Microsystems & Nanoengineering
·
2026
·Vol. 12
·期 1
·23
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IF 9.9
Lin Rui,Jiang Zhixian,Chi Yanzhi,Xing Lili,Long Zhihe,Xue Xinyu,Chen Meihua
Conventional diabetes management requires frequent invasive procedures such as finger-prick blood sampling and subcutaneous injections to coordinate glucose monitoring and medication. Here, we propose a novel, flexible, wearable, battery-free skin patch that synchronizes painless glucose monitoring and regulation capabilities with smartphone-mediated wireless control. This patch integrates bendable fluorescent hydrogel microneedles for minimally invasive glucose monitoring (50 to 450 mg/dL range) and thermoresponsive microneedles for metformin delivery. In diabetic mouse models, it accurately tracked interstitial glucose levels and, upon hyperglycemia detection, reduced blood glucose within 1 h (effects lasting 5–6 h). This system provides glucose monitoring with wireless data transmission and precise drug administration while eliminating pain, infection risk, and high costs. Its lightweight, disposable design offers a practical solution for improved diabetes care.
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Science China-Chemistry
·
2026
·
IF 9.7
Zheng Xia,Fu Yaoqiang,Ning Jing,Wang Haorui,Liu Hongfei,Cui Chunhua
Direct formate fuel cells (DFFCs) are becoming one of the most promising next-generation energy devices owing to their high energy density, low toxicity, and carbon neutrality. However, their practical application is hindered by the sluggish kinetics of the formate oxidation reaction (FOR) on conventional palladium (Pd)-based catalysts due to the strong adsorption of hydrogen intermediates (H ads ) that block the active sites. Herein, we tackled the above problem by tailoring the Pd electrocatalytic properties through the interfacial interaction with the hydroxyl group-abundant and oxophilic Co(OH) 2 substrate. This resulted in an impressive mass activity of 5.02 A mg
−1 Pd
for the synthesized Pd/Co(OH) 2 , approximately three times that of commercial Pd/C. Moreover, under high formate concentration, Pd/Co(OH) 2 exhibits significantly improved stability, i.e. , up to 24000 s sustainable current density with 100% selectivity toward CO 2 (CO 2 is actually converted to carbonate in alkaline media). Kinetic isotope effect (KIE) analysis and in situ Raman spectroscopy based mechanistic study reveal the excellent FOR performance of Pd/Co(OH) 2 originates from the partially oxidized Pd facilitated H ads oxidative removal and the more hydrophilic surface induced competitive HCOO − adsorption over H ads . This study demonstrates a rational strategy to optimize the Pd-based FOR electrocatalysts through the electronic and interfacial interactions with appropriate substrate to modulate the key intermediate adsorption-reaction kinetics.
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Carbon Neutrality
·
2026
·Vol. 5
·期 1
·4
·
IF 12.5
Wang Shaona,Yang Yang,Xu Wenqing,Bai Zhuoshu,Su Fabing,Wang Yixi,Bai Dingrong,Zhu Tingyu
As an integrated CO 2 capture and utilization (ICCU) process, direct electrochemical reduction of amine captured-CO 2 reduction reaction (cCO 2 RR) has enormous advantages in energy efficiency and operating cost. The low product selectivity is an urgent issue. Here, we found that the hydroxyl (-OH) on CeO 2 can significantly enhance CO selectivity. After hydroxyl modification, the CO faraday efficiency (FE CO ) was surprisingly increased by 188% (relative increase rate). The correlation coefficient between -OH quantity and FE CO is as high as 0.98. Further study indicated that the presence of -OH can lead to a more compact electrochemical double layer (EDL) and charge transfer resistance by proton transfer. The -OH can also enhance CO 2 adsorption and stabilize the intermediate species (*COOH). DFT results further demonstrate that the rate-determining step was proton transfer from the surface -OH to MEACOO − , -OH modification can reduce the energy barrier to as low as 0.39 eV. This work provides additional insights into improving selectivity in amine-based cCO 2 RR, advancing the development of ICCU technology.
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Nature Chemical Biology
·
2026
·
IF 13.7
Guo Hengke,Wan Wang,Huang Yanan,Zhao Nan,Wu Ci,Zhong Bowen,Sun Rui,Feng Huan,Yan Jing,Shen Di,Dong Xuepeng,Zhao Qun,Zhang Xin,Zhang Lihua,Liu Yu
Lipid droplets (LDs) dynamically interact with other organelles, such as mitochondria, in surveillance of cellular metabolic homeostasis. The transient nature of LDs, however, poses technical challenges to snapshot molecular information underlying these interactions. Herein, we present a small-molecule-based photocatalytic protein proximity labeling method (named LipoID) to enable in situ labeling, capturing and profiling of the LD-interacting proteome. This method is enabled by a set of LD-targeting probes designed to catalyze protein modifications nearby LDs using nucleophilic substrates. Profiled by liquid chromatography–tandem mass spectrometry, LipoID identifies tethered interorganellar interactions, particularly with mitochondria, in addition to reliable capture of validated LD biomarkers (for example, perilipins (PLINs)). Coupled with comparative proteomics, LipoID discovers mitochondrial voltage-dependent anion channel 3 as a potential regulator of LD–mitochondria proximity through interacting with PLIN3 on LDs. Further metabolomics analysis suggested remodeled lipid metabolism in line with the LD–mitochondria interaction. Together, LipoID enables in situ profiling of the LD interactome and reveals interorganellar regulation.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 3.9
Fu Guoning,Peng Cheng,Wu Wei,Xiong Tianying,Lv Fanghui,Li Kuan,Liu Dong
Copper-based catalysts for Suzuki coupling reactions face limitations in efficiency and stability, while conventional palladium catalysts require high costs and harsh conditions. To address these challenges, we developed a bifunctional copper-loaded black phosphorus (Cu/BP) material. Initially, a series of Cu/BP catalysts (1–5 wt% Cu) were synthesized via wet chemical reduction. Subsequently, catalytic performance was evaluated using vector network analysis and a microwave catalysis system. Key results were obtained: Cu/BP-3 exhibited exceptional microwave absorption (minimum reflection loss: − 36.31 dB; effective bandwidth: 6.64 GHz). Under microwave heating (90 °C) with ultralow copper loading (0.25 mol%) in H 2 O/CH 3 OH (1:1 v/v), > 99.7% bromobenzene conversion was achieved within 2 h. This represents a 5.5-fold enhancement compared to conventional oil-bath heating. The catalyst maintained > 95% yields for bromobenzene substrates bearing strong electron-withdrawing/donating groups and ortho-substituents. Remarkably, > 95.4% activity retention was observed after 10 cycles, with copper leaching < 0.01 ppm. This work demonstrates that Cu/BP efficiently activates C–Br bonds through synergistic dielectric energy localization and interfacial charge transfer (P → Cu). It provides a new strategy for designing green, stable non-precious metal catalysts for microwave-driven reactions.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 1
·58
·
IF 5.3
Yin Zhaojiang,Zhang Jing,Li Binghui,Fan Hao,Wang Mei,Cui Hanfeng
A dual-mode sensor based on intramolecular catalytic hairpin assembly strategy (intra-CHA) is proposed for Survivin mRNA detection. Intra-CHA, a triplex complex of tetraferrocene-labeled H1/H2, shortens H1-H2 distance and increases their local concentrations, accelerating reaction by 2.8-fold vs. free-CHA. Ruthenium-based covalent organic frameworks (RuCOFs) with Ru(dcbpy) 3 2+ as luminophore has dual fluorescence-electrochemiluminescence (FL-ECL) properties. EDTA-incorporated RuCOFs@EDTA expands active sites, enhancing ECL efficiency 8-fold. Intra-CHA system is covalently conjugated to RuCOFs@EDTA through amide bond linkages. Target mRNA-triggered strand displacement reactions induce structural reconfiguration of the intra-CHA probes, resulting in controlled spatial segregation of tetraferrocene from the RuCOFs@EDTA interface. This results in the recovery of FL and ECL signals, enabling rapid and highly sensitive detection of Survivin mRNA. Experimental results show that the detection limits reach 0.04 fM (in the FL mode) and 0.009 fM (in the ECL mode) respectively, with excellent selectivity, stability, and reproducibility. The system has been successfully applied to detect Survivin mRNA in actual serum samples, providing a novel strategy for Survivin mRNA detection and paving the way for developing future diagnostic strategies for early cancer screening. Graphical
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2026
·
IF 3
Sheng Zhizheng,Zhou Jian,Ye Zhaoqi,Wang Tingting,Wang Weihua,Wang Yangdong,Teng Jiawei,Xie Zaiku
Mass transfer on surface of nano-zeolites plays an important impact on their catalytic performance. In this work, we investigated a diffusion-controlled strategy to regulate the interface effect and the dynamic behavior of guest molecules at the interface of nanoZSM-5 via chemical deposition of different silicon (Si) or tungsten (W) species, thereby affecting its performance in methanol to propylene (MTP) reaction. It was verified that only about 1% of sedimentary species form stable surface structures by binding with surface hydroxyl groups and defect hydroxyl groups. Under a pressure of 0.2–5 kPa, Si and W modification respectively increased the surface diffusion efficiency of methanol by 50% and decreased it by 60%, demonstrating the bidirectionality of the control strategy. Meanwhile, acidity and structural characterization confirmed that these properties were not strongly affected. Catalytic results showed that surface diffusion enhancement increased the selectivity of ethylene and propylene, and remained stable within 120 h. Mechanism studies have shown that the dynamics of the accumulated surface species is a key intermediate process that connects surface diffusion and catalytic performance.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·161
·
IF 36.3
Tang Bin,Zhang Yuchen,Ji Bifa,Yu Geng,Zheng Yongping,Zhou Xiaolong,Kamonsutthipaijit Nuntaporn,Buangam Pornsuwan,Tunmee Sarayut,Nakajima Hideki,Rittihong Ukit,Pan Qingguang,Zhang Fan,Tang Yongbing
Carbon microdomain engineering using ion-mediated structural control tailors oriented high-activity nitrogen species and creates specific closed pores.
This strategy accelerates sodium-ion desolvation kinetics, thereby enhancing sodium storage performance even at high current densities.
The optimized carbon material achieves exceptional rate performance and cycling stability, making it one of the top-tier materials for sodium-ion batteries.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·195
·
IF 36.3
Shen Liying,Hu Chuyan,Huang Zhenhui,Yang Jiarui,Jia Yanwei,Zhao Yufeng,Berger Rüdiger,Liu Qiang,Zhou Yu
Ceramic-gel composite electrolytes (CGEs) attract significant attention as solid-state electrolytes (SSEs) for sodium metal batteries owing to their favorable ionic conductivity and interfacial compatibility. However, conventional CGEs generally feature insufficient mechanical strength and consequent uncontrollable dendrite growth, remaining long-standing fundamental challenges that severely limit practical applications. Herein, this study presents a high-strength CGE that enables efficient stress transfer, achieving a compressive strength of 20.1 MPa (20 times higher than conventional gel electrolytes), while maintaining excellent ionic conductivity and effectively suppressing sodium dendrites. The 3D-Na 3 Zr 2 Si 2 PO 12 framework further serves as a thermal barrier, imparting the CGE with superior flame retardancy. Additionally, Na/CGE/NVP-K 0.05 cells exhibit 75.9% capacity retention after 10,000 cycles at 5C (25 °C) and deliver 78.5 mAh g −1 at 30C (60 °C). Remarkably, the CGE exhibits excellent low-temperature adaptability, retaining nearly 100% capacity at –20 °C. These results highlight a viable strategy for designing safe and high-performance solid-state sodium metal batteries toward practical deployment.
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JOURNAL OF MOLECULAR HISTOLOGY
·
2026
·Vol. 57
·期 1
·30
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IF 2.2
Xiang Shouyu,Liu Wei,Tang Cheng,Xie Chuhai,Hu Hailan,Zhou Jianhui,Cao Yanming,Ling Long
Bone marrow mesenchymal stem cells (BMSCs) play a significant role in bone defect repair. Currently, the limited survival and function of transplanted BMSCs pose major obstacles to tissue repair mediated by these cells. Therefore, the exploration of BMSCs transplantation activity has become an urgent clinical problem. In this experiment, we constructed lentiviral vectors with overexpression and silencing of miR-19b-3p and utilized a rat fracture model. The effects of BMSCs proliferation were examined using CCK-8, the Annexin V-FITC apoptosis kit and TUNEL assay, the effects of BMSCs osteogenic differentiation were detected using ALP and Alizarin red staining. Furthermore, Western blotting and qRT-PCR were employed to examine the expression of key proteins in the PTEN/Akt/mTOR signaling pathway and autophagy-related proteins. Moreover, the impact of miR-19b-3p on bone microstructure was assessed using Micro CT, HE, Safranin O/Fast Green, as well as Masson staining, and Immunohistochemistry analysis examined PTEN, p62 and Runx2 expression levels on fracture site. By constructing lentiviral vectors with overexpression and silencing of miR-19b-3p, we found that silencing miR-19b-3p significantly promoted the proliferation as well as the osteogenic differentiation of BMSCs under hypoxia. Western blotting and qRT-PCR results showed that silencing miR-19b-3p significantly increased PTEN, LC3, and Beclin1 expression while decreasing p-Akt, p-mTOR, and p62 expression. Furthermore, by constructing the fracture rats and administering hypoxia-treated BMSCs transfected with miR-19b-3p via tail vein injection, we found that silencing miR-19b-3p obviously increased the formation of trabecular and promoted the healing of the fractures. Immunohistochemistry analysis showed that silencing miR-19b-3p upregulated PTEN and Runx2 expression levels and suppressed p62 expression with statistical significance. In summary, these findings suggest that miR-19b-3p may regulate BMSCs’ autophagy and osteogenic differentiation under hypoxia via the PTEN/Akt/mTOR signaling pathway, thereby promoting fracture healing and providing a potential target for the treatment of fractures.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·171
·
IF 36.3
Dai Xin-jian,Wang Xin,Hu Ji-hang,Jiang Pan,Wang Xiao-qing
Highly elastic, fatigue-resistant, and conductive lamellar wood sponges are developed via a cell wall reconfiguration strategy.
The strain-induced conductivity changes in lamellar wood sponge enable tunable electromagnetic interference shielding effectiveness and high-sensitivity pressure sensing (0.72 kPa −1 ).
The wood sponge exhibits a low through-plane thermal conductivity of 0.037 W m −1 K −1 , which is compression-tunable for smart thermal management.
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Nature Communications
·
2026
·
IF 18.1
Topatana Win,Sun Yuchao,Xie Tianao,Zhu Yiyuan,Yang Taorui,Shen Ruijing,Ran Peng,Li Chengao,Chen Jiadong,Shen Xuqiu,Lu Ziyi,Han Yina,Shan Yukai,Li Shijie,Chen Tianen,Cai Xiujun,Deng Renren,Juengpanich Sarun,Chen Mingyu
Persistent luminescence is a promising approach for photodynamic therapy (PDT) in deep-seated tumors, as it provides sustained light within tissues, eliminating the need for continuous external illumination. However, the uncontrollability of light within the body complicates precise spatiotemporal regulation. In this study, we report X-ray preactivated elimusertib-loaded tumor-targeted photodynamic nanoparticles (ETPNs), featuring reversible “on-off” afterglow properties. The excellent afterglow properties of X-ray-activated porous NaYF 4 :Er@NaGdF 4 persistent luminescence nanoparticles enable the continuous activation of chlorin e6 (Ce6) to generate reactive oxygen species (ROS), leading to DNA damage. The integration of elimusertib potentiates ROS-induced DNA damage and activates the cGAS-STING pathway, thereby enhancing immuno-photodynamic therapeutic efficacy. All in vivo experiments were conducted using female mice. Our findings highlight the potential of ETPNs to advance the therapeutic landscape for deep-seated tumors, offering a robust and controllable platform for combined immuno-photodynamic therapy.
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