ENVIRONMENTAL POLLUTION
·
2021
·
IF 8.071
Yi-Huan Xu,Christer Hogstrand,Yi-Chuang Xu,Tao Zhao,Hua Zheng,Zhi Luo
Oxytetracycline (OTC) and Cu are prevalent in aquatic ecosystems and their pollution are issues of serious concern. The present working hypothesis is that the toxicity of Cu and OTC mixture on physiological activity of fish was different from single OTC and Cu alone. The present study indicated that, compared to single OTC or Cu alone, Cu+OTC mixture reduced growth performance and feed utilization of grass carp, escalated the contents of Cu, OTC and TG, increased lipogenesis, induced oxidative stress , damaged the mitochondrial structure and functions and inhibited the lipolysis in the liver tissues and hepatocytes of grass carp. Cu+OTC co-treatment significantly increased the mRNA abundances and protein expression of Nrf2. Moreover, we found that Cu+OTC mixture-induced oxidative stress promoted Nrf2 recruitment to the SREBP-1 promoter and increased SREBP-1-mediated lipogenesis; Nrf2 sited at the crossroads of oxidative stress and lipid metabolism , and mediated the regulation of oxidative stress and lipid metabolism. Our findings clearly indicated that OTC and Cu mixture differed in environmental risks from single antibiotic or metal element itself, and thus posed different toxicological responses to aquatic animals. Moreover, our findings suggested that Nrf2 functioned as an important antioxidant regulator linking oxidative stress to lipogenic metabolism, and thus elucidated a novel regulatory mechanism for lipid metabolism.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Xueying Yang,Jian Zhang,Ming Xu,Xiangdong Zhang,Junlian Ren,Haina Bai
The advanced oxidation technology of persulfate has great potential in removing pollutants. Appropriate bimetallic activation method has obvious synergistic effect on the formation of free radicals and non-free radicals, and can also promote the electron transfer process. Therefore, in this paper, Ni was doped on the iron-based metal organic framework (MIL-88A) to form bimetallic catalyst and used as persulfate activator for oxytetracycline (OTC) degradation. The introduction of Ni increased the specific surface area of the catalyst and significantly improved its catalytic performance. Within 30 min, the degradation efficiency of 5 mg/L OTC reached 81.30%. The used catalyst can be simply recovered by standing, and the catalytic stability is high. The composition of main reactive oxygen species (ROS) in pollutant decomposition was clarified through the analysis of degradation mechanism. In addition to typical •OH、SO 4 •− and O 2 •− , non-free radical 1 O 2 was also generated. Based on LC-MS detection and toxicological experiments, the possible degradation pathways were proposed and the toxicity was analyzed. This material provides a new insight for activating PS to remove refractory organic compounds, and promotes the application of Fe-MOF materials in environmental pollution remediation.
✓ 已验证
产品关联
DOI
高影响因子
Results in Engineering
·
2025
·
IF 7.9
Ning Wang,Yingqi Luo,Xiaoxiao Yang,Hejia Sun,Yonghong Liu,Yunfeng Li
The pervasive contamination of water bodies by antibiotics necessitates the development of efficient remediation technologies. Herein, A visible-light-responsive BiOI/TiO 2 p-n heterojunction photocatalyst was engineered through a facile solvothermal approach, achieving exceptional oxytetracycline (OTC) degradation in simulated complex aquatic environments. The optimized BiOI/TiO 2 (2:1) composite degraded 92.8% of 20 mg/L OTC within 90 min––2.3-fold and 3.1-fold faster than pristine BiOI and TiO 2 , respectively––while exhibiting a record-high specific degradation rate ((SDR): 5.16×10⁻ 5 mg/(g·W·min)). Systematic characterizations (XPS/EIS/EPR) revealed that the built-in electric field at the p-n interface spatially separates charges, suppresses recombination by 54.5%, and extends carrier lifetime. Crucially, the composite maintained >85% efficiency in saline (0.1 M NaCl) and organic-rich water (20 mg/L HA), with <6% activity loss after 5 cycles due to Bi-O-Ti interfacial stabilization (XRD/ICP-MS). Mechanistic studies identified dual reactive pathways: h + -directed oxidation (primary) and ·O 2 ⁻-mediated cleavage (secondary), achieving >70% mineralization (TOC). This work provides a scalable interfacial engineering strategy for designing robust photocatalysts applicable to antibiotic-contaminated wastewater.
✓ 已验证
产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Zhipeng Dai,Lu Zhao,Shuchuan Peng,Zhengbo Yue,Xinyuan Zhan,Jin Wang
The regulation of surface electrons by non-metal doping of biochar (BC) is environmentally and ecologically significant. However, systematic studies on the regulation of surface electrons by transition metal doping are lacking. The present study is based on the observation that the removal efficiency of oxytetracycline (OTC) by Mn-doped BC is eight times higher than that of undoped BC in 20 min. The effects of Mn doping on the crystal phase formation, persistent free radicals (PFRs), electron density, molecular orbitals, and nucleophilic active sites of BC are investigated, and the intermediate products of OTC are evaluated. Mn doping enhances the signal for sp 2 -hybridised carbon–carbon double bond, forms more delocalised π-bonds, and promotes the formation of free radicals centred on the carbon atoms. The specific surface area of BC increases, and manganese oxide is formed on the its surface. Density functional theory calculations show that Mn doping accelerates the electron transfer of BC, provides additional electrons for the BC system, and makes this system more ionised. OTC molecules preferentially attack the nucleophilic reaction sites near Mn atoms based on molecular electrostatic potential measurements. Therefore, this study provides new insights into the surface electronic structures regulated by transition metal elements.
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Rongjie Yi,He Guo,Huijuan Wang,Daolin Du,Qi Zhang,Chengwu Yi
In this study, the degradation of oxytetracycline (OTC) in aqueous solution by humid O 2 strong ionization dielectric barrier discharge (DBD) with a 2.2 t/h large volume was investigated. Based on the electron spin resonance (ESR) results and the detection of O 3 and H 2 O 2 concentrations, the existence of high concentrations of hydroxyl radicals ( OH) (0.85 mmol/L), O 3 (14.2 mg/L), and H 2 O 2 (63.3 mg/L) produced via humid O 2 strong ionization discharge DBD was verified. In addition, the effects of the reaction conditions, including the input voltage (2.1–3.8 kV), the initial pH value (3.1–10.3), the OH inhibitors, the inorganic ions, and the natural organic matter (NOM), on the OTC degradation efficiency were measured, and the optimal parameters were determined based on the results of single factor experiments. The results showed that the OTC removal efficiency and the kinetic constant can be increased by enhancing the input voltage, and about 93.7% of the OTC was removed at 3.8 kV and in a neutral pH (6.9) solution. The presence of OH inhibitors, inorganic ions and NOM in the solution can reduce the OTC removal efficiency and the kinetic constant. Moreover, compared to dry O 2 strong ionization dielectric DBD, the active particle yield ( OH, O 3 , H 2 O 2 ), the kinetic constant, and the TOC removal by humid O 2 strong ionization discharge DBD were better. Subsequently, five main by-products were identified and four different transformation pathways, including hydroxylation (+16 Da), deamidation (−46 Da), demethylation (−14 Da), and dehydration (−18 Da), were observed. In addition, the acute toxicity of the intermediates was reduced, but the mutagenicity of the biotoxicity was positive.
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Sitong Huang,Jia Sun,Ke Xiao,Wenqing Zhang,Yuanlan Wang,Leixia Meng
To tackle the issue of interference from structural analogs in oxytetracycline (OTC) detection and to meet the growing demand for food safety monitoring, a photoelectrochemical (PEC) sensor employing molecular imprinting on a MOF-on-MOF heterojunction as photoactive substrate was constructed to achieve selective and accurate determination of OTC. The solvothermal and stirring synthesis of the MIL-125-NH 2 @Cu-hemin MOF heterojunction exhibit enhanced photocurrent, owing to efficient charge separation and expanded light absorption. The molecularly imprinted polymer (MIP) featured specific cavities to selectively capture OTC and regulate interfacial electron transfer. Under optimal conditions, the sensor showed a wide linear range (0.1 nmol L −1 –10 mmol L −1 ), a low detection of limit (LOD) of 42 pmol L −1 , and a limit of quantification (LOQ) of 140 pmol L −1 . By combining heterojunction-optimized photoelectric properties with MIP-based selective recognition, the sensor successfully detected OTC in complex food matrices, demonstrating its potential for food safety.
✓ 已验证
DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 23
·4306
·
IF 5.719
Huifang Wu,Mengqi Xu,Yubing Chen,Haoliang Zhang,Yongjun Shen,Yanfeng Tang
The specific detection of oxytetracycline (OTC) residues is significant for food safety and environmental monitoring. However, rapid specific determination of OTC from various tetracyclines is still challenging due to their similar chemical structures. Here, nitrogen-doped carbon dots (NCDs) with excitation and pH-dependent optical properties and a high-fluorescence quantum yield were successfully synthesized, which were directly employed to fabricate a dual-response fluorescence probe by self-assembly with Eu3+(NCDs/Eu3+) for the ratiometric determination of OTC. The addition of OTC into the probe greatly enhances the characteristic emission of Eu3+due to the “antenna effect”, and the incorporation of NCDs into the probe further improves the Eu3+fluorescence by remarkably weakening the quenching effect caused by H2O molecules and efficiently shortening the distance of energy transfer from OTC to Eu3+. Meanwhile, the fluorescence of NCDs apparently decreases due to aggregation-caused quenching. The results demonstrate that a ratiometric detection of OTC (0.1–25 µM) with a detection limit of 29 nM based on the double response signals is achieved. Additionally, visual semi-quantitative assay of OTC can be realized with the naked eye under a 365 nm UV lamp according to the fluorescence color change of the as-fabricated probe. This probe exhibits acceptable specificity and anti-interference for OTC assay, holding promise for the fast detection of OTC in real water and milk samples.Keywords:oxytetracycline;nitrogen-doped carbon dots;lanthanide;ratiometric;visual analysis
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Huihui Jiang,Qian Liu,Hang Zhang,Peilin Yang,Tianyan You
The development of effective strategies for the detection of oxytetracycline (OTC) in soil is of great importance for preserving agri-environmental safety and human health. Herein, a novel photoactive material of metal-organic framework (MOF) derived ZnO nanopolyhedra/graphitic carbon nitride (ZnO/g-C 3 N 4 ) heterojunction was designed by mixing calcination of zeolite imidazole framework-8 (ZIF-8) and melamine . A self-powered photoelectrochemical aptasensor for the sensitive and selective detection of OTC in soil was proposed using ZnO/g-C 3 N 4 as the photoanode . The photoactivity of the MOF derived ZnO nanopolyhedra was regulated effectively by the introduction of g-C 3 N 4 , which resulted in a 7-fold increase in the photocurrent of the ZnO nanopolyhedra at a bias potential of 0 V. It was assigned to the higher carrier density of ZnO/g-C 3 N 4 . By virtue of the amplified photocurrent of ZnO/g-C 3 N 4 , the specificity of the OTC aptamer and the anti-interference ability of the self-powered sensing method, the designed aptasensor demonstrated the advantages of a wide linear range (0.005–200 nM), low limit of detection (1.49 × 10 −3 nM), good selectivity and good reproducibility. For real soil sample analysis, satisfactory recoveries were obtained and further verified by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Li Tian,Shuning Yang,Guangping Ma,Pengfei Han,Hanyue Jiang,Wenzhuo Wang,Juan Lu
The electrochemiluminescence (ECL) sensor for detecting oxytetracycline (OTC) was constructed by sequentially modifying luminol@β-cyclodextrin (β-CD) and Ni-MOF@Pt NPs on the electrode surface. In this platform, luminol serves as a luminescent reagent, and Pt NPs serve as co-reaction accelerators of the system. β-CD and Ni-MOF are used as carriers to carry luminol and Pt NPs respectively, and the luminescence intensity was further improved by increasing the carrying capacit. In addition, the OTC quenching strategy is adopted, and the constructed sensor is based on the energy transfer of luminol. Under optimal conditions, this sensor exhibited the linear detection range of OTC was found to be between 2.0 × 10 −12 M to 2.0 × 10 −7 M, with a detection limit of 6.7 × 10 −13 M (S/N = 3). The sensor showed good high selectivity and ultra-sensitivity, and obtained satisfactory results when detecting honey and milk samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2024
·
IF 7
Yang Qiu,Fujie Yan,Huilin Yu,Honghao Li,Shengyao Xia,Jie Zhang,Jiajin Zhu
The antibiotic oxytetracycline (OTC) can be detected in contemporary natural aquatic environments and has been implicated in causing intestinal damage in humans exposed to OTC-contaminated food or water. The irreversible damage caused by high concentrations of OTC to the intestine suggests that treatment through dietary means could still be necessary. This study proved the effectiveness of kefir extract (KE) in reversing intestinal damage caused by oxytetracycline (OTC) exposure. Following a 24-hour KE treatment subsequent to OTC exposure from 3 to 8 days post-fertilization of zebrafish larvae, molecular-level and microbiomic assessments revealed significant improvements. These included reduced expression of proinflammatory factors (IL-8 and IL-1β), increased antioxidant levels, and reversed unhealthy distribution of intestinal microbiota. Furthermore, KE supplementation showed potential in enhancing intestinal motility in the experiment of Nile red staining and fluorescent microbead transit. However, histological analysis showed that this short-term treatment with KE only partially reversed the intestinal morphological changes induced by OTC, suggesting that a longer treatment period might be necessary for complete restoration.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2015
·
IF 4.169
Yunyun Sun,Jing Tian,Lu Wang,Hongyuan Yan,Fengxia Qiao,Xiaoqiang Qiao
A simple and time-saving one pot synthesis of magnetic graphene/carbon nanotube composites (M-G/CNTs) was developed that could avoid the tedious drying process of graphite oxide, and G/CNTs were modified by Fe 3 O 4 nanoparticles in the reduction procedure. It contributed to a shorten duration of the synthesis process of M-G/CNTs. The obtained M-G/CNTs were characterized and the results indicated that CNTs and Fe 3 O 4 nanoparticles were served as spacer distributing to the layers of graphene, which was beneficial for enlarging surface area and improving extraction efficiency. Moreover, M-G/CNTs showed good magnetic property and outstanding thermal stability. Then M-G/CNTs were applied as adsorbent of magnetic dispersive solid-phase extraction for rapid extraction and determination of oxytetracycline in sewage water. Under the optimum conditions, good linearity was obtained in the range of 20–800 ng mL −1 and the recoveries were ranged from 95.5% to 112.5% with relative standard deviations less than 5.8%.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AQUATIC TOXICOLOGY
·
2026
·
IF 4.3
Junyue Zheng,Chen Wang,Miaomiao Teng,Tong Li,Jiazhen Jiang,Xiangguang Chen,Fengchang Wu
Glyphosate (Gly) is the most commonly used herbicide in the world. Glyphosate and its main degradation product, aminomethylphosphonic acid (AMPA), are often detected in aquatic environments and may pose a threat to the health of aquatic organisms. It is well established that Gly is mainly enriched in the intestine and degraded into AMPA. However, it remains unclear whether they disrupt the gut microbiota and cause liver health effects, as well as whether they have a synergistic effect with antibiotics. We investigated herein the effects of zebrafish exposure to Gly, AMPA and oxytetracycline (OTC) alone or in combination on the gut-liver axis. Our results suggest that Gly, AMPA, and OTC induce lipid accumulation, inflammatory response and oxidative damage in the liver, which is associated with a higher Firmicutes/Bacteroidetes ratio in the intestine and a higher levels of lipopolysaccharide in serum. Compared with the single exposure groups (OTC, Gly, and AMPA), the toxic effects of the gut-liver axis were more severe in the combined exposure groups (Gly+OTC, AMPA+OTC). Our results indicate that the health risks posed by Gly, AMPA and OTC through the gut microbiota of aquatic organisms are a neglected hot spots.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）