MICROCHEMICAL JOURNAL
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2021
·
IF 4.821
Zeming Huang,Jiehao Lei,Hong Ruan,Yongyang Gong,Guan Wang,Li Zhou
Sulfur quantum dots (SQDs), the rising star in fluorescent nanomaterials, have captured increasing attention due to their unique attributes. However, the development of SQDs with targeted fluorescence response to analyte is still a challenge. Herein, we report a robust fluorescent SQDs material that possess both molecular recognition and fluorescence detection capability by employing hydroxypropyl-β-cyclodextrin (HP-β-CD) as ligand. The prepared SQDs simultaneously display fine aqueous dispersibility, stable and tunable fluorescence, and favorable biocompatibility, which enable them promising for applications in cellular imaging and sensing. Owing to the synergistic effect of inner filter effect (IFE) and host-guest interaction, the SQDs can be utilized as an effective fluorescent probe for tartrazine (TTZ) detection with excellent sensitivity and selectivity. The limit of detection can reach 82 nM with a wide linear range of 0–30 μM. Furthermore, the fluorescent SQDs were successfully utilized to detect TTZ in river water and food samples with satisfactory performance.
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Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 18
·4039-4045
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IF 5.344
Quanbao Ma,Xun Fang,Junting Zhang,Lili Zhu,Xiabing Rao,Qi Lu,Zhijun Sun,Huan Yu,Qunlin Zhang
The discrimination of cysteamine (CA) from mercapto amino acids (including glutathione, cysteine and homocysteine, GSH/Cys/Hcy) with high efficiency is essential to detect biothiols in a physiological environment. Herein, a nano-assembly was constructed by combining one-pot synthesized β-cyclodextrin-modified AuNPs and encapsulated rhodamine 6G (R6G-β-CD@AuNPs) without covalent modification. Interestingly, when the pH value of the tested solution was approximately the isoelectric point (pI) of the biothiol, the quenched fluorescence of R6G-β-CD@AuNPs was obviously restored by the introduction of the biothiol, which was due to the replacement of the R6G-β-CD composite by the biothiol on the surfaces of AuNPs via a stronger S–Au bond. The pI-mediated surface ligand exchange process was designed for the first time for the discrimination and detection of CA and GSH/Cys/Hcy at the pH values of 9.5 and 5.5, respectively. Under the optimized conditions, the enhanced fluorescence intensity displayed a good linear response to the concentration of each biothiol, with the detection limits of CA, GSH, Cys and Hcy calculated as 66.8, 417.6, 652.7 and 603.4 nM, respectively. The ingenious fabrication of the R6G-β-CD@AuNPs sensing platform eliminated the interferences from cholesterol by host–guest interactions and enabled high selectivity for the detection of biothiols in human serum samples. The pI-mediated sensing platform exhibits great potential for biothiol-related therapeutic drug monitoring.
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Environmental Science-Nano
·
2020
·Vol. 7
·期 7
·2087-2101
·
IF 7.683
Ibrahim Abdelhai Senosy,Zhi-Heng Lu,Talat Mahmoud Abdelrahman,Mei-Nan Ou Yang,Hao-Ming Guo,Zhong-Hua Yang,Jian-Hong Li
Environmental water contaminated with pesticides, especially fungicides, is a persistent problem worldwide with grave public health consequences. Existing methods of removing fungicides often cannot address the problem quickly and economically. In the current work, a novel β-cyclodextrin modified Fe3O4@MIL-100(Fe) composite (Fe3O4@MIL-100(Fe)/β-CD) was synthesized and utilized as an adsorbent for the removal of fungicides from environmental water. Characterization of the adsorbent revealed that β-CD had been successfully tethered to the shell of Fe3O4@MIL-100(Fe) via tetrafluoroterephthalonitrile as a cross-linker. The main parameters which could affect the adsorption efficiency were investigated, such as the amount of adsorbent, pH value of the solution, adsorption equilibrium time, and ionic strength. The adsorption performance of Fe3O4@MIL-100(Fe)/β-CD was assessed, and the β-CD modified surface exhibited high adsorption capacities for triazole fungicides. Moreover, the regeneration of the adsorbent was explored across 5 successive cycles, and the results indicated excellent stability. Finally, the proposed material was successfully applied to the removal of four fungicides in real environmental water samples, and the adsorption efficiencies ranged from 64.52 to 102.10 mg g−1. Compared with other materials, Fe3O4@MIL-100(Fe)/β-CD displayed outstanding adsorption capacity and a short adsorption equilibrium time, and it could offer a new platform for the removal of trace triazole fungicides in complicated matrices.
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FOOD AND CHEMICAL TOXICOLOGY
·
2020
·
IF 4.679
Desen Yang,Wanqin Wu,Guoping Gan,Dingkun Wang,Jing Gong,Ke Fang,Fuer Lu
The neuroprotective effects and potential mechanisms of (-)-Syringaresinol-4-O-β-D-glucopyranoside (SRG), a natural lignan glycoside extracted from Cortex Albizziae , were investigated using corticosterone (CORT)-induced PC12 cells as an in vitro anxiety model. PC12 cells were treated with 100 μM CORT and 5, 10, or 20 μM SRG for 48 h. Cell viability and lactate dehydrogenase (LDH) leakage were measured. Apoptosis were detected using FITC-coupled Annexin V (AV) and propidium iodide (PI) staining flow cytometric analyses and TUNEL assays. Rhodamine 123 and Fluo-3-AM staining flow cytometric analyses were used to detect mitochondrial membrane potential (ΔΨm) and intracellular calcium concentration ([Ca 2+ ] i ), respectively. Western blot was used to detect brain-derived neurotrophic factor (BDNF), Bax, Bcl-2, cAMP-response element binding protein (CREB), cytosolic cytochrome c (Cyt c ), caspase-3, and cleaved caspase-3. Experimental data showed that SRG promoted cell proliferation , reduced LDH release, inhibited apoptosis, improved ΔΨm values, decreased [Ca 2+ ] i , up-regulated CREB, BDNF, and Bcl-2, down-regulated Bax and Cyt c protein expression levels, and reduced caspase-3 activity. This suggests that SRG has neuroprotective and antiapoptotic effects in the pathogenesis of anxiety disorders, and its mechanisms are partly connecte to inhibition of the mitochondrial apoptotic pathway and activation of pathways involving CREB and BDNF.
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Journal of Environmental Chemical Engineering
·
2020
·
IF 4.3
John Michael Tesha,Derrick S. Dlamini,Saood Qaseem,Zhenyu Cui,Jianxin Li
Polysulfone–Styrene Maleic Anhydride (PSF/SMA) ultrafiltration (UF) membranes were prepared by the thermally induced phase separation (TIPS) method. The morphology of the UF membranes was fine tuned by varying the concentration of SMA. The surface of the membranes was then modified by dip-coating with β-cyclodextrin (β–CD) and Trimesoyl Chloride (TMC) to form tight UF membranes. The effects of β–CD on the separation performance, structure, and morphology of the flat sheet PSF/SMA membrane were examined. The tight UF membranes were characterized and then tested for the removal of Bovine Serum Albumin (BSA) and Congo red from water. The thickness was varied by increasing the concentration of β-CD. When increasing the concentration of β-CD from 2.0 % w/v to 8.0 % w/v, the thickness of the top layer increased from 8 μm to 18 μm, respectively. Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) and X-Ray Photoelectron Spectroscopy (XPS) were used to confirm the successful deposition of the TMC and β-CD at the surface of the membrane. It was also established through Atomic Force Microscopy (AFM) that the roughness of membranes increases with an increase in β-CD concentration. The contact angle of the tight UF PSF/SMA blend membranes declined from 79.8° to 55.9° at the addition of β-CD implying that the hydrophilicity of the membranes improved. The lowest pure water flux of 40 Lm −2 h -1 was achieved by the membrane coated with 8.0 % w/v of β-CD. However, the highest pure water flux of 127 Lm −2 hr −1 was observed on the uncoated PSF/SMA UF membrane at 3 % wt/wt SMA. The highest BSA rejection (94 %) was recorded from PSF/SMA with a coating layer containing 8 % wt/v of β-CD concentration. Furthermore, the maximum Congo red dye rejection (96 %) was achieved by the tight UF membrane when β-CD concentration was 8 wt/v and the SMA was 3 % wt/wt.
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CHEMOSPHERE
·
2020
·
IF 5.778
Farid Mzee Mpatani,Aaron Albert Aryee,Alexander Nti Kani,Qiehui Guo,Evans Dovi,Lingbo Qu,Zhaohui Li,Runping Han
The presence of emerging micropollutants and dyes in water resource has raised global concern about their intense effects to aquatic environments, ecosystem and human health in general. So far, various adsorbents have been suggested for reducing the levels of bisphenol A, methylene blue and neutral red contamination in wastewaters. However, a number of these adsorbents seemed to have low adsorptive capacities and regeneration performances. In view of these, batch experiment was performed to decontaminate these pollutants from aqueous solutions using an optimized bagasse-β-cyclodextrin polymer (SB-β-CD). Characterization studies of SB-β-CD were performed using FTIR , pH point of zero charge, XRD and BET methods. Adsorption of BPA, MB and NR was favored at lower temperature (298 K) and pH of 7.0, 9.0 and 6.0, respectively. The maximum adsorption capacity of BPA, MB and NR at 298 K was 121, 963 and 685 mg g −1 , respectively. Hydrogen bonding through host-guest inclusion and electrostatic interactions could respectively attribute to uptake of BPA and MB/NR onto SB-β-CD. Adsorption kinetics of three pollutants followed pseudo-second-order model. Langmuir and Freundlich models were fitted to describe the adsorption of BPA and MB/NR, respectively. Thermodynamic parameters confirmed the occurrence of physical adsorption which is spontaneous and exothermic in nature. SB-β-CD loaded with BPA and MB/NR was certainly reused by 75% ethanol and 0.1 mol L −1 HCl solutions, respectively. Novel SB-β-CD showed better adsorptive capacity and regeneration performances; consequently can offers practical application for removal of BPA, MB and NR from wastewaters.
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Catalysis Science & Technology
·
2020
·Vol. 10
·期 9
·2986-2993
·
IF 5.721
Wenda Hu,Zixin Chi,Yan Wan,Shuai Wang,Jingdong Lin,Shaolong Wan,Yong Wang
This work presents a novel method to selectively convert levoglucosan to lactic acid (LA) via initially adding LA as the Brønsted acid together with modified Sn-β as the Lewis acid. Sn-β catalysts exchanged with various cations significantly enhance the yield of LA, following the order Sn-β < Sn-β–Na < Sn-β–K < Sn-β–Mg, Sn-β–Ca. The role of exchanged alkali ions stems from removing the remaining Brønsted acid sites in the zeolite and tuning the framework oxygen with more Lewis base sites. The exchange with alkaline earth cations such as Ca2+ and Mg2+ appears to be more effective in promoting the retro-aldol condensation due to the synergetic effect of their stronger Lewis acid that can stabilize the oxygen atom of deprotonated alkoxides during the reaction. The LA yield from levoglucosan can reach up to 66% on Sn-β–Ca under the optimized conditions. We also demonstrated that such a synergetic effect of alkaline-earth ion exchanged Sn-β shows great universality toward enhanced retro-aldol condensation, which can significantly promote the yield of methyl lactate over glucose conversion in methanol solvent.
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ANALYST
·
2020
·Vol. 145
·期 9
·3257-3265
·
IF 3.978
Yue Li,Xinxin Xu,Liqiang Liu,Hua Kuang,Liguang Xu,Chuanlai Xu
In this study, a gold immunochromatographic assay (GICA) based on a penicillin receptor protein (PBP) is proposed to simultaneously detect penicillin, cephalosporin, and carbapenem antibiotics in milk and chicken. A mutant PBP, carboxy-terminal of the β-lactam sensor-transducer protein (BlaR-CTD, I188KS19CG24C) from Bacillus licheniformis ATCC14580 was expressed in E. coli as a soluble His-tag fusion protein. The purified BlaR-CTD mutant was labeled with colloidal gold (CG-BlaR-CTD-M) and applied to develop GICA. The GICA method was performed based on a competitive form, where the binding of the ampicillin-bovine serum albumin conjugate (Amp-BSA) to CG-BlaR-CTD-M was inhibited by free β-lactams in samples. The performance of the assay was confirmed by analysis of milk and chicken samples. The limits of detection of 21 β-lactam antibiotics met the maximum residue limits set by the European Union and China. The GICA gave results within 10 min, thus providing a rapid and reliable method for the on-site detection of multiple β-lactams in milk and chicken samples.
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CHEMISTRY-A EUROPEAN JOURNAL
·
2020
·Vol. 26
·期 24
·5494-5499
·
IF 4.857
Xiaojuan Liu,Qingqing Wen,Li Xiang,Xuebing Leng,Yaofeng Chen
Graphical A five-coordinate samarium(II) monoalkyl complex is synthesized and structurally characterized. This complex shows high catalytic activity and high stereo- and regioselectivity in the hydrosilylation of various aryl and methyl-substituted unsymmetrical internal alkynes with secondary hydrosilanes under mild conditions (see scheme). The synthesis and catalytic applications of trivalent rare-earth metal alkyl complexes have been well developed, but the chemistry of divalent rare-earth metal alkyl complexes lagged much behind. Herein, we report the synthesis, structure, and catalytic applications of a samarium(II) monoalkyl complex supported by a β-diketiminato-based tetradentate ligand, [LSmCH(SiMe 3 ) 2 ] (L=[MeC(NDipp)CHC(Me)NCH 2 CH 2 N(Me)CH 2 CH 2 NMe 2 ] − , Dipp=2,6-( i Pr) 2 C 6 H 3 ). This complex is synthesized by the salt metathesis reaction of samarium iodide [LSm( μ -I)] 2 and KCH(SiMe 3 ) 2 in 63 % yield. Its structure is characterized by single-crystal X-ray diffraction, showing a distorted square-pyramid coordination geometry. This samarium(II) monoalkyl complex exhibits high catalytic activity in the hydrosilylation of aryl and methyl-substituted unsymmetrical internal alkynes with secondary hydrosilanes, selectively providing the α-( E ) products in high yields.
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ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Qing Yao,Zhi-Wei Huang,Yuan-Yuan Zhai,Meng Yue,Lan-Zi Luo,Peng-Peng Xue,Yong-Hui Han,He-Lin Xu,Longfa Kou,Ying-Zheng Zhao
Islet transplantation has been considered the most promising therapeutic option with the potential to restore the physiological regulation of blood glucose concentrations in type 1 diabetes treatment. However, islets suffer from oxidative stress and nonspecific inflammation in the early stage of transplantation, which attributed to the leading cause of islet graft failure. Our previous study reported that bilirubin exerted antioxidative and anti-inflammatory effects on hypothermic preserved islets, which inspire us to utilize bilirubin to address the survival issue of grafted islets. However, the application of bilirubin for islet transplantation is limited by its poor solubility and fast clearance. In this study, we designed a supramolecular carrier (PLCD) that could improve the solubility of bilirubin and slowly release bilirubin to protect islets after cotransplantation. PLCD was synthesized by conjugating activated β-cyclodextrin (β-CD) to the side chain of ε-polylysine (PLL) and acted as a carrier to load bilirubin via host–guest interactions. The constructed bilirubin supramolecular system (PLCD-BR) significantly improved the solubility and prolonged the action time of bilirubin. In vitro results confirmed that PLCD-BR coculture substantially enhanced the resistance of islets to excessive oxidative stress and proinflammatory stimulation and maximumly maintained the islet function. In vivo, PLCD could prolong drug duration at the transplant site, and the localized released bilirubin could protect the islets from oxidative stress and suppress the production of inflammatory cytokines. Crucially, islet transplantation with PLCD-BR significantly extended the stable blood glucose time of diabetic mice and produced a faster glucose clearance compared to those cotransplanted with free bilirubin. Additionally, immunohistochemical analysis showed that PLCD-BR had superior antioxidative and anti-inflammatory abilities and beneficial effects on angiogenesis. These findings demonstrate that the PLCD-BR has great potentials to support successful islet transplantation.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2021
·
IF 4.432
Feiran Zhou,Xinyi Hu,Weijing Feng,Minghui Li,Bin Yu,Chenxing Fu,Caiwen Ou
Intimal hyperplasia-induced restenosis is a common response to vascular endothelial damage caused by mechanical force or other stimulation, and is closely linked to vascular remodeling . Curcumin , a traditional Chinese medicine , exhibits potent protective effects in cardiovascular diseases; for example, it attenuates vascular remodeling. Although the suppressive effects of curcumin on diseases caused by vascular narrowing have been investigated, the underlying mechanisms remain unknown. Long non-coding RNAs (lncRNAs) regulate various pathological processes and affect the action of drugs. In the present study, we found that the curcumin remarkably downregulated the expression of lncRNA H19 and thereby inhibited intimal hyperplasia-induced vascular restenosis. Furthermore, the inhibition of the expression of H19 by curcumin resulted in the inactivation of the Wnt/β-catenin signaling. Overall, we show that curcumin suppresses intimal hyperplasia via the H19/Wnt/β-catenin pathway, implying that H19 is a critical molecule in the suppression of intimal hyperplasia after balloon injury by curcumin. These insights should be useful for potential application of curcumin as a therapeutic intervention in vascular stenosis.
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CHEMOSPHERE
·
2021
·
IF 7.086
Amir E. Kaziem,Liupeng Yang,Yigang Lin,Zixia Song,Hanhong Xu,Zhixiang Zhang
Understanding the lethal effects of pesticides nano formulations on the targeted organisms (pathogens) and the non-targeted organisms (fish, earthworms, etc) is essential in assessing the probable impact of new technologies on agriculture and environment. Here we evaluated the bioactivity and the biotoxicity of new type of fungicide smart-delivery formulation based on conjugating carboxymethylated- β -glucans on the mesoporous silica nanoparticles (MSNs) surface after loading chlorothalonil (CHT) fungicide in the MSNs pores. The obtained formulation has been characterized with FE-SEM, and HR-TEM. The CHT loading efficiency has been measured with TGA . The bioactivity of the obtained formulation ( [email protected] β -glucans) has been tested against four pathogens , fusarium head blight ( Fusarium graminearum ), sheath rot ( Sarocladium oryzae ), rice sheath blight ( Rhizoctonia solani ), and soyabean anthracnose ( Colletotrichum truncatum ) compared with CHT WP 75% commercial formulation (CHT-WP) and technical CHT. The environmental biotoxicity of [email protected] β -glucans compared with CHT-WP has been tested toward earthworm ( Eisenia fetida ) and zebra fish ( Danio rerio ). The results showed that [email protected] β -glucans has an excellent bioactivity against the subjected pathogens with better inhabiting effects than CHT-WP. [email protected] β -glucans toxicity to Eisenia fetida was found 2.25 times lower than CHT-WP toxicity. The LC 50 of [email protected] β -glucans to zebra fish after the first 24h was 2.93 times higher than CHT-WP. After 96h of treatment, the LC 50 of [email protected] β -glucans was 2.66 times higher than CHT-WP. This work highlighted the necessity to increase the mandatory bioassays of nano formulations with the major non-target organisms in the environmental risk assessment of new pesticide formulations.
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