ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Yi Jintao,Fu Nani,Zhong Wenhui,Liu Xia,Zhou Anqi,Li Xun
Amoxicillin (AMO), a penicillin antibiotic, and ciprofloxacin (CIP), a quinolone antibiotic, are widely used to combat bacterial infections and are frequently co-administered to enhance therapeutic efficacy. However, improper use of AMO and CIP may lead to antibiotic residues in the environment, posing serious threats to human health. The visual detection of AMO and CIP remains significant challenges. Herein, the Eu-DPA@CQDs was used for the dual-mode detection of AMO and CIP, which was synthesized by CQDs doped in europium-DPA metal-organic framework. In the colorimetric mode, the catalase-mimicking Eu-DPA@CQDs oxidized TMB to blue oxTMB. Upon addition of AMO, the oxTMB was reduced, causing color fading. Subsequent introduction of CIP restored nanozyme activity, regenerating the blue signal and enabling dual-analyte antibiotic detection. In the fluorescence mode, the Eu-DPA@CQDs probe exhibited dual emission at 440 nm and 613 nm. Upon AMO addition, the fluorescence at both wavelengths was quenched, accompanied by a color change from red to purple. In the presence of CIP, the emission at 440 nm increased and redshifted to 490 nm, while the signal at 613 nm was quenched, resulting in a multicolor transition from red to cyan. The Eu-DPA@CQDs sensor enabled rapid and dual-mode detection of AMO and CIP. The colorimetric method exhibited wide linear ranges of 0.005–25 μM for AMO and 0.007–4.25 μM for CIP, with detection limits of 1.67 nM and 3.75 nM, respectively. A visible color transition from dark blue to colorless was observed with increasing AMO concentration, while the addition of CIP reversed the signal back to dark blue. Similarly, the fluorescence detection achieved wide linear ranges from 0.005 to 30 μM for AMO and 0.005 to 15 μM for CIP, with detection limits as low as 4.74 nM and 3.11 nM, respectively, also within only 1 min. As the concentration of AMO increased, the color shifted from red to purple. In contrast, increasing CIP concentration induced a color transition from red to cyan. These color transitions were both clearly visible to the naked eye. The sensor demonstrated excellent selectivity and anti-interference capability, providing a reliable platform for accurate, sensitive, and quantitative determination of both antibiotics in real samples. Graphical abstract
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
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IF 4.6
Han Yan-Chun,Li Fang-Shuo,Zhang Jian-Chao,Wang Quan,Yang Guo-Hui,Yu Miao,Wang Feng,Duan Yong-Xin,Zong Lu,Li Bo-Xiao,Zhang Jian-Ming
Silica aerogels (SAs) impart low density and excellent thermal insulation to polymer systems, yet incorporating hydrophobic SAs into aqueous rubber latex systems remains challenging owing to their poor dispersibility and potential to destabilize the latex. Although previous studies have dispersed SAs in aqueous poly(vinyl alcohol) (PVA), the stability of such dispersions and their effectiveness as bridging media for latex integration have not been thoroughly evaluated, which limits their practical application in latex compounding. This study systematically examined how the surface chemistry governs hydrolytic stability, interfacial behavior, and latex compatibility in PVA-assisted aqueous processing. Two hydrophobic SAs were prepared: ethoxy-modified SA (E-SA) and methyl-modified SA (M-SA). Both initially formed a homogeneous PVA slurry, but E-SA rapidly hydrolyzed its surface —OCH 2 CH 3 groups, releasing ethanol, becoming hydrophilic, and undergoing irreversible nanopore collapse. In contrast, M-SA maintains its structural integrity and hydrophobicity because its —Si(CH 3 ) 3 groups are highly resistant to hydrolysis. This divergence dictates the behavior during latex blending. The ethanol released from E-SA disrupts electrostatic and steric stabilization, inducing latex coagulation, whereas M-SA/PVA dispersions preserve colloidal stability across diverse latex systems. As a practical demonstration, M-SA-reinforced chlorosulfonated polyethylene (CSM) rubber latex composites show more than a 50% reduction in thermal conductivity while maintaining chemical resistance, enabling high-performance insulating protective gloves and coatings. This work establishes a critical link between aerogel surface chemistry and aqueous processing stability, providing a mechanistic foundation for the rational design of water-based rubber/silica aerogel composites and next-generation thermal insulation materials.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
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IF 4.6
Zhang Di,Shao Meng-Di,Wang Xin,Gui Zhou
Nanoscale red phosphorus (NRP) was synthesized via a phosphorus-amine dissolution method and immobilized onto mesoporous silica nanospheres (MSNs) to obtain hybrid NRP@MSN particles with improved dispersion stability. Epoxy resin (EP) composites containing 2 wt% fillers were prepared to evaluate their thermal and flame-retardant behaviors. Compared with EP, the NRP@MSNs/EP composite significantly enhanced fire safety, resulting in a 52.8% reduction in the peak heat release rate, a 13.9% decrease in total smoke production, and a 165% increase in char yield. Mechanical testing revealed a notable toughening effect under impact loading. The improved flame retardancy originates from the combined nano-barrier effect of MSNs and the catalytic charring and radical-quenching functions of NRP. This work demonstrates an efficient strategy for stabilizing NRP and highlights its strong potential as an environmentally friendly flame retardant for EP systems.
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JOURNAL OF PLANT GROWTH REGULATION
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2026
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IF 4.2
Ren Yong,Lu Enke,Li Qingqing,Sun Kang,Yang Longhui,Li Ruosen,Nurdawuleiti Shawulie,Liu Lu,Cheng Siren
Rice seedlings, with immature defense systems, are highly susceptible to adverse conditions, severely hindering establishment and yield. While exogenous riboflavin regulates rice growth and stress resistance, its role in modulating comprehensive seedling quality (a core yield-determining trait) remains understudied. This study systematically evaluated riboflavin’s effects on two fragrant rice varieties (Meixiangzhan, Nanjingxiangzhan) with four concentrations (0, 10, 20, 40 mg·L⁻¹) at the seedling stage. The key results showed that 20 mg·L⁻¹ riboflavin (optimal concentration) significantly enhanced root architecture (length, surface area, volume, diameter) and coordinated biomass accumulation (leaf/root fresh/dry weights) across three sampling stages (3d, 6d, 9d after treatment). It also elevated chlorophyll a/b, carotenoid contents, antioxidant enzyme (SOD, POD, CAT) activities, and osmolyte (soluble protein, proline) levels, while reducing oxidative damage (MDA, H 2 O 2 )-except for transient leaf-specific fluctuations at 3d. Meixiangzhan showed stronger responsiveness than Nanjingxiangzhan, linked to varietal differences in root traits and redox sensitivity. This study elucidates that riboflavin improves rice seedling quality via synergistic regulation of root development, photosynthetic capacity, and antioxidant homeostasis. As an eco-friendly, cost-effective biostimulant, it offers a practical strategy to enhance transplanting survival, stress tolerance, and yield potential in rice production.
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Journal of the Australian Ceramic Society
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2026
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IF 2.6
Chen Yuan,Wang Shu,Li Xin
Heavy metal pollution is a globally environmental crisis as the demand for electronic products being steadily on the increase. In our work, a novel transition metal Sn-doping strategy has been proposed to reconstruct the valence band of CdS by s-p orbit hybridization. An easy and mild solvothermal method was employed to synthesize the Sn-doped CdS nanoparticles, in which Sn 2+ ions substitute Cd 2+ ions to occupy CdS lattice. This Sn-doping modification effectively narrows the bandgap and regulates the energy band structure of CdS. In this case, it has caused an extension of the visible light absorption range, an enhancement of photogenerated carrier separation efficiency, and an improvement of thermodynamic potential, as well as a photostability from photocorrosion. For the optimization effect of Sn doping, the 4 at% Sn-doped CdS sample has performed the highest efficiency of photocatalytic reduction Cr (VI) degradation, achieving 84.8% Cr (VI) removal within 10 min, as 1.3 times higher than that of bare CdS. This research establishes an experimental framework for the advancement of efficient and stable nano-photocatalysts, with implications for band engineering in metal dichalcogenide semiconductors.
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NATURE
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2026
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IF 56.1
Wang Xukang,Ma Yuanzhu,Niu Yihan,Xiong Bo,Zhang Anke,Zhang Guoxun,Chen Yifan,Wei Wei,Fang Lu,Wu Jiamin,Dai Qionghai
Volumetric additive manufacturing has emerged as a promising technique for the flexible production of complex structures, with diverse applications in engineering, photonics and biology 1 , 2 . However, present methods still face a trade-off between resolution and volumetric build rate, restricting efficient and flexible production of high-resolution 3D structures. Here we propose a method, called digital incoherent synthesis of holographic light fields (DISH), to generate high-resolution 3D light distributions through continuous multi-angle projections with a high-speed rotating periscope without the requirement of sample rotation. The iterative optimization of the holograms for different angles in DISH maintains 19-μm printing resolution across the 1-cm range that is far beyond the depth of field of the objective and enables high-resolution in situ 3D printing of millimetre-scale objects within only 0.6 s. Acrylate materials in a range of viscosities are used to demonstrate the general compatibility of DISH. Integrating DISH with a fluid channel, we achieved mass production of complex and diverse 3D structures within low-viscosity materials, demonstrating its potential for broad applications in diverse fields.
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Drug Delivery and Translational Research
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2026
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IF 6.9
Li Jiaqi,Long Meng,Xu Fanjun,Abudureyimu Zulalan,Li Jing,Guo Teng,Feng Nianping,Zhang Yongtai
In the current study, polysaccharides (APS) extracted from the dried roots of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao were demonstrated to promote hair regeneration. However, with an average molecular weight of 20,000, they exhibit poor transdermal absorption. To enhance local efficacy, we synthesized chemically crosslinked hyaluronic acid (cHA) and prepared γ-cyclodextrin-modified potassium metal–organic frameworks (MOFs) loaded with minoxidil (MDX) (MDX@MOF).The aforementioned materials were mixed with APS to form soluble microneedles (MDX@MOF-APS/cHA-MNs). Their oblique spike structure facilitates local fixation after skin penetration. MOF-based drug loading increased MDX water solubility by ninefold, while cHA provided significant sustained-release effects.Furthermore, APS enhances the mechanical properties of hydrogel microneedles and optimizes drug delivery. Notably, APS promotes human hair follicular papilla cell proliferation in a dose-dependent manner and exhibits synergistic effects with MDX. Concurrently, MDX@MOF-APS/cHA-MNs significantly prolong drug retention time in the skin, effectively improving hair coverage and growth rate in androgenetic alopecia mice. In summary, APS emerges as a clinical candidate for treating androgenetic alopecia, while novel microneedles with unique composition and structure enrich topical delivery strategies. Graphical abstract
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BMC Veterinary Research
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2026
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IF 3.1
Yao Lulu,Kang Yunzhe,Zhao Xuyang,Wang Lucai,Lv Lijie,Zhu Wenhui,Yang Xiuwen,Zhuang Guoqing,Sun Aijun
Background N6-methyladenosine, the most prevalent post-transcriptional modification in eukaryotes, plays a critical role in regulating gene expression and disease pathogenesis. Concurrently, G-quadruplex structures are implicated in key biological processes, including the regulation of transcription and post-transcriptional events. Emerging evidence suggests that m 6 A modifications and G4 structures colocalize within viral genomes and human pre-mRNAs; however, their functional interplay remains poorly understood. Results Using existing MeRIP-seq data from Marek’s disease virus (MDV)-infected samples, we investigated the colocalization pattern and its potential role in viral infection. Our bioinformatic analyses revealed that the predicted G4 structures were predominantly two G-tetrad G-quadruplexes. Genes with m 6 A-G4 colocalization were significantly enriched in pathways related to immune response and tumorigenesis. Then we verified the presence of co-localization on the CCL4 , which inhibited CCL4 expression. Co-localization also affected viral replication and regulated ICP4 expression. Conclusions We systematically characterized the features of G4 structures co-localized with m 6 A modifications during MDV infection, investigated the role in viral replication and gene regulation, and provided experimental evidence for m 6 A-G4 co-localization. These findings shed new light on the epitranscriptomic regulatory mechanisms employed by an oncogenic virus and may inform the development of novel antiviral and anti-tumor therapeutic strategies.
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CELL BIOLOGY AND TOXICOLOGY
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2026
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IF 5.7
Peiqi Wang,Haoxin Fu,Jun Wu,Ruibin Li,Lu Cao,Ren-Ai Xu,Weihong Lin
Acalabrutinib is a frontline agent for chronic lymphocytic leukemia (CLL). The objective of this experiment was to screen 21 cardiovascular drugs with a focus on elucidating the metabolic inhibition of acalabrutinib by finerenone in vitro and in vivo. The ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was applied to quantify acalabrutinib and its major active metabolite ACP-5862 in liver microsomes in vitro and in rats in vivo. The half-maximal inhibitory concentrations (IC 50 ) of finerenone in rat liver microsomes (RLM), human liver microsomes (HLM) and recombinant human CYP3A4 (rCYP3A4) were 7.00, 21.29 and 3.52 μM, respectively. In RLM and rCYP3A4, finerenone inhibited the metabolism of acalabrutinib via mixed-type inhibition (competitive and non-competitive), with a non-competitive inhibition observed in HLM. Compared with the control group, in vivo pharmacokinetic analysis indicated that finerenone co-administration increased acalabrutinib exposure, as reflected by 4.08-, 7.16-, and 3.96-fold increases in AUC (0-t) , AUC (0-∞) , and half-life (t 1/2 ), respectively, accompanied by an 86.02% reduction in the clearance (CL z/F ). Its metabolite ACP-5862 demonstrated a 57.47% and 65.12% decrease in AUC (0-t) and the maximum concentration (C max ), respectively, while CL z/F was increased by 0.79-fold. Finally, acalabrutinib and finerenone were evaluated for binding to cytochrome P450 3A4 (CYP3A4) by molecular docking, yielding binding energies of -2.36 and -2.19 kcal/mol, respectively. Thus, in vivo and in vitro results consistently indicated that finerenone inhibited the metabolism of acalabrutinib, providing the basis for individualized dosing considerations.
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FIBERS AND POLYMERS
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2026
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IF 3.1
Cui Jie,Deng Hangjun,Qi Dongming,Zhou Guiyang,Chen Tao
To enhance the surface hydrophilicity of polyphenylene sulfide (PPS) fibers and expand their industrial applications in fire-resistant/radiation-resistant workwear, water electrolysis hydrogen production diaphragms, and fiber paper, this study modified PPS nonwovens using three polyphenols: dopamine, gallic acid, and tannic acid. Specifically, the catechol groups in polyphenols were utilized to adsorb hydrolyzed titanium dioxide (TiO 2 ) from an aqueous solution of ammonium hexafluorotitanate, thereby forming polyphenol/PPS/TiO 2 composites materials. The physicochemical properties (e.g., morphology, elemental composition) and surface properties (e.g., hydrophilicity, mechanical performance, etc.) of modified and unmodified fabrics were characterized using a suite of analytical techniques, including Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), contact angle measurement, water absorption testing, thermogravimetric analysis (TGA), and stress–strain testing. Additionally, the effects of polyphenol type, polyphenol concentration, and reaction time on hydrophilicity of the modified nonwovens were investigated to determine the optimal modification conditions. Results showed that polyphenol modification, combined with subsequent TiO 2 treatment, significantly improved the surface hydrophilicity of PPS nonwovens while preserving their favorable mechanical properties and friction resistance. Among the three polyphenols, the dopamine/PPS/TiO 2 composite exhibited the best wettability: when 2% dopamine (mass concentration) and subjected to 18 h of deposition, the water contact angle decreased from 146.0° (for unmodified PPS) to 51.9°, and the water absorption capacity of the PPS nonwovens increased to 508.4 mL/m 2 /s.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2026
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IF 1.7
Cui Yiqun,Ma Fuqiu,Jia Fengyan,Wang Guixiang
With the growing application of 177 Lu-based radiopharmaceuticals, efficient separation of no-carrier-added (NCA) 177 Lu from its isotopic precursor ytterbium has become an urgent need in radiochemistry. However, the adjacent positions of lutetium and ytterbium in the lanthanide series lead to highly similar physicochemical properties, rendering conventional separation methods ineffective. In this study, P507@PS-DVB resin was synthesized via a facile one-pot method by reacting the extractant P507 with polymerizable monomers, exhibiting an optimized microstructure and functional group distribution conducive to the selective adsorption of Lu(III) over Yb(III). Key factors affecting adsorption and separation performance were systematically evaluated. Under optimized conditions, the resin demonstrated a Lu(III) adsorption capacity of 55.4 mg/g. Furthermore, a two-step separation process consisting of primary enrichment and secondary purification was developed, achieving a Lu(III) recovery exceeding 60% alongside an 82% removal rate of Yb(III). This work presents both a promising material for NCA 177 Lu production and a viable strategy for lanthanide separation.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Yao Yaqi,Xu Zhenna,Ding Haoran,Zhu Yehan,Yang Shen shen,Wang Shuo,Fan Simiao,Hu Jingwen,Zhou Mengjiao,Wu Hongfei,Xu Zihang,Xia Jingyao,Li Yubo
Acute liver injury (ALI) represented a significant clinical challenge due to its high mortality rate and the absence of specific therapeutic interventions. Plant-derived exosome-like nanoparticles (ELNs) had recently garnered increasing attention in the field of disease prevention and treatment, owing to their favorable biocompatibility and potential for targeted delivery. In this study, we isolated and systematically characterized ELNs from the medicinal plant yam (Yam ELNs). Structural analysis revealed that Yam ELNs possess a homogeneous bilayer membrane structure with an average particle size of 214.7 nm and demonstrated considerable stability in gastrointestinal fluids. These nanoparticles were found to be enriched with lipids (primarily phosphatidylcholine, PC), functional proteins (including GPX1 and GSTP1), and microRNAs (such as the miR159 family). In vivo imaging and cellular uptake assays indicated that Yam ELNs were efficiently internalized by the liver and HepG2 cells. Using a carbon tetrachloride (CCl₄)-induced ALI model, we demonstrated that oral administration of Yam ELNs significantly reduced serum markers of liver injury (ALT and AST), ameliorated oxidative stress imbalance (as evidenced by decreased MDA and increased GSH levels), and attenuated histopathological damage in the liver. Furthermore, in vitro experiments confirmed that Yam ELNs modulate cellular oxidative stress through their cargo of endogenous functional RNA molecules, thereby exerting a prophylactic protective effect. Desorption electrospray ionization mass spectrometry imaging (DESI-MSI) visually demonstrated that Yam ELNs remodel the spatial distribution of glycerophospholipid metabolism and suppress lipid peroxidation and the propagation of inflammation. Targeted lipidomics analysis further revealed that disturbances in several core metabolic pathways, including glycerophospholipid metabolism and linoleic acid metabolism, were corrected by Yam ELNs. As a result, the homeostasis of key phospholipid species, such as PE, PI, and PS, was maintained, and the propagation of inflammatory responses was limited. Notably, Yam ELNs pretreatment significantly reduced serum levels of lipopolysaccharide (LPS) and downregulated hepatic Toll-like receptor 4 (TLR4) expression, indicating preservation of intestinal barrier integrity and attenuation of endotoxin-triggered hepatic inflammation. Furthermore, an integrated correlation analysis based on gut microbiota 16S rRNA sequencing, fecal metabolomics, and untargeted serum metabolomics clarified the relationships between differential serum metabolites, fecal metabolites, and microbial community structure. Following treatment with Yam ELNs, modulation of gut microbiota composition was observed, marked by the enrichment of Lactobacillus spp. These microbial shifts correlated with concurrent improvements in both serum lipid profiles and fecal metabolite profiles. Collectively, these effects were associated with enhanced hepatoprotective efficacy, suggesting a gut-initiated and metabolism-mediated mechanism underlying the prophylactic protection against ALI. In summary, this study systematically establishes the substantial potential of Yam ELNs in the prevention and treatment of liver injury, offering a novel strategy for the development of natural vesicle-based liver-targeted therapies. Graphical abstract
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