Soft Matter
·
2012
·Vol. 8
·期 23
·6364-6370
·
IF 4.39
Fenggui Chen,Chunliang Li,Xiaoyan Wang,Guangming Liu,Guangzhao Zhang
In the present study, by use of the atom transfer radical polymerization (ATRP) method, we have prepared well-defined 6-arm star-shaped poly[2-(dimethylamino)ethyl methacrylate] (PDEM) and poly(acrylic acid) (PAA) containing a fluorescent triphenylene core and have studied the pH and ion-species sensitive fluorescence properties of such two star polyelectrolytes. The results obtained by analytical ultracentrifugation indicate that the star PDEM molecules will aggregate together as the pH increases over the pKa but the star PAA molecules will keep a monomeric state over the whole pH range. For both PDEM and PAA, the fluorescence intensity decreases with increasing pH, indicating that the fluorescence intensities of PDEM and PAA are dominated by aggregation induced fluorescence quenching and the chain conformation controlled nonradiative relaxation, respectively. This suggestion is further confirmed by the fact that the star PDEM molecules can form excimers at high pHs and no excimer emission peak can be observed for the star PAA molecules. In the studies of ion-specific fluorescence properties at different pH, for both of the two polyelectrolytes, the ion specificity is determined by the counterion condensation for the charged chains, whereas nonelectrostatic ion adsorption governs the specific ion effect for the uncharged chains.
研究领域:
高分子化学
·
物理化学
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DOI
高影响因子
Polymers
·
2025
·Vol. 17
·期 9
·1204
·
IF 4.9
Yi Guo,Cheng Yao
In this study, polymerized silicone surfactants were modified with polyether and tertiary amine groups with the aim of improving the surface performance. Various PSiEO/(PO)-OH(CH3) surfactants were synthesized and their structures and performance were characterized through1H NMR, FTIR spectroscopy, static surface tension, dynamic surface tension, zeta potential, and dynamic light scattering measurements. Subsequently, the modified silicones were incorporated as surfactants in aqueous solutions with different pH values. The surfactants with different hydrophobic/hydrophilic groups and end-capping groups exhibited different surface performances over a wide pH range. Thermodynamic parameters indicated that the micellization and adsorption of these surfactants were endothermic and spontaneous processes driven by entropy. The processes were hindered by increasing the solution pH and modification with hydrophobic groups. The aggregation behavior was significantly different under acidic, neutral, and basic aqueous conditions.
研究领域:
材料科学
·
表面化学
·
物理化学
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DOI
PubMed
高影响因子
ACS ES&T Water
·
2025
·
IF 4.3
Wen-Long Wang,Peng-Hui Liu,Jung-Hyun Son,Hang Su,Min-Yong Lee,Hong-Ying Hu,Qian-Yuan Wu,Uwe Hübner
The combination of ozonation and Mn(II) (O3/Mn(II)) is expected to synergistically eliminate recalcitrant organic micropollutants in water. However, the decay of O3, formation of •OH and reactive manganese species (RMnSs), and synergism in micropollutant degradation have not been comprehensively understood. Herein, the synergism of O3 and Mn(II) was observed to be pH-dependent. Compared to ozonation alone, O3/Mn(II) preferentially formed Mn(V and VI) and slightly increased •OH yield (from 0.22 to 0.30) at acidic pH 4–5, while it preferentially formed Mn(VII) and significantly increased OH yield (from 0.52 to 0.74) at circumneutral pH 6–7. Thereafter, O3/Mn(II) prominently increased RMnS exposure at acidic pH, while it dramatically diminished O3-exposurse to increase •OH exposure at circumneutral pH. As a result, O3/Mn(II) outperformed ozonation alone for the degradation of various O3-resistant micropollutants (3.7–7.9 times faster). For example, the RMnSs (82.7% contribution) and •OH (84.2% contribution) were the dominant contributors to the degradation of the isothiazolinone biocide (5-chloro-2-methyl-4-isothiazolin-3-one) at acidic and circumneutral pH, respectively. Mn(II) can enhance the removal of O3-resistant micropollutants in relatively clean waters (e.g., tap water), but its effectiveness was limited in more contaminated waters (e.g., WWTP effluent). These findings support the practice and pH optimization of the O3/Mn(II) in various water types.
研究领域:
环境科学
·
水处理工程
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DOI
高影响因子
Gels
·
2024
·Vol. 10
·期 12
·840
·
IF 5
Xinxia Zhang,Yafeng Ding,Jiangtao Zhou,Qianqian Xu,Ting Li,Li Wang
The study aimed to prepare complex gels of sonicated quinoa protein (QP) and polysaccharides, comparing the effects of different protein components and pH on gel properties. FTIR analysis demonstrated that the β-structure in protein at pH 7.0 was enhanced by ultrasonic treatment, which could promote the formation of a gel network. Moreover, XG-AG (gel prepared by xanthan gum and albumin) and XG-GG (gel prepared by xanthan gum and globulin) exhibited higher levels of disulfide bonds and free sulfhydryl groups in the gel, requiring more energy to break the intermolecular sulfide bonds during heating. Under the same heating conditions, the rheological properties and gel strength of XG-UQPG (gel prepared by xanthan gum and ultrasonically treated QP) were superior to those of XG-UGG (gel prepared by xanthan gum and ultrasonically treated globulin) and XG-UAG (gel prepared by xanthan gum and ultrasonically treated albumin). Additionally, XG-UGG (pH 7.0) demonstrated the highest water holding capacity (WHC) and oil holding capacity (OHC). This was attributed to the disulfide bonds created in the proteins by the ultrasound treatment, encouraging them to interact to form more uniform holes in gel that can hold more water/oil molecules. Conversely, at pH 4.5, the WHCs of the gels were reduced due to the presence of rougher protein structures. These findings shed light on the impact of protein composition on gel properties and offer insights into enhancing the quality of quinoa protein gel.
研究领域:
食品科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Kai Dong,Qiuya Lei,Runhao Guo,Xianglong Wu,Yanni Zhang,Ning Cui,Jian-Yu Shi,Tingli Lu
Purpose: The levels of reactive oxygen species (ROS) in tumor cells are much higher than that in normal cells, and rise rapidly under the influence of exogenous or endogenous inducing factors, eventually leading to the apoptosis of tumor cells. Therefore, this study prepared a dual pH/reducing-responsive poly (N-isopropylacrylamide-co-Cinnamaldehyde-co-D-α-tocopheryl polyethylene glycol 1000 succinate, PssNCT) nanogels, which employed two exogenous ROS inducers, cinnamaldehyde (CA) and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), to selectively induce apoptosis by regulating ROS levels in tumor cells.Methods: The PssNCT nanogels were prepared by the free radical precipitation polymerization under the crosslink between pH-sensitive hydrazone and reducing-sensitive disulfide bonds, followed by the physicochemical and morphological characteristics investigations. Plasma stability, dual pH/reducing responsive degradation and in vitro release were also assessed. In cell experiments, cytotoxicity in different cells were first detected. The intracellular ROS levels and mitochondrial functions of tumor cells were then evaluated. Moreover, the apoptosis and western-blot assays were employed to verify the association between ROS levels elevation and apoptosis in tumor cells.Results: The nanogels exhibited a round-like hollow structure with the diameter smaller than 200nm. The nanogels were stable in plasma, while showed rapid degradation in acidic and reducing environments, thus achieving significant release of CA and TPGS in these media. Furthermore, the sufficient amplification of ROS signals was induced by the synergistically function of CA and TPGS on mitochondria, which resulted in the opening of the mitochondrial apoptotic pathway and enhanced cytotoxicity on MCF-7 cells. However, nanogels barely affected L929 cells owing to their lower intracellular ROS basal levels.Conclusion: The specific ROS regulation method achieved by these nanogels could be explored to selectively kill tumor cells according to the difference of ROS signals in different kinds of cells.
研究领域:
肿瘤学
·
药剂学
·
生物化学
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Zhongjiao Feng,Jiasheng Wu,Meiyu Jiang,Jie Sha,Weimin Liu,Haohui Ren,Wenjun Zhang,Chun-Sing Lee,Pengfei Wang
The pH homeostasis of Golgi plays a vital role in maintaining normal cell functions. An effective near-infrared fluorescent probe that can sense pH changes in Golgi apparatus is of great significance. Here, a Golgi-targeting fluorescent probe ( Golgi-hNR) based on a rhodamine derivative is presented to show a highly sensitive response to pH variations. Golgi-hNR displays a conspicuous pH-dependent behavior at 664 nm from pH 7.4–3.0 with a remarkable fluorescence off-on response. The pKa value of Golgi-hNR is measured to be 3.62. Confocal fluorescence imaging reveals that Golgi-hNR diffuses into Golgi with high selectivity . Using Golgi-hNR , we have successfully visualized real-time tracking of Golgi pH variations for medical therapy in living cells.
研究领域:
细胞生物学
·
医学
✓ 已验证
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Xuedi Ma,Zheng Zhang,Zhao Li,Zhengzong Wu,Lu Lu,Katsuyoshi Nishinari,Meng Zhao,Bo Cui
The impact of phase separation behavior on the performance of hydrogels has always been the research focus. This study explored the relationship of “pH-microstructure-hydrogel properties” of phase-separated hydrogels composed of type-A gelatin (GE, 5 wt%) and hydroxypropyl starch (HPS, 3 wt%). The results revealed that changes in the microstructure of the hydrogel at different pHs significantly impacted the gel properties. At pH 4.00 and 11.00, phase separation occurred in the GE/HPS gel with a microstructure of HPS-in-GE. In particular, at pH 5.00, 6.00, 7.00, and 9.00, severe phase separation resulted in the separation of substantial aggregates of HPS and GE, resulting in a continuous phase structure. At pH 2.00 and 3.00, phase separation was suppressed, resulting in a homogeneous microstructure. Compared to the phase-separated gels at pH 4.00–11.00, the homogeneous systems at pH 2.00 and 3.00 displayed a synergistic effect with higher gel strength. Analysis of intermolecular forces in the GE/HPS gel indicated that hydrogen bonding was the primary interaction force. Furthermore, the addition of GE/HPS into hawthorn jelly at about pH 3.00 effectively preserved the structural appearance and exhibited higher levels of hardness, thus improving the sensory properties of hawthorn jelly. In summary, phase separation decreased the storage modulus of GE/HPS gel, but the compatibility of GE/HPS macromolecules exhibited synergistic effects at 2.00 and 3.00 and improved the hydrogel mechanical properties. This work provides some new insights for GE/HPS-based gel foods.
研究领域:
食品科学
·
材料科学
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产品关联
DOI
高影响因子
CELLULOSE
·
2024
·
IF 4.9
Zhang Yu-Ping,Zhao Chang-Hua,Yuan Pei,Wan Li
Materials with stimulus-responsive wettability are attracting increasing attention because of their potential applications in oil/water separation and oil spill remediation. Herein, a pH-responsive filter paper was rapidly fabricated by initially forming a complex between TiO 2 and octadecylamine, followed by immersion in an ethanolic solution of SiO 2 nanoparticles. The resultant filter paper exhibited superhydrophobicity and superoleophilicity in air when the solution pH was greater than 6.0, whereas it became superhydrophilic and superoleophobic when the solution pH was less than 2.0. The treated filter paper was used for the controllable separation of complex oil/water/oil ternary mixtures, demonstrating its strong response to pH changes. The pH-responsive filter paper effectively separated both immiscible oil/water mixtures and different kinds of oil-in-water emulsions with separation efficiencies exceeding 99%. The durability of the pH-responsive filter paper was demonstrated by its ability to maintain a separation efficiency of around 99%, even after 25 cycles of separating a typical emulsion of tetrachloromethane in water. The developed approach has the potential to provide innovative smart materials for the treatment of oil-contaminated wastewater. Graphical abstract
研究领域:
材料科学
·
环境科学
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Meihui Gao,Xianjing Zhang,Shiqi Li,He Gao,Xinyu Li,Dongyuan Xu,Longbin Xu
Background Wearable pH sensors have emerged as promising tools for real-time health monitoring, particularly for sports and clinical applications, due to their ability to monitor key physiological indicators such as sweat pH. Sweat analysis provides valuable insights into metabolic processes and physical exertion. However, the development of flexible, stable, and highly sensitive sensors for accurate sweat pH detection remains a challenge. Conductive polymer such as polyaniline (PANI), have gained attention due to their unique properties, but further improvements in mechanical flexibility and sensor performance are needed to fully realize their potential for wearable biosensing applications. Results We present a boric acid-functionalized PANI-ABA/PA hydrogel, synthesized via electrochemical deposition, where boric acid plays a crucial role in crosslinking the rigid PANI material into a flexible, porous grid structure. This crosslinking improves the mechanical properties of the hydrogel while enhancing its ion-exchange capacity, leading to greater sensitivity and selectivity for H + ions. PANI-ABA/PA hydrogel exhibits super-Nernstian behavior (77.80 mV pH −1 ) across the physiological pH range (3.00–10.00), with rapid response times, minimal temperature drift, and excellent repeatability. Moreover, the hydrogel exhibits outstanding antifouling properties, ensuring consistent performance even in dynamic environments. Real-time human subject testing confirms the sensor's ability to accurately monitor sweat pH during physical activity, providing reliable and real-time data. These results highlight the promising potential of the PANI-based hydrogel for wearable biosensors in health monitoring. Significance and novelty This study highlights the role of boric acid in facilitating the formation of a crosslinked PANI-based grid structure, which improves the sensor's performance in wearable applications. Enhanced sensitivity, stability, and mechanical flexibility make this smart wearable sensor a promising candidate for continuous, non-invasive health monitoring. It opens new opportunities for real-time athletic performance tracking, personalized healthcare, and disease diagnostics, positioning it as a leading technology for future wearable health-monitoring systems.
研究领域:
生物医学工程
·
材料科学
·
可穿戴设备
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Zhao Dang,Libin Liu,Yan Li,Yu Xiang,Gailan Guo
The development of stimuli-responsive materials with the ability of controllable oil/water separation is crucial for practical applications. Here, a novel pH responsive nonfluorine-containing copolymer was designed. The copolymer together with silica can be dip-coated on different materials including cotton fabric, filter paper, and polyurethane foam. The coated materials exhibit switchable superhydrophilicity and superhydrophobicity and can be applied in continuous separation of oil/water/oil three phase mixtures, different surfactant stabilized emulsion (oil-in-water, water-in-oil, and oil-in-acidic water) as well as oil uptake and release via in situ and ex situ pH change. We expect that the coatings highlight the practical applications because of the cost-effective preparation process and fluorine-free strategy.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2024
·
IF 4.5
Kai Liu,Bolin Zhao,Zihao Sun,Nini Luo,Xiaofang Li
Liver fibrosis is characterized by the aberrant accumulation of extracellular matrix (ECM) components, primarily due to the persistent activation of hepatic stellate cells (HSCs). It is well-known that chronic liver inflammation from various etiologies leads to hepatocellular damage, which activates HSCs, initiating and exacerbating fibrosis. This presents a significant challenge for therapeutic interventions aimed at restoring ECM balance. Here, we present CPT-pH@RLs, a novel drug delivery system consisting of pH-sensitive liposomes modified with erythrocyte membranes (RBCm), designed to deliver cryptotanshinone to the liver. The results of cellular uptake and real-time in vivo imaging indicate that the modification of RBCm reduces the uptake of CPT-pH@RLs by macrophages and prolongs the in vivo cycling time of these particles. CPT-pH@RLs effectively reduce liver inflammation by inhibiting secretion of interleukin-1β (IL-1β). Moreover, they improve liver function, decrease ECM deposition, and alleviate liver fibrosis. Our findings demonstrate that CPT-pH@RLs represent a safe and effective passive targeting drug delivery system for anti-inflammatory and ECM normalization therapies, offering a promising approach for the reversal of liver fibrosis.
研究领域:
药理学
·
生物医学工程
·
肝脏病学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2012
·
IF 2.103
Xinjie Zhang,Chunmei Gao,Mingzhu Liu,Yinjuan Huang,Xiyong Yu,Enyong Ding
An easy, comprehensive and inexpensive method is demonstrated to produce asymmetric polymer/inorganic nanocomposites in a large quantity. With the aid of Pickering emulsion, unmodified particles aggregate on the surface of emulsion droplets and are fixed in place when the wax solidifies. The exposed surfaces of immobilized SiO 2 particles are modified chemically by 2-(dimethylamino) ethylmethacrylate (DMAEMA). With the removal of wax, the exposed side of particles can be further modified chemically by N-isopropylacrylamide (NIPAAm). Based on these procedures, dual responsive asymmetric nanocomposite particles are achieved with both pH and temperature sensitivities. Due to their dual-stimuli and asymmetric structure, these particles have potential applications in molecule targeting, drug delivery and as building blocks for the assembly of complex nanostructure.
研究领域:
材料科学
·
化学工程
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）