JOURNAL OF CHEMICAL ECOLOGY
·
2026
·Vol. 52
·期 4
·58
·
IF 2.1
Ma Qianwen,Li Qin,Tan Tingting,Meng Yifei,Wang Hongquan,Chen Yiqu,Tang Xiaoqin
Quercus aquifolioides is an ecologically important oak species on the Qinghai–Tibet Plateau that experiences significant damage from Soritia leptatina . To clarify the behavioral response of S. leptatina to leaf volatiles of Q. aquifolioides , we analyzed leaf-associated volatile organic compounds using solid-phase microextraction coupled with gas chromatography–mass spectrometry (SPME–GC–MS), measured electrophysiological and behavioral responses of adult S. leptatina to selected leaf volatiles using electroantennography (EAG) and Y-tube olfactometer assays, and evaluated the field-trapping potential of bioactive volatiles. The detected leaf-associated profile included C6 green-leaf-volatile derivatives, long-chain fatty acids and fatty-acid esters, terpenes, and aromatic compounds. Unmated male and female adults showed strong EAG responses to leaf acetate, palmitic acid, and myristic acid, with the highest response recorded for 10 µg/µL leaf acetate (0.97 mV). Y-tube assays indicated that leaf acetate, myristic acid, and naphthalene elicited significant behavioral attraction at specific concentrations ( P < 0.05), whereas palmitic acid did not show significant attraction in this assay. Field trapping experiments further showed that palmitic acid and myristic acid increased adult captures, with 100 µg/µL myristic acid producing the highest catch (137 individuals). These results suggest that myristic acid and palmitic acid may be useful for monitoring, early warning, and environmentally friendly management of S. leptatina , although their behavioral roles should be interpreted according to assay type and concentration.
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DOI
PubMed
高影响因子
Journal of Central South University
·
2026
·
IF 4.7
Guo Meng-wei,Chai Zheng,Shao Wei-chun,Gao Ming-yuan,Deng Rong-rong,Ru Juan-jian,Xu Cun-ying,Li Yan,Hua Yi-xin,Zhang Qi-bo
Zinc anode slime (ZAS), a metallurgical byproduct generated during zinc electrowinning, contains Mn, Pb, Fe, and trace amounts of Ag. Hydrodynamic instabilities in the electrolyte circulation system cause ZAS particles to remain suspended, thereby compromising electrodeposition kinetics and the purity of cathodic zinc. Consequently, periodic removal and valorization of ZAS are necessary. This study proposes a novel hydrometallurgical route for recovering high-purity Mn 2 O 3 from ZAS. The process integrates sulfuric acid leaching with thiourea (TU) reduction, followed by sequential purification, precipitation, and calcination. Under optimized conditions (ZAS:TU mass ratio of 10:3, 200 g/L H 2 SO 4 , solid-to-liquid ratio of 1:5, temperature of 60°C, duration of 2 hours, and 100-mesh ZAS particle size), a leaching efficiency of 91.39% for Mn is achieved. Subsequent precipitation recovers 96.21% of Mn as Mn(OH) 2 , resulting in Mn 2 O 3 after calcination. Kinetic analysis indicates that the reaction follows the unreacted shrinking core model, with mixed control by interfacial reactions and ion diffusion ( E a =35.87 kJ/mol). This work elucidates the reaction mechanisms and establishes a viable route for the valorization of industrial metallurgical residues.
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DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4.6
Chen Jian-Jun,Zhang Jian-Ye,Ye Si-Yi,Wang Chen-Yu,Zhao Yan-Yun,Qiao Xi-Ya,Xu Xin-Yu,Shuai Feng-Ping,Zhang Hai-Fei,Bao Yong-Xin,Liu Zeng-He,Zhu Yu-Tian
Photo-curing three-dimensional (3D) printing enables complex geometries, personalized customization, rapid curing, and excellent spatial resolution; however, conventional photocured resins often suffer from limited mechanical performance, functionality, and sustainability. Herein, we present a novel photothermal dual-curing strategy based on dynamic imidazole-urea-epoxy chemistry to produce 3D printed materials with exceptional strength and toughness. This chemistry is triggered during post-printing thermal treatment, which not only creates new covalent crosslinks, but also synergistically integrates the toughness of polyurethane with the strength of epoxy, resulting in a reinforced network. This transformation also drives a dramatic 26-fold increase in the elastic modulus (from 13 MPa to 338 MPa), enabling a single material to be programmed from a soft and flexible state into a rigid and structural solid. Such a stark property shift unlocks unique functionalities, including shape programmability, enhanced portability, and adaptive performance for multiscenario applications. Furthermore, we extend this strategy to commodity polyurethane foam (PUF) waste and successfully upcycle it into high-performance 3D printing resins. Our work establishes a versatile approach for manufacturing strong, tough, multifunctional, and sustainable 3D printed materials.
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DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Li Qian,Li Rui,He Meng,Qin Mengmei,Cheng Chuanqi,Zhang Bin
Electrochemical dehalogenative deuteration in D 2 O offers a sustainable and site-specific strategy for synthesizing deuterated molecules. However, this process is limited by restricted deuterium transfer in the interfacial hydrogen bond gap zone at the alkaline interface, resulting in a sluggish reaction rate. Here, an iodide-derived copper catalyst is designed to convert 2-monochloroacetic acid (MCAA) to acetic acid (AA), achieving a yield rate of 1.43 mmol h −1 and lowering the potential by 200 mV compared with that of copper. Mechanistic studies reveal that, as hydrogen bond acceptors, iodide ions enhance the connectivity of interfacial water through I − ···H − O − H···O interactions, thereby facilitating deuterium shuttling and resulting in an Eley−Rideal deuteration mechanism. Moreover, the facilitated electron transfer and enhanced adsorption of MCAA induced by chemically adsorbed iodide ions contribute to the activation of MCAA. 19.8 g of AA- d 4 is obtained at 2.5 A within 40 h, highlighting the great promise of the iodide-modified strategy in catalyst and microenvironment design.
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高影响因子
BIOTECHNOLOGY LETTERS
·
2026
·Vol. 48
·期 5
·125
·
IF 2.5
Wang Shuang,Chen Qiongqiong,Lyu Liting,Zhao Zongbao Kent
Lycopene is a high-value carotenoid with broad applications in the food, pharmaceutical, and cosmetic industries. The oleaginous yeast Rhodotorula toruloides naturally synthesizes mixed carotenoids but fails to accumulate lycopene, primarily due to the bifunctional activity of lycopene cyclase/phytoene synthase Car2, which efficiently converts lycopene into downstream cyclic carotenoids. Here, we engineered R. toruloides for efficient lycopene production using a combinatorial strategy that includes pathway blocking, heterologous enzyme screening, precursor enhancement, and fermentation optimization. CRISPR/Cas9-mediated CAR2 knockout abolished endogenous phytoene synthesizing and lycopene cyclizing activities. Heterologous complementation with exogenous phytoene synthase (CrtB) restored phytoene biosynthesis, and the resultant loss of cyclase activity blocked lycopene cyclization, facilitating robust intracellular lycopene accumulation. Screening three heterologous phytoene synthases identified EgCrtB from Euglena gracilis as the superior enzyme. Co-overexpression of endogenous rate-limiting enzymes involved in the mevalonate pathway further boosted precursor supply. Combined with nitrogen-limited cultivation, which synergistically enhanced lycopene accumulation, the final engineered strain achieved a lycopene content of 0.74 mg/g DCW and a titer of 7.24 mg/L. This work verifies that metabolic pathway modification combined with fermentation regulation can effectively drive lycopene synthesis and accumulation in R. toruloides , offering an early-stage proof-of-concept for further advancing lycopene bioproduction in oleaginous yeast.
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DOI
高影响因子
AAPS Journal
·
2026
·Vol. 28
·期 5
·133
·
IF 3.4
Luo Haozhong,Pan Wenxiu,Liu Wenxue,Zhang Yuchen,Zou Meijuan,Piao Hongyu
To address the challenges associated with keloid pharmacotherapy, we developed a melittin (MEL)-modified paclitaxel (PTX) liposomal delivery system as a reconstitutable lyophilized formulation intended for subcutaneous injection. MEL, an amphipathic membrane-active peptide, was incorporated as a functional component to enhance liposome-cell interactions and facilitate intracellular delivery of PTX. This design aimed to improve the in vitro anti-keloid activity of PTX liposomes while providing a lyophilized injectable formulation suitable for reconstitution before use. After MEL modification, the zeta potential shifted upward with increasing MEL content, supporting MEL surface modification of PTX liposomes through electrostatic interactions. Moreover, freeze-dried MEL-modified PTX liposomes showed comparable particle size, zeta potential, and release behavior to the original liposomes. Although the encapsulation efficiency (EE%) of PTX and the modification efficiency (ME%) of MEL were slightly reduced after lyophilization, the formulation maintained good storage stability at 4 ± 2°C for 6 months. Confocal microscopy and flow cytometry analyses using coumarin 6 (C6) instead of PTX showed enhanced cellular uptake in human keloid fibroblasts (HKF). The CCK-8 assay indicated that although MEL-Liposome (600:1) alone did not obviously inhibit HKF proliferation under the tested conditions, MEL-PTX-Liposome (600:1) showed significantly stronger antiproliferative activity than PTX-Liposome. Specifically, MEL-PTX-Liposome (600:1) reduced HKF cell migration to 16.8% (control, 92.6%; PTX-Liposome, 36.9%), representing a significant improvement over PTX-Liposome. These findings support MEL-modified PTX liposomes as a promising reconstitutable lyophilized injectable formulation for subcutaneous anti-keloid therapy and provide a formulation basis for further translational development. Graphical
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 42
·33149-33167
·
IF 4.4
Guo Hongyan,Shi Dandan,Wang Yiying,Zhao Caiying,Zhong Kaipeng,Cao Jiajia,Xu Naicai,Bian Shaoju
With the increasing popularity of electric vehicles, the demand for lithium batteries is growing. Extracting lithium from salt-lake brine is an important method for lithium separation. This study successfully synthesized high-valence Zr 4+ -doped spinel manganese oxides using a hydrothermal-calcination approach to enhance adsorption capacity and address capacity degradation issues during the cycling of manganese-based lithium-ion sieves (Mn-based LIS). The results indicate that Zr 4+ -doping reduces the particle size and increases specific surface area from 24.22 to 32.70 m 2 g −1 . The adsorption isotherm was well fitted by the Langmuir model for 2% ZrCl 4 -doped H 1.6 Mn 1.6-x Zr x O 4 (2-HMZO) indicating a monolayer chemisorption mechanism, and the theoretical maximum adsorption capacities ( q m ) of 2-HMZO at 298, 308, and 318 K were 55.13, 58.24, and 65.92 mg g −1 , respectively. The adsorption capacity of the 2-HMZO achieved 88% of its theoretical adsorption capacity. After ten cycles of adsorption and desorption, the material maintained the Mn dissolution loss of 3.77%. Meanwhile, theoretical calculations confirmed that Zr 4+ doping enhances structural stability and facilitates easier Li + transport. Combined characterization results further confirmed that the primary Li + adsorption mechanism of 2-HMZO involves ion exchange. This research provides experimental evidence for advancing the practical application of Mn-based LIS and achieving efficient lithium extraction from salt-lake brines. Graphical abstract A spinel-type Zr-doped H 1.6 Mn 1.6 O 4 adsorbent was synthesized via hydrothermal, solid-state and ion-exchange methods, using high-valence Zr 4+ as the dopant ion. The introduction of Zr 4+ significantly enhanced the Li + adsorption capacity of HMO, and it also exhibited excellent ion selectivity in real brine samples. The primary adsorption mechanisms are ion exchange and surface electrostatic interactions. Furthermore, the adsorbent well retains its intact spinel structure even after ten consecutive adsorption-desorption cycles.
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DOI
高影响因子
Nature Microbiology
·
2026
·Vol. 11
·期 10
·2883-2900
·
IF 18.7
Zhang Yulin,Dong Zhongwei,Chen Xiaoting,Peng Ke,Huang Qingye,Rao Wutian,Song Shu,Zhang Liming,Gao Shujun,Zhu Caixia,Wang Yuyan,Robertson Erle,Yuan Zhenghong,Wei Fang,Cai Qiliang
Chaperone-mediated autophagy (CMA) is a critical regulator of cancer progression and antiviral responses, often modulated by post-translational modifications. SUMOylation, a reversible post-translational modification, is implicated in viral infection and tumorigenesis, yet its role in CMA regulation remains unclear. Here we demonstrate that oncogenic viruses hijack CMA by inducing nuclear localization and SUMOylation of lysosomal-associated membrane protein 2A (LAMP2A), a central lysosomal receptor. Specifically, tripartite motif containing 32 (TRIM32) mediates SUMO2/3 conjugation to LAMP2A at lysine residues K104, K132 and K289. Using Kaposi’s sarcoma-associated herpesvirus as a model, we found that TRIM32-induced LAMP2A SUMOylation activates CMA, thereby promoting viral persistence, tumour growth and angiogenesis in vivo. Importantly, TRIM32 expression positively correlates with LAMP2A in tumour tissues from patients with Kaposi’s sarcoma-associated herpesvirus-, Epstein–Barr virus- and human papillomavirus-associated cancers, and peptide inhibitors targeting SUMOylated LAMP2A demonstrate potent antitumour and antiviral efficacy in vitro and in mice. Together, our findings position LAMP2A as a promising druggable target for treating virus-associated cancers.
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DOI
高影响因子
Stress Biology
·
2026
·Vol. 6
·期 1
·63
·
IF 6.4
Adam Saber Y.,Ennab Wael,Zhu Cuipeng,Yuan Long,Ahmed Abdelkareem A.,Essa Mohamed Osman Abdalrahem,Husien Hosameldeen Mohamed,Saleh Ahmed A.,Kim In Ho,Liu Hao-Yu,Cai Demin
T-2 toxin is a trichothecene mycotoxin produced by Fusarium species and can cause disease after contaminated food or feed ingestion. This study aimed to investigate the impact of lycopene (Ly) on systemic inflammation, oxidative stress, and dysbiosis in mice exposed to T-2 toxin. A total of 20 male BALB/c mice (6 weeks old, weighing 23.5 ± 0.32 g) randomly divided into four groups ( n = 5): Control (Cont), Ly, T-2, and T-2 + Ly groups. Findings revealed that Ly enhanced the body weight, feedd, and water intake that have been reduced by T-2. Ly increased the villus height (VH) and VH: crypt depth (CD) and decreased CD and villus width (VW) in ileum compared to the T-2 group. In alpha diversity, Staphylococcus and Corynebacterium were the most prevalent in Cont group; Staphylococcus , and Lactobacillus , were the most prevalent in T-2 group; Candidatus-Arthromitus and Staphylococcus were the most prevalent in T-2 + Ly group. Moreover, T-2 mice had significantly ( p < 0.05) greater levels of interleukin-1 beta (IL-1β), interferon gamma (IFN-γ), Interleukin-17 (IL-17), and tumor necrosis factor-alpha (TNF-α) than Cont, while the Ly significantly ( p < 0.05) lowered their concentration. The T-2 mice had significantly ( p < 0.05) higher levels of reactive oxygen species (ROS) and malondialdehyde (MDA), while their catalase (CAT),, glutathione (GSH), adenosine triphosphate (ATP), and superoxide dismutase 1(SOD1) activities were significantly ( p < 0.05) lower than Cont. Ly significantly ( p < 0.05) restored their concentration. Moreover, there was a significant reduction ( p < 0.05) of hexanoic, butyric, acetic, pentanoic, and Heptanoic acids in the T-2 mice compared to Cont. In contrast, treatment with Ly was found to significantly restore their levels compared to T-2 group. We conclude that Ly administration in the context of T-2–induced toxicity may help attenuate systemic oxidative stress and inflammation, possibly through modulation of gut microbiota and fecal short-chain fatty acids (SCFAs).
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DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2026
·
IF 15.5
He Jiachen,Wu Jianjun,Wang Lin,Yin Siwei,Yu Kun,Liu Yanyun,Xu Dejia,Ji Tuo,Gao Yuzhi,Du Yikuan,Gao Xuzhu,Cai Limin,Xie Chaoming,Lu Xiong
Resection of bone-metastatic tumors is often accompanied by severe bone erosion and structural defects. Three‐dimensional (3D) printed hydrogel scaffolds with tailorable architectures and mechanical robustness are increasingly employed to restore bone integrity after tumor removal. Here, a 3D-printed sodium alginate/GelMA hydrogel scaffold is engineered to remodel the local microenvironment for simultaneous tumor ablation and bone repair, aiming to overcome the persistent challenge of functionally modifying hydrogel scaffolds to achieve both effective tumor eradication and bone regeneration. The scaffold encapsulates dendritic cell-derived exosomes loaded with the STING agonist Cyclic dinucleotide (Dex-CDN), together with methacrylated osteogenic growth peptide (OGP-MA), while a dopamine–manganese coordination nanozyme (DM) forms a mussel‐inspired catalytic coating on the surface. Under the acidic tumor milieu, DM exhibits peroxidase‐like activity to trigger Fenton reactions, deplete glutathione, and induce oxidative stress–mediated tumor cell death. Under physiological conditions, DM displays superoxide dismutase‐ and catalase‐like activities, scavenging reactive oxygen species and maintaining redox homeostasis to promote osteogenesis. Sustained Dex‐CDN release activates STING signaling and elicits potent antitumor immunity, whereas OGP‐MA triggers BMP/Smad‐mediated osteogenic differentiation. This integrated scaffold unites catalytic therapy, immune activation, and osteoinduction, offering a promising strategy for localized tumor control and bone regeneration following bone metastatic tumor resection.
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产品关联
DOI
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2026
·Vol. 132
·期 10
·974
·
IF 3
Liu Guanlin,Zhou Lei,Xiao Yongshuang,Cao Yan,Wang Jiaxiang,Liu Yidong,Lei Jiyu,Shi Hainan,Huang Jintao,Min Yonggang
Traditional polyimides (PI) have poor solubility in common organic solvents due to the high rigidity of the main chain and strong intermolecular forces. Consequently, the traditional negative photosensitive polyimides (PSPIs) processing needs to use a large amount of DMF, NMP and other toxic organic solvents to dissolve the poly(amic acid) (PAA), which causes the problems of volatile organic compounds emission, difficult recovery and high cost. With increasing environmental concerns, it is essential to fundamentally address the solubility limitations of PIs to reduce their dependence on hazardous solvents and improve environmental compatibility. 3,5-diaminobenzoic acid (DABA) was used to improve the solubility of PI. The carboxyl groups in DABA molecules were introduced as pendant groups along the PI main chains, which greatly increased the polarity of the polymer and provided more reactive sites for the photosensitive compound, thus significantly improving the solubility of PAA in a milder and more environmentally friendly solvent system. In this study, a series of photosensitive poly(amic acid) (PSPAA) samples with varying DABA contents were synthesized. The structure, mechanical properties, thermal properties, and morphology of PI were investigated by FTIR, DMA, TGA, and SEM, respectively, through which the optimal DABA ratio was obtained.
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DOI
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2026
·Vol. 132
·期 9
·968
·
IF 3
Shahbaz Muhammad Ali Hamza,Nasir Hamid,Afzal Amir Muhammad,Imran Muhammad,Chine Zied,Mumtaz Sohail,Kumar Abhinav,Kamran Muhammad Arshad
Developing multifunctional electrode materials that integrate high energy storage capacity with catalytic activity is essential for next-generation energy systems. Herein, a hierarchically engineered NiSnSe₂@r-GO@Ni-MOF composite was synthesized by the use of a two-step hydrothermal process, combining the high conductivity of r-GO, the porous framework of Ni-MOF, and the redox activity of NiSnSe₂. Structural and morphological investigations (SEM, XRD, Raman, XPS, and BET–BJH) confirmed the formation of a well-integrated mesoporous architecture with a large available electroactive sites and effective electron–ion transport. Electrochemical evaluation exhibited a high specific capacity of 1297.8 C g⁻¹. The assembled asymmetric device (NiSnSe₂@r-GO@Ni-MOF//AC) achieved an energy density of 44.8 Wh kg⁻¹ and a power density of 1120 W kg⁻¹, with 90% capacity retention over 7,000 cycles. Additionally, the composite exhibited excellent HER response and delivered a low overpotential of 49 mV and a Tafel slope of 52 mV dec⁻¹. The boosted bifunctional enactment is accredited to strong interfacial coupling and stabilizes the electrode structure, which highlights a scalable strategy for designing efficient multifunctional heterostructure to overcome the energy crisis in the present era.
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高影响因子
危险品化学品经营许可证（带存储）