FOOD HYDROCOLLOIDS
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2024
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IF 11
Jingxian Niu,Qianzhu Lin,Xiaojing Li,David Julian McClements,Hangyan Ji,Zhengyu Jin,Chao Qiu
In this study, four different types of essential oil monomer and tannic acid were used to prepare different kinds of essential oil-tannin particles. As well as encapsulating the chemically labile essential oils, these particles could also be used as Pickering emulsifiers to prepare oil-in-water emulsions. These emulsions were co-stabilized using the essential oil-tannin particles in combination with chitosan. The resulting Pickering emulsions were shown to have good storage stability, viscoelastic properties, antioxidant activity , and antibacterial activity. The emulsions co-stabilized by cinnamaldehyde-tannin and chitosan had the smallest particle size and largest shear viscosity, shear modulus, and physical stability. An in vitro digestion study showed that the cinnamaldehyde encapsulated within these emulsions also had a relatively high bioaccessibility. Considerable differences were observed in the stabilities of emulsions prepared with different oil phase volume fractions. The more concentrated emulsions did not exhibit phase separation after 30 days storage, which was attributed to the fact that the close packing of the oil droplets prevented their movement. This study shows that essential oil-polyphenol particles can be used as multifunctional ingredients, such as antioxidants, antimicrobial agents, and emulsifiers.
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ULTRASONICS SONOCHEMISTRY
·
2025
·
IF 9.7
Ruihua Zhang,Shuting Li,Mingyan Ai,Shenghuizi Chen,Chunlan Zhang,Zhiqiang Zhou,Lili Huang,Xiang Li,Jiankang Lu
Cantaloupe seed protein isolate (CSPI) has attracted the attention of its low cost, easy digestion and balanced composition of essential amino acids. However, due to the low solubility of CSPI, its application in the food industry is limited. Therefore, the present study investigated the effect of ultrasound-assisted phosphorylation on the solubility of CSPI and the structural properties were characterized. The solubility of cantaloupe seed protein increased from 9.17 % to 63.27 % by ultrasound assisted phosphorylation, and resulting in an increase in the absolute value of CSPI potential, a decrease in particle size, and a stable structure, which could be used for the construction of the food emulsification system. The modified CSPI was combined with chitosan (CS) to prepare stabilized Pickering emulsion for subsequent stability study. The results showed that stable Pickering emulsions could be prepared with CSPI at pH 7, CS 0.5 % and oil phase fraction 55 %. Ultrasound-assisted phosphorylation enhanced electrostatic interaction between CS’s –NH 3 groups and CSPI’s –COO−groups which improved the storability of stabilized Pickering emulsion. This will help to broaden the application range of CSPI and provide a theoretical basis for CPI stable Pickering emulsion.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Xuan Du,Suraya Abdul Rashid,Luqman Chuah Abdullah,Norizah Abdul Rahman
Guided by efficient utilization of natural abundant cellulose and chitosan as separation materials, it is desired to tailor the composition of electrospun cellulose acetate/chitosan (CL/CS) membranes to achieve their optimal application in the management of aquatic heavy metal pollution. In this work, CL/CS membranes with enhanced surface area of 11.3–38.6 m 2 /g were successfully fabricated via electrospinning technique by dissolving cellulose acetate and chitosan into the environmental-friendly electrospinning solvent of LiOH/thiourea/H 2 O. Electrospun CL/CS membranes allowed the efficient sorption of Cr(VI), Pb(II) and Cu(II) with favorable kinetics (8.0 h), and excellent capacities (127.6 mg/g for Cr(VI), 66.2 mg/g for Pb(II), 46.7 mg/g for Cu(II) at pH 5.0, T 298 K). Meanwhile, they presented favorable efficiencies in the removal of these multiple heavy metals from acid simulated wastewaters. The spectroscopic analysis results indicated that the sorption mechanism should be dominant by the surface complexation of heavy metals with hydroxyl O-/amino N-species, the electrostatic attraction (protonated NH 3 + with negatively charged HCrO 4 - , deprotonated O - with positively charged Pb(II) and Cu(II)), as well as the reduction of Cr(VI) to Cr(III) by surface reductive N-species. This work demonstrated the feasibility of electrospun CL/CS membranes as a promising choice for the remediation of aquatic heavy metals.
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INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
·
2025
·
IF 5.2
Hehe Yang,Yan Lu,Liangliang Bao,Yao Liu,Dongqi Liu,Zhimei Zhong
Three pyridine-3-formyl chitosan derivatives were successfully prepared, and the preservation performance of the derivatives was examined. According to the results, the derivatives exhibited better antifungal and antioxidant properties than that of chitosan. At a supply concentration of 0.5 mg/mL, 2-ANACS could scavenge DPPH radicals at a rate of (92.82 ± 0.38)%. Additionally, all three derivatives exhibited less cytotoxicity and higher biocompatibility. In the freshness preservation studies of cherry tomatoes, the three derivatives considerably decreased the weight loss rate and postponed the drop in V C and titratable acid content. After 32 days of 2.0 g/L VPPCS treatment, the weight loss of cherry tomatoes was (4.0 ± 0.52) % among them. Still, the weight loss of cherry tomato in the chitosan treatment and blank control was (5.5 ± 1.33) % and (5.94 ± 1.02) %, respectively, which was considerably decreased by VPPCS therapy. These findings demonstrated that adding niacin improved chitosan's antifungal and antioxidant properties, extended the shelf life of cherry tomatoes, and increased the potential uses of chitosan and its derivatives in fruit preservation.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Lizhen Zhang,Zhengjie Liu,Mingzhu Ma,Yadong Zhao,Wenhua Miao,Yan Chen,Weiling Shi,Qihe Chen
Active packaging is a novel food packaging concept where natural active ingredients enhance the packaging's performance. This study aimed to develop a chitosan (CS)-based nanoemulsion combined with melleolides (CS-M) as a novel edible active coating for preserving fresh salmon. Additionally, the study evaluated the physical stability, microstructure, rheology, and antibacterial properties of CS-M, as well as the preservation effects on salmon when combined with atmospheric cold plasma (ACP). Results showed that CS-M maintained uniform particle size and stable dispersity over 7 days, demonstrating long-term stability, particularly at 4 °C. Compared to CS and melleolides alone, CS-M exhibited superior antibacterial activity against S. aureus and E. coli , effectively inhibiting microbial growth during salmon preservation. Furthermore, CS-M alone demonstrated a good preservation effect, which was significantly enhanced when combined with ACP. In conclusion, the CS-based nanoemulsion containing melleolides shows strong potential for salmon preservation, with its effectiveness further enhanced by ACP.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Qian Liao,Longfei Lin,Ruying Tang,Zhuo Xu,Shasha Kong,Dan Lv,Donghan Bai,Yuling Liu,Hui Li
Oral mucosal lesions (OML), which represent a major public health issue worldwide, include any pathological changes in the oral mucosa, such as ulcers, pigmentation, and swelling. Due to its humid and dynamic complex environment, designing oral mucosal preparations poses significant challenges. Drawing inspiration from mussels, this study employed an eco-friendly one-pot strategy for the preparation of chitosan/polydopamine (CS/PDA) films. We demonstrated that CS-induced polymerization of dopamine monomers under acidic conditions, which might be attributed to the large number of hydrogen bonding sites of CS chains. PDA markedly enhances properties of the CS film and exhibits concentration dependence. At the concentration of 1 wt% PDA, the lap-shear strength and tensile strength of CS/PDA films reached 5.01 ± 0.24 kpa and 4.20 ± 0.78 kpa, respectively, indicating that the mucosal adhesion ability was significantly improved. In comparison with the single CS film, the swelling rate of CS/PDA film decreased by about 30 %. Rheological results also showed that the storage modulus returned to 93 % after cyclic large strain, while the single CS film only recovered to 73 %. Moreover, these films demonstrated good biocompatibility and enhanced oral ulcer healing in rats, providing a new and practical option for the local treatment of OML.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Lei Liu,Lei He,Liping Jin,Haojie Shi,Shuhan Ye,Lingxin He,Wei Wang,Wenwen Guo
To obtain cotton fabrics with high-efficiency flame retardancy, a novel nanohybrid MXene modified with phosphorylated chitosan (CS) was successfully prepared through a simple chemical modification strategy. It was subsequently employed in the fabrication of PC@T-MXene-functionalized cotton fabric (PC@T-MXene-C) through an impregnation process. The thermal stability and flame retardancy of the pure and treated cotton textiles were analyzed via TGA, LOI, VBT flammability tests and cone calorimetry. Compared with those of the original cotton textile and PCS-decorated cotton fabric (PC-C), the thermal and flame-retardant performance of PC@T-MXene-C was significantly enhanced. When the weight gain of the treated cotton fabric was 12 % (PC@T-MXene-C3), the LOI of PC@T-MXene-C3 significantly reached 35 %, and the peak heat release rate (PHRR) and total heat release (THR) decreased by 80.7 % and 43.7 %, respectively, compared with those of the original cotton textile. Additionally, PC@T-MXene-C3 retained 39.1 % of the char residual at high temperature under a nitrogen atmosphere in the TGA analysis. This eco-friendly biomass-based flame-retardant coating provides a new strategy for fabricating green flame-retardant systems without the use of hazardous compounds.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yilin Yu,Ning Kong,Zhaoyang Hou,Libo Men,Pei Yang,Zhengjin Wang
Developing a packaging material with integrated cushioning, intelligent and active functions is highly desired but remains challenging in the food industry. Here we show that a sponge-like porous hydrogel with pH-indicating and antibacterial additives can meet this requirement. We use polyvinyl alcohol and chitosan as the primary polymers to construct a hydrogel with hierarchical structures through a freeze-casting method in combination with salting-out treatment. The synergy of aggregated polymer chains and the sponge-like porous structure makes the hydrogel resilient and efficient in energy absorption. It also enables rapid movement of molecules/particles and fast reaction due to the large specific surface area of the pore structures and the large amount of free water in it, leading to a sensitive pH-indicating function. The hydrogel shows an obvious color variation within a wide pH range in 3 min. The silver nanoparticles are fixed in the dense polymer networks , enabling a lasting release of silver ions . The porous structure makes the silver ion reach the protected item in a short time, achieving an antibacterial effect against S. aureus and E. coli with little cytotoxicity. This work paves the way for fabricating multifunctional hydrogels for diverse advanced packaging systems.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Ashuang Liu,Shengyong Cui,Lei Song,Xiangshu Guo,Zhimao Huang,Shancan Wang,Kai Cheng,Ying Xiao,Youfen Fan,Rong Wang
Hemostatic powders are widely used for managing bleeding from wounds with various irregular shapes. However, their limited liquid absorption capacity and difficulty in removal after application remain significant clinical challenges. Herein, we introduce a multifunctional hemostatic powder composed of dually crosslinked poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride- co -acrylic acid) (pMATC- co -AA) and N -[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride (HTCC), which are integrated via electrostatic interactions and hydrogen bonding. This hemostatic powder exhibits superb liquid-absorbing capacity (94.5 times its own weight in water and 9.1 times in blood), sufficient adhesive properties (5.9 kPa on pig skin), and on-demand removability. It significantly reduces the number of viable Escherichia coli and Staphylococcus aureus by 4.61 and 4.04 orders of magnitude, respectively, thus providing an effective microbiological barrier for the wound. Furthermore, a series of in vivo and in vitro experiments confirm the powder's excellent hemostatic properties. The hydrogel formed on the wound after hemostasis can be removed by saline rinsing on demand, due to its superb liquid-absorbing capacity. Notably, the powder demonstrates good in vivo biocompatibility, with minimal risk of impeding wound healing, and it facilitates the healing process during the later stages. In sum, the hemostatic powder offers a promising solution for trauma bleeding control and acute wound treatment.
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AAPS PHARMSCITECH
·
2025
·Vol. 26
·期 4
·1-17
·
IF 4
Luo Zhilin,Sun Yao,Cai Shihao,Liu Hongting,Zhao Conglu,Xu Xiang,Xu Aiguo,Zhou Honggang,Yang Cheng,Gu Xiaoting,Ai Xiaoyu
Idiopathic Pulmonary Fibrosis (IPF) is a rare and serious chronic interstitial lung disease that may endanger the lives of patients. The median survival time of patients with idiopathic pulmonary fibrosis is short, and the mortality rate is higher than that of many types of cancer. At present, pirfenidone (PFD) and nintedanib (NDNB) have been approved by FDA for IPF, but they can only delay the process of pulmonary fibrosis and cannot cure the disease. Therefore, it is urgent to develop other drugs with the effect of improving pulmonary fibrosis. Ellagic acid (EA) can inhibit the Wnt-signaling pathway and has an effect in treating pulmonary fibrosis induced by bleomycin (BLM) in mice. However, its solubility is poor, resulting in its low bioavailability and limited therapeutic benefits, so its clinical application has been limited. Herein, based on the characteristics of nano-drug lung delivery system, chitosan (CS) was selected as the carrier, and ellagic acid-loaded chitosan nanoparticles (EA-CS-NPs) were prepared by ionic gelation method. The EE% and DL% of prepared EA-CS-NPs was 73.73 ± 4.52% and 6.23 ± 1.09%, the particle size was 119.6 ± 5.51 nm (PDI = 0.234 ± 0.017), the zeta potential was 29.833 ± 0.503 mV. The morphology of the nanoparticles was observed by TEM microscope, which was round, uniform dispersion, indicating that the preparation process is stable and feasible. The toxicity experiment showed that EA-CS-NPs maintained 80% cell viability, significantly higher than that of the NDNB group, indicating lower toxicity and better inhibitory effects on TGF-β1-stimulated MLg and NIH-3T3 cells. Wound healing assay results showed that the inhibitory effect of EA-CS-NPs on cell migration was more pronounced than that of EA in the same amount of EA-containing drugs. Drug uptake experiments revealed that EA-CS-NPs significantly enhanced drug uptake in MLg and NIH-3T3 cells. In vivo , Cy7-CS-NPs exhibited higher fluorescence intensity in rat lungs compared to Cy7 solution, indicating better lung retention. The in vivo efficacy test showed that compared with the EA group, EA-CS-NPs could better reduce the area of pulmonary fibrosis and collagen deposition, improve lung function, and have a longer retention time in the lung. In summary, our results revealed that EA-CS-NPs may be a good choice for the treatment of pulmonary fibrosis. Graphical
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CARBOHYDRATE RESEARCH
·
2024
·
IF 2.4
Lin Wang,Yu Pang,Zhongwen Su,Meihua Xin,Mingchun Li,Yangfan Mao
N -(sodium 2-hydroxypropylsulfonate) chitosan (HSCS), N -sulfonate chitosan (SCS) and N -isonicotinic sulfonate chitosan (ISCS) were prepared. The structures of the prepared chitosan derivatives were characterized by nuclear magnetic resonance ( 1 H NMR) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, ultraviolet–visible (UV–vis) spectroscopy and elemental analysis (EA). Antibacterial and antibiofilm activities of these chitosan derivatives were evaluated in vitro . The minimum inhibitory concentration (MIC) of HSCS and SCS against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) were 0.625 mg/mL and 0.156 mg/mL, respectively. ISCS exhibited MIC values of 0.313 mg/mL and 0.078 mg/mL against E. coli and S. aureus , respectively. ISCS demonstrated superior antibacterial and antibiofilm properties compared to SCS and HSCS. These findings suggest that the incorporation of a pyridine structure into sulfonate chitosan enhances its antibacterial and antibiofilm activities, and the prepared ISCS has a promising application prospect for controlling the reproduction of microorganisms in the field of food packaging.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Fenglei Chen,Xiaoshuai Peng,Keng Chen,Jiapeng Song,Yue Fan,Peng Wang,Xingxing Shi,Zhaopeng Cai
Dural defects and subsequent cerebrospinal fluid (CSF) leakage are common complications in spinal and cranial surgeries. However, current clinical patches often fail to achieve long-term adhesion and effective sealing, as the presence of CSF can weaken interfacial bonding and ultimately result in adhesion failure. Herein, a new class of chitosan-based adhesive patch (PLLA/CP) is designed by constructing an adhesive hydrogel layer containing chitosan-dopamine (CS-DA) on the surface of fibrous poly(L-lactic acid) (PLLA) layer. Benefitting from electrostatic crosslinking within the hydrogel layer and the mechanical reinforcement of PLLA layer, our patch exhibits a low swelling ratio (3.8 %) without compromising wet adhesion (87.1 kPa). The interfacial mechanical interlocking between the adhesive hydrogel and fibrous dissipative layer contributes to its high burst pressure tolerance (327.7 mmHg). Moreover, the catechol groups in CS-DA endow PLLA/CP patch with the ability to scavenge intracellular reactive oxygen species and suppress inflammation. Furthermore, our PLLA/CP patch achieves long-term adhesion, prevents CSF leakage, and promotes defect repair through anti-inflammatory and immunomodulatory effects in a rabbit dural defect model, while also demonstrating effective hemostasis in a liver injury model. By integrating excellent anti-inflammatory, pro-healing, and immunomodulatory properties, this work presents a promising strategy for wet tissue repair.
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