Small
·
2023
·Vol. 19
·期 16
·2206868
·
IF 13.3
Guanglei Li,Chenxin Wang,Yao Chen,Fei Liu,Haoxin Fan,Bin Yao,Jia Hao,Yiting Yu,Dan Wen
Wearable glucose sensors are of great significance and highly required in mobile health monitoring and management but suffering from limited long-term stability and wearable adaptability. Here a simultaneous component and structure engineering strategy is presented, which involves Pt with abundant Ni to achieve three-dimensional, dual-structural Pt-Ni hydrogels with interconnected networks of PtNi nanowires and Ni(OH) 2 nanosheets, showing prominent electrocatalytic activity and stability in glucose oxidation under neutral condition. Specifically, the PtNi (1:3) dual hydrogels shows 2.0 and 270.6 times’ activity in the glucose electro-oxidation as much as the pure Pt and Ni hydrogels. Thanks to the high activity, structural stability, good flexibility, and self-healing property, the PtNi (1:3) dual gel-based non-enzymatic glucose sensing chip is endowed with high performance. It features a high sensitivity, an excellent selectivity and flexibility, and particularly an outstanding long-term stability over 2 months. Together with a pH sensor and a wireless circuit, an accurate, real-time, and remote monitoring of sweat glucose is achieved. This facile design of novel dual-structural metallic hydrogels sheds light to rationally develop new functional materials for high-performance wearable biosensors.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Tian Zhang,Qiang Zheng,Congkun Xie,Gonglin Fan,Yifan Wang,Yongjun Wu,Yike Fu,Jie Huang,Duncan Q. M. Craig,Xiujun Cai,Xiang Li
As a result of their radiation-free nature and deep-penetration ability, tumor theranostics mediated by ultrasound have become increasingly recognized as a modality with high potential for translation into clinical cancer treatment. The effective integration of ultrasound imaging and sonodynamic therapy (SDT) into one nanoplatform remains an enormous challenge yet to be fully resolved. Here, a novel theranostic system, consisting of rattle-type SiO2 (r-SiO2) loaded with Mn-doped In2S3/InOOH (SMISO), was designed and synthesized to enable an improved ultrasound imaging-guided therapy. With Mn-doped In2S3/InOOH (MISO) and a heterojunction structure, this novel sonosensitizer facilitates the generation of reactive oxygen species (ROS) for SDT. By coupling interfaces between the shell and core in rattle-type SiO2, multiple reflections/scattering are generated, while MISO has high acoustic impedance. By integrating r-SiO2 and MISO, the SMISO composite nanoparticles (NPs) increase the acoustic reflection and provide enhanced contrast for ultrasound imaging. Through the effective accumulation in tumors, which was monitored by B-mode ultrasound imaging in vivo, SMISO composite NPs effectively inhibited tumor growth without adverse side effects under ultrasound irradiation treatment. This work therefore provides a new approach to integrate a novel gas-free ultrasound contrast agent and a semiconductor sonosensitizer for cancer theranostics.
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DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 8
·2392-2403
·
IF 4
Amir Said,Guanyun Zhang,Caiyun Liu,Dexin Wang,Huihui Niu,Yanshu Liu,Guanjie Chen,Chen-Ho Tung,Yifeng Wang
The cycloaddition reaction of CO2 to epoxides is quite promising for CO2 capture and storage as well as the production of value-added fine chemicals. Herein, a novel atomically precise lead-doped titanium-oxide cluster with the formula Ti10Pb2O16(phen)4(Ac)12(DMF)2 (denoted as Ti10Pb2; phen = 1,10-phenanthroline; Ac = acetate; DMF = dimethylformamide) was synthesized through a facile solvothermal process, and is a molecular photocatalyst with surface-anchored main-group metal active sites. Its structure was characterized by single-crystal X-ray diffraction and other complementary techniques. Ti10Pb2 showed high photo-response and charge-separation efficiency under simulated sunlight irradiation. Ti10Pb2 was successfully used in the cycloaddition reaction of CO2 with epoxides under solvent-free conditions. While its catalytic activity due to the Lewis acidity was moderate, simulated solar light irradiation further enhanced the reaction rate, demonstrating the synergistic effect of photocatalysis and Lewis-acid thermocatalysis.
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Acta Biomaterialia
·
2023
·
IF 9.7
Dawei Jiang,Luqi Pan,Xiao Yang,Zhixiao Ji,Cheng Zheng,Zhizhen Meng,Bin Liang,Weian Zhang,Jinfei Chen,Changcan Shi
The newly attractive peroxynitrite (ONOO − ) therapy can prominently enhance antibacterial therapeutic efficacy. However, it is a great challenge but urgently needed to generate ONOO − with adjustable release rate and dosage in order to satisfy personalized treatments for different disease types and severities. Herein, PSNO@IR780 nanoparticles are fabricated via co-assembly of an amphiphilic PEG- b -PAASNO block copolymer grafted with abundant nitric oxide (NO) donor units and IR780 as a photothermal and photodynamic agent. Photo-controllable burst generation of ONOO − from PSNO@IR780 nanoparticles could be realized based on synergistic reactions of rapid NO release induced by increased local temperature and efficiently produced superoxide anion radical (O 2 •− ) from IR780. The maximum ONOO − release dosage is up to 6.73 ± 0.07 µM and release rate is up to 98.1 ± 1.38 nM/s. Furthermore, the ONOO − release behavior can be precisely manipulated by varying sample concentrations, irradiated durations, output power densities, and laser switches, respectively. Ultra-efficiently generated ONOO − from biocompatible PSNO@IR780 nanoparticles significantly elevated broad spectrum antibacterial efficiency through damaging bacterial membranes . Thus, PSNO@IR780 nanoparticles may present a new insight into preparation of burst and controllable generating ONOO − materials, and provide new opportunities for antibacterial therapy. Statement of significance 1. Polymeric NO donor (PEG- b -PAASNO) grafted with abundant NO donor units was synthesized. 2. PSNO@IR780 nanoparticles were prepared by co-assembly of IR780 and amphiphilic PEG- b -PAASNOpolymer. 3. The maximum ONOO − release dosage from PSNO@IR780 nanoparticles was 6.73 ± 0.08 µM. 4. The fastest ONOO − release rate from PSNO@IR780 nanoparticles was 98.1 ± 1.4 nM/s. 5. Ultra-efficiently generated ONOO − significantly elevated antibacterial efficiency via damaging bac-terial membranes.
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Food Analytical Methods
·
2023
·Vol. 16
·期 4
·689-698
·
IF 2.9
Chu Qiqi,Wu Xinze,Chen Huaixia,Dang Xueping,Liu Xiaolan
A Cu 7 Zn 2 cluster functionalized copolymer monolithic column was prepared and applied as the adsorbent of pipette tip micro-solid phase microextraction of eight phthalate esters (PAEs). The physical morphology, chemical composition, thermal stability, and specific surface area of the monolithic column were characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, thermogravimetric analysis, and N 2 adsorption and desorption experiment. Cu 7 Zn 2 cluster acted as the adsorption site effectively improved the adsorption selectivity and capacity of the copolymer monolith for PAEs. The adsorption mechanism of Cu 7 Zn 2 copolymer monolith for 8 PAEs was deduced to be mainly the H-bond interaction. And, the chemical doping and copolymerization of Cu 7 Zn 2 cluster made the composite monolithic column more stable with a long service life. Under the optimized extraction conditions, a micro-solid phase extraction-high performance liquid chromatography method with ultraviolet detector (μ-SPE-HPLC-UV) was developed for the determination of 8 PAEs in edible oil. Wide linear ranges of 0.5–1000 μg/kg with correlation coefficients ( R 2 ) above 0.996 were obtained. The limits of detection (LODs) were in the range of 0.1–0.9 μg/kg. The proposed method was applied for the detection of 8 PAEs in edible oil with satisfactory recoveries between 83.5~100.2%, and the relative standard deviations were less than 8.1%. The results indicated that the Cu 7 Zn 2 functionalized copolymerized monolithic column was an ideal enrichment medium for the detection of PAEs in complex samples.
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DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 8
·2335-2344
·
IF 4
Jie Jin,Shanshan Wu,Jing Wang,Yunqi Xu,Shouhu Xuan,Qunling Fang
In this work, a MXene@AgPd/polydopamine (PDA) nanosheet with excellent photothermal conversion efficiency was successfully synthesized by a simple redox-oxidative polymerization method. Interestingly, AgPd bimetallic nanocrystals sandwiched between a MXene nanosheet and PDA layer have cage-like nanostructure, which is favorable for high catalytic efficiency and antibacterial performance. Importantly, the MXene@AgPd/PDA nanosheet exhibits good catalytic activity for the reduction of 4-nitrophenol (1.2 min−1 mg−1) and the catalytic dynamics can be improved by about 1.2 times under NIR (near-infrared light, 808 nm, and 2.5 W cm−2) irradiation. As the PDA shell is well protected, the MXene@AgPd/PDA nanosheet retained more than 90% catalytic activity after 6 cycles. In addition, due to the presence of the Ag component, the MXene@AgPd/PDA nanosheet exhibited good antibacterial activity against both Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria. Under near-infrared light irradiation, its antibacterial activity was further enhanced due to the NIR photothermal effect.
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PEST MANAGEMENT SCIENCE
·
2022
·Vol. 78
·期 8
·3442-3455
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IF 4.462
Zhiping Che,Xiaolong Guo,Yuanhao Li,Song Zhang,Lina Zhu,Jiaxuan He,Di Sun,Yihao Guo,Yibo Liu,Ruxue Wei,Xiaobo Huang,Shengming Liu,Genqiang Chen,Yuee Tian
Background Paeonol is extracted and isolated as a rich and sustainable natural bioresource from the root bark of Paeonia suffruticosa , the derivatives of which exhibit numerous biological activities. It is well known that ester compounds play a very important role in pest control, such as organophosphorus, carbamate and pyrethroid pesticides. Results To discover biorational natural product-based pesticides, three series of (60) paeonol ester derivatives ( 7a–t , 8g , p , 9g , p , 10g–j , n–u , 11g , u , 12g , u , 13a–p , 14b , c , and 15b , c ) were prepared by structural modification of paeonol, and their structures were well characterized by proton nuclear magnetic resonance ( 1 H-NMR), carbon-13 nuclear magnetic resonance ( 13 C-NMR), high-resolution mass spectrometry (HRMS), and melting point. Furthermore, we assessed the compounds as insecticidal, nematicidal, and anti-oomycete agents against three serious agricultural pests, Mythimna separata , Heterodera glycines , and Phytophthora capsici . Among all tested compounds: (i) compound 8p showed more significant insecticidal activity than toosendanin, and the final mortality rates of 8p and toosendanin against M. separata (1 mg mL −1 ) were 70.4%, and 51.9%, respectively; (ii) compound 7a exhibited more promising nematicidal activity than paeonol, and the median lethal concentration (LC 50 ) values of 7a and 1 against H. glycines were 15.47 and 50.80 mg L −1 , respectively; (iii) compounds 7n and 13m displayed more significant anti-oomycete activity compared to zoxamide against Phytophthora capsici , and the median effective concentration (EC 50 ) values of 7n , 13m , and zoxamide were 23.72, 24.51, and 26.87 mg L −1 , respectively; and the protective effect of the compounds against Phytophthora capsici in vivo further confirmed the effectiveness of the agents. Conclusion This study suggested that the introduction of a nitro at the C5 or C3 position of paeonol could improve its bioactivity against M. separata , H. glycines , and Phytophthora capsici . © 2022 Society of Chemical Industry.
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Journal of Ocean University of China
·
2022
·Vol. 21
·期 3
·782-788
·
IF 1.179
Zhang Pengpeng,Zhang Miaomiao,Dong Kaiyu,Zhang Yicong,Yang Shuang,Wang Yuanhong,Jiang Tingfu,Yu Mingming,Lv Zhihua
Chito-oligosaccharide (COS) had shown a variety of biological activities and potential biomedical implications. The present study investigated the pharmacokinetics, bioavailability, and in vitro absorption of COS with degrees of polymerization (DPs) 2–7 and explored the influence of DPs on them. From Caco-2 cell permeation studies, COS were low permeability compounds with no directional effects, suggesting a low in vivo absorption mediated by facilitation diffusion and paracellular absorption. After an intragastrical administration to rats, COS2 showed the highest systemic exposure in six oligosaccharides. The bioavailability of COS2–7 was 7.33%, 6.11%, 4.67%, 4.13%, 4.02%, 0.99%, respectively. Differences in bioavailability for each COS correlated to structural variations, with high DPs contributing to a decrease in bioavailability. In conclusion, COS could be absorbed by the intestinal tract both in vitro and in vivo . The very low oral bioavailability of COS could be due to low permeability. DPs can affect absorption and bioavailability of COS2–7. This study provided evidence for the absorption characteristics of COS2–7 to help us better understanding the pharmacological actions.
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Journal of Environmental Sciences
·
2022
·
IF 6.796
Ruijie Xie,Dongxue Lei,Xiaowen Xie,Ziyi Suo,Dennis Y.C. Leung,Jianping Cao,Fang Ruimei,Haibao Huang
Vacuum ultraviolet (VUV) photolysis is a facile method for volatile organic compounds (VOCs) elimination, but is greatly limited by the relatively low removal efficiency and the possible secondary pollution. To overcome above drawbacks, we developed an efficient method for VOCs elimination via VUV photolysis coupled with wet scrubbing process. In this coupled process, volatile toluene, a representative of VOCs, was oxidized by the gas-phase VUV photolysis, and then scrubbed into water for further oxidation by the liquid-phase VUV photolysis. More than 96% of toluene was efficiently removed by this coupled process, which was 2 times higher than that in the gas-phase VUV photolysis. This improvement was attributed to the synergistic effect between gas-phase and liquid-phase VUV photolysis. O 3 and HO • are the predomination reactive species for the toluene degradation in this coupled process, and the generation of O 3 in gas-phase VUV photolysis can efficiently enhance the HO • production in liquid-phase VUV photolysis. The result from in-situ proton transfer reaction ionization with mass analyzer (PTR-MS) further suggested that most intermediates were trapped by the wet scrubbing process and efficiently oxidized by the liquid-phase VUV photolysis, showing a high performance for controlling the secondary pollution. Furthermore, the result of stability test and the reuse of solution demonstrated that this coupled process has a highly stable and sustainable performance for toluene degradation. This study presents an environmentally benign and highly efficient VUV photolysis for gaseous VOCs removal in the wet scrubbing process.
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Biosensors-Basel
·
2022
·Vol. 12
·期 5
·326
·
IF 5.743
Shuwen Cheng,Danyao Tang,Yi Zhang,Libin Xu,Kunping Liu,Kejing Huang,Zhengzhi Yin
A novel electrochemical sensor designed to recognize and detect tartrazine (TZ) was constructed based on a molecularly imprinted polydopamine (MIPDA)-coated nanocomposite of platinum cobalt (PtCo) nanoalloy-functionalized graphene oxide (GO). The nanocomposites were characterized and the TZ electrochemical detection performance of the sensor and various reference electrodes was investigated. Interestingly, the synergistic effect of the strong electrocatalytic activity of the PtCo nanoalloy-decorated GO and the high TZ recognition ability of the imprinted cavities of the MIPDA coating resulted in a large and specific response to TZ. Under the optimized conditions, the sensor displayed linear response ranges of 0.003–0.180 and 0.180–3.950 µM, and its detection limit was 1.1 nM (S/N = 3). The electrochemical sensor displayed high anti-interference ability, good stability, and adequate reproducibility, and was successfully used to detect TZ in spiked food samples. Comparison of important indexes of this sensor with those of previous electrochemical sensors for TZ revealed that this sensor showed improved performance. This surface-imprinted sensor provides an ultrasensitive, highly specific, effective, and low-cost method for TZ determination in foodstuffs.Keywords:platinum cobalt nanoalloy;molecularly imprinted polydopamine;graphene oxide;tartrazine;electrochemical sensor
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MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Xiaojiao Du,Jun Sun,Yan Li,Wenhan Du,Ding Jiang
A highly sensitive electrochemiluminescence (ECL) aptasensor for lincomycin (Lin) detection was designed based on a novel self-accelerated ECL luminophore of Ag 3 PO 4 -Ti 3 C 2 nanohybrids. The Ag 3 PO 4 -Ti 3 C 2 nanohybrids demonstrated prominent ECL performances with K 2 S 2 O 8 as co-reactant, and the Ti 3 C 2 as co-reaction accelerator, which catalyzes K 2 S 2 O 8 into more active radicals and inducing a tremendous amount of excited-state luminophores. Besides, it can be used for loading aptamer molecules owing to its large surface area. Given these attributes, a self-accelerated ECL aptasensor for Lin detection was constructed based on the effect of target induced aptamer dissociating. Under optimized conditions, the ECL aptasensor exhibited wide linear relationship of 1.0 × 10 −4 nmol/L to 1.0 × 10 2 nmol/L, low detection limit of 6.17 × 10 −5 nmol/L (S/N = 3) and good stability and reproducibility for Lin detection. The aptasensor was successfully applied for the Lin detection in milk and water samples, implying immense potential in real applications.
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CHINESE JOURNAL OF CHEMISTRY
·
2022
·Vol. 40
·期 15
·1821-1830
·
IF 5.56
Xin Lu,Yijun Liu,Nan Qin,Chenxi Du,Yanyu Hu,Yao Chen,Haopeng Sun
Comprehensive Summary The cholinesterases are essential targets implicated in the pathogenesis of Alzheimer's disease (AD). We have identified tryptophan-tetrahydroisoquinoline derivatives as selective micro-nanomolar butyrylcholinesterase (BChE) inhibitors. Molecular docking was applied for the rational design and binding mode analysis. They were defined according to their target inhibitory activity, low cytotoxicity, predicted permeability through the blood-brain barrier (BBB), and in vivo cognitive improvement. Additionally, the preferred compound showed ability to decrease self-induced Aβ 1-42 aggregation and Aβ 1-42 induced SH-SY5Y cell injury. Altogether, these factors indicated their potential as unique lead compounds for AD treatment.
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危险品化学品经营许可证（带存储）