JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2025
·Vol. 150
·期 17
·13775-13790
·
IF 3.1
Song Lingjun,Xia Yongpeng,Wang Yitong,Hu Haopan,He Yuting,Li Bin,Sun Lixian,Sun Yujia,Xu Fen
The development of multifunctional, environmentally friendly, and energy-efficient composite phase change materials (CPCMs) is crucial for improving energy recovery and utilization in various applications and environments. Herein, we utilized the salt template method, assisted by polyvinylidene fluoride (PVDF), to design a novel three-dimensional porous carbon network based on expanded graphite (EG) and loaded with reduced graphene oxide (rGO) as an enhancing bridge. The resulting interconnected and dense three-dimensional porous carrier was employed for the melt encapsulation of octadecane (OD). DSC analysis revealed that the prepared CPCMs possess an excellent heat storage density of 168.93 J g −1 and a thermal storage capacity of > 99.9%. Notably, the continuous three-dimensional carbon network of EG and rGO in the CPCMs, with strong full-spectrum absorption and rapid photon and phonon transmission, led to a synergistic enhancement. The thermal conductivity of OD@6EG/PVDF/rGO reached 6.3840 W m −1 K −1 , surpassing that of most carbon-based CPCMs. The composite material exhibited a photo-thermal conversion efficiency of 96.3% and an electro-thermal conversion efficiency of 74.4%, enabling the stable operation of a self-assembled photo-thermal-electric energy conversion system. After 200 heating–cooling cycles, the CPCMs demonstrated significant thermal and shape stability. Moreover, OD@EG/PVDF/rGO possessed self-cleaning and microwave absorption properties, expanding its potential for multifunctional applications. This study lays the foundation for the application of carbon-based materials in thermal management and energy conversion technology. Graphical
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Minerals Metallurgy and Materials
·
2025
·Vol. 33
·期 1
·315-321
·
IF 7.2
He Shengzhi,Sun Chunwen
Heteroatom-doped carbon is considered a promising alternative to commercial Pt/C as an efficient catalyst for the oxygen reduction reaction (ORR). This study presents the synthesis of iron-loaded, sulfur and nitrogen co-doped carbon (Fe/SNC) via in situ incorporation of 2-aminothiazole molecules into zeolitic imidazolate framework-8 (ZIF-8) through coordination between metal ions and organic ligands. Sulfur and nitrogen doping in carbon supports effectively modulates the electronic structure of the catalyst, increases the Brunauer–Emmett–Teller surface area, and exposes more Fe–N x active centers. Fe-loaded, S and N co-doped carbon with Fe/S molar ratio of 1:10 (Fe/SNC-10) exhibits a half-wave potential of 0.902 V vs. RHE. After 5000 cycles of cyclic voltammetry, its half-wave potential decreases by only 20 mV vs. RHE, indicating excellent stability. Due to sulfur’s lower electronegativity, the electronic structure of the Fe–N x active center is modulated. Additionally, the larger atomic radius of sulfur introduces defects into the carbon support. As a result, Fe/SNC-10 demonstrates superior ORR activity and stability in alkaline solution compared with Fe-loaded N-doped carbon (Fe/NC). Furthermore, the zinc–air battery assembled with the Fe/SNC-10 catalyst shows enhanced performance relative to those assembled with Fe/NC and Pt/C catalysts. This work offers a novel design strategy for advanced energy storage and conversion applications.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·
IF 15.7
Yuan Jiashuai,Jian Chuanyong,Gong Yujia,Ju Qiankun,Cai Qian,Kang Jiahao,Liu Wei
Layered dielectric materials and their van der Waals (vdW) heterostructures offer high potential for next-generation two-dimensional (2D) electronic devices, but materials that combine a wide bandgap and high dielectric constant are rare. Here, we present the controllable synthesis of quasi-vdW layered samarium oxysulfate (Sm 2 O 2 SO 4 ) single crystals via a molten-salt-assisted chemical vapor deposition (CVD) method. These atomically thin crystals exhibit remarkable dielectric properties, including a wide bandgap (~5.54 eV), high dielectric constant (~18), robust breakdown voltage (>12 MV cm -1 ) and good thermal reliability. By integrating ultrathin Sm 2 O 2 SO 4 nanoplates with 2D molybdenum disulfide (MoS 2 ) via vdW forces, we fabricate field-effect transistors (FETs) showing a subthreshold swing down to 65.2 mV dec -1 , hysteresis down to 5.4 mV, on/off current ratios of ~10 9 , and gate leakage currents down to around 7 × 10 -7 A cm -2 . Furthermore, a high gate coupling ratio (GCR ~ 0.83) non-volatile memory device was developed based on the MoS 2 /h-BN/MLG/Sm 2 O 2 SO 4 /MLG heterostructure. The flash memory achieves ultrafast (~50 ns) programming/erasing operations, robust endurance (>2000 cycles) and long-term retention (>10 years). This work shows promising results for the integration of Sm 2 O 2 SO 4 as a high- κ dielectric in future 2D devices, with implications for low-power, high-performance electronics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PLANT PATHOLOGY
·
2020
·Vol. 158
·期 4
·965-974
·
IF 1.582
Liang Xiaoyu,Peng Yun,Zou Lijun,Wang Meng,Yang Ye,Zhang Yu
Colletotrichum leaf disease (CLD), mainly caused by the Colletotrichum gloeosporioides species complex (CGSC), is a serious disease of rubber tree in most rubber-growing countries. Few fungicides are available for rubber farmers to manage this disease. To control CLD effectively, it is important to test the baseline sensitivity and efficacy of fungicides against CGSC isolates. Penthiopyrad is a new succinate dehydrogenase inhibitor (SDHI) that has been registered for use in many countries. In this study, baseline sensitivity to penthiopyrad was established by mycelial growth methods using 91 CGSC isolates collected from rubber trees in China. The EC 50 values of penthiopyrad ranged from 0.243 to 3.377 mg/L with a mean EC 50 value of 1.685 mg/L. Penthiopyrad greatly decreased the mycelial biomass and increased cell membrane permeability of CGSC isolates. The mycelia were severely distorted, and the number of top branches increased with penthiopyrad treatment. Penthiopyrad inhibited succinate dehydrogenase activity, causing a decrease in the ATP content of CGSC isolates, and significantly inhibited conidia germination and appressorium formation on rubber tree leaves. The protective and curative efficacy of 100 mg/L penthiopyrad reached up to 98.53% and 66.79% against CLD, respectively. Our results demonstrated the high inhibitory activity of penthiopyrad against CGSC isolates and its potential for CLD management on rubber tree.
✓ 已验证
DOI
高影响因子
Food Biophysics
·
2025
·Vol. 20
·期 4
·191
·
IF 3.2
Hu Wenmei,Qin Xianglin,Huang Kai,Ren Erfang,Miao Yifan,Liao Siru,Zhang Siqi,Chen Shan
This research primarily investigates the encapsulation of curcumin within curdlan-whey protein isolate(CUR-WPI) composite gels and the subsequent release of the encapsulated compound. Results demonstrated that the composite gel could effectively encapsulate curcumin, with the highest encapsulation rate reaching 83.6%. The main force for the gel to encapsulate curcumin was electrostatic interaction and hydrogen bond. Fluorescence spectroscopy showed that curcumin can bind to WPI through hydrophobic interactions and suppress WPI's natural fluorescence. The composite gel exhibits excellent water-holding capacity (WHC) and the favorable texture profile analysis (TPA), which improved the photostability (2.57 times) and storage stability of curcumin (6.09 times). Moreover, the release rate of curcumin from the composite gel in intestinal fluid was higher than that in the stomach, which was related to the non-digestible characteristics of the curdlan and the dense network structure of the gel. The release kinetics results indicated that the main release mechanism of curcumin in the composite gel during the simulated digestion process was the diffusion mechanism. In conclusion, CUR-WPI composite gel is a good delivery carrier for curcumin, indicating its potential value for application in functional dairy products. Graphical
✓ 已验证
产品关联
DOI
高影响因子
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
·
2025
·
IF 1.5
Jiang Yu-cheng,Hai Jun-qi,Zhu Di,Long Xiang-li
The commercial production of benzaldehyde through the toluene chlorination and hydrolysis method not only releases chloride-laden effluents into the environment but also excludes its application into the field of food and medicine due to the residual chlorine. To develop a green process that produces chlorine-free product efficiently and cheaply, a keggin-type polyoxometalate designed with Co as a heteroatom, Mo, W and Mn as ligand atoms and La as a counter cation has been loaded on activated carbon to catalyze the production of benzaldehyde from the oxidation of toluene in liquid-phase by oxygen. The optimum catalyst preparation conditions are as follows: polyoxometalate loading 35%(wt), pH 1 = 7.1, pH 2 = 3.8, T 1 = T 2 = 85 °C and activated in N 2 at 220 ℃ for 4 h. Characterization has been done with ICP-OES, FT-IR, XRD and TG. The polyoxometalate synthesized is proved to be Keggin-type structure. The catalyst Na 4.2 LaCoMn 0.3 W 1.5 Mo 10.2 O 40 ·18.53H 2 O@AC manifests the best performance in catalyzing the production of benzaldehyde from the partial oxidation of toluene with a toluene conversion of 18.55%, benzaldehyde selectivity of 33.61% and benzaldehyde yield of 6.23%.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·784
·
IF 12.6
Lv Jiali,Cheng Chen,Liu Xinran,Song Jinhua,Li Daxiang,Wang Yijun,Du Yiqun
The physicochemical properties of oral drug delivery carriers significantly influence their interactions with the intestinal barrier, which, in turn, affect their in vivo fate and therapeutic efficacy. As a delivery system with a hierarchical structure and high stability, Pickering emulsions have demonstrated significant advantages in enhancing the bioavailability of encapsulated bioactive compounds. However, the specific role of their inherent flexibility in modulating interactions with the intestinal barrier and influencing delivery efficiency remains poorly understood. In this study, a flexible Pickering emulsion (FPPE) stabilized by chitosan nanoparticles was developed for encapsulating epigallocatechin gallate, aiming to investigate the role and underlying mechanism of its flexible structure in mucus penetration, cellular uptake, and biodistribution in the intestinal tract. Upon reaching the intestinal tissue, FPPE exhibited deformable adaptation, facilitating efficient mucus permeation, prolonged gastrointestinal retention, and enhanced drug absorption. Moreover, FPPE enhanced macrophage uptake and mitochondrial membrane potential, reduced reactive oxygen species scavenging, and triggered macrophage reprogramming. Compared to rigid chitosan microspheres, FPPE more effectively alleviated intestinal inflammation and promoted intestinal barrier repair in a dextran sulfate sodium-induced acute colitis mouse model. This study reveals how Pickering emulsion flexibility facilitates intestinal mucus delivery, guiding their future design and application. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 237
·期 5
·317
·
IF 3
Wang Kexun,Wang Yichen,Zhu Xueqiang,Zhou Lai
This study investigates the in situ degradation of naphthalene (NAP) in contaminated soil using a biochar-supported nano zero-valent iron (BC@nZVI) composite to activate persulfate (PS). NAP, a persistent polycyclic aromatic hydrocarbon (PAH), poses significant ecological risks due to its carcinogenicity and environmental mobility. The BC@nZVI composite was synthesized via a two-step hydrothermal–carbonization method and characterized using XRD, SEM, TEM, BET, and FT-IR, confirming its enhanced stability and reduced aggregation compared to bare nZVI. Sandbox experiments optimized critical injection parameters, demonstrating that a PS dosage of 2% soil mass and a BC@nZVI:PS mass ratio of 1:2 achieved 76.6% NAP degradation within 4.5 cm of the injection well after 72 h. Pre-injection of BC@nZVI followed by PS at a high flow rate (2.68 L·min⁻ 1 ) enhanced reagent distribution, yielding degradation rates of 44.1–80.3% across a 9 cm radius. Reduced injection volumes (3.2 L) or reversed injection sequences diminished efficiency by 14–25%, while excessive reagents induced radical self-quenching (e.g., SO 4 − · scavenging) and Fe 2 ⁺ overconsumption. Compared to conventional Fe 2 ⁺-activated systems, the BC@nZVI/PS system exhibited superior soil penetration, sustained radical generation, and reduced PS consumption, effectively addressing challenges in heterogeneous soil remediation. These findings provide actionable strategies for scalable PAH-contaminated site remediation, balancing high efficacy with operational and environmental feasibility. Graphical
✓ 已验证
产品关联
DOI
高影响因子
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
·
2019
·Vol. 393
·期 6
·951-966
·
IF 2.058
Tong Rui,Zhang Jingru,Wang Chunyan,Li Qian,Wang Ling,Ju Mingxiu
Cervical cancer is the fourth most common female malignancy worldwide and microRNA (miR)-574-5p is a candidate oncogene in multiple cancers. The present study aimed to investigate the role and mechanism of miR-574-5p in cervical cancer. miR-574-5p inhibitors or mimics were transfected into cervical cancer cells to study the function of miR-574-5p. The effects of miR-574-5p on cell growth, invasion, and chemosensitivity were evaluated using CCK8, flow cytometry, transwell, immunofluorescence, and Western blotting analysis. Further depletion or forced expression of QKI was performed to explore the regulatory mechanism of miR-574-5p in cervical cancer. Up-regulation of miR-547-5p and down-regulation of QKI were observed in 30 cervical cancer tissues versus 30 adjacent normal tissues. Silencing of miR-574-5p increased apoptosis, inhibited proliferation, cell cycle progression, and cell invasiveness, as well as enhanced chemosensitivity towards cisplatin and doxorubicin in cervical cancer cells. Overexpression of miR-574-5p exerted promoting effect on cancer progression and metastasis. Knockdown of miR-574-5p induced an up-regulation of E-cadherin and down-regulation of cyclinD1, N-cadherin, matrix metallopeptidase 9 (MMP-9), and β-catenin in cervical cancer cells Moreover, QKI was verified as a target of miR-574-5p and involved in regulation of miR-574-5p-induced cervical cancer cell progression and metastasis. miR-574-5p functions to be oncogenic in cervical cancer, and its inhibition suppresses cervical cancer progression and metastasis as well as enhances chemosensitivity by targeting QKI. Therefore, miR-574-5p is suggested as a potential therapeutic target for cervical cancer treatment.
✓ 已验证
DOI
PubMed
高影响因子
Lipids in Health and Disease
·
2018
·Vol. 17
·期 1
·1-7
·
IF 2.663
Luo Mengdie,Su Xin,Yi Yuhong,Yang Yang,Peng Daoquan
Background Angiopoietin-like protein 8(ANGPTL8) and apolipoprotein CIII (apoCIII) were found to inhibit the activity of lipoprotein lipase (LPL) and disrupt the clearance of triglyceride-rich lipoproteins (TRLs), leading to hypertriglyceridemia. Whether any relationship exists between these two important modulators of triglyceride metabolism has not been reported. Besides, whether ANGPTL8 concentration is altered in the patients with coronary artery disease (CAD) is still unclear. Methods A hospital-based case-control study was conducted. Sixty-eight CAD subjects and fifty-two nonCAD controls were recruited. Plasma apoCIII, ANGPTL8 was measured. Results ANGPTL8 and apoCIII concentration exhibited no significant difference between CAD group and nonCAD group. Both ANGPTL8 and apoCIII were significantly correlated with triglyceride level( r = − 0.243, P = 0.008; r = 0.335, P < 0.001, respectively). Regression analysis revealed that apoCIII was an independent contributor to triglyceride level independent of ANGPTL8 concentration (standardized β = 0.230, P < 0.01). Conclusion ApoCIII may mediate the effects of ANGPTL8 on triglyceride metabolism.
✓ 已验证
DOI
PubMed
高影响因子
Neuroscience Bulletin
·
2021
·Vol. 37
·期 9
·1271-1288
·
IF 5.203
Li Hao,Wu Shihao,Ma Xia,Li Xiao,Cheng Tianlin,Chen Zhifang,Wu Jing,Lv Longbao,Li Ling,Xu Liqi,Wang Wenchao,Hu Yingzhou,Jiang Haisong,Yin Yong,Qiu Zilong,Hu Xintian
Whether direct manipulation of Parkinson’s disease (PD) risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue. Here, we used an adeno-associated virus serotype 9 (AAV9)-delivered CRISPR/Cas9 system to directly co-edit PINK1 and DJ-1 genes in the substantia nigras (SNs) of two monkey groups: an old group and a middle-aged group. After the operation, the old group exhibited all the classic PD symptoms, including bradykinesia, tremor, and postural instability, accompanied by key pathological hallmarks of PD, such as severe nigral dopaminergic neuron loss (>64%) and evident α-synuclein pathology in the gene-edited SN. In contrast, the phenotype of their middle-aged counterparts, which also showed clear PD symptoms and pathological hallmarks, were less severe. In addition to the higher final total PD scores and more severe pathological changes, the old group were also more susceptible to gene editing by showing a faster process of PD progression. These results suggested that both genetic and aging factors played important roles in the development of PD in the monkeys. Taken together, this system can effectively develop a large number of genetically-edited PD monkeys in a short time (6–10 months), and thus provides a practical transgenic monkey model for future PD studies.
✓ 已验证
DOI
PubMed
高影响因子
Nano Research
·
2021
·Vol. 15
·期 1
·593-602
·
IF 8.897
Feng Liandong,Yang Li,Li Longjie,Xiao Junying,Bie Nana,Xu Chao,Zhou Jun,Liu Hongmei,Gan Lu,Wu Yuzhou
The therapeutic efficacy of programmed cell death protein 1/programmed cell death-ligand 1 (PD-1/PD-L1) blockade immunotherapy is extremely dampened by complex immunosuppressive mechanisms including regulatory T cells (Treg), M2 macrophages (M2), and prostaglandin E2 (PGE2). The pivotal roles of PGE2 have been recognized by directly inactivating CD8+ T cells and indirectly inducing Treg and M2. Therefore, PGE2 abolishment through inactivating cyclooxygenase-2 (COX-2) could be robust to sensitize tumour toward anti-PD-1/PD-L1 immunotherapy, which has gone into clinical trials. However, exploring this promising strategy in nanomedicine to enhance immunotherapy remains unrevealed. The key challenge to synergistically combine COX-2 inhibition and anti-PD-1/PD-L1 lies in the different pharmacokinetic profiles and the spatial obstacles since PD-1/PD-L1 interaction occurs extracellularly and COX-2 locates intracellularly. Thus, the programmed release nanoparticles (termed as Cele-BMS-NPs) are rationally designed, which are composed of pH-sensitive human serum albumin derivative, BMS-202 compound as PD-1/PD-L1 inhibitor, glutathione (GSH)-activatable prodrug of celecoxib (COX-2 inhibitor). The in vitro experiments demonstrate that this smart Cele-BMS-NPs could extracellularly release BMS-202 under the acidic tumour microenvironment, and the intracellularly release of celecoxib in response to the elevated GSH concentration inside tumour cells. After systemic administration, the intratumoral infiltration of CD8+ T cells is significantly enhanced and meanwhile immunosuppressive M2, Treg, and PGE2 are reduced, thereby eliciting the anti-tumour immune responses toward low immunogenic tumours and postsurgical tumour recurrences.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）