FIBERS AND POLYMERS
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2021
·Vol. 22
·期 6
·1664-1674
·
IF 2.153
Qin Siyuan,Tian Yanhong,Zhang Xuejun,Wu Yifan
A class of N-P-Si-containing synergistic flame retardant T-K, the phosphoric triamide (TEDAP, T) modified with epoxy silane coupling agent KH560 (K) on molecular polarity and structure, was successfully synthesized and utilized as sizing agent of carbon fiber (CF) for surface treatment in carbon fiber reinforced epoxy (CF/EP) composites. Time of flight mass spectrometer (TOF-MS) and Fourier transform infrared spectroscopy (FT-IR) results showed the successful synthesis of T-K and different degrees of oligomerization of T. Scanning electron microscope (SEM) and interlaminar shear strength (ILSS) characterized the surface and interface morphology of CF and relevant composites, indicating that the interface performance was preserved under selected T-K structure. Thermogravimetric (TG) and limiting oxygen index (LOI) testing results reflected the delayed decomposition of CF on T −5% from 450 °C to 700 °C, and increased LOI values of composites from 34% to 44%, illustrating the significant enhancement on flame retardancy in composites by the application of T-K.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Huijiao Wang,Zhongyi Li,Fengyuan Zhang,Yuxiang Wang,Xian Zhang,Jianbing Wang,Xuwen He
Three types of Magnéli phase anodes (Ti/Ti 4 O 7 , Ti/Ti 4 O 7 -PbO 2 -Ce, and Ti/Ti 4 O 7 nanotube arrays (NTA)) were fabricated, characterized, and compared with other typical active and non-active anodes (i.e., BDD, Ti/Pt, Ti/RuO 2 -IrO 2 , and Ti/IrO 2 -Ta 2 O 5 ) for electro-oxidation treatment of p -nitrophenol (PNP) solution and a real coal chemical concentrated brine in this study. Characterization results indicate a nanotube array structure of Ti/Ti 4 O 7 NTA, and a compact coating of Ti 4 O 7 microparticles and PbO 2 -Ce nanocrystals on the Ti substrate for Ti/Ti 4 O 7 and Ti/Ti 4 O 7 -PbO 2 -Ce, respectively. The three anodes present relatively high oxygen evolution potentials (2.16–2.44 V vs SCE), showing good capacity of electro-generating reactive oxidative species for pollutant degradation. After 30 min of EO treatment, Ti/Ti 4 O 7 NTA and Ti/Ti 4 O 7 removed 89–92% of PNP, which were 10–60% higher than Ti/Pt, Ti/RuO 2 -IrO 2 , and Ti/IrO 2 -Ta 2 O 5 , and were almost comparable with BDD (95%). Furthermore, Ti/Ti 4 O 7 NTA and Ti/Ti 4 O 7 kept very efficient for mineralization of PNP solution and real coal chemical concentrated brine. For Ti/Ti 4 O 7 -PbO 2 -Ce, its degradation efficiency was lower than other two Magnéli phase anodes, but still competitive compared with other active anodes. Thanks to their high removal efficiencies, the three Magnéli phase anodes required relatively low energy demand for pollutant mineralization. Besides, operational parameters such as electrolyte and current density were also very significant for efficient pollutant removal. The results of this study suggest Magnéli phase electrodes as promising and cost-effective anode materials for industrial wastewater treatment, with Ti/Ti 4 O 7 NTA and Ti/Ti 4 O 7 being more efficient options.
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Biomaterials Science
·
2021
·Vol. 9
·期 11
·4199-4210
·
IF 6.843
Hao Li,Mengna Li,Pei Liu,Kaiyang Wang,Haoyu Fang,Junhui Yin,Daoyu Zhu,Qianhao Yang,Junjie Gao,Qinfei Ke,Hongping Yu,Yaping Guo,Youshui Gao,Changqing Zhang
Due to the native skin limitations and the complexity of reconstructive microsurgery, advanced biomaterials are urgently required to promote wound healing for severe skin defects caused by accidents and disasters. Accumulating evidence has supported that substance P (SP) has a potential effect on skin regeneration. However, SP application is seriously impeded by its poor stability and oxidative reactions occurring during production, transportation, and storage. An SP-conjugated chitosan hydrochloride hydrogel (CSCl–SP) fabricated in this study demonstrated an enhanced capacity to repair full-thickness skin defects. CSCl–SP provided a stable in vitro delivery system for SP. The dissolution of CSCl–SP promoted the proliferation, migration, and tube formation, as well as angiogenesis-related gene and protein expression in human umbilical vein endothelial cells. CSCI-SP also stimulated the proliferation, migration, and production of anabolic growth factor in human fibroblasts. Moreover, CSCl–SP significantly promoted the neurite outgrowth in Neuro-2A cells. In vivo, CSCl–SP dramatically strengthened the vascularization, extracellular matrix deposition and remodeling, and nerve regeneration, thereby promoting efficient recovery of the full-thickness skin defect. Thus, synchronized multifunction of the CSCl–SP hydrogel makes it a promising and smart material for intractable skin defects.
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POLYMER
·
2020
·
IF 4.231
Yufei Liu,Siyuan Jiang,Wei Yan,Jun Qin,Min He,Shuhao Qin,Jie Yu
Improving complexation at the interfaces and regulating the crystal transformation behaviors of polyamide 6 (PA6) composites with high mechanical and thermal properties are essential for the industrial applications of PA6. In this work, the effects of adding p (N-(4-F-phenylmaleimide)-alt-styrene) (PFS) on the crystal transformation, thermostability, thermal conductivity , and mechanical properties of PA6 were investigated and discussed systematically. The resu---lts from heat deflection temperature (HDT), dynamic mechanical analysis (DMA ) and thermal conductivity tests indicate that PFS greatly increases the HDT, glass-transition temperature ( T g ), and thermal conductivity of PA6. Simultaneously, when the content of PFS is 10%, the tensile strength and flexural moduli of PA6/PFS composites are increased by 10.5 and 17.8% compared with that of pure PA6, respectively. The results from differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) show that PFS induces the transformation of PA6 from γ to α crystals by interfacial complexation. This work offers a facile approach for producing materials with high thermal and mechanical performances that can be potentially used in automobiles, electronics, and related technologies.
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FOOD AND CHEMICAL TOXICOLOGY
·
2020
·
IF 4.679
Fei Zhou,Weisu Huang,Tao Xu,Lipeng Wu,Qi Chen,Jiyu Peng,Xin Liu,Baiyi Lu
Acteoside is one of the most widespread phenylethanoid glycosides with pharmacological activities , including antioxidant, neuroprotective property, etc. However, its bioavailability is poor due to the low absorption and P-gp efflux. This study aimed to select food derived P-gp inhibitors for promoting the acteoside absorption and investigate whether the inhibitors could increase the bioavailability and stability of acteoside. Results showed that EGCG and quercetin significantly decreased the BL-to-AP efflux and promoted the AP-to-BL influx of acteoside across Caco-2 monolayers with optimum concentrations of 320 μM EGCG or 240 μM quercetin adding to 320 μM acteoside. EGCG increased the bioavailability of acteoside to 1.43-fold, but quercetin had no such effect. Further study showed that EGCG and quercetin had no effects on the storage and digestion stability of acteoside. This work revealed that EGCG could improve the acteoside absorption across the Caco-2 monolayers and enhance the bioavailability of acteoside in rats.
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NEW JOURNAL OF CHEMISTRY
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2020
·Vol. 44
·期 8
·3194-3205
·
IF 3.288
Jiabin Liu,Bowen Yang,Minghuan Gao,Lisha You,Yuansen Zhang,Zhiying Li,Linna Guo,Tiesheng Li,Penglei Chen,Minghua Liu
A series of novel efficient polyhedron-like WO3/butterfly-like Ag2MoO4 p–n junction photocatalysts (denoted as AMW-x) were designed and synthesized. The exact phase structure, microscopic morphology, electrochemical properties, physical properties and optical properties of the prepared samples were characterized by XRD, SEM, EDS, TEM, HRTEM, UV-DRS, PL, FL, XPS, UPS, BET, MS (Mott–Schottky test), EIS and photocurrent measurements. The photocatalyst could effectively degrade rhodamine B (RhB) under UV/Solar region light illumination. In this system, a p–n junction structure formed by the two different materials effectively enhanced the generation rate of photo-induced electrons and reduced the transfer resistance. These results exhibited that enhanced photocatalytic performance of materials were prepared. The activity of AMW-20 was 548.2/496.8, 57.9/146.1, and 3.7/17 times higher than polyhedron-like WO3, butterfly-like Ag2MoO4, and commercial powder (P25) under UV/Solar region light illumination. The photocatalytic mechanism mode for the improved photocatalytic performance was also proposed.
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INDUSTRIAL CROPS AND PRODUCTS
·
2020
·
IF 4.244
Chen Shen,Xiqing Wang,Yawei Zhu,Jiao Jiao,Sansan Bao,Ping Kou,Hongyi Pan,Yanyan Li,Yujie Fu
In this study, a novel p -toluenesulfonic acid (PTSA) based deep eutectic solvent (DES) was prepared successfully for biodiesel production by one-pot method. The DES consisting of PTSA and tetrabutylammonium bromide (TBAB) exhibited the best catalytic activity among the five prepared DESs. Central composite design (CCD) and response surface methodology were conducted to investigate reaction factors. The maximum oil extraction yield 90.33 % and fatty acid methyl esters (FAMEs) conversion yield 96.53 % were obtained under the optimal condition: microwave temperature 72 °C, microwave power 500 W, time 40 min, the ratio of liquid to seed weight 27:1 and DES amount 11 wt%. The chemical composition of FAMEs and main physical-chemical properties were investigated and the results demonstrated that the prepared biodiesel product possessed high quality. The study showed the prepared DES was a green and efficient catalyst for rapid and simultaneous extraction and transesterification seed oil for biodiesel production by one-pot method.
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ACTA PHARMACOLOGICA SINICA
·
2020
·Vol. 42
·期 3
·470-481
·
IF 5.064
Xie Qiu-shi,Zhang Jia-xin,Liu Ming,Liu Pei-hua,Wang Zhong-jian,Zhu Liang,Jiang Ling,Jin Meng-meng,Liu Xiao-nan,Liu Li,Liu Xiao-dong
P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are involved in intestinal barrier. Short-chain fatty acids (SCFAs) play important roles in maintaining intestinal barrier. In this study we explored how SCFAs affected the expression and function of intestinal P-gp and BCRP in rats. Rats received 150 mM acetate, propionate or butyrate in drinking water for 4 weeks. In SCFA-treated rats, the expression and function of intestinal P-gp were decreased, but those of intestinal BCRP were increased; intestinal p-p65 was also decreased, which was positively related to P-gp protein expression. Among the three SCFAs tested, butyrate exhibited the strongest induction or inhibitory effect, followed by propionate and acetate. Similar results were observed in mouse primary enterocytes and Caco-2 cells treated with acetate (5 mM), propionate (2 mM), or butyrate (1 mM). In Caco-2 cells, addition of butyrate, vorinostat, and valproate (two classic HDAC inhibitors), Bay117082 (selective inhibitor of NF-κB activation) or NF-κB p65 silencing significantly decreased the expression of P-gp and the level of phosphorylated p65 (p-p65). Furthermore, butyrate attenuated the expression of P-gp and p-p65 induced by TNF-α (NF-κB activator) and theophylline (HDAC activator). However, vorinostat, valproate, Bay117082, TNF-α or p65 silencing hardly affected BCRP protein expression. But GW9662 (selective PPARγ antagonist) or PPARγ silencing abolished BCRP induction by butyrate and troglitazone (PPARγ agonist). SCFAs-treated rats showed higher intestinal protein expression of PPARγ, which was positively related to BCRP protein expression. Butyrate increased plasma exposure of fexofenadine but decreased that of rosuvastatin following oral dose to rats. In conclusion, SCFAs exert opposite effects on the expression and function of intestinal P-gp and BCRP; butyrate downregulated P-gp expression and function possibly via inhibiting HDAC/NF-κB pathways; butyrate induced BCRP expression and function partly via PPARγ activation.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2019
·
IF 14.229
Wei Li,Xiao Wang,Min Li,Shu-ao He,Qiong Ma,Xuechuan Wang
Hydrogen is known as an alternative new energy for its advantages of non-pollution and high calorific value, and photocatalysis technology is regarded as one of the most effective means to produce hydrogen in recent years. In this topic, aiming at the poor photoresponse, fast combination of photo-induced carriers and unstable structure of traditional photocatalysts, the three-dimensional porous g-C 3 N 4 /graphene oxide framework was constructed by compounding two-dimensional graphene oxide and two-dimensional g-C 3 N 4 via hard template (SiO 2 nanoparticles) method and selective chemical etching. Then, silver bromide nanoparticles , a superior photosensitizer, were immobilized on the three-dimensional porous framework to construct the three-dimensional porous g-C 3 N 4 /graphene oxide-AgBr photocatalyst with Ag plasmas by solvothermal method. Research showed that this novel photocatalyst based on Z-scheme heterostructure (GO-AgBr), p-n heterostructure (g-C 3 N 4 -AgBr) and Ag plasmas presented high-efficient visible-light driven hydrogen evolution (3.69 mmol/g/h) at the absence of Pt co-catalyst, which is higher than the majority of existing catalysts, and it also possessed strong stability on its activity and structure. Accordingly, the enhanced hydrogen evolution and photostability were attributed to the highly ordered structure and fast interfacial electron conduction of three-dimensional porous framework, superior photosensitivity of AgBr and synergistic effect of Ag plasmas. Therefore, this study provided a potential method for exploitation of hydrogen energy.
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Aging-US
·
2019
·
IF 5.515
Chao Guo,Junrong Zhu,Jingwen Wang,Jialin Duan,Shanbo Ma,Ying Yin,Wei Quan,Wei Zhang,Yue Guan,Yi Ding,Aidong Wen,Yingdong Zhang
Mitochondrial dysfunction and oxidative damage are closely related to the pathogenesis of Parkinson's disease (PD). The pharmacological mechanism of protocatechuic aldehyde (PCA) for PD treatment have retained unclear. The purposes of the present study were to clarify the neuroprotective effects of post-treatment of PCA for PD treatment by mitigating mitochondrial dysfunction and oxidative damage, and to further determine whether its effects were mediated by the polo-like kinase 2/phosphorylated glycogen synthase kinase 3 β/nuclear factor erythroid-2-related factor 2 (PLK2/p-GSK3β/Nrf2) pathways. We found that PCA improved 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced behavioral deficits and dopaminergic cell loss. Moreover, PCA increased the expressions of PLK2, p-GSK3β and Nrf2, following the decrease of α-synuclein (α-Syn) in MPTP-intoxicated mice. Cell viability was increased and the apoptosis rate was reduced by PCA in 1-methyl-4-phenylpyridinium iodide (MPP + )-incubated cells. Mitochondrial membrane potential (MMP), mitochondrial complex I activity and reactive oxygen species (ROS) levels in MPP + -incubated cells were also ameliorated by treatment with PCA. The neuroprotective effects of PCA were abolished by inhibition or knockdown of PLK2, whereas overexpression of PLK2 strengthened the protection of PCA. Furthermore, GSK3β and Nrf2 were involved in PCA-induced protection. These results indicated that PCA has therapeutic effects on PD by the PLK2/p-GSK3β/Nrf2 pathway.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2016
·
IF 5.589
Jianyong Zhu,Ruimin Wang,Lanlan Lou,Wei Li,Guihua Tang,Xianzhang Bu,Sheng Yin
The phytochemical study of Pedilanthus tithymaloides led to the isolation of 13 jatrophane diterpenoids (1–13), of which eight (1–8) are new. Subsequent structural modification of the major components by esterification, hydrolysis, hydrogenation, or epoxidation yielded 22 new derivatives (14–35). Thus, a jatrophane library containing two series of compounds was established to screen for P-glycoprotein (Pgp)-dependent MDR modulators. The activity was evaluated through a combination of Rho123 efflux and chemoreversal assays on adriamycin resistant human hepatocellular carcinoma cell line HepG2 (HepG2/ADR) and adriamycin resistant human breast adenocarcinoma cell line MCF-7 (MCF-7/ADR). Compounds 19, 25, and 26 were identified as potent MDR modulators with greater chemoreversal ability and less cytotoxicity than the third-generation drug tariquidar. The structure–activity relationship (SAR) was discussed, which showed that modifications beyond just increasing the lipophilicity of this class of Pgp inhibitors are beneficial to the activity. Compound 26, which exhibited a remarkable metabolic stability in vitro and a favorable antitumor effect in vivo, would serve as a promising lead for the development of new MDR reversal agents.
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Materials Advances
·
2023
·
IF 5
Xamxikamar Mamat,Zehong Gao,Longyi Chen
Over use or long term exposure of acetaminophen (APAP) could cause severe damage to human health. Currently APAP related events is still a global burden. Therefore, secure management of APAP is important for avoiding possible APAP induced incidents. Rapid sensing of APAP in human body fluids can help in better moniotoring of the health condition and provide information for necessary medical aid. Electrochemical sensor utilizing functional nanomaterials and nanostructures have been proved to be a facile approach for sensing APAP in human body fluids. Among various fucntional nanmaterials, the transition element doped Fe3O4 nanoparticle decorated carbon materials have found extensive applications in catalysis, energy and environmental etc. areas. In order to explore the versatility of Zn doped Fe3O4 nanoparticle incorporated with biomass carbon electrocatalyst in electrochemical sensing area, we prepared the N, S and P doped biomass carbon material (NSP-BC) from the biomass of Elaeagnus Angustifolia gum through pyrolysis approach. Then, facile one-pot polyol solvothermal synthesis method was adpoted for deposition of Zn doped Fe3O4 nanoparticle onto the NSP-BC. Among the synthesized electrocatalysts, the Zn/Fe ratio of 0.132 electrocatalyst was found to show the highest Ipa response current towards APAP molecule. The electrocatalysts were systematically characterized by scanning electron microscope, energy-dispersive X-ray spectroscopy, element mapping, X-ray photoelectron spectroscopy, X-ray powder diffractometer, Raman spectroscopy, inductively coupled plasma-optical emission spectroscopy and electrochemical analysis. The electrocatalyst modified glassy carbon electrode sensor achieved a wide linear sensing range of APAP from 2.5 to 500 μM covering urinary physiological APAP concentration range with a limit of detection of 63.9 nM and a sensitivity of 0.64 μA μM-1 cm-2. The electrocatalyst modified GCE sensor also exhibited satisfactory recovery rates of APAP in urine samples. This facile synthesized Zn-doped Fe3O4 nanoparticle @ NSP-BC electrocatalyst has potential application in clinical diagnostics and pharmaceutical analysis.
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