FOOD AND CHEMICAL TOXICOLOGY
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2020
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IF 4.679
Fei Zhou,Weisu Huang,Tao Xu,Lipeng Wu,Qi Chen,Jiyu Peng,Xin Liu,Baiyi Lu
Acteoside is one of the most widespread phenylethanoid glycosides with pharmacological activities , including antioxidant, neuroprotective property, etc. However, its bioavailability is poor due to the low absorption and P-gp efflux. This study aimed to select food derived P-gp inhibitors for promoting the acteoside absorption and investigate whether the inhibitors could increase the bioavailability and stability of acteoside. Results showed that EGCG and quercetin significantly decreased the BL-to-AP efflux and promoted the AP-to-BL influx of acteoside across Caco-2 monolayers with optimum concentrations of 320 μM EGCG or 240 μM quercetin adding to 320 μM acteoside. EGCG increased the bioavailability of acteoside to 1.43-fold, but quercetin had no such effect. Further study showed that EGCG and quercetin had no effects on the storage and digestion stability of acteoside. This work revealed that EGCG could improve the acteoside absorption across the Caco-2 monolayers and enhance the bioavailability of acteoside in rats.
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高影响因子
ACTA PHARMACOLOGICA SINICA
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2020
·Vol. 42
·期 3
·470-481
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IF 5.064
Xie Qiu-shi,Zhang Jia-xin,Liu Ming,Liu Pei-hua,Wang Zhong-jian,Zhu Liang,Jiang Ling,Jin Meng-meng,Liu Xiao-nan,Liu Li,Liu Xiao-dong
P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are involved in intestinal barrier. Short-chain fatty acids (SCFAs) play important roles in maintaining intestinal barrier. In this study we explored how SCFAs affected the expression and function of intestinal P-gp and BCRP in rats. Rats received 150 mM acetate, propionate or butyrate in drinking water for 4 weeks. In SCFA-treated rats, the expression and function of intestinal P-gp were decreased, but those of intestinal BCRP were increased; intestinal p-p65 was also decreased, which was positively related to P-gp protein expression. Among the three SCFAs tested, butyrate exhibited the strongest induction or inhibitory effect, followed by propionate and acetate. Similar results were observed in mouse primary enterocytes and Caco-2 cells treated with acetate (5 mM), propionate (2 mM), or butyrate (1 mM). In Caco-2 cells, addition of butyrate, vorinostat, and valproate (two classic HDAC inhibitors), Bay117082 (selective inhibitor of NF-κB activation) or NF-κB p65 silencing significantly decreased the expression of P-gp and the level of phosphorylated p65 (p-p65). Furthermore, butyrate attenuated the expression of P-gp and p-p65 induced by TNF-α (NF-κB activator) and theophylline (HDAC activator). However, vorinostat, valproate, Bay117082, TNF-α or p65 silencing hardly affected BCRP protein expression. But GW9662 (selective PPARγ antagonist) or PPARγ silencing abolished BCRP induction by butyrate and troglitazone (PPARγ agonist). SCFAs-treated rats showed higher intestinal protein expression of PPARγ, which was positively related to BCRP protein expression. Butyrate increased plasma exposure of fexofenadine but decreased that of rosuvastatin following oral dose to rats. In conclusion, SCFAs exert opposite effects on the expression and function of intestinal P-gp and BCRP; butyrate downregulated P-gp expression and function possibly via inhibiting HDAC/NF-κB pathways; butyrate induced BCRP expression and function partly via PPARγ activation.
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INDUSTRIAL CROPS AND PRODUCTS
·
2020
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IF 4.244
Chen Shen,Xiqing Wang,Yawei Zhu,Jiao Jiao,Sansan Bao,Ping Kou,Hongyi Pan,Yanyan Li,Yujie Fu
In this study, a novel p -toluenesulfonic acid (PTSA) based deep eutectic solvent (DES) was prepared successfully for biodiesel production by one-pot method. The DES consisting of PTSA and tetrabutylammonium bromide (TBAB) exhibited the best catalytic activity among the five prepared DESs. Central composite design (CCD) and response surface methodology were conducted to investigate reaction factors. The maximum oil extraction yield 90.33 % and fatty acid methyl esters (FAMEs) conversion yield 96.53 % were obtained under the optimal condition: microwave temperature 72 °C, microwave power 500 W, time 40 min, the ratio of liquid to seed weight 27:1 and DES amount 11 wt%. The chemical composition of FAMEs and main physical-chemical properties were investigated and the results demonstrated that the prepared biodiesel product possessed high quality. The study showed the prepared DES was a green and efficient catalyst for rapid and simultaneous extraction and transesterification seed oil for biodiesel production by one-pot method.
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NEW JOURNAL OF CHEMISTRY
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2020
·Vol. 44
·期 8
·3194-3205
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IF 3.288
Jiabin Liu,Bowen Yang,Minghuan Gao,Lisha You,Yuansen Zhang,Zhiying Li,Linna Guo,Tiesheng Li,Penglei Chen,Minghua Liu
A series of novel efficient polyhedron-like WO3/butterfly-like Ag2MoO4 p–n junction photocatalysts (denoted as AMW-x) were designed and synthesized. The exact phase structure, microscopic morphology, electrochemical properties, physical properties and optical properties of the prepared samples were characterized by XRD, SEM, EDS, TEM, HRTEM, UV-DRS, PL, FL, XPS, UPS, BET, MS (Mott–Schottky test), EIS and photocurrent measurements. The photocatalyst could effectively degrade rhodamine B (RhB) under UV/Solar region light illumination. In this system, a p–n junction structure formed by the two different materials effectively enhanced the generation rate of photo-induced electrons and reduced the transfer resistance. These results exhibited that enhanced photocatalytic performance of materials were prepared. The activity of AMW-20 was 548.2/496.8, 57.9/146.1, and 3.7/17 times higher than polyhedron-like WO3, butterfly-like Ag2MoO4, and commercial powder (P25) under UV/Solar region light illumination. The photocatalytic mechanism mode for the improved photocatalytic performance was also proposed.
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Polymers
·
2019
·Vol. 11
·期 2
·374
·
IF 3.164
Xuan Yang,Qunzhang Tu,Xinmin Shen,Pengxiao Zhu,Yi Li,Shuai Zhang
In order to enhance the interfacial adhesion of poly(p-phenylene terephthalamide) (PPTA) fibers to the rubber composites, a novel method to deposit multi-walled carbon nanotubes (MWCNTs) onto the surface of PPTA fibers has been proposed in this study. This chemical modification was performed through the introduction of epoxy groups by Friedel–Crafts alkylation on the PPTA fibers, the carboxylation of MWCNTs, and the ring-opening reaction between the epoxy groups and the carboxyl groups. The morphologies, chemical structures, and compositions of the surface of PPTA fibers were characterized by scanning electron microscope, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy. The results showed that MWCNTs were uniformly deposited onto the surface of PPTA fibers with the covalent bonds. The measurement of contact angles of the fibers with polar solvent and non-polar solvent indicated that the surface energy of deposited fibers significantly increased by 41.9% compared with the untreated fibers. An electronic tensile tester of single-filament and a universal testing machine were utilized to measure the strength change of the fibers after modification and the interfacial adhesion between the fibers and the rubber matrix, respectively. The results showed that the tensile strength had not been obviously reduced, and the pull-out force and peeling strength of the fibers to the rubber increased by 46.3% and 56.5%, respectively.Keywords:poly(p-phenylene terephthalamide) fibers;multi-walled carbon nanotubes;surface properties;adhesive properties
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Aging-US
·
2019
·
IF 5.515
Chao Guo,Junrong Zhu,Jingwen Wang,Jialin Duan,Shanbo Ma,Ying Yin,Wei Quan,Wei Zhang,Yue Guan,Yi Ding,Aidong Wen,Yingdong Zhang
Mitochondrial dysfunction and oxidative damage are closely related to the pathogenesis of Parkinson's disease (PD). The pharmacological mechanism of protocatechuic aldehyde (PCA) for PD treatment have retained unclear. The purposes of the present study were to clarify the neuroprotective effects of post-treatment of PCA for PD treatment by mitigating mitochondrial dysfunction and oxidative damage, and to further determine whether its effects were mediated by the polo-like kinase 2/phosphorylated glycogen synthase kinase 3 β/nuclear factor erythroid-2-related factor 2 (PLK2/p-GSK3β/Nrf2) pathways. We found that PCA improved 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced behavioral deficits and dopaminergic cell loss. Moreover, PCA increased the expressions of PLK2, p-GSK3β and Nrf2, following the decrease of α-synuclein (α-Syn) in MPTP-intoxicated mice. Cell viability was increased and the apoptosis rate was reduced by PCA in 1-methyl-4-phenylpyridinium iodide (MPP + )-incubated cells. Mitochondrial membrane potential (MMP), mitochondrial complex I activity and reactive oxygen species (ROS) levels in MPP + -incubated cells were also ameliorated by treatment with PCA. The neuroprotective effects of PCA were abolished by inhibition or knockdown of PLK2, whereas overexpression of PLK2 strengthened the protection of PCA. Furthermore, GSK3β and Nrf2 were involved in PCA-induced protection. These results indicated that PCA has therapeutic effects on PD by the PLK2/p-GSK3β/Nrf2 pathway.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2019
·
IF 14.229
Wei Li,Xiao Wang,Min Li,Shu-ao He,Qiong Ma,Xuechuan Wang
Hydrogen is known as an alternative new energy for its advantages of non-pollution and high calorific value, and photocatalysis technology is regarded as one of the most effective means to produce hydrogen in recent years. In this topic, aiming at the poor photoresponse, fast combination of photo-induced carriers and unstable structure of traditional photocatalysts, the three-dimensional porous g-C 3 N 4 /graphene oxide framework was constructed by compounding two-dimensional graphene oxide and two-dimensional g-C 3 N 4 via hard template (SiO 2 nanoparticles) method and selective chemical etching. Then, silver bromide nanoparticles , a superior photosensitizer, were immobilized on the three-dimensional porous framework to construct the three-dimensional porous g-C 3 N 4 /graphene oxide-AgBr photocatalyst with Ag plasmas by solvothermal method. Research showed that this novel photocatalyst based on Z-scheme heterostructure (GO-AgBr), p-n heterostructure (g-C 3 N 4 -AgBr) and Ag plasmas presented high-efficient visible-light driven hydrogen evolution (3.69 mmol/g/h) at the absence of Pt co-catalyst, which is higher than the majority of existing catalysts, and it also possessed strong stability on its activity and structure. Accordingly, the enhanced hydrogen evolution and photostability were attributed to the highly ordered structure and fast interfacial electron conduction of three-dimensional porous framework, superior photosensitivity of AgBr and synergistic effect of Ag plasmas. Therefore, this study provided a potential method for exploitation of hydrogen energy.
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ACS Applied Energy Materials
·
2018
·
IF 0
Tingting Liu,Bomin Feng,Xiuju Wu,Yanli Niu,Weihua Hu,Chang Ming Li
It is desirable yet challenging to develop highly active and durable hydrogen evolution reaction (HER) electrocatalysts with Pt-comparable activity for future energy devices. In this work, we report Ru2P nanoparticle decorated P/N dual-doped carbon nanofibers on carbon cloth (Ru2P@PNC/CC-900) as a highly efficient and durable hierarchical HER electrocatalyst in both acidic and alkaline media. Electrochemical tests show that this Ru2P@PNC/CC-900 possesses Pt-comparable HER activity to support 10 mA cm–2 HER current density at low overpotential of 15 and 50 mV in acidic and alkaline condition, respectively. Density functional theory calculations reveal that coupling Ru2P nanoparticles with heteroatom-doped carbon fibers leads to enhanced intrinsic HER activity. The integrative hierarchical architecture further endows high surface areas with good mechanical robustness to support abundant catalytically active sites and possesses excellent electrical conductivity and efficient access for mass transportation to facilitate the HER process.
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JOURNAL OF CATALYSIS
·
2018
·
IF 6.759
Qifan Wu,Bin Zhang,Chao Zhang,Xiangchun Meng,Xinluona Su,Shan Jiang,Ruhui Shi,Yan Li,Weiwei Lin,Masahiko Arai,Haiyang Cheng,Fengyu Zhao
The selectivity of 3-nitrostyrene (NS) hydrogenation over 0.5 wt-% Pt catalysts supported on carbon materials can be switched simply by changing reduction temperature. When the reduction temperature was 150 °C, 1-ethyl-3-nitrobenzene (ENB) was mainly produced in a selectivity of 93% at a conversion of 95% (at 100 °C). When the reduction was conducted at a higher temperature of 450 °C, in contrast, the main product was switched to 3-aminostyrene (AS) in a selectivity of 96% at a conversion of 91%. That is, the Pt/C catalysts reduced at low and high temperatures could preferentially catalyze the hydrogenation of vinyl and nitro groups of NS, respectively. This switching of the product selectivity may be ascribed to actions of surface oxygen-containing functional groups and surface hetero P species. The quantity and nature of these surface species were examined in detail by a few different methods. For the low-temperature reduced catalyst, surface acidic groups present close to Pt nanoparticles (∼2 nm) would interact with the nitro group of a NS molecule and make its vinyl group more likely to interact with the surface active metal species of Pt nanoparticles; this facilitates the hydrogenation of the latter and produces ENB selectively. For the high-temperature reduced catalyst, however, P species would interact with Pt and form Pt-PO x complex, on which a NS molecule is likely to be adsorbed with its nitro group, facilitating the selective production of AS via its hydrogenation. It is demonstrated that surface functional groups and surface hetero atoms (like P), in addition to main active metal species (like Pt), should have direct actions in the catalysis for such a catalyst that exposes a larger quantity of surface functional groups and/or hetero atoms compared to the number of supported metal nanoparticles .
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高影响因子
ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
Tingting Liu,Heng Liu,Xiuju Wu,Yanli Niu,Bomin Feng,Wei Li,Weihua Hu,Chang Ming Li
Molybdenum (Mo) based materials including its phosphides, carbides, nitrides , oxides, dichalcogenides and metallic alloys have received particular interest in recent years for sustainable hydrogen evolution reaction (HER) electrocatalysis . In this study, a novel Mo 2 C/MoP hybrid nanoparticle embedded N, P co-doped carbon nanofibers on carbon fiber paper (Mo 2 C-MoP NPC/CFP-800) is successfully prepared as a highly efficient hierarchical HER electrocatalyst . Benefitting from its structural advantages and compositional merits, this Mo 2 C-MoP NPC/CFP-800 electrocatalyst displays remarkable catalytic activity as well as excellent durability for HER. Only 85 and 146 mV overpotential is required to drive a HER current density of 10 mA cm −2 in acidic and alkaline solution, respectively. Remarkably, this electrocatalyst is also able to fulfill efficient HER even in seawater . Further, this work reveals that the Mo 2 C/MoP hybrid nanoparticle is superior to MoP nanoparticle under present system in HER electrocatalysis, which may offer valuable clues on further design and synthesis of HER electrocatalysts.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2019
·
IF 5.107
Yuanming Tan,Zhongqiao Sun,Hao Meng,Yide Han,Junbiao Wu,Junli Xu,Yan Xu,Xia Zhang
MOFs/polymer hybrid membranes combine the special surface activity of MOFs and the excellent carries nature of porous polymer and thus exhibit unexpected adsorption/separation performances in the solid-phase extraction. In this paper, a new kind of MOFs/polymer composite membrane , MIL-68(Al)/PVDF have been fabricated for the first time through blending the MIL-68(Al) nanoparticles and polyvinylidene fluoride (PVDF) casting solution and following the lyotropic phase transition. Some means such as SEM, XRD and FT-IR are used to character the structure of these hybrid membranes. The membrane performances including the hydrophilic/hydrophobic properties, membrane porosity and membrane water flux are also measured. The effects of doping amount of MIL-68(Al) on the structure and performances of MIL-68(Al)/PVDF hybrid membranes are discussed. Two persistent organic pollutants : p -nitrophenol (PNP) and methylene blue (MB) are chosen as main adsorption objects to evaluate the adsorption activity of MIL-68(Al)/PVDF hybrid membranes. The influences of various conditions on the adsorption activities are investigated in detail and the optimum adsorption conditions are determined. All the MIL-68(Al)/PVDF hybrid membranes exhibit enhanced adsorption capacity compared to pristine PVDF, and the adsorption activities of hybrid membranes are promoted continually with the increasing doping contents of MIL-68(Al). The adsorption thermodynamics analysis indicates that the adsorption process is mainly characterized by Langmuir monolayer adsorption and chemical adsorption . The coordination bonding formed between NO 2 of PNP and Al(III) of MIL-68(Al), and the acid-base interaction between the sulfur of MB and Al(III) of MIL-68(Al) may be responsible to the highest removal efficiency of PNP and MB. The good dynamics adsorption and regeneration performances indicate the prospect applications of these MOFs/PVDF hybrid membranes in the separation of organic contaminants from industrial waste water.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2018
·
IF 4.841
Bing-huang Wang,Qian Zhang,Jun-ming Hong
In this study, the ion-gelation method was applied to fabricate novel Fe–carbon–bentonite–alginate beads (Fe 0 /C-BABs). Fe 0 /C-BABs could effectively control Fe release during persulfate (PS) activation in N -acetyl- p -aminophenol (APAP) oxidation. A novel two-stage approach that combined Fe 0 /C-BABs and an oyster-shell-filled bed (OSFB) column was developed to address the low pH and high Fe concentration of the effluent of the traditional PS process. The application of the Fe 0 /C-BABs and OSFB column regulated pH levels and Fe release during the advanced oxidation of APAP. The characteristics of Fe 0 /C-BABs were also investigated through scanning electron microscopy, energy dispersive spectrometry, and Fourier transform infrared spectroscopy. The long-term operation performance of Fe 0 /C-BABs in a continuous fixed-bed reactor under simultaneous PS and APAP feeding was also evaluated. The effects of initial PS concentration, pH, fixed-bed weight, in-flow rate, and dissolved oxygen (DO) were investigated. Under selected conditions, 86.3% efficiency was achieved during the first stage of APAP degradation (effluent pH of 3.05, Fe contents: 106.25 mg L −1 ). Water quality improved after the effluent was passed through the OSFB column (effluent pH of 6.32, Fe contents: 21.43 mg L −1 ). Moreover, this study analyzed the free radicals and intermediates produced during APAP degradation to identify the possible routes of APAP degradation.
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危险品化学品经营许可证（带存储）