Materials Today Bio
·
2024
·
IF 8.7
Xinxin Zhan,Jianglong Yan,Dong Xiang,Hao Tang,Lulu Cao,Yufeng Zheng,Hong Lin,Dandan Xia
Polyetheretherketone (PEEK) is considered as a promising dental implant material owing to its excellent physicochemical and mechanical properties. However, its wide range of applications is limited by its biologically inert nature. In this study, a near-infrared (NIR) light responsive bioactive coating with gold nanoparticles (AuNPs) and metronidazole adhered to the PEEK surface via dopamine polymerization. Compared to pure PEEK, the hydrophilicity of the treated PEEK surface was significantly improved. In addition, under NIR light, the surface coating exhibited photothermal conversion effect, and gold nanoparticles and the antibiotic can be released from the coating. This improved the antibacterial properties of PEEK materials. Moreover, the coating was more conducive to the early adhesion of bone mesenchymal stem cells. The results of in vitro and in vivo osteogenic activity studies showed that the developed coating promoted osseointegration of PEEK implants, and NIR light irradiation further improved the antibacterial ability and osteogenic activity of PEEK implants. Through RNA sequencing, the potential underlying mechanism of promoting bone formation of the AuNPs coating combined metronidazole was interpreted. In summary, the developed coating is a potential surface treatment strategy that endows PEEK with enhanced osseointegration and antibacterial properties.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yu Zhang,Chunhua Ren,Huayang Liu,Jingyi Duan,Mengyao Wang,Ziao Zhou,Jinyou Duan,Huaimin Wang,Xiaoli Zhang
Antibiotic-resistant bacterial infections are increasing at an alarming rate, posing a significant threat to global health and highlighting the urgent need for innovative therapeutic strategies. Herein, we developed a near-infrared (NIR) photoactivatable amphiphilic precursor molecule of peptide-vancomycin conjugate (PFTV), which could in situ self-assemble into a nanogermicidal agent on bacterial surfaces upon exposure to NIR light. This approach aimed to effectively treat infections caused by vancomycin-resistant Enterococcus (VRE). Our findings indicated that the in situ self-assembly of PFTV triggered by NIR light demonstrated superior antiplanktonic activity compared to free vancomycin, with the minimum inhibitory concentration reduced by two orders of magnitude. Additionally, this strategy enhanced PFTV penetration and removal of VRE biofilms, achieving a bacterial killing efficiency of 99%. Mechanistic studies revealed that the combination of PFTV and NIR light treatment eradicated antibiotic-resistant bacteria via two main actions: membrane perturbation and disruption of cellular homeostasis. Furthermore, the in situ self-assembly of PFTV upon NIR light irradiation demonstrated significant therapeutic efficacy in treating VRE-induced infections and accelerating wound healing in vivo by mitigating inflammation responses and promoting neovascularization. This work has reported an on-demand activated strategy to facilitate peptide-antibiotic conjugate in situ self-assembly into a multivalent nanoantibacterial agent, which could provide novel paradigm for targeted drug delivery and combating multidrug-resistant pathogens.
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Materials Today Bio
·
2025
·
IF 10.2
Li Miao,Xue Lu,Yaoyao Wei,Jie Zhou,Yuanyuan Liu,Yang Zhang,Changle Meng,Mingyang Li,Hua Zhang,Wen Chen,Han Zhang
In diabetic wounds, the presence of hyperglycemia is often accompanied by a persistent inflammatory response, oxidative stress damage, impaired angiogenesis and bacterial infections around the wound, resulting in impaired proliferation of dermal and epidermal cells and impaired skin regeneration in diabetic wounds. To solve the above problems, this study designed a near-infrared (NIR) light-responsive multifunctional poloxamer hydrogel (EGF/PDA-MXene Gel). The Gel is composed of two-dimensional nanomaterials (2D NMs) MXene as the core, modified by polymer, further loaded with epidermal growth factor (EGF), and has antibacterial, antioxidant, photothermal properties. Meanwhile, EGF/PDA-MXene Gel can be used as a drug repository, alleviating the problem of short half-life, and realizing the sustained release of EGF. The NIR photothermal property induces protein denaturation leading to the death of pathogenic bacteria, avoiding the common clinical problem of antibiotic resistance. In addition, EGF/PDA-MXene Gel promotes diabetic chronic wound healing by promoting epidermal regeneration, collagen deposition, angiogenesis, and several other mechanisms. Therefore, the Gel preparation strategies that combine bioactive molecules with 2D NMs, which maintains the activity of EGF while exploiting the antimicrobial advantages of 2D NMs photothermally, provide a new and promising therapeutic approach for accelerating the repair of chronic infected wounds.
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Journal of Environmental Sciences
·
2024
·
IF 5.9
Songlin Cai,Ciyuan Huang,Linji Yang,Yuchen Wang,Lingxiao Li,Shangfei Yao,Ke Sun,Caiyun Wang,Guanhui Tan,Tao Yang,Shengjie Wang,Bingsuo Zou,Tao Liu
The widespread use of personal care products poses significant risks to both ecosystems and human health. The construction of photocatalysts with the advantages of enhanced visible light absorption, efficient charge separation and high stability is important for the degradation of persistent environmental pollutants. Herein, we have prepared two D-A heterojunction organic semiconductor photocatalysts: PV-BDTC1:IDTCN/Biochar and PV-BDTC2:IDTCN/Biochar by a simple design method that can be widely applied. Under visible light irradiation, PV-BDTC2:IDTCN/Biochar showed better removal ability for indomethacin, with reaction rate constants 14.7 and 5.1 times higher than those of PV-BDTC2:IDTCN and Biochar, respectively. This is attributed to the construction of a heterojunction between the donor and the acceptor, which expands the light absorption range and promotes the separation of photogenerated carriers, thereby giving the material the ability to produce a large number of reactive oxygen species during the photocatalytic reaction. In addition, Biochar well ensures the stability of D-A heterojunction films under long-term operating conditions. This work highlight the potential of natural biomaterials in constructing effective D-A heterojunction organic photocatalysts/adsorbents for combatting water pollution.
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CHEMICAL ENGINEERING COMMUNICATIONS
·
2025
·
IF 2
Van Thi Thanh Ho,Khuong Anh Nguyen Quoc,Quynh Le Nguyen Huong,Bao Gia Pham Dinh,Tam Thi My Luu,Duy Huynh Minh Nguyen,Thao Nguyen Phuong,Han Tran Ngoc,Tuan Huynh Nguyen Anh
Volatile organic compounds (VOCs) are hazardous chemicals that significantly threaten public health, making their remediation an increasingly pressing concern. Among the various solutions proposed, the use of TiO2 photocatalysts has garnered attention because of their practicality, cost-effectiveness, high catalytic activity, and human-friendly nature. This study discussed the potential of Wolfram (W)-doped TiO2 catalyst in enhancing VOC degradation under UV light irradiation and used xylene as the target VOC. The nanostructured W-doped TiO2 materials were fabricated without surfactants or post-reaction calcination at a low temperature for 10 h, yielding promising results. We carefully investigated these nanomaterials’ characterization using microscopic and spectroscopic techniques such as XRD, TEM, SEM, EDS, XRF, EIS, and XPS. The XPS analysis revealed W-O-Ti linkages and improved charge separation, while EIS showed enhanced conductivity and reduced charge transfer resistance, with 1.5 mol% W achieving optimal performance. These results evaluate the successful synthesis of W-doped TiO2, which can be applied to VOC treatment. Notably, the photocatalytic degradation of xylene gas reached 99.77% within 10 min of UV illumination. This result demonstrates the outstanding properties of this catalyst as a promising solution for VOCs pollution control.
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Heliyon
·
2024
·
IF 3.4
Shuwen Ding,Xiaohui Zhang,Gaopeng Wang,Jiaying Shi,Jiayu Zhu,Jiayu Yan,Jing Wang,Junhua Wu
In diabetic patients, compromised angiogenesis due to endothelial dysfunction leads to delayed intraoral wound healing. However, the moist and dynamic environment of the oral cavity impedes the use of normal wound dressings. Sulfated chitosan (SCS) is a promising biomaterial that promoting angiogenesis. Here, a light-responsive hydrogel combined with SCS explored intraoral wound healing. We designed a SCS-modified hydrogel combined with alginate Methacryloyl (AlgMA) and acrylamide (AM) and demonstrated efficient wet adhesion and mechanical properties suitable for the wet and dynamic oral environment. In vitro , the SAA hydrogel improved the tube formation of human umbilical vein endothelial cells (HUVECs) under high-glucose conditions. Further investigations revealed that the SAA hydrogel can regulate HUVEC-macrophage interactions, leading to a shift in macrophage polarization from M1 to M2, thereby fostering an environment conducive to angiogenesis under high-glucose condition. The results demonstrated the substantial therapeutic impact of the SAA hydrogel on diabetic oral defect repair by effectively enhancing the local blood supply and angiogenesis.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jiayue Wang,Reili Li,Jinke Wang,Yujie Gao,Meiyi Wang,Huashan Wang
As an essential material for manufacturing lithium batteries, the demand of lithium is increasing, which means novel extracting method from various lithium-containing solutions is necessary. Spiropyran molecules undergo a photoisomerization reaction under light, transitioning from a closed-ring form (colorless) to an open-ring form (colored), generating multiple coordination sites to form coordination bonds with metal ions. In this paper, a polyacrylamide/carboxymethyl chitosan composite aerogel grafted with photoresponsive spiropyragroups (Fe 3 O 4 /CNTs@PAM/CS-SP), used for extracting lithium from solutions, was prepared by dual cross-linking and vacuum freeze-drying. Batch adsorption experimental results showed that the incorporation of Fe 3 O 4 nanoparticles further enhances its adsorption capability, as it enables rapid separation of the aerogel from water using an external magnetic field and also improves the adsorption efficiency due to its magnetic properties. The aerogel exhibits good adsorption capacity in the pH range of 9–12 and shows selectivity for Li in simulated brine, achieving a maximum adsorption capacity of 176.5 mg/g at 35 °C and a Li concentration of 1 g/L. The preparation of this aerogel offers a novel and effective approach to creating environmentally friendly adsorbents, providing a new method for extracting lithium from lithium-containing solutions.
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ACS Applied Optical Materials
·
2025
·
IF 3.8
Yujiao Jiang,Ziyi Ye,Mengling Yu,Zhengxing Gong,Xinfeng Zhang
With the widespread use of personal electronic devices, excessive blue light exposure that causes retinal cell damage and skin hyperpigmentation has attracted increasing attention. However, an effective indicator for real-time in-house monitoring of blue light is still lacking. In this study, we developed a screen-attachable visual hydrogel indicator for facile in-house monitoring of blue light. The indicator is fabricated by encapsulating both a blue light-responsive photosensitizer (fluorescein) and 3,3′,5,5′-tetramethylbenzidine (TMB) within an agarose hydrogel. Upon exposure to blue light, the photosensitizer generates reactive oxygen species (ROS), which oxidize colorless TMB to blue oxTMB. The proximity of fluorescein and TMB within the hydrogel nanopores significantly facilitates the oxidation reaction. Hence, using a hydrogel as the reaction carrier not only makes the indicator screen-attachable but also greatly enhances its sensitivity. The color change of TMB is good linearly with the blue light doses in the range of 0.15–1.2 J/cm2 with a detection limit about 0.082 J/cm2, much lower than the threshold (0.75 J/cm2) for oxidative eye stress. Green and red light from the electronic products caused no interference for the monitoring of blue light. It was successfully applied for monitoring the cumulative dose of blue light emitted from the three types of electronic products (i.e., laptops, tablets, and light-emitting diode (LED) lamps) by simply attaching the indicator on the screen or on the desk. This hydrogel indicator, with the merits of screen-attach ability, facile use, and high sensitivity, is quite appealing for in-house monitoring of blue light from electronic products.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Jiaxing Zhu,Ciyu Ge,Borui Jiang,Xiang Zhang,Jiajun Luo,Jiang Tang
Tin-halide perovskites (THPs) offer a promising alternative to lead-halide perovskites (LHPs), addressing environmental concerns while providing excellent optoelectronic properties. However, the performance of THP light-emitting diodes (LEDs) remains inferior to their lead-halide counterparts due to challenges such as Sn 2 ⁺ oxidation, rapid crystallization, and high defect densities. Here, for the first time, a multifunctional Lewis-base reducing ligand triphenylphosphine (TPP) is reported, which simultaneously suppresses Sn 2+ oxidation and passivates defects in 2D THPs TEA 2 SnI 4 (TEA represents 2-thienylethylamine). The P atom in TPP, with its lone pair electrons on the 3p orbital, has low electronegativity and high electron density, which can effectively suppress Sn 2+ oxidation. Furthermore, σ-donation and π-conjugation effects from the three phenyl groups in the TPP molecule enable it to strongly coordinate with Sn 2+ , which passivates defects in TEA 2 SnI 4 . These properties enhance the stability and optoelectronic properties of THPs. When the optimized THP films are implemented as active layers in LEDs, they exhibit a narrow electroluminescence full-width at half-maximum of 28 nm, Commission Internationale de l'Eclairage x-coordinate exceeding 0.7, and a peak external quantum efficiency of 10.12%, sevenfold higher than the pristine devices. This work demonstrates the potential of molecular additives to enhance the device performance of tin-based perovskites.
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MOLECULES
·
2019
·Vol. 24
·期 22
·4136
·
IF 3.06
Yanping Shi,Chao Sun,Xiaoqi Gao,Wei Zhao,Nan Zhou
In this paper, we designed a new quantitative and qualitive detection method for biothiols by using fluorescence method and resonance light scattering (RLS) technique. Nitrogen doped carbon quantum dots (C/N-dots) were obtained from tartaric acid and ethylenediamine by hydrothermal method, and then their morphology and optical properties were characterized by different techniques. A detection system consisting of C/N-dots and Ag+complex was established. In this system, C/N-dots possessed the photoluminescent property and the Ag+complex owned the RLS property, so, by combining the two luminescent properties to achieve complementary advantages, we could detect biothiols and solve the problem of distinguishing between Cys and GSH. Additionally, we optimized detecting conditions and investigated the detection mechanism of fluorescence quenching and RLS detecting. Results showed that the analytical response of fluorescence was linear in the range 0–140 μM and the detection limit (LOD) was calculated to be 6.6 μM for Cys, and the addition of GSH had no effect on fluorescence. RLS response ranges were 0–167 μM for Cys and 0–200 μM for GSH, with LOD down to 64 nM and 74 nM, respectively. Furthermore, the probe was successfully used for detecting Cys in fetal bovine serum (FBS) samples by fluorescence method, and also, by RLS technique, the content of GSH in FBS samples was detected.Keywords:carbon quantum dots;RLS technique;IFE;biothiols;Ag+complex
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SOLID STATE SCIENCES
·
2018
·
IF 1.861
Xiaojuan Li,Bo Jin,Jingwen Huang,Qingchun Zhang,Rufang Peng,Shijin Chu
In this study, novel ternary Fe 2 O 3 /ZnO/ZnFe 2 O 4 (ZFO) composites were successfully prepared through a simple hydrothermal reaction with subsequent thermal treatment. The as-prepared products were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) analysis, Barrett-Joyner-Halenda (BJH) measurement, and UV–vis diffuse reflectance spectroscopy (UV–vis DRS). The photocatalytic degradation of rhodamine B (Rh B) under visible light irradiation indicated that the ZFO composites calcined at 500 °C has the best photocatalytic activity (the photocatalytic degradation efficiency can reach up to 95.7% within 60 min) and can maintain a stable photocatalytic degradation efficiency for at least three cycles. In addition, the photocatalytic activity of ZFO composites toward dye decomposition follows the order cationic Rh B > anionic methyl orange. Finally, using different scavengers, superoxide and hydroxyl radicals were identified as the primary active species during the degradation reaction of Rh B.
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MICROCHEMICAL JOURNAL
·
2018
·
IF 2.746
Wenqing Deng,Rui Dai,Pingyue Hu,Qianqian Li,Xiaoli Xiong,Ke Huang,Feng Huo
A novel colorimetric sensor based on red-emitting bovine serum albumin‑golden nanoclusters (BSA-AuNCs) and green-colored fluorescein that exhibited traffic light-type color change was developed for ratiometric and visual detection of mercury (Hg). In the presence of Hg 2+ , the red fluorescence from BSA-AuNCs was quenched while the green fluorescein was inert thus as a reference. And it presented traffic light-type (red, yellow and green) color in the low, middle and high concentration of Hg 2+ . A potential mechanism was investigated by Energy Dispersive Spectrometer (EDS) and X-ray photoelectron spectroscopy (XPS). The selective quenching mechanism may be due to the formation of gold amalgam bonds between BSA-AuNCs and Hg 2+ . A linear correlation was constructed for Hg 2+ in the concentration range of 10–500 μg L −1 . A limit of detection (LOD) of 7.4 μg L −1 and a relative standard deviation (RSD, n = 7) of 0.4% were obtained, which can be used to monitor the concentration of Hg 2+ . In visual detection, as low as 0.1 μg mL −1 of Hg 2+ can be easily discriminated from the blank with the naked eye. The proposed method was validated by analysis of certified environment and food samples with satisfactory results.
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