CELLULOSE
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2025
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IF 4.8
Zhang Qi,Meng Huibiao,Shi Yonggen,Shao Linjun,Xing Guiying,Zhang Xianman
The efficient adsorption of precious palladium metal ions from industrial wastewater is crucial for both reducing environmental pollution and recycling valuable palladium resources. In this research, a combination of electrospinning and annealing treatment was employed to fabricate low-cost and stable silica gel incorporated chitosan composite nanofibers, which were served as an efficient adsorbent for adsorbing Pd 2+ ions from aqueous solution. The fiber morphology was analyzed by scanning electron microscopy (SEM). Brunauer–Emmett–Teller (BET) analysis and positron annihilation lifetime spectroscopy (PALS) were employed to analyze the microstructure. The surface area of composite nanofibers reaches the maximum of 81.46 m 2 /g with 23.1% loading of silica gel. These fiber adsorbents were used to adsorb the Pd 2+ ions in aqueous solution and the related factors of silica gel content, the annealing temperature and the adsorption parameters (e.g. adsorption time, solution pH, and initial Pd 2+ concentration) were investigated and optimized. The adsorption results demonstrate that the unique fibrous structure and the incorporation of silica gel significantly enhance the adsorption efficiency for Pd 2+ ions with a maximum adsorption capacity of ~ 113 mg/g. The adsorption mechanism analysis reveals the involvement of chelation and electrostatic interaction between the amino groups in chitosan and Pd 2+ ions. Thermodynamic analysis indicates that the adsorption process is endothermic and spontaneous with ΔH 0 and ΔS 0 values of − 26.59 kJ/mol and 96.02 J/mol K, respectively. Moreover, the fibrous adsorbent exhibits outstanding recyclability, retaining 85.2% of its initial adsorption capacity after five successive reuse cycles. In conclusion, this low-cost and high-performance fibrous adsorbent holds great potential for the efficient separation and recovery of precious Pd 2+ ions from industrial wastewater.
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高影响因子
CARBOHYDRATE POLYMERS
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2025
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IF 12.5
Fenglei Chen,Xiaoshuai Peng,Keng Chen,Jiapeng Song,Yue Fan,Peng Wang,Xingxing Shi,Zhaopeng Cai
Dural defects and subsequent cerebrospinal fluid (CSF) leakage are common complications in spinal and cranial surgeries. However, current clinical patches often fail to achieve long-term adhesion and effective sealing, as the presence of CSF can weaken interfacial bonding and ultimately result in adhesion failure. Herein, a new class of chitosan-based adhesive patch (PLLA/CP) is designed by constructing an adhesive hydrogel layer containing chitosan-dopamine (CS-DA) on the surface of fibrous poly(L-lactic acid) (PLLA) layer. Benefitting from electrostatic crosslinking within the hydrogel layer and the mechanical reinforcement of PLLA layer, our patch exhibits a low swelling ratio (3.8 %) without compromising wet adhesion (87.1 kPa). The interfacial mechanical interlocking between the adhesive hydrogel and fibrous dissipative layer contributes to its high burst pressure tolerance (327.7 mmHg). Moreover, the catechol groups in CS-DA endow PLLA/CP patch with the ability to scavenge intracellular reactive oxygen species and suppress inflammation. Furthermore, our PLLA/CP patch achieves long-term adhesion, prevents CSF leakage, and promotes defect repair through anti-inflammatory and immunomodulatory effects in a rabbit dural defect model, while also demonstrating effective hemostasis in a liver injury model. By integrating excellent anti-inflammatory, pro-healing, and immunomodulatory properties, this work presents a promising strategy for wet tissue repair.
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2025
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IF 4
Songhong Zhang,Xinyu Gao,Mingyan Zhang,Yuye Wang,Weilong Cheng,Wenjing Zhang,Xiaoling Lou,Junxian Yun
A novel composite anion-exchange chitosan (CS) cryogel was synthesized via cryo-polymerization of CS and poly(butyl methacrylate) (pBMA) nanogels followed by graft polymerization with (vinylbenzyl)trimethylammonium chloride (VBTAC), which was then employed for the efficient separation of ovalbumin from egg white. Characteristics of the CS-pBMA-VBTAC cryogel were investigated experimentally, and the effects of sample volume, buffer pH and elution salt concentration on the ovalbumin separation were systematically evaluated. The results demonstrated that the present cryogel possessed an interconnected supermacroporous structure, high permeability, and excellent column efficiency. Notably, its adsorption capacity for bovine serum albumin reached 19.49 mg mL -1 , which is 4.4 and 5.6 times higher than that of VBTCA-grafted cryogels based on 2-hydroxyethyl methacrylate and acrylamide, respectively. Furthermore, the CS-pBMA-VBTAC cryogel maintained consistent adsorption performance over 20 runs of the replicate chromatographic separation of bovine serum albumin. Under optimal conditions of a loading volume equivalent to 6-fold column volumes, buffer pH 5.8 and elution with 0.8 M NaCl, the ovalbumin purity and recovery of 99.1 % and 96.1 %, were achieved, respectively, indicating that the CS-pBMA-VBTAC cryogel could be an excellent adsorbent material with promising potential for the high-efficiency separation of proteins like ovalbumin.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Tingting Li,Xiaohui Yang,Jiaojiao Qiao,Yang Liu,Ting Zhang
In order to improve the adsorption capacity of attapulgite, a novel composite adsorbent EDTA/CS-ATP was synthesized by integrating attapulgite (ATP), chitosan (CS), and ethylenediaminetetraacetic acid (EDTA) by hydrothermal carbonization and grafting method. Under optimized conditions, the composite adsorbent achieved a removal ratio of 92.46 % and an adsorption capacity of 66.31 mg/g for methylene blue (MB) removal. Characterizations revealed that introducing CS and EDTA to ATP enhanced the electrostatic and hydrophobic interactions of ATP, which is beneficial for MB adsorption. Kinetic and thermodynamics studies showed that the adsorption followed pseudo-second-order kinetics and the Langmuir model, indicating a chemisorption-driven monolayer binding mechanism. Hydrogen bonding, electrostatic attraction, and π-π interactions were identified as the key mechanisms contributing to MB capture. Notably, compared to traditional EDTA-based materials mainly used for heavy metal removal, the EDTA/CS-ATP composite has the multifunctional sites to match the cationic and aromatic structure of MB, exhibiting highly selective and efficient MB removal. This work presents an environmentally friendly and scalable strategy for treating wastewater contaminated with cationic dyes, offering a promising solution for practical applications in water purification.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Xiaojing Zhang,Jiwei Peng,Xiaobo Wang,Wentong Yang,Luxin Cao,Kaiqi Fan
Despite significant progress in Janus-type adhesion hydrogels, achieving programmable adhesion asymmetry through simple interfacial engineering remains a formidable challenge. Herein, we introduce a mold-directed solid – gel interface strategy to fabricate Janus polyacrylamide/chitosan hydrogels with special unilateral adhesion contrast based on the abundant reactive groups (-NH 2 , -OH) of chitosan and through hydrogen bonding or electrostatic interactions., exhibiting an 18-fold difference in adhesion strength between the two sides. The amine groups on the surface of the hydrogels are spatially regulated by engineering interfacial reactions between the precursor solutions and asymmetric mold materials, achieving complete group coordination interaction at the aluminum (Al) interface while preserving cationic groups at the polytetrafluoroethylene (PTFE) interface. This interfacial confinement strategy effectively prevents metal ion migration between surfaces, thereby overcoming the interlayer contamination limitations inherent to conventional coating methods. The optimized hydrogel demonstrates remarkable acoustic performance, with an impedance of 1.59 MRayl that is comparable to commercial ultrasound gels. Moreover, the asymmetric adhesion endows the hydrogel with dual functionality: the adhesion surface ensures stable probe coupling during prolonged monitoring, while the slippery interface allows for tissue-adaptable sliding, enhancing the signal-to-noise ratio compared to conventional gels in carotid artery Doppler measurements. This solid-gel interfacial engineering paradigm establishes a new pathway for designing medical adhesions with spatiotemporal property gradients, offering particular advantages for dynamic bio-interfaces that require simultaneous attachment and sliding functionalities.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yanan Gao,Xue Hu,Haiying Zhang,Simin Chen,Jiaqi Yu,Deqiao Dong,Haihe Zhan,Bingmiao Gao,Dingguo Li,Zhenmiao Qin,Yan Liu
Myocardial infarction (MI) is a critical heart disease with a high mortality rate, posing a serious risk to human health. Injectable hydrogels possess considerable therapeutic promise for managing MI through the application of tissue-engineered scaffolds for cell delivery. However, the oxidative stress microenvironment of MI lesions leads to low cell retention and survival. In this study, a thermo-sensitive resveratrol micelles (RES-M) loaded chitosan hydrogel (RM-CH) was developed against oxidative stress injury in cardiomyocytes (CMs). RM-CH had better scavenging ability against DPPH and ABTS radicals compared to industry-standard ascorbic acid. RM-CH had good biodegradability, histocompatibility and cytocompatibility. The injection process of the hydrogel did not cause cell injury. DHE and DCFH-DA staining showed that it can improve the survival of CMs by fighting against the oxidative stress microenvironment. Live/Dead staining of CMs in hydrogels showed that the addition of RES-M could rescue cell survival under oxidative stress. Hence, this work highlights the potential clinical applications of RM-CH which may present an ideal scaffold material for injectable cardiac tissue engineering.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Jiuxiao Dong,Xiaoru Yang,Jianhua Li,Hongzhi Liu
The functionalized modification of epoxy silsesquioxane (GSQ) with the sodium salt of glutamic acid was successfully achieved via an epoxy-amine click reaction, resulting in the preparation of sodium carboxylate group-rich Glu-GSQ hybrid nanofillers. These hybrid nanofillers were subsequently incorporated into a hydrogel matrix composed of carboxymethyl chitosan and polyacrylamide, leading to the development of a novel PCH-Glu hybrid hydrogel material with enhanced properties. Remarkably, the optimized PCH-Glu3 hybrid hydrogel exhibits exceptional mechanical properties, demonstrating an ultrahigh fracture elongation of 3528 % coupled with a Young's modulus of 9.57 kPa. Furthermore, the material combines excellent biosafety with notable electrical conductivity (0.39 S/m), making it particularly suitable for strain sensing applications. When fabricated into flexible sensor devices, PCH-Glu3 displays outstanding sensing performance with gauge factors (GF) of 2.68 and 3.63 within the 0–900 % strain range, enabling both wide-range deformation detection and multi-level sensitivity response. In practical applications, the developed sensor demonstrates remarkable capability in precisely monitoring human motion, effectively capturing real-time electrical signal variations associated with diverse physiological movements, including joint motions and subtle facial expressions. These findings highlight the great potential of PCH-Glu3 hydrogel in advanced wearable electronics and human-machine interface technologies.
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高影响因子
MINERALS ENGINEERING
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2025
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IF 5
Ting Xiao,Wenjie Zou,Congzhong Tian,Wentao Hu,Zhijun Zhang,Chengyan Xu,Fang Zhou
Green and efficient flocculants are crucial for the effective treatment and recycling of mine wastewater. Herein, the flocculation performance and mechanism of a novel amphoteric chitosan-based flocculant CMC-g-CPAM on kaolinite suspensions were investigated through settling tests, zeta potential measurements, floc size distribution, quartz crystal microbalance with dissipation (QCM-D) and atomic force microscopy (AFM) measurements. Settling tests results revealed that CMC-g-CPAM displayed exceptional flocculation performance, achieving a settling rate of 18.21 m/h for kaolinite at natural pH, higher than that of chitosan-grafted-cationic acrylamide Chi-g-CPAM (11.19 m/h). The in-situ adsorption layer of CMC-g-CPAM on silica and alumina surfaces was more rigid than that of Chi-g-CPAM. Subsequently, more kaolinite particles were flocculated by CMC-g-CPAM, and formed a denser floc layer. The adsorption amounts of CMC-g-CPAM and Chi-g-CPAM on silica surfaces were found to be greater than those observed on alumina surfaces at natural pH. This phenomenon was related to the different surface charges of silica and alumina, electrostatic interactions between the polymers and surfaces. From AFM measurements, an attraction between the CMC-g-CPAM functionalized probe and the functional substrate as they approached each other and a weak adhesion force among CMC-g-CPAM (0.31 nN over 50 nm) were observed. These indicated the presence of intermolecular interactions among CMC-g-CPAM, which contributed to the formation of compact flocs. In contrast, an obvious repulsion was detected when the Chi-g-CPAM functionalized probe approached the functional substrate, inhibited the entanglement of polymer chains. Meanwhile, the interactions between multiple molecules and the substrate displayed a large adhesion force (2.10 nN over 150 nm), attributed to the less rigid adsorption layer of Chi-g-CPAM. Our findings would provide new insights into the design of flocculants and effective wastewater treatment.
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高影响因子
FOOD CHEMISTRY
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2025
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IF 9.8
Jiayan Zhang,Changyong Cai,Yuxiao Hu,Zhijian Tan
Aqueous two-phase Pickering emulsions (ATPPEs) are advantageous because they are biocompatible and environmentally friendly. Developing active packaging films using ATPPE with antimicrobial, antioxidant, and sustained-release properties is an effective strategy to extend food shelf life. In this study, an ATPPE stabilized by cellulose nanocrystals (CNC) was prepared using a polyethylene glycol (PEG)/dextran (Dex) aqueous two-phase system (ATPS), encapsulating epigallocatechin gallate (EGCG) as a bioactive component. An active packaging films based on chitosan and EGCG-loaded ATPPE were prepared and characterized, which revealed that the ATPPE is highly biocompatible with the chitosan matrix. And the prepared composite film provides protection and sustained release for EGCG, as well as excellent mechanical, barrier, antibacterial and antioxidant properties. This composite film significantly inhibited the spoilage of bananas and tomatoes, extending their shelf life to 8 and 12 d, respectively. Hence, the developed active packaging film is a promising material for fruit preservation.
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高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Ashuang Liu,Shengyong Cui,Lei Song,Xiangshu Guo,Zhimao Huang,Shancan Wang,Kai Cheng,Ying Xiao,Youfen Fan,Rong Wang
Hemostatic powders are widely used for managing bleeding from wounds with various irregular shapes. However, their limited liquid absorption capacity and difficulty in removal after application remain significant clinical challenges. Herein, we introduce a multifunctional hemostatic powder composed of dually crosslinked poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride- co -acrylic acid) (pMATC- co -AA) and N -[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride (HTCC), which are integrated via electrostatic interactions and hydrogen bonding. This hemostatic powder exhibits superb liquid-absorbing capacity (94.5 times its own weight in water and 9.1 times in blood), sufficient adhesive properties (5.9 kPa on pig skin), and on-demand removability. It significantly reduces the number of viable Escherichia coli and Staphylococcus aureus by 4.61 and 4.04 orders of magnitude, respectively, thus providing an effective microbiological barrier for the wound. Furthermore, a series of in vivo and in vitro experiments confirm the powder's excellent hemostatic properties. The hydrogel formed on the wound after hemostasis can be removed by saline rinsing on demand, due to its superb liquid-absorbing capacity. Notably, the powder demonstrates good in vivo biocompatibility, with minimal risk of impeding wound healing, and it facilitates the healing process during the later stages. In sum, the hemostatic powder offers a promising solution for trauma bleeding control and acute wound treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Qiqi Han,Fangzheng Zhao,Tong Wu,Chunyue Zhao,Jiahui Li,Shuaibing Huang,Tingbin Zhang,Jinfeng Xing
Uncontrolled bleeding of wound is one of the main causes of death, and wound often has bacterial infection and inflammation to hinder wound healing. In this study, natural polyphenol procyanidin was added to gelatin and quaternized chitosan, and a pure natural sponge (GQ 2 O) was prepared by mechanical stirring, crosslinking and freeze-drying. The macroporous structure of GQ 2 O was formed by natural soybean lecithin as blowing agent combined with mechanical stirring, and the three-dimensional network structure was crosslinked by Genipin. The use of natural compounds avoids the toxicity of traditional chemical blowing agents and crosslinkers. GQ 2 O has excellent water absorption ability (2060.1 %), suitable mechanical property (28.1 kPa), biodegradability, biocompatibility, antibacterial and antioxidant properties, and shows rapid hemostasis and accelerate wound healing performances in vivo . In the rat liver injury model, the bleeding time and blood loss of GQ 2 O were significantly lower than those in gauze group, commercial hemostatic gelatin sponge group and blank group. In the rat back full-thickness skin defect model, the wound inflammation was significantly relieved by GQ 2 O treatment, and the wound healing rate reached 98.9 % on the 14th day. Therefore, GQ 2 O has great potential for rapid hemostasis and promoting wound healing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Junyan Guo,Zhengke Zhang,Gulden Goksen,Mohammad Rizwan Khan,Naushad Ahmad,Wanli Zhang,Hao Deng
This study examines the effects of edible chitosan coatings reinforced with tannic acid (TA) and ferric iron (Fe 3+ ) double crosslinking on the quality of wax apples stored at room temperature. The effects of chitosan (CS) and CS/TA/Fe coatings on wax apple weight loss, decay index, respiration rate, titratable acidity, total phenolics, and other quality parameters were investigated. The weight loss and decay index of wax apples increased over time, with the CS coating delaying both compared to untreated fruits. On the final storage day, the CS/TA/Fe coating reduced weight loss by 34.35 % and maintained SSC at 9.17 ± 0.49. Additionally, the activities of catalase (CAT), ascorbate peroxidase (APX), polygalacturonase (PG), and pectin methyl esterase (PME) were evaluated. Compared to other groups, the CS/TA/Fe coating more effectively preserved the CAT and APX activities while delaying the increase in PG and PME activities. CS/TA/Fe coating preserved wax apple cell wall integrity and reduced respiration and oxidative damage (malondialdehyde levels), likely via a CS/TA/Fe supramolecular network limiting gas exchange, thus extending shelf life and maintaining quality.
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高影响因子
危险品化学品经营许可证（带存储）