MATERIALS AND CORROSION-WERKSTOFFE UND KORROSION
·
2022
·Vol. 73
·期 7
·1153-1162
·
IF 1.832
Cunhua Wei,Ge Xu,Jin Yu
A novel triazine derivative, 2, 4-diamino-6-dodecamido-1, 3, 5-triazine (DT), is synthesized by the dehydration condensation of melamine and lauric acid, and its inhibitive performances for the corrosion of Q235 carbon steel in 1 mol/L HCl solution is investigated by electrochemical polarization, electrochemical impedance spectroscopy, scanning electron microscopy, and atomic force microscope. The results reveal that its best inhibition efficiency reaches 96.98% at a concentration of 2.5 g/L. The calculation results of kinetic and thermodynamic parameters indicate that the adsorption of DT on carbon steel surface obeys Langmuir adsorption isotherm with both physical and chemical adsorption. It is demonstrated that long-chain amide (>8C) substituted 1, 3, 5-triazine derivative has the synergistic corrosion inhibition effect of the surface fixation on metal iron and the hydrophobic adsorption layer.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Ke Cai,Wei Pi,Jiangyang Qin,Chenxi Peng,Dandan Wang,Yingying Gu,Yong Mei
In this study, an electrochemical immunosensor was constructed to detect the cytokeratin 19 fragment antigen 21-1 (CYFRA 21-1) in human serum. CYFRA 21-1 is the most sensitive tumor marker of non-small cell lung cancer (NSCLC), its content in normal human serum should be less than 3.3 ng/mL. When lung cancer cells dissolve or die, a myriad of CYFRA 21-1 is released into a tumor patient’s blood circulation , and its serum content elevates strikingly. Consequently, detecting CYFRA 21-1 by an electrochemical biosensor is expected to provide a new method for the early detection and prevention of lung cancer. In this study, a composite of UiO-66-NH 2 and carboxylated multi-walled carbon nanotubes (CMWCNTs) was used as the substrate material of a sensor; the resulting sensor had a large specific surface area and strong electrical conductivity . Moreover, gold nanoparticles (AuNPs) were used to bind to antibodies through an Au-S bonds. Also, a supersensitive detection of CYFRA 21-1 was achieved through the specific bindings of antigens and antibodies. Under optimal detection conditions, the change of current signal intensity of the immunosensor was proportional to the logarithm of CYFRA 21-1 concentration and had a linear relation in the range of 0.005–400 ng/mL, while the detection limit was 1.15 pg/mL (S/N = 3). The proposed immunosensor had high precision, stability, and selectivity . More importantly, the sensor was been successfully applied to detect CYFRA 21-1 in human serum with high recovery, providing a new method for early screening and dynamic monitoring of lung cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 16
·1-11
·
IF 2.8
Chen Yuan,Huang Rui,Tao Cheng,Hao Hua,Yao Zhonghua,Liu Hanxing,Cao Minghe
Dielectric film capacitors are widely studied in recent years owing to their advanced power density and excellent mechanical and thermal stability. Despite the fact that extensive research has been done, the energy storage density still needs to be further improved. Herein, the highly polarized phase and amorphous phase are introduced into barium zirconate titanate simultaneously by the sol–gel method to fabricate (1− x )BaZr 0.2 Ti 0.8 O 3 − x Bi 0.5 Na 0.5 TiO 3 ((1− x )BZT− x NBT) amorphous films, researching the impact of amorphous phase and NBT levels on microstructure, energy storage, and dielectric properties of the films systematically. This material can generate a giant recoverable energy density of 86.35 J cm −3 and a great energy efficiency of 89.2% when x = 0.10, showing great thermal stability in energy storage property and dielectric property at 20–200 °C and excellent cycling reliability up to 10 5 cycles, which indicate the potential of 0.9BZT–0.1NBT film in the energy storage field. More importantly, there is no research on BZT-NBT films in the published literatures up to now. This work verifies the feasibility of this system in energy storage films and provides a new avenue to design lead-free dielectric materials.
✓ 已验证
产品关联
DOI
高影响因子
TETRAHEDRON
·
2021
·
IF 2.457
Qin He,Fangdi Dong,Longjiang Xing,Huahong He,Xiaoping Chen,Huaqian Wang,Shaomin Ji,Yanping Huo
A series of perylene derivatives bearing electron-donating group (amino) and electron-withdrawing group (nitro, maleimide) at the 1- and 3-position have been synthesized. Interestingly, 3-monosubstituted perylenes shown different photophysical properties compared with 1-monosubstituted perylenes. 3-nitroperylene ( 3-NO ) attained 80.62% photoluminescence quantum yield ( Φ PL ) in toluene which is higher than 3-aminoperylene ( 3-NH , Φ PL = 71.70%) and 1-aminoperylene (1-NH, Φ PL = 48.04%), but for 1-nitroperylene ( 1-NO ), no fluorescence in any solvent were observed. The calculated ground-state geometries of 3-monosubstituted perylenes actually correspond to nearly planar structures, but the molecules substituted at the 1-position all have a twisted structure. Among them, 3-NO had a great π-conjugated system, resulting in the allowed ππ∗ fluorescence. In contrast, the twisting structure of 1-NO enhanced nonradiative decay pathways, coupled with the electron-withdrawing effect of the nitro group, which can explain the non-luminescence of 1-NO . Furthermore, the moleculars with maleimide group were used as “off-on” fluorescent probes and successfully used for imaging biothiols in living H1299 lung cancer cells. The fluorescence of probe 2 (substitutes at 3-position of perylene) afforded a 188-fold intensity increase after reaction with thiol which is much higher than (65-fold) probe 1 (substitutes at 1-position) because of the better π-conjugated structure. We envision that the investigation on the effects of substitute at 1-and 3-positions of perylene may be helpful for a rational design and application of highly fluorescent molecule base on perylene.
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2023
·
IF 13.3
Qian Liang,Xuezhi Liu,Junyan Tang,Xiao Yan,Lei He,En Chen,Sihan Wu,Junjie Liu,Mi Tang,Zhiquan Chen,Zhengbang Wang
The performances of solid-state polymer electrolytes are urgently required to be further improved for high energy density lithium metal batteries. Herein, a highly reinforced ultrathin composite polymer electrolyte (PLPP) is successfully fabricated in a large scale by densely filling the well-dispersed mixture of polyethylene oxide (PEO), Li-salt (LiTFSI) and a polymer of intrinsic microporosity (PIM-1) into porous poly(tetrafluoroethylene) (PTFE) matrix. Based on the macro-plus-micro synergistic enhancement of the PTFE with excellent mechanical properties and the soluble PIM-1 with suitable functional groups, the PLPP electrolyte exhibits excellent properties including mechanical stress, thermal stability, lithium-ion transference number, voltage window and ionic conductivity, which are all superior to the typical PEO/LiTFSI electrolytes. As a result, the Li/PLPP/Li symmetric cell can stably cycle for > 2000 h, and the LiFePO 4 /PLPP/Li full cell exhibits excellent rate performance (>10 C) and high cycling stability with an initial capacity of 158.8 mAh g −1 and a capacity retention of 78.8% after 300 cycles. In addition, the excellent mechanical properties as well as the wide voltage window reasonably result in the stable operation of full cells with either high-loading cathode up to 28.1 mg cm −2 or high voltage cathode with high energy density.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2017
·Vol. 183
·期 3
·1035-1048
·
IF 1.751
Zhang Li-Shuang,Fang Yue,Zhou Ying,Ye Bang-Ce
Protocatechuate 3,4-dioxygenase (P34O), which is isolated from Rhizobium sp. LMB-1, catalyzes the ring cleavage step in the metabolism of aromatic compounds, and has great potential for environmental bioremediation. However, its structure is very sensitive to different environmental factors, which weaken its activity. Immobilization of the enzyme can improve its stability, allow reusability, and reduce operation costs. In this work, the relative molecular mass of the native P34O enzyme was determined to be 500 kDa by gel filtration chromatography on Sephadex G-200, and the enzyme was immobilized onto (3-aminopropyl) triethoxysilane-modified Fe 3 O 4 nanoparticles (NPs) by the glutaraldehyde method. The optimum pH of immobilized and free P34O was unaffected, but the optimum temperature of immobilized P34O increased from 60 to 70 °C, and the thermal stability of immobilized P34O was better than that of the free enzyme and showed higher enzymatic activity at 60 and 70 °C. In addition, with the exception of Fe 3+ , most metal ions and organic chemicals could not improve the activity of free and immobilized P34O. The kinetic parameters of the immobilized P34O were higher than those of the free enzyme, and immobilized P34O on Fe 3 O 4 NPs could be reused ten times without a remarkable decrease in enzymatic activity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
·
2023
·
IF 3.6
Zhang Yuying,Zhang Pingping,Zhang Xin,Liu Ye
Honokiol, a bioactive component found in Magnolia officinalis , has shown in protecting against ischemic stroke in animal models. However, its poor water solubility has limited its clinical applications. In this study, we introduced a hydrophilic building block on the aromatic ring of honokiol, resulting in the synthesis of four new compounds (HH-A, -B, -C and -D) with significantly improved water solubility. We then investigated the neuroprotective effects of these compounds in mouse and rat models of transient middle cerebral artery occlusion/reperfusion (tMCAO/R) brain injury. Among the compounds tested, HH-A, also known as (S)-6-((3′,5-diallyl-2,4′-dihydroxy-[1,1′-biphenyl]-3-yl)amino)-6-oxohexane-1,5-diaminium chloride, showed the most promising results. HH-A was found to significantly reduced the infarct volume and brain edema in mice. It also outperformed the other three compounds and honokiol, even surpassing the effects of edaravone dexborneol. Additionally, HH-A demonstrated dose-dependent improvements in body weight, neurological deficits, and infarct volume. Further analysis in tMCAO/R rat model revealed that HH-A treatment led to significant upregulations of Nrf2 and HO-1 in the brain. HH-A also significantly reduced the expression of HNE, and exhibited anti-apoptotic effects by decreasing the expression of Bax and increasing the expression of Bcl-2. This was further supported by a decrease in the number of TUNEL positive cells. Taken together, the neuroprotective effects of HH-A may be attributed to its ability to target the Nrf2/HO-1 signaling pathway, leading to reduced oxidative stress and apoptosis in the brain. These findings suggest that HH-A has potential as a therapeutic agent for the treatment of ischemic stroke.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Bioscience-Landmark
·
2023
·Vol. 28
·期 12
·327
·
IF 3.1
Ruoxia Wu,Jiaqing Xiong,Ting Zhou,Zhen Zhang,Zhen Huang,Sha Tian,Yongli Wang
Objective: The use of immune checkpoint inhibitors (ICIs) provides promising strategies for hepatocellular carcinoma (HCC) treatment. This study aimed to explore impact and underlying mechanism of the combination therapy of quercetin and anti-programmed cell death 1 (anti-PD-1) antibody on HCC. Methods: Orthotopically transplanted HCC tumors in mice were treated with quercetin, anti-PD-1 antibody, or a combination of both therapies. Histopathological changes and programmed cell death ligand 1 (PD-L1) expression were characterized by hematoxylin and eosin (H&E) and immunohistochemistry (IHC) staining. The diversity and differences of gut microbiota (GM) were evaluated through 16S rRNA sequencing. Levels of macrophage immunity-related cytokines were quantified by enzyme-linked immunosorbent assay (ELISA), quantitative real-time polymerase chain reaction (RT-qPCR), and Western blot. Results: Combination therapy reduced necrosis, fibrosis, and PD-L1 expression in liver tissues. Additionally, combination therapy reduced GM imbalance and increased abundance of Firmicutes, Actinobacteria, and Verrucomicrobiota at the phylum level as well as Dubosiella and Akkermansia at the genus level. Combination therapy improved macrophage immunity, raised the expressions of CD8a, CD4, CD11b, interleukin (IL)-10, and interferon (IFN)-γ , and declined the expressions of IL-4, IL-6, toll-like receptor 4 (TLR4), an inhibitor of nuclear factor κBα (IκBα), and the NFκB subunit p65. Upon combination therapy, expressions of M2 macrophage-related genes arginase-1 (Arg-1), IL-10, transforming growth factor-β (TGF-β), and matrix metalloproteinase-9 (MMP-9) were upregulated. Instead, M1 macrophage-related genes IL-6, IL-12a, IL-1β, and tumor necrosis factor-α (TNF-α) were downregulated. Conclusions: Quercetin/anti-PD-1 antibody combination therapy reshaped HCC tumor microenvironment in mice in parallel with regulating the GM and macrophage immunity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Jiani Zhang,Risheng Bai,Zhaochi Feng,Jiyang Li
Aiming to promote the activity of TS-1 zeolite in catalytic oxidative desulfurization (ODS), a general amide-assisted strategy was proposed to synthesize hierarchical TS-1 zeolite with rich and homogeneously distributed Ti(OH 2 ) 2 (OH) 2 (OSi) 2 species. Strong interactions between acrylamide (AM) and Si/Ti as well as self-polymerization of AM in synthetic gels change the zeolite formation process, thus to effectively construct Ti(OH 2 ) 2 (OH) 2 (OSi) 2 , promote Ti evenly distribution and form micro-mesopore structure. The activity of Ti(OH 2 ) 2 (OH) 2 (OSi) 2 was evaluated by ODS of refractory sulfur-containing compounds. The advantages of Ti(OH 2 ) 2 (OH) 2 (OSi) 2 over TiO 4 in substrate adsorption and reactive intermediate formation for ODS were further proved by theoretical calculations. By adjusting AM amount to optimize the Ti(OH 2 ) 2 (OH) 2 (OSi) 2 content and distribution, the obtained catalyst achieves 134.8 h -1 of turnover frequency and 100 % DBT removal at ten minutes, and maintains > 92 % removal after seven cycles at 333 K. This facile active-site construction strategy is promising to be extended to other heteroatom-containing zeolite catalysts.
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2023
·Vol. 16
·期 20
·6712
·
IF 3.4
Zhishun Zhu,Xiulan Zhang
In this paper, zeolitic imidazolate framework-8 was modified by N-(3-aminopropyl)-imidazole to obtain a novel MOF called AMOF. Subsequently, AMOF served as a carrier for the delivery of 2-mercapto-1-methyl imidazole (MMI) to inhibit the corrosion of Cu. Scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction were applied to characterize the morphologies and structures of AMOF and AMOF@MMI. Ultraviolet-visible spectroscopy and thermogravimetric analysis were adopted to value the capacity of the load and release of the AMOF, respectively. The mass ratio of loaded MMI molecules was 18.15%. In addition, the inhibition behavior of AMOF@MMI for Cu was evaluated by polarization curves and electrochemical impedance spectroscopy. The results indicated that the AMOF loaded MMI successfully, and the released MMI could adsorb on the Cu surface and inhibit the Cu corrosion. The inhibition efficiency could reach 88.2%. The binding and interaction energies between the AMOF surface and the MMI were −16.41 kJ/mol and −20.27 kJ/mol.Keywords:corrosion inhibitor;ZIF-8;loading and delivery;AMOF;theoretical calculation
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Weigao Han,Fang Dong,Weiliang Han,Xiaosheng Huang,Zhicheng Tang
The activation of oxygen species is always a challenging problem in the oxidative dehydrogenation (ODH) of 1-butene with CO 2 . The oxygen species play an important role in improving the conversion, yield, selectivity, and stability of FeAlO x -based catalysts. In this paper, the framework-confined (FC) strategy was used to active the oxygen species. The changed crystalline phase from Fe 2 O 3 to FeAlO 4 illustrated the introduction of Fe species destroyed the Al 2 O 3 lattice and more active oxygen species were released. Compared with the WI-Fe 2 O 3 /Al 2 O 3 samples, the ratio of active lattice oxygen was increased from 0.03 to 0.1 and the ratio of Fe 3+ was also increased from 0.63 to 0.76 in the FC-FeAlO x samples. After doping with other metal species, the ratio of active lattice oxygen was further increased. The 1-butene conversion could reach 80 % and the 1, 3-Butadiene selectivity could reach 33 % over the FC-FeCrAlO x samples. Besides this, the FC-FeCrAlO x samples showed an outstanding thermal stability, which might be caused that Cr species could reduce the coke formation. The FC-FeCaAlO x samples had a higher utilization rate of CO 2 , which might be caused that Ca species could improve the basicity of the catalyst.
✓ 已验证
产品关联
DOI
高影响因子
NUTRITION
·
2023
·
IF 4.4
Jiabao Tang,Xiaohua Li,Wei Li,Chun Cao
Objective Enteral nutrition (EN) is the key therapy in septic patients. Different formulas of EN have various effects on gastrointestinal sepsis. Therefore, we investigated the effects of EN supplemented with octanoic acid (OA) on lipopolysaccharide (LPS) induced intestinal injury and explored the potential mechanism. Methods First, to investigate the effects of EN supplemented with OA on LPS-induced intestinal injury, rats were randomly divided into four groups: the sham, LPS, LPS + EN, and LPS + EN + OA groups. Then, to explore whether EN supplemented with OA can prevent LPS-induced intestinal injury via the PPARγ/STAT-1/MyD88 pathway, rats were randomly divided into five groups: the sham, LPS, LPS + EN + OA, LPS + EN + OA +SR202, and LPS + pioglitazone groups. All rats received nutritional support for three days. We examined the serum levels of inflammatory factors, pathological changes, goblet cell density, intestinal tight junction protein expression, and the PPARγ/STAT-1/MyD88 pathway in the ileum and colon. In addition, the effect of OA on intestinal epithelium injury was also explored in vitro. Results EN supplemented with OA significantly decreased the serum levels of inflammatory factors and prevented intestinal barrier dysfunction compared with EN alone (P < 0.05). Inhibiting the PPARγ/STAT-1/MyD88 pathway exacerbated effects of EN supplemented with OA on intestinal injury (P < 0.05). Activation of the PPARγ/STAT-1/MyD88 pathway prevented intestinal injury (P < 0.05). OA also exerted a similar effect on intestinal epithelium injury in vitro. Conclusion EN supplemented with OA prevents LPS-induced intestinal injury via the PPARγ/STAT-1/MyD88 pathway.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）