Nature Communications
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2025
·Vol. 16
·期 1
·1-20
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IF 15.7
Phillips Aaron F.,Zhang Rumin,Jaffe Mia,Schulz Ryan,Carty Marysol Chu,Verma Akanksha,Feinberg Tamar Y.,Arensman Michael D.,Chiu Alan,Letso Reka,Bosco Nazario,Queen Katelyn A.,Racela Allison R.,Stumpff Jason,Andreu-Agullo Celia,Bettigole Sarah E.,Depetris Rafael S.,Drutman Scott,Su Shinsan M.,Cogan Derek A.,Eng Christina H.
Chromosome instability is a prevalent vulnerability of cancer cells that has yet to be fully exploited therapeutically. To identify genes uniquely essential to chromosomally unstable cells, we mined the Cancer Dependency Map for genes essential in tumor cells with high levels of copy number aberrations. We identify and validate KIF18A, a mitotic kinesin, as a vulnerability of chromosomally unstable cancer cells. Knockdown of KIF18A leads to mitotic defects and reduction of tumor growth. Screening of a chemical library for inhibitors of KIF18A enzymatic activity identified a hit that was optimized to yield VLS-1272, which is orally bioavailable, potent, ATP non-competitive, microtubule-dependent, and highly selective for KIF18A versus other kinesins. Inhibition of KIF18A’s ATPase activity prevents KIF18A translocation across the mitotic spindle, resulting in chromosome congression defects, mitotic cell accumulation, and cell death. Profiling VLS-1272 across >100 cancer cell lines demonstrates that the specificity towards cancer cells with chromosome instability differentiates KIF18A inhibition from other clinically tested anti-mitotic drugs. Treatment of tumor xenografts with VLS-1272 results in mitotic defects leading to substantial, dose-dependent inhibition of tumor growth. The strong biological rationale, robust preclinical data, and optimized compound properties enable the clinical development of a KIF18A inhibitor in cancers with high chromosomal instability.
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CANCER IMMUNOLOGY IMMUNOTHERAPY
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2025
·Vol. 74
·期 3
·1-17
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IF 5.1
Han Tianci,Guo Xiaoqi,Xie Junwei,Tong Wei,Zhang Liang
Objective Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with a high metastasis rate and a poor prognosis. ETS variant transcription factor 1 (ETV1) plays an important role in multiple malignancies. However, its function in ESCC progression and tumor microenvironment (TME) remains to be explored. In this study, we characterized the role of ETV1 in ESCC process and TME. Methods Gene expression and immune infiltration in ESCC samples from the Cancer Genome Atlas (TCGA) were analyzed. The expression of ETV1 in clinical samples was detected by real-time PCR, western blot and immunohistochemistry staining. Cell growth was detected by CCK-8 and colony formation assays. Macrophage phenotypes were determined using flow cytometry. Immunofluorescence double staining was used to detect the tumor-associated macrophage (TAM) infiltration. The tumor volume was recorded and weighed. Transcriptional activity was measured using dual-luciferase assay, chromatin immunoprecipitation (ChIP) assay and DNA pull-down assay. Results In this study, through analysis of ESCC samples from TCGA database and the clinic, we noticed that ETV1 was highly expressed in ESCC tumor tissues and was associated with TAM infiltration. Overexpression of ETV1 promoted ESCC cell proliferation in vitro and xenograft tumor growth in nude mice, while ETV1 knockdown elicited the opposite effects. Furthermore, ETV1 upregulation in tumor tissues was found to drive M2 macrophage infiltration both in vitro (transwell assays) and in vivo (xenograft tumor models). C–C motif chemokine ligand 2 (CCL2), a key factor inducing M2 macrophage polarization, was also found to be elevated in ESCC tumor tissues. Mechanism study demonstrated that ETV1 facilitated M2 macrophage infiltration via the transcriptional modulation of CCL2. In addition, the cause of the changes in ETV1 activity and expression was investigated. The E2 small ubiquitin-like modifier (SUMO) binding enzyme UBC9 increased ETV1 activity and expression, indicating the presence of SUMO modification in ETV1. Conclusions Our data deciphered the mechanism of ETV1-mediated M2 macrophage infiltration in the TME of ESCC, which has important implications for the development of novel prognostic and therapeutic targets to optimize current therapies against ESCC.
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JOURNAL OF MATERIALS SCIENCE
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2024
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IF 3.5
Ma Shuwen,Zhu Binji,Gan Ruihui,Wang Yue,Zhou Bangguo,Shi Jingli,Song Yan,Shao Xiaodong,Ma Chang
The development of highly active non-precious metal bifunctional oxygen catalysts is of great significance in improving the efficiency of zinc-air batteries (ZABs). In this work, Co 3 O 4 is modified by a simple sulfur-doping strategy, which achieves a sulfur-doped Co 3 O 4 (S-Co 3 O 4 ) with significantly-enhanced oxygen catalytic activity. The doping of sulfur promotes the exposure of cobalt active sites and brings abundant oxygen vacancies, which provide additional active sites and enhance the conductivity of Co 3 O 4 . Consequently, S-Co 3 O 4 exhibits a low overpotential of 318 mV in the oxygen evolution reaction (OER) and an improved half-wave potential (0.788 V) for oxygen reduction reaction (ORR). In addition, the sulfur doping increases the ORR kinetic current density of pristine Co 3 O 4 by a factor of 49. The assembled ZABs based on S-Co 3 O 4 cathodes show a higher peak power density (98.90 mW cm −2 ) than the commercial Pt/C + RuO 2 -based ZABs. This work reveals that the intrinsic oxygen catalytic activity of Co 3 O 4 can be significantly strengthened by sulfur doping, which can modify its structural characteristics and introduce structural defects. Graphical abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-8
·
IF 15.7
Hong Cheng-Bin,Hua Wangde,Liu Lieke,Liu Haichao
α-Ketoglutaric acid (KGA) and methanetriacetic acid (MTA) are important multi-functional carboxylic acids with versatile applications. However, their synthetic processes are still not green and efficient. Herein, we report a novel one-pot approach for sustainable synthesis of KGA and MTA from biomass-derived pyruvic and glyoxylic acids under mild conditions. KGA is synthesized via cross-aldol condensation of pyruvic and glyoxylic acids to 2-hydroxy-4-oxopentanedioic acid, followed by its sequential dehydration and hydrogenation on Pd/TiO 2 , affording a high yield of 85.4% on a molar basis of glyoxylic acid at 110 °C and 1.0 MPa H 2 . The synthesis of MTA involves cross-aldol condensation of KGA and glyoxylic acid to 3-(carboxymethyl)-2-hydroxy-4-oxopentanedioic acid and its subsequent hydrodeoxygenation on Pd/TiO 2 and MoO x /TiO 2 in a high yield of 86.2% at 200 °C and 2.0 MPa H 2 . This novel approach provides a rationale for the sustainable production of various multi-functional carboxylic acids that are still not easily available.
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JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-17
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IF 10.6
Wang Hui,Tang Cui,Xiang Yuxia,Zou Chan,Hu Jianming,Yang Guoping,Zhou Wenhu
Thrombotic diseases impose a significant global health burden, and conventional drug-based thrombolytic therapies are encumbered by the risk of bleeding complications. In this study, we introduce a novel drug-free nanomedicine founded on tea polyphenols nanoparticles (TPNs), which exhibits multifaceted capabilities for localized photothermal thrombolysis. TPNs were synthesized through a one-pot process under mild conditions, deriving from the monomeric epigallocatechin-3-gallate (EGCG). Within this process, indocyanine green (ICG) was effectively encapsulated, exploiting multiple intermolecular interactions between EGCG and ICG. While both TPNs and ICG inherently possessed photothermal potential, their synergy significantly enhanced photothermal conversion and stability. Furthermore, the nanomedicine was functionalized with cRGD for targeted delivery to activated platelets within thrombus sites, eliciting robust thrombolysis upon laser irradiation across diverse thrombus types. Importantly, the nanomedicine’s potent free radical scavenging abilities concurrently mitigated vascular inflammation, thus diminishing the risk of disease recurrence. In summary, this highly biocompatible multifunctional nanomaterial holds promise as a comprehensive approach that combines thrombolysis with anti-inflammatory actions, offering precision in thrombosis treatment.
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International Journal of Environmental Science and Technology
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2025
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IF 3.4
Shen ZR.,Zeng ZH.,Yang Q.
Unaged microplastics, as well as residual monomers or additives from the processing stage would affect the plants, animals, and human body. Aged microplastics (MPs) containing degradation products are widespread pollutants. There is a gap in the effects of aged microplastics on human body. Through static digestion simulation experiments, this study investigates the interaction between aged polystyrene microplastics (PS MPs) with different molecular weights and simulated digestive fluids. The findings reveal that degradation products existing on the surface of PS MPs are released into the simulated digestive fluids, leading to a "dual reduction" in both the physical size and molecular weight of MPs. This result implies that the potential risk of cells ingesting MPs increases due to the ageing of plastics. Moreover, these degradation products impact the micro-environment of digestive enzymes, consequently leading to conformational changes in the macromolecules of these enzymes. The longer the ageing time, the greater degradation products are released and the more solute is adsorbed, which may pose even graver hazards to the bio-safety. This study contributes to assessing the effects and potential risks of aged PS MPs on human health. It emphasizes the importance of investigating the risk of aged MPs that could enter cells, inducing some hazardous effects after digestion.
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KOREAN JOURNAL OF CHEMICAL ENGINEERING
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2025
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IF 3.2
Liu Yang,Liang Kaili,Zhang Keqin,Du Bowen,Hu Lishuang,Yuan Zhilei,Zhang Jianren,Lu Yuewen,Yu Qi,Lv Zhixing
The output energy properties of the AP/Ti, Cl-20/Ti, HMX/Ti, and DAP-4/Ti mixtures were compared using an oxygen bomb calorimeter. The thermal decomposition processes of the above four kinds of mixed energetic materials were studied with a differential scanning calorimeter (DSC), and the apparent activation energies of the mixed materials were calculated using the Kissinger equation. The combustion flames of the four energetic materials were captured through high-speed photography, and the combustion properties of the mixed energetic materials with titanium powders were analyzed. The results indicate that the combustion heat value of DAP-4/Ti mixed energetic materials is up to 10,133 J·g −1 , significantly higher than the 8613 J·g −1 of the Cl-20/Ti mixture and the 9720 J·g −1 of the HMX/Ti mixture. The combustion process of the DAP-4/Ti mixture only takes 145 ms. The heat release, burning rate, and flame strength of the DAP-4/Ti mixture are better than those of other mixed energetic materials. The calculated apparent activation energy of DAP-4/Ti mixture is 150.4 kJ·mol −1 , which is 55 kJ·mol −1 lower than that of DAP-4. The apparent activation energies of Cl-20/Ti and HMX/Ti are 173.6 kJ·mol −1 and 317.2 kJ·mol −1 , respectively. These findings demonstrate that DAP-4/Ti mixed energetic materials exhibit good energy characteristics and combustion performance.
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Advanced Fiber Materials
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2025
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IF 21.3
Sun Tiantian,Liang Yifang,Ning Nanying,Wu Hanguang,Tian Ming
The development of the highly stretchable and strain-insensitive conductive fibers exhibiting extremely small resistance change under large deformation is crucial for the electronic signal stability in the smart wearable fields. In this paper, an all-polymeric conductive microfiber (PU@PVA-PEDOT:PSS SI-CF) with desirable performances has been developed by using microfluidic spinning technology (MST), during which process the instinct strain-insensitive conductive polymer hydrogel core with semi-interpenetrating network is constructed into the helical structure. The configuration and performances of the PU@PVA-PEDOT:PSS SI-CF have been optimized by regulating the processing parameters of MST, and the fabricated microfiber exhibits excellent stretchability (up to 500%), high conductivity (147 S cm −1 ), super conductance strain insensitivity (ultra-low resistance change of 5% at 100% strain), as well as excellent durability (2000 stretching-releasing cycles). The PU@PVA-PEDOT:PSS SI-CF shows great smart wearable application potential as the stretchable wire, the self-powered sensor, and the electro-thermal heater.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2025
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IF 5
He Kaijun,Zhou Guanpeng,Li Yanyan,Shen Jiajia
Polyamide 11 (PA11) is a novel type of 100% bio-based and renewable fiber which can not achieve good dyeing results for conventional water bath dyeing techniques due to its smooth surface and long carbon chain hydrophobic structure. Furthermore, conventional dyeing processes typically involve extensive use of water and chemical reagents, driving up production costs and exerting serious ecological damage. The development of a new dyeing method suitable for bio-based PA11 fibers is crucial for sustainable development in the textile industry. In this study, we present a novel method for achieving effective dyeing of bio-based PA11 fibers using only dyes, calcium chloride (CaCl 2 ), and recyclable ethanol (EtOH), eliminating the necessity for additional chemical reagents. The dyeing process operates at a reduced temperature (80 ℃) and bypasses the pre-treatment stage for PA11. Compared to the traditional aqueous dyeing, the novel method significantly enhances dye uptake (> 98%) and color depth (K/S value) of PA11, while maintaining comparable color fastness ( ≧ grades 3–4), and acceptable mechanical properties. In addition, the new dyeing method has minimal impacts on the structure and performance of bio-based PA11 fibers. This is of great significance for the development and application of bio-based PA11 in the field of chemical fibers. Graphical abstract
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CELLULOSE
·
2025
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IF 4.8
Song Jiangxiao,Yu Yihao,Zhang Yan,Wu Jiahui,Wang Wei,Qi Dongming
The lightweight and adjustable properties of electromagnetic interference (EMI) shielding textiles make them an ideal choice as a layer in firefighting suits designed for complex electromagnetic environments. Enhancing the flame retardant performance of EMI shielding textiles is essential to mitigate rapid combustion risks in extreme conditions, such as high temperatures or fires, thereby reducing fire spread and minimizing damage caused by fire escalation. This study demonstrates the rapid and efficient preparation of flame retardant EMI shielding textiles by employing a spray method to coat cotton fabrics with Poly (3,4-ethylenedioxythiophene)-poly (styrenesulfonate) (PEDOT:PSS) doped with ethylene glycol (EG) and phytic acid (PA). The resulting coating exhibited a shielding effectiveness test (SE T ) value of 46.61 dB, effectively blocking 99.99% of electromagnetic waves (EMWs). Even after undergoing 600 bending cycles, the SE T value could still maintain 42.34 dB. PA not only functions as a dopant to significantly enhance the electrical conductivity of PEDOT:PSS but also confers superior flame retardant properties. In comparison with untreated cotton fabric, the peak heat release rate (pHRR) was reduced from 140.77 to 10.73 kW/m 2 , representing an impressive reduction of 92.37%. The total heat release (THR) decreased from 3.97 to 2.04 MJ/m 2 , marking a substantial decrease of 48.61%. The coated fabric exhibited excellent flame retardant and EMI shielding performance. Furthermore, this innovative material is anticipated to find extensive applications in smart wearables and sensor technologies.
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Silicon
·
2024
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IF 2.8
Mo Zhangchao,Zhu Xiaoxiao,Jiang Xuesong,Ding Juxuan,Wang Ling,Ban Boyuan,Sun Jifei,Chen Jian
Improving the purity of glass fiber powder represents a crucial challenge that needs to be addressed in the development of the glass fiber industry. To investigate the flotation behavior of glass fiber powder and the adsorption mechanism of the collector on its surface, the effect of flotation time, collector type, and concentration in flotation experiments was studied. Zeta potential, Fourier transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS) were used for systematic analysis. The results show that flotation effectively removes the visible impurities mixed in the glass fiber powder. The collection capacity of poly (propylene glycol) bis (2-aminopropyl ether) (PEA) generally surpasses that of conventional monoamine collectors. With the novel collector PEA, especially at a concentration of 6 × 10 −5 mol/L of PEA-D2000, the flotation recovery rate of glass fiber powder can reach approximately 95%. Furthermore, a flotation mechanism for the glass fiber powder using amine-based collectors is proposed. It is adsorbed onto the surface of glass fiber powder through − NH 3 + /−NH 2 groups, primarily by hydrogen bonding, and supplemented by electrostatic adsorption.
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ARCHIVES OF MICROBIOLOGY
·
2024
·Vol. 206
·期 12
·1-13
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IF 2.3
Zhai Yafei,Wang Yuhao,Wang Bohua,Niu Liyuan,Xiang Qisen,Bai Yanhong
Dielectric barrier discharge (DBD) plasma can be used to control food spoilage and food pathogens. However, DBD plasma may induce sublethal injury in microorganisms, constituting a considerable risk to food safety. This research was designed to investigate the sublethal injury and recovery of Escherichia coli O157:H7 after DBD plasma treatment. The results indicated that the sublethal injury ratios of cells rose along with the augmentation of treatment time and input power of DBD plasma under mild treatment conditions, whereas injury accumulation ultimately culminated in cell death. The highest sublethal ratio of 99.3% was obtained after DBD plasma treatment at 18 W for 40 s. When solutions such as phosphate buffered saline (PBS), peptone water, glucose solution, and tryptic soy broth (TSB) were used for cell recovery, TSB was proven to be the most efficacious, facilitating the completion of recovery within 2 h. The repair ratio of injured cells increased as the recovery pH (3.0–7.0) and temperature (4–37 ºC) increased. Moreover, Mg 2+ and Zn 2+ were demonstrated to be necessary for the recovery process, while Ca 2+ presented a weak effect. Understanding the sublethal injury of bacteria resulting from DBD plasma treatment and their repair conditions can provide useful insight into avoiding the occurrence of sublethal injury as well as inhibiting the occurrence of recovery during food processing and storage.
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