain this desired capability, NIR up conversion nanoparticles (UCNPs) were prepared and doped in the optical lens materials, aiming to obtain a NIR light “visible” optical lens. It is demonstrated that the doping of UCNPs in the optical lens materials does not significantly impact on their mechanical properties, optical properties, surface properties and it exhibits excellent biocompatibility in cell and animal experiments. More importantly, the UCNPs doping can convert NIR light into visible light within the material effectively and stably. The eyes can “see” the NIR light after wearing such UCNPs doped optical lens. Such NIR light visible optical lens could have great potential in actual applications.Graphical Abstract
研究领域:
光学
·
纳米技术
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2021
·
IF 4.598
Chunqing Niu,Xinyu Liu,Yiyu Wang,Xiang Li,Jian Shi
In order to realize effective controlled release of medicine to specific sites, the near-infrared (NIR) light responsive hydrogel has recently attracted noticeable attention as an innovative vehicle for a reserving and releasing the drug remotely “on demand” via stimuli-responsive NIR irradiation on/off. Herein, a modulated drug delivery platform was developed based on a silk fibroin (SF)/sodium alginate (SA) composite hydrogel incorporated with indocyanine green (ICG) as components. The gelation time of the crosslinked composite hydrogel ranged from 15 to 35 min, mainly depending on the concentration of SF. These materials are typical elastic hydrogels display stiffness between 260 and 2210 Pa. Besides, the compressive modulus E of the hydrogels varied in the range of 0.89–1.71 kPa by changing blend ratios. Scanning electron microscope (SEM) revealed the hydrogels showed highly porous (~89%) and tailored pore size in the range of 132–215 µm. And SF mainly remained silk I structure in the composite hydrogel and bovine serum albumin (BSA) and tetracycline hydrochloride (TH) still kept their own structure after encapsulation. SF/ [email protected] hydrogels exhibited desirable stability and swelling properties. Additionally, these hydrogel extracts displayed good cellular compatibility in vitro . Under near-infrared (NIR) radiation exposure, the hydrogels exhibited photothermal properties such as temperature rise by 8 °C, sufficient to stimulate drug release. Furthermore, hydrogels demonstrated NIR stimulated drug release, which was evaluated using BSA and TH, the drug loaded photothermal hydrogels can effectively increase the amount of drug released under NIR light trigger for just 1 min. The NIR-responsive hydrogels can provide a new option for developing natural ploymer based delivery vehicles to regulate drug release on demond using NIR irradiation remotely.
研究领域:
材料科学
·
药剂学
·
生物医学工程
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产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2023
·Vol. 35
·期 25
·2300615
·
IF 29.4
Shuxin Wei,Wei Lu,Huihui Shi,Shuangshuang Wu,Xiaoxia Le,Guangqiang Yin,Qingquan Liu,Tao Chen
Intelligent rewritable display systems have been long expected to reduce the heavy consumption of single-use or transient devices in the age of Internet-of-Things. However, it remains challenging to construct such systems with integrated functionality of remote control, rapid activation, multicolor and multimode display. Herein, by learning from the unique multilayer arrangement of chromatophores in chameleon skins, a promising kind of rewritable hydrogel multicolor systems is presented that can combine the merits of near-infrared (NIR) light-writing and projecting modes for on-demand information display. Specifically, the systems have typical multilayer layout consisting of poly(dimethylsiloxane) (PDMS)-sealed carbon nanotubes (CNTs) film as photothermal control unit and embedded fluorescent hydrogels as multicolor display unit, in which thermoresponsive hydrogel is constrained within non-responsive hydrogel. Such rational structure design results in the establishment of one promising display mechanism via the cascading “light trigger–heat generation–fluorescence output” process. On this basis, rapid and reversible hand-written display of arbitrary information is achieved within 5 s. Also, sustainable light-projecting display of predesigned multicolor patterns is demonstrated due to the multilayer design that ensures easy patterning of photothermal control or hydrogel display layer. This study brings functional-integrated merits for novel rewritable display systems and open new possibility to construct high-end products for information display/transmission.
研究领域:
材料科学
·
光电技术
·
显示技术
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
InfoMat
·
2024
·
IF 22.7
Huan Li,Yu Gao,Xin Hong,Kanghui Ke,Zilong Ye,Siwei Zhang,Kefei Shi,Zhuo Peng,Hao Yan,Man-Chung Tang,Youwei Yao,Ben Zhong Tang,Guodan Wei,Feiyu Kang
Broadband photodetectors (PDs) capable of multi-wavelength detection have garnered significant interest for applications in environmental monitoring, optical communication, spectral analysis, and imaging sensing. Low-bandgap Pb–Sn hybrid perovskite photodetectors can extend the spectral response from the ultraviolet–visible (UV–vis) range to the near-infrared (NIR) and reduce the toxicity associated with Pb 2+ . The strategic introduction of Sn 2+ into Cs 0.15 FA 0.85 Pb x Sn 1− x I 3 ( x = 1, 0.8, 0.6, 0.5, 0.4, 0.2, and 0) not only preserves the cubic crystal structure with conformal multigrain growth but also broadens the film's absorption spectrum from 800 to 1000 nm NIR region. This indicates a well-controlled tunability of the Pb–Sn binary perovskite system. Specifically, the self-powered photodetector with a device structure of ITO/NiO x /PTAA/Cs 0.15 FA 0.85 Pb 0.5 Sn 0.5 I 3 /PCBM/BCP/Ag has shown remarkable optoelectrical properties. It exhibits a high external quantum efficiency (EQE) of up to 80% across the spectrum from 300 to 1000 nm, a responsivity ( R ) exceeding 0.5 A/W, and high detectivity ( D *) value of 1.04 × 10 12 Jones at 910 nm and 3.38 × 10 11 Jones at 1000 nm after weak attenuation. Intriguingly, the dark current of the Cs 0.15 FA 0.85 Pb 0.5 Sn 0.5 I 3 device is four orders of magnitude lower than that of devices made with pristine Pb or Sn only, strongly correlating with its significantly increased built-in potential and reduced trap density. Consequently, it demonstrates a −3 dB bandwidth of 2.23 × 10 4 Hz, fast rise and decay times of 61 and 30 μs, respectively, and a linear dynamic range (LDR) of 155 dB. Benefiting from its high sensitivity, a 5 × 5 PD array for NIR imaging and non-invasive pulse detection for photoplethysmography applications has been successfully demonstrated, showcasing the prosperous potential of Pb–Sn hybrid perovskite in the NIR range.
研究领域:
材料科学
·
光电子学
·
成像技术
·
传感器与执行器
✓ 已验证
DOI
高影响因子
DYES AND PIGMENTS
·
2022
·
IF 5.122
Feng Lu,Lili Li,Ting Zhao,Bingqiang Ding,Jiawei Liu,Qi Wang,Chen Xie,Quli Fan,Wei Huang
Fluorescence imaging at longer wavelength and autofluorescence-free imaging were two main strategies to improve the optical imaging performance of traditional near-infrared (NIR) fluorescence imaging, and the design of corresponding imaging agents were heavily explored recently. Herein, polymer-blend dots (PBdots) with strong fluorescence and afterglow luminescence in both NIR-I (700–900 nm) and NIR-II (900–1700 nm) windows were successfully fabricated by encapsulating two functional semiconducting polymers into one nanoparticle . With efficient intra-particle interactions, the PBdots exhibited an afterglow lifetime of 181 s after 730 nm NIR laser activation, which can be activated in vivo. The obtained PBdots with similar emission intensities in NIR-I and NIR-II regions enable fair comparison between different optical imaging modalities , which provides a clear guidance for the choice of suitable imaging modality for different purpose. As the first imaging agents which integrate NIR-II fluorescence imaging and NIR-I afterglow imaging, the PBdots also provide both high resolution and large signal-to-background ratio for blood vessel, lymph node and tumor imaging in living mice.
研究领域:
材料科学
·
生物医学工程
·
光学
·
纳米技术
·
成像科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）