ANALYTICAL CHEMISTRY
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2021
·
IF 6.986
Mengxia Cheng,Hong Shu,Ye Peng,Xiaoxiao Feng,Guoquan Yan,Lei Zhang,Jun Yao,Huimin Bao,Haojie Lu
Sialylated N-glycan isomers with α-2,3 and α-2,6 linkages play crucial and distinctive roles in diverse physiological and pathological processes. Changes of α-2,3-linked sialic acids in sialylated N-glycans are especially important in monitoring the initiation and progression of diseases. However, the specific analysis of α-2,3-sialylated N-glycan linkage isomers remains challenging due to their extremely low abundance and technical limitations in separation and detection. Herein, we designed an integrated strategy that combines linkage-specific derivatization and a charge-sensitive separation method based on microfluidic chip capillary electrophoresis–mass spectrometry (microchip CE–MS) for specific analysis of α-2,3-sialylated N-glycan linkage isomers for the first time. The α-2,6- and α-2,3-sialic acids were selectively labeled with methylamine (MA) and N,N-dimethylethylenediamine (DMEN), respectively, which selectively makes α-2,3-sialylated N-glycans positively charged and realizes online purification, concentration, and discrimination of α-2,3-sialylated N-glycans from other N-glycans in microchip CE–MS. This new approach was demonstrated with standard multisialylated N-glycans, and it was found that only the α-2,3-sialylated N-glycans migrated and were detected in order according to the number of α-2,3-sialic acids. Finally, this strategy was successfully applied in highly sensitive profiling and reproducible quantitation of the serum α-2,3-sialylated N-glycome from ovarian cancer (OC) patients, where 7 of 33 detected α-2,3-sialylated N-glycans significantly changed in the OC group compared with healthy controls.
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PubMed
高影响因子
Surfaces and Interfaces
·
2021
·
IF 4.837
Ikram Ullah,T.A. Taha,Asma M. Alenad,Ikram Uddin,Asif Hayat,Ashiq Hayat,Muhammad Sohail,Ahmad Irfan,Javid Khan,Arkom Palamanit
In this study, sulfated zirconia with loading of platinum (Pt) and platinum alumina (PA-Al 2 O 3 ) promoted sulfated zirconia (SZ) catalysts were synthesized by hydro-thermal route. The samples were characterized by XRD, BET, FT-IR, NH 3 -TPD, and TGA. The catalytic efficiency of all the synthesized catalysts was tested on the isomerization of n -butane. The results indicated that the conversion of n -butane (71.04%), selectivity to i -butane (98.96%), and yield of i -butane (70.30%) is significantly high for PA/SZ sample than that of Pt modified SZ and bare SZ. The results of this study suggest that the SZ modified by Pt/Al 2 O 3 (PA) provided better catalytic performance and higher stability (within 25 h of TOS), when compared with SZ, and Pt-modified SZ.
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高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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2021
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IF 3.575
Dandan Zheng,Jinglong Wang,Genju Li,Lulu An,Ying Qu,Qinxiu Zhang,Wenhui Ye,Xin Zhao,Zhongxi Zhao
Autophagy-impairment is involved in the pathological process of chronic obstructive pulmonary disease (COPD), and relates to inflammation and emphysema in lung injury. This study aimed to elucidate the protective effect of S -Allylmercapto- N -acetylcysteine (ASSNAC) against COPD via regulating the autophagy. Firstly, porcine pancreatic elastase (PPE)-induced COPD model in A549 cells was established, and ASSNAC was verified to alleviate the autophagy-impairment from the results of western blotting analysis of LC3BⅡ/Ⅰ and monodansylcadaverine (MDC) staining of autophagosome . Secondly, Balb/c mice were stimulated by PPE to induce the COPD model in vivo . The histological analysis of lung tissues presented that ASSNAC could alleviate the lung injury induced by PPE. Thirdly, the secretions of NO , TNF- α and IL-1 β in serum and BALF were reduced by ASSNAC compared with the PPE group. Finally, the mechanism of therapeutic effects of ASSNAC against COPD through regulating the autophagy-impairment was clarified. That is, ASSNAC inhibits the phosphorylation of PI3K/Akt/mTOR signaling pathways. In a word, this research provides a reference for ASSNAC to be an effective drug for pulmonary diseases.
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PubMed
高影响因子
FUEL
·
2021
·
IF 6.609
Zhanjun Cheng,Wenhao Yin,Jing Tian,Wei He,Jinglan Wang,Jiuzhong Yang,Lili Xing,Beibei Yan,Guanyi Chen
The pyrolysis of di- n -propyl ether (DPE), a potential biofuel candidate, was studied under a temperature range of 850–1350 K in a flow reactor at low and atmospheric pressures. Synchrotron vacuum ultraviolet photoionization mass spectrometry was used for isomeric identification and mole fraction measurements of the pyrolysis products, especially the free radicals. Specific products were observed and measured for the unimolecular decomposition reactions of DPE. A detailed kinetic model of DPE pyrolysis was developed based on the n -propanol combustion model. Modeling analyses including the rate of production (ROP) and sensitivity analyses were performed to reveal the consumption pathways of DPE, as well as the formation and consumption pathways of intermediates and products. ROP and sensitivity analyses indicated that the consumption reaction of DPE was mainly controlled by the unimolecular decomposition reactions and H-abstractions at both low and atmospheric pressures. The pericyclic reaction, leading to n -propanol + propylene, was the most important unimolecular decomposition reactions, especially at low pressure. The H-abstraction reactions of DPE played crucial roles in its consumption. Further β -C–C and β -C–O scission reactions of the three primary radicals can produce some oxygenated and hydrocarbon products. Relatively high mole fractions of C1–C3 aldehydes and C1–C3 alkane, alkene, and alkyl radicals were observed, which demonstrated the structural feature of DPE. Comparison of the product distribution between DPE and n -propanol were also analyzed.
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
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2021
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IF 5.455
Junfeng Miao,Xiaoxi Dong,Shasha Wang,Yuelong Xu,Zuozhao Zhai,Lihui Zhang,Bin Ren,Zhenfa Liu
The preparation method of porous carbon traditionally involves many steps and requires inert atmosphere resulting in time-consuming and high-cost. We reported a simple and easy method of N-doped micro/meso porous carbon (NPC) via a one-step carbonization of polyvinylpyrrolidone, melamine and ammonium chloride in air. The influences of PVP mass and carbonization temperature on surface group function, the morphology, microstructure and pore distribution of NPC samples were studied by Fourier transform infrared spectroscopy , X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy , X-ray diffraction, Raman spectroscopy and surface area analysis. The thermal behavior of NPC was analyzed by thermogravimetric analysis coupled to Fourier transform infrared spectroscopy. Moreover, the electrochemical performances of the as-prepared NPC samples were measured by cyclic voltammetry , galvanostatic charge-discharge and electrochemical impedance spectroscopy . The micro/meso pores and high content of pyridine-N and quaternary-N endowed NPC samples with high capacitive performance and long cyclic life. The specific capacitance of the prepared NPC sample could reach as high as 215.9 F g −1 at 1 A g −1 and 89.5 F g −1 even at 10 A g −1 . Especially, the symmetric supercapacitor assembled by NPC-3-900 achieved 13.2 W h kg −1 at 350 W kg −1 and excellent cyclic performance (91.4% after 10,000 GCD circles).
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高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2021
·Vol. 32
·期 11
·4450-4463
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IF 3.665
Kexin Chen,Dong Yang,Yongqian Shi,Yuezhan Feng,Libi Fu,Chuan Liu,Ming Chen,Fuqiang Yang
The design of high-performance compounded flame retardants based on multielement can be of great significance for reducing the flammability of polymer materials. In this article, a new type of N-P-Cu containing supermolecular assembly network (MPCSN) flame retardant was prepared and subsequently added into thermoplastic polyurethane elastomer (TPU)/silicon microencapsulated ammonium polyphosphate (SiAPP) composites. The obtained results indicated that a series of TPU/SiAPP/MPCSN composites exhibited strong adhesions with the TPU matrix. Additionally, the thermal and flame retardant performances of TPU composites were markedly improved after the introduction of different proportions of SiAPP to MPCSN. For example, the peak of heat release rate, the total heat release, the peak of smoke production rate, the total smoke release of the TPU composite containing 7.5 wt% SiAPP and 2.5 wt% MPCSN (TPU/SiAPP3/MPCSN1) remarkably decreased by 68.7%, 52.9%, 52.4%, and 49.4%, respectively, besides the highest LOI value (27.5 vol%) and UL-94 V-0 rating, compared with those of pure TPU. The improved flame retardance of the TPU/SiAPP3/MPCSN1 composite was due to the explanations: On one hand, a compact intumescent char effectively protected the TPU matrix from heat and oxygen and retarded the gaseous products permeation into the combustion zone; on the other hand, evolved phosphorus-containing free radicals captured the H• and HO• generated from the TPU material. The synergistic effect of SiAPP and MPCSN resulted in strong flame suppression, accompanied by 10.8% and 37.8% reductions in FIGRA and Av-EHC, respectively. This article offers a facile approach to fabricate highly effective flame-retardant TPU composites.
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高影响因子
Catalysis Science & Technology
·
2021
·Vol. 11
·期 6
·2327-2339
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IF 6.119
Xianliang Qiao,Xinyu Liu,Zhiqiang Zhou,Qingxin Guan,Wei Li
Mercury chloride is a key catalyst for acetylene hydrochlorination to produce vinyl chloride, which is the main raw material for the manufacture of PVC. However, the extensive use of mercury has caused serious environmental problems. Herein, a green poly(o-phenylenediamine) framework was synthesized for acetylene hydrochlorination. The polymer is composed of a phenazine backbone with defined pyridinic N species, which is an ideal model system for the study of the catalytic role of pyridinic N in the reaction. The polymer has bifunctional properties. When acting as a polymer catalyst, it achieved ≈95% conversion of acetylene at 280 °C and exhibited a satisfying stability during a 100 h continuous test. Active sites and reaction paths on the pyridinic N structure were well explored through catalytic experiments, spectroscopic characterizations, and density functional theory calculations. As an important extension of its application, the polymer was then used as a suitable precursor to prepare an N-doped carbon catalyst. The polymer-derived carbon catalyst exhibited surprising acetylene hydrochlorination activity, which was comparable to that of a 6 wt% Hg/C catalyst. This work proposes a new strategy for constructing highly efficient mercury-free catalysts with target active species and will contribute to the sustainable development of the PVC industry.
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高影响因子
JOURNAL OF FOOD SCIENCE
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2021
·Vol. 86
·期 2
·546-562
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IF 3.167
Yadi Liu,Guoxiao Lai,Yinrui Guo,Xiaocui Tang,Ou Shuai,Yizhen Xie,Qingping Wu,Diling Chen,Xujiang Yuan
Previous research has shown that the extracts from the Ganoderma lucidum spore (GS) have potentially cardioprotective effects, but there is still abundant room for development in determining its mechanism. In this study, the rat model of cardiac dysfunction was established by intraperitoneal injection of trimethylamine- N -oxide (TMAO), and the extracts of GS (oil, lipophilic components, and polysaccharides) were given intragastrically at a dose of 50 mg/kg/day to screen the pharmacological active components of GS. After 50 days of treatments, we found that the extraction from GS reduced the levels of total cholesterol, triglyceride, and low-density lipoprotein; increased the levels of high-density lipoprotein; and reduced the levels of serum TMAO when compared to the model group ( P < 0.05); especially the GS polysaccharides (DT) and GS lipophilic components (XF) exhibited decreases in serum TMAO compared to TMAO-induced control. The results of 16S rRNA sequencing showed that GS could change the gut microbiota, increasing the abundance of Firmicutes and Proteobacteria in the DT-treated group and XF-treated group, while reducing the abundance of Actinobacteria and Tenericutes . Quantitative proteomics analysis showed that GS extracts (DT and XF) could regulate the expression of some related proteins, such as Ucp1 (XF-TMAO/M-TMAO ratio is 2.76), Mpz (8.52), Fasn (2.39), Nefl (1.85), Mtnd5 (0.83), Mtnd2 (0.36), S100a8 (0.69), S100a9 (0.70), and Bdh1 (0.72). The results showed that XF can maintain the metabolic balance and function of the heart by regulating the expression of some proteins related to cardiovascular disease, and DT can reduce the risk of cardiovascular diseases by targeting gut microbiota.
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高影响因子
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
·
2020
·Vol. 45
·期 5
·7120-7128
·
IF 3.741
Menglu He,Jia Jia,Qing Sun,Weixin Zhang
SUMMARY Li-O 2 battery has attracted much attention due to its ultra-high theoretical energy density in the field of electrochemical energy storage. The introduction of efficient electrocatalyst can effectively accelerate the reaction rate of ORR and OER, so as to improve the coulomb efficiency and poor cycle stability of Li-O 2 battery. In this work, a novel hollow N-doped carbon sphere is prepared by using MOF and polystyrene as template, and act as highly efficient oxygen electrocatalyst for rechargeable Li-O 2 batteries. The hollow structure can provide enough oxygen diffusion channel, deposition and decomposition space for reduction products. N doping into the hollow carbon structure can increase the charge density of adjacent carbon atoms and enhance its catalytic activity of ORR/OER. As a result, the Li-O 2 battery using the hollow N-doped carbon sphere as air cathode exhibited an high specific capacity of 18 762 mAh/g (at a current density of 500 mA/g) and remarkable cycling stability of 212 cycles (at a current density of 500 mA/g and limited capacity of 1000 mAh/g), outperforming the carbon material with common structure. This work highlights the importance of air cathode structure and efficient catalyst, provides a new idea for the design of air cathode of Li-O 2 battery, and expands the scope of future research.
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高影响因子
JOURNAL OF SOLUTION CHEMISTRY
·
2020
·Vol. 49
·期 9
·1237-1249
·
IF 1.273
Li Dan,Guo Meng,Wu Qian,Li Menglei,Ruan Nannan,Gao Lijun
The density, viscosity and excess properties of biodiesel–alcohol fuel blends are investigated for research into the blending of fuels. Four n -alkanols (1-propanol, 1-butanol, 1-pentanol and 1-hexanol) as additives were mixed with ethyl laurate to form binary systems for density and viscosity measurement. Excess molar volumes and viscosity deviations of the four binary systems (1-propanol + ethyl laurate), (1-butanol + ethyl laurate), (1-pentanol + ethyl laurate), and (1-hexanol + ethyl laurate) were calculated from the experimental density and viscosity data and fitted with the Redlich–Kister equation. Grunberg–Nissan and McAllister equations were used to correlate viscosities and the correlated values from McAllister equation are in good agreement with the experimental data. The results may be useful for the research and development of biodiesel–alcohol fuel blends.
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高影响因子
Catalysts
·
2020
·Vol. 10
·期 10
·1126
·
IF 3.52
Jun Liu,Xuli Li,Haobo Hou,Min Zhou
To further boost the charge separation and photocatalytic activity of TiO2under visible light, the anatase–rutile mixed-phase nitrogen-doped (N-doped) TiO2nanoparticles were successfully synthesized through a facile one-step calcining procedure using TiN as raw materials. The crystal phases, morphologies, chemical compositions, textural structures, and optical properties of as-obtained N-doped TiO2were characterized by the corresponding analytical techniques. The photocatalytic activities of as-fabricated samples were evaluated by degrading 4-chlorophenol (4-CP) and methylene blue (MB) aqueous solution under visible light irradiation. The results revealed that the ratio of rutile to anatase increased with the improvement of sintering temperature, and the sample prepared at 500 °C had the best photocatalytic activity. This might be because it possessed the most appropriate rutile/anatase proportion as well as the nitrogen doping. The transient photocurrent responses, photoluminescence spectra (PL) measurements, and active species trapping experiments were implemented to disclose the photocatalytic mechanism. This work will provide a further insight into the synthesis of highly efficient N-doped TiO2photocatalysts for organic contaminant removal.Keywords:N-doped TiO2;charge separation;photocatalytic activity
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Wei Peng,Xiaoxiao Yang,Linchang Mao,Junhong Jin,Shenglin Yang,Jingjing Zhang,Guang Li
Developing highly active and robust bifunctional non-precious oxygen electrocatalysts for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) is of paramount importance for enhancing the efficiency of zinc-air battery. Herein, Co nanoparticles anchored in N doped hollow and porous carbon nanofibers (CoN-HPCNF) are obtained via an in-situ growth-pyrolysis approach with the hybrid of ZIF-67 and carbon nanofibers as the precursor. Originating from its high surface area, firm and hierarchical porous structure, effective doping of N as well as synergistic effect from Co nanoparticles and HPCNF, the optimized CoN-HPCNF shows prominent bifunctional catalytic activity and long-term stability toward OER and ORR. Importantly, the assembled aqueous zinc-air battery with the prepared catalyst as the air cathode delivers a peak power density of 126.6 mW cm −2 and narrow charge-discharge voltage gap together with excellent operation durability (more than 280 h at the current density of 5 mA cm −2 ), outdoing the commercial precious metal catalysts (Pt/C + IrO 2 ).
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高影响因子
危险品化学品经营许可证（带存储）