INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
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2025
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IF 5.2
Hehe Yang,Yan Lu,Liangliang Bao,Yao Liu,Dongqi Liu,Zhimei Zhong
Three pyridine-3-formyl chitosan derivatives were successfully prepared, and the preservation performance of the derivatives was examined. According to the results, the derivatives exhibited better antifungal and antioxidant properties than that of chitosan. At a supply concentration of 0.5 mg/mL, 2-ANACS could scavenge DPPH radicals at a rate of (92.82 ± 0.38)%. Additionally, all three derivatives exhibited less cytotoxicity and higher biocompatibility. In the freshness preservation studies of cherry tomatoes, the three derivatives considerably decreased the weight loss rate and postponed the drop in V C and titratable acid content. After 32 days of 2.0 g/L VPPCS treatment, the weight loss of cherry tomatoes was (4.0 ± 0.52) % among them. Still, the weight loss of cherry tomato in the chitosan treatment and blank control was (5.5 ± 1.33) % and (5.94 ± 1.02) %, respectively, which was considerably decreased by VPPCS therapy. These findings demonstrated that adding niacin improved chitosan's antifungal and antioxidant properties, extended the shelf life of cherry tomatoes, and increased the potential uses of chitosan and its derivatives in fruit preservation.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
·
IF 6.6
Lizhen Zhang,Zhengjie Liu,Mingzhu Ma,Yadong Zhao,Wenhua Miao,Yan Chen,Weiling Shi,Qihe Chen
Active packaging is a novel food packaging concept where natural active ingredients enhance the packaging's performance. This study aimed to develop a chitosan (CS)-based nanoemulsion combined with melleolides (CS-M) as a novel edible active coating for preserving fresh salmon. Additionally, the study evaluated the physical stability, microstructure, rheology, and antibacterial properties of CS-M, as well as the preservation effects on salmon when combined with atmospheric cold plasma (ACP). Results showed that CS-M maintained uniform particle size and stable dispersity over 7 days, demonstrating long-term stability, particularly at 4 °C. Compared to CS and melleolides alone, CS-M exhibited superior antibacterial activity against S. aureus and E. coli , effectively inhibiting microbial growth during salmon preservation. Furthermore, CS-M alone demonstrated a good preservation effect, which was significantly enhanced when combined with ACP. In conclusion, the CS-based nanoemulsion containing melleolides shows strong potential for salmon preservation, with its effectiveness further enhanced by ACP.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Qian Liao,Longfei Lin,Ruying Tang,Zhuo Xu,Shasha Kong,Dan Lv,Donghan Bai,Yuling Liu,Hui Li
Oral mucosal lesions (OML), which represent a major public health issue worldwide, include any pathological changes in the oral mucosa, such as ulcers, pigmentation, and swelling. Due to its humid and dynamic complex environment, designing oral mucosal preparations poses significant challenges. Drawing inspiration from mussels, this study employed an eco-friendly one-pot strategy for the preparation of chitosan/polydopamine (CS/PDA) films. We demonstrated that CS-induced polymerization of dopamine monomers under acidic conditions, which might be attributed to the large number of hydrogen bonding sites of CS chains. PDA markedly enhances properties of the CS film and exhibits concentration dependence. At the concentration of 1 wt% PDA, the lap-shear strength and tensile strength of CS/PDA films reached 5.01 ± 0.24 kpa and 4.20 ± 0.78 kpa, respectively, indicating that the mucosal adhesion ability was significantly improved. In comparison with the single CS film, the swelling rate of CS/PDA film decreased by about 30 %. Rheological results also showed that the storage modulus returned to 93 % after cyclic large strain, while the single CS film only recovered to 73 %. Moreover, these films demonstrated good biocompatibility and enhanced oral ulcer healing in rats, providing a new and practical option for the local treatment of OML.
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FIBERS AND POLYMERS
·
2024
·Vol. 25
·期 11
·4149-4160
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IF 2.2
Hu Ke,Chen Hongxuan,Lin Yihui,Han Shitong,Wang Qi,Peng Houqian,Wang Ying,Zhao Jiwu,Xi Hailing,Wen Na,Long Jinlin
Abstract Polypropylene (PP) nonwovens have been widely used in disposable protective masks and protective clothing, which are essential to protect healthcare workers from highly infectious diseases such as COVID-19. However, realizing the disinfection reusable function of PP nonwovens to reduce carbon emission or white waste pollution after extensive use has been still a great challenge. Herein, Durable Antimicrobial and Anti-fungal Post-disinfection polypropylene nonwovens were developed by co-grafting of Triclosan and Chitosan. The antibacterial performance test results showed that the as-prepared co-grafted polypropylene nonwoven has a > 99.9% of antimicrobial efficiency against E. coli , S. aureus as well as multi-drug-resistant P. aeruginosa , and the excellent anti-fungal performance against fungus ( C. albicans ) and mold ( A. niger ). Moreover, it retained excellent Antimicrobial and Anti-fungal Properties after disinfection 3 times with boiling water, 40 × diluted 84 disinfectant and 75% alcohol for 5 min. This work provided ideas for developing more effective pathogen protection and longer-lasting personal protective equipment to reduce the environmental impact of medical masks and personal protective equipment in terms of energy consumption, carbon emissions and waste generation. Graphical Abstract Polypropylene (PP) nonwovens have been widely used in disposable protective masks and protective clothing, which are essential to protect healthcare workers from highly infectious diseases such as COVID-19. The as-prepared PP-AA-CS-TCL nonwovens exhibited an antibacterial efficiency of > 99.9% against E. coli , S. aureus , and P. aeruginosa as well as the excellent anti-fungal properties against C. albicans and A. niger. And the antimicrobial and anti-fungal activities were maintained even after disinfection 3 times with boiling water, 40x diluted 84 disinfectant and 75% alcohol for 5 minutes each. This provides a new way of thinking about reusing disposable surgical products with polypropylene nonwoven and reducing environmental pollution.
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CARBOHYDRATE RESEARCH
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2024
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IF 2.4
Lin Wang,Yu Pang,Zhongwen Su,Meihua Xin,Mingchun Li,Yangfan Mao
N -(sodium 2-hydroxypropylsulfonate) chitosan (HSCS), N -sulfonate chitosan (SCS) and N -isonicotinic sulfonate chitosan (ISCS) were prepared. The structures of the prepared chitosan derivatives were characterized by nuclear magnetic resonance ( 1 H NMR) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, ultraviolet–visible (UV–vis) spectroscopy and elemental analysis (EA). Antibacterial and antibiofilm activities of these chitosan derivatives were evaluated in vitro . The minimum inhibitory concentration (MIC) of HSCS and SCS against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) were 0.625 mg/mL and 0.156 mg/mL, respectively. ISCS exhibited MIC values of 0.313 mg/mL and 0.078 mg/mL against E. coli and S. aureus , respectively. ISCS demonstrated superior antibacterial and antibiofilm properties compared to SCS and HSCS. These findings suggest that the incorporation of a pyridine structure into sulfonate chitosan enhances its antibacterial and antibiofilm activities, and the prepared ISCS has a promising application prospect for controlling the reproduction of microorganisms in the field of food packaging.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
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IF 5.3
Chun Liu,Chengqiang Wang,Yang Liu,Jiahui Huang,Wenning Xu,Jianjun Li,Yihan Wang,Yizhou Xu,Lixin Zhu,Haixia Xu
Oxidative stress plays a crucial role in steroid-induced osteonecrosis of the femoral head (SONFH). Although several antioxidant strategies have been investigated for treating SONFH, their antioxidant efficiencies and therapeutic effects remain unsatisfactory. Here, we developed a selenium nanoparticles/carboxymethyl chitosan/alginate (SeNPs/CMC/Alg) antioxidant hydrogel and evaluated its ability to treat SONFH. In vitro assays indicated that the SeNPs/CMC/Alg hydrogel exhibited excellent properties, such as low cytotoxicity, sustained SeNPs release, and favorable antioxidant activity. Under oxidative stress, the SeNPs/CMC/Alg hydrogel promoted reactive oxygen species (ROS) elimination and enhanced the osteogenic and proangiogenic abilities of bone marrow mesenchymal stem cells (BMSCs). After establishing a rabbit model of SONFH, the SeNPs/CMC/Alg hydrogel was transplanted into the femoral head after core decompression (CD) surgery. Radiographic and histological analyses revealed that the hydrogel treatment alleviated SONFH by eliminating ROS and promoting osteogenesis and angiogenesis compared to those in the CD and CMC/Alg groups. In vitro and in vivo studies indicated that the Wnt/β-catenin signaling pathway was activated by the SeNPs/CMC/Alg hydrogel in both hydrogen peroxide-conditioned BMSCs and necrotic femoral heads. These findings indicate that local transplantation of the SeNPs/CMC/Alg hydrogel is beneficial for treating SONFH, as it promotes ROS elimination and activation of the Wnt/β-catenin signaling pathway.
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Materials Research Express
·
2024
·Vol. 11
·期 11
·115308
·
IF 1.8
Yang Gao,Huanjun La,Haonan Min,Zhenzhong Hou
Hydrogels have demonstrated significant potential in wound dressings, owing to their adjustable water content, excellent biocompatibility, and other advantages. An ideal wound dressing requires absorbing exudate while maintaining mechanical properties to prevent secondary damage to the wound under external pressure. In this study, Polyacrylic Acid (PAA)/Chitosan (CS) double network hydrogels were prepared via radical polymerization, and the swelling ratio, compressive modulus, and other parameters were experimentally measured. A hyperelastic finite element model of the hydrogel was then established, and its rationality was validated by experiments. Based on the model, the impacts of CS content and dynamic water content on the compressive properties of PAA/CS hydrogels were analyzed. Tetracycline hydrochloride was loaded into PAA/CS hydrogels, the drug release performance and adhesion experiments were carried out. The results indicated that, compared with the hydrogels with 2.5% and 5% CS content, the hydrogel with 1% CS content had the highest swelling ratio, which was 1774%. Meanwhile, its equilibrium water content could attain 94.6%. When the water content varied within the range from 45% to 75%, the compressive strength of the hydrogel with 5% CS content ranged from 0.33 MPa to 1.22 MPa, similar to that of skin tissue. Additionally, the prepared drug-loaded PAA/CS hydrogels exhibited a drug release pattern approximately following the Korsmeyer-Peppas model within 7 days. They also exhibited remarkable adhesion to porcine skin and different substrate surfaces. This study provides a basis for the clinical application of PAA/CS double network hydrogels as wound dressings in the repair of infected wounds.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Li Ma,Yilong Yao,Xiong Zhao,Junsheng Hou,Lei huang,Zihan Ding,Xinlan Lu,Jinjia Wei,Nanjing Hao
The uniformity and monodispersity of the chitosan microsphere are essential requirements for its related applications, and the appearance of undesired satellite droplets needs to be avoided. However, preparing monodispersed, uniform, and size-controllable chitosan microspheres is still a significant challenge. In this paper, a droplet-based microfluidic strategy is developed for the chitosan and fluorescent chitosan microsphere synthesis with controllable size and monodispersity. A water-in-oil droplet microfluidic reaction system is formed, and the monodispersed viscous droplet generation one by one in a step T-junction microchannel and solidified microspheres is observed via a chemical cross-reaction. A side microchannel is designed to separate satellite droplets successfully and improve the quality of the product. The effects of flow rates of two phases, phase ratio, and reaction time are investigated experimentally. The stable operating range for viscous droplets is given. The size of the chitosan could be tuned from 50 to 200 μm, and the production rate could reach up to 1.2 mL·h–1. This work not only provides valuable guidance for polymer microsphere synthesis but also helps to understand the microdispersion mechanism of the non-Newton viscous fluid in depth.
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MACROMOLECULAR MATERIALS AND ENGINEERING
·
2025
·
IF 4.6
Yi Zhou,Zhiliang Huang,Bangjun Deng,Chunli Gong,Hai Liu
Anion exchange membranes (AEMs), which serve as one of the key components in fuel cells, fulfill dual functions: conducting hydroxide ions and blocking the anode and cathode. To balance the relationship between ionic conductivity, mechanical properties, and dimensional stability, quaternized polydopamine (QPDA) nanoparticles were synthesized via a three-step process, including dopamine self-polymerization, grafting with branched polyethylenimine, and quaternization. These QPDA nanoparticles were subsequently used as a novel nanofiller to modify a blend quaternized chitosan (QCS) and polyvinyl alcohol (PVA) polymer, resulting in the QPDA/QCS-PVA composite membranes. The composite samples exhibited improved water uptake, dimensional stability, and ionic conductivity. With the optimal QPDA loading of 6%, the composite membrane achieved a conductivity of 48.4 mS cm −1 at 80°C, which was 2.27 times that of the pure membrane (21.3 mS cm −1 ). The membranes also demonstrated enhanced mechanical properties and alkaline stability, benefiting from the uniform dispersion of QPDA nanoparticles and chemical cross-linking within the composite system. These QPDA/QCS-PVA composite membranes with an optimal balance between performance and stability can be expected to be novel biomass-based AEMs.
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PACKAGING TECHNOLOGY AND SCIENCE
·
2025
·
IF 3.7
Yang Zou,Yanfen Zhang,Wenjuan Gu,Ruquan Huang,Pengfei Guo,Jikuan Pan,Huiyu Xie,ZheKai Lin,ChuLi Ma,Huawei Duan
In this study, the effectiveness of enzymatic treatments on cellulose for improving the properties of moulded pulp products was investigated. Three treatment systems were evaluated: laccase (L) alone, an L/lauryl gallate (LG) binary system, and a L/LG/chitosan (CTS) ternary system. The optimal conditions for the L/LG/CTS system were determined as 40.0 U·g −1 L, 1.0 wt.% LG, 1.0 wt.% CTS, 3.0 wt.% pulp consistency, a reaction temperature of 50°C, and a reaction time of 4 h. Compared with untreated moulded pulp products, which exhibited poor barrier properties (static water contact angle: 0°, Cobb 60 : 141.21 ± 5.24 g·m −2 , Kit test: 0/12) and limited mechanical performance (tightness: 1.04 ± 0.03 g·cm −3 , tensile index: 29.86 ± 1.32 N·m·g −1 , bursting index: 0.85 ± 0.07 kPa·m 2 ·g −1 , tear index: 5.72 ± 0.28 mN·m 2 ·g −1 , folding resistance: 82 ± 2), the L/LG/CTS-treated products demonstrated notable improvements. Specifically, hydrophobic/oleophobic properties improved markedly (static water contact angle: 104.5° ± 2.9°, Cobb 60 : 14.83 ± 0.71 g·m −2 , Kit test: 8/12) and mechanical strength increased substantially (tightness: 1.18 ± 0.03 g·cm −3 , tensile index: 34.78 ± 0.96 N·m·g −1 , bursting index: 1.88 ± 0.09 kPa·m 2 ·g −1 , tear index: 6.23 ± 0.30 mN·m 2 ·g −1 , folding resistance: 93 ± 5). SEM analysis revealed changes in fibre arrangement and improved fibre network cohesion in treated samples. These findings indicate that the L/LG/CTS ternary system is a highly effective and sustainable strategy for enhancing both barrier and mechanical properties of moulded pulp products, positioning them as a promising alternative to petroleum-based plastics for food packaging applications. Although the L/LG/CTS system uses biodegradable components, future investigations are required to comprehensively evaluate the biodegradability of the final treated products.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2025
·
IF 2.6
Olanrewaju Yaasir Olatunji,Yao Rui,Wu ZhenYu,Turakulov Fozil Mamaraim Ugli,Jiang Guohua
This study presents the development of a highly stable and sensitive glucose biosensor based on glucose oxidase (GOx) immobilized with chitosan (CS) on electrochemically deposited platinum nanoparticles (PtNPs). The biosensor was fabricated by electrodepositing PtNPs onto a glassy carbon electrode (GCE), followed by immobilization of GOx using CS as a biocompatible matrix. Incorporating PtNPs significantly enhanced the electrochemical activity and electron transfer kinetics, resulting in improved sensitivity, while CS improved the biosensor's stability over time. The biosensor demonstrated a wide linear detection range of 1–13 mM glucose, with a detection limit of 0.176 mM. The biosensor exhibited high sensitivity of 23.48 µA mM⁻¹ cm⁻² and demonstrated good reproducibility and long-term stability. These results highlight the roles of CS and PtNPs in enhancing biosensor performance, indicating promising potential for practical glucose monitoring applications in clinical diagnostics.
Graphical abstract
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Xiaotong Zou,Shaohua Zhao,Kaiwei Xu,Ke Liu,Lingtao Li,Miaosen Zhang,Chang Yan,Xiaojuan Zhang,Changqing Fang
Bioactive composite films have emerged as promising candidates for sustainable food packaging due to their multifunctional performance and environmental compatibility. In this study, a novel active packaging film (SL/CS) was developed by incorporating Schizochytrium limacinum (SL) oil-based Pickering emulsions, stabilized by soy protein isolate (SPI), into a chitosan (CS) matrix via a casting method. SL oil is a marine-derived bioactive lipid rich in polyunsaturated fatty acids and antioxidant carotenoids. Its incorporation into the CS film increased the surface contact angle to 91.79° and reduced the water vapor permeability (WVP) to 1.354 × 10 −12 g·cm/cm 2 ·s·Pa, indicating improved moisture barrier capacity. Additionally, UV–vis analysis confirmed that the SL-10 % film effectively blocked UV light across 200–380 nm. The DPPH radical scavenging activity of the SL/CS film was 89.67 % at 10 % SL oil loading. Antibacterial assays revealed maximum inhibition zone diameters of 28.84 mm for S. aureus and 14.90 mm for E. coli , with corresponding growth inhibition rates reaching 95.19 % and 88.19 %. In strawberry preservation experiments, the SL/CS film extended the shelf life of strawberries by reducing weight loss and mitigating the loss of firmness and titratable acidity during storage. Therefore, the results of this work support the potential of SL/CS films as a natural and effective packaging material for postharvest fruit preservation.
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