Nature Communications
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2026
·
IF 18.1
Wu Tingting,Liu Ying,Wang Wei,Sun Rong,Wang Yanyan,Pan Jiangpeng,Zhu Jingfei,Fan Kelong,Xu Qiuran,Jiang Wei
Septic cardiomyopathy (SC) is a severe complication of sepsis that significantly increases patient mortality. The onset of SC is associated with excessive reactive oxygen species (ROS), leading to increased oxidative stress and iron accumulation. Herein, we develop a library of conductive polypyrrole-polythiophene copolymer (PPy- co -PTh)-stabilized nanozymes by coordinating different metal ions within the copolymer framework. From this library, we identify a PPy- co -PTh stabilized ruthenium-based nanozyme (Ruzyme), which exhibits significant catalase- and superoxide dismutase-like activity, as well as nitrogen radical scavenging capability. Modifying the conductive interface significantly improves the catalytic activity and stability of the Ruzyme by lowering the catalytic energy barrier, reducing excessive oxidation caused by ROS, and facilitating the continuous decomposition of ROS. To achieve precise targeted delivery to myocardial mitochondria, (5-carboxypentyl) triphenyl phosphonium bromide (TPP-COOH) and a cardiac-targeting peptide (CTP) are conjugated onto the surface of the Ruzyme. In vitro, the stabilized nanozymes effectively scavenge ROS, reduce iron accumulation, and inhibit iron-dependent cell death, thereby lowering lipid peroxidation. In male SC mice, they improve cardiac function, demonstrating therapeutic benefits. Given the growing interest in nanozymes for cardiovascular diseases, this study provides a potential foundation for the development of therapeutic agents for severe cardiomyopathy and related conditions.
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METABOLIC BRAIN DISEASE
·
2026
·Vol. 41
·期 1
·153
·
IF 3.8
Li Chunlei,Li Yuan,Liu Tongyan,Zong Yue,Zhou Lingyun
Spinal cord injury (SCI) is a highly disabling condition affecting the central nervous system (CNS). Neuroinflammation and neuronal apoptosis are two critical factors in the pathological process of SCI. Although electroacupuncture (EA) has been reported to alleviate neuroinflammation in brain injury, the underlying molecular mechanism remains unclear. Transcriptome sequencing of spinal cord tissues was performed to identify potential key factors and pathways involved in EA post-SCI. DHCR24, a cholesterol synthesis regulator, was selected as a key candidate and DHCR24 was downregulated after SCI (log 2 FC = -1.6, P < 0.01), and this downregulation was notably reversed by EA treatment (log 2 FC = 1.04, P < 0.01). We investigated the neuroprotective effect of DHCR24 against neuron death and neuroinflammation in SCI, with a particular focus on its effects on the Wnt signaling pathway. SCI-induced DHCR24 downregulation was associated with decreased expression of the axonal regeneration marker NF and increased activation of Iba1/CCR7-positive microglia, accompanied by enhanced neuronal apoptosis and inflammatory factor release. Importantly, functional validation experiments demonstrated that DHCR24 was required for the therapeutic effects of EA. Complementary in vitro studies in LPS/IFN-γ-stimulated BV2 microglia cells confirmed the role of DHCR24 in microglial polarization and neuronal survival, likely via Wnt signaling activation. Integrating transcriptomic and mechanistic evidence, we demonstrate that DHCR2 promotes Wnt pathway activation, reduces neuronal apoptosis and neuroinflammation, and ultimately enhances spinal cord repair. This study provides evidence supporting the potential clinical application of EA in SCI recovery and identifies DHCR24 may be a key mechanistic target underlying its therapeutic effects. Graphical
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Science China-Life Sciences
·
2026
·Vol. 69
·期 7
·2360-2375
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IF 9.6
Wang Tianxiao,Shao Weihua,Zhou Ting,Li Yuchao,Qin Ran,Chen Ziyu,Cao Jikang,Hu Xinyu,Cang Jingxuan,Sun Chang,Wang Yuli,Jiang Huijun,Han Feng,Pan Yongchu,Yuan Hua,Jiang Jiandong,Wu Fan
Radiotherapy-induced osteoradionecrosis of the jaw (ORNJ) affects quality of life by causing severe pain, persistent infections, and stomatognathic dysfunction. Current ORNJ treatments are limited by several factors, including surgical trauma and notable individual differences. Oxidative stress, which is a critical driver of radiation-induced injury, promotes inflammation and disrupts the balance between bone formation and resorption. Here, we developed ceria-doped silicate nanozymes (CeSNs) to eliminate reactive oxygen species (ROS) by inducing a superoxide dismutase-like (SOD-like) and catalase-like (CAT-like) cascade. ROS-eliminating mitophagy contributed to the restoration of jawbone radiation injury. Dl-3-n-butylphthalide (NBP) encapsulated in CeSNs (NBP@CeSNs) demonstrated improved pH-responsive release for enhanced angiogenesis, while the silicon ions of silicate enhanced jawbone osteogenesis, thus providing the nanozymes with angiogenesis and osteogenesis capabilities. Our NBP@CeSNs nanozymes provided a promising pathway for ORNJ treatment.
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
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2026
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IF 2.6
Xu Xiaobin,Gao Qiang,Ma Yue,Dong Chengwei,Ye Bing,Zhou Fei
M142 aluminum alloy, commonly used in piston systems, exhibits inadequate performance under prolonged high-temperature and high-load conditions. This study developed a TiO 2 nanoparticle-reinforced Ni-Fe composite coating via electrodeposition to address this. The effect of FeSO 4 ·7H 2 O concentration on Ni-Fe coatings was first investigated. The results show that hardness increased with FeSO 4 ·7H 2 O concentration, while the wear rate initially decreased and then increased. Adding TiO 2 nanoparticles effectively mitigated the adverse effects of high Fe content, leading to a dense, homogeneous composite structure (NFT15). Compared to the NF25 coating, the TiO 2 -reinforced coating demonstrated a 19.5% increase in hardness, a 30% improvement in adhesion strength, and a 30.9% decrease in wear rate. It also exhibited superior thermal stability, maintaining structural integrity and showing a 41.7% hardness increase after thermal cycling. Finally, a multi-performance evaluation identified the composite coating with 15 g L −1 TiO 2 as possessing the optimal overall properties.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 7
·489
·
IF 5.4
Zhao Jingyu,Sun Haiyue,Li Yunlun,Liu Hongyan,Zhang Haijun,Xin Junhong
The efficient enrichment and simultaneous detection of trace levels of angiotensin (Ⅰ, Ⅱ, Ⅲ) and aldosterone in plasma pose certain technical challenges. Herein, we propose a novel strategy where a cationic covalent organic framework (Py-BPy 2+ -COF) was served as an attractive adsorption material for efficient enrichment of angiotensin (Ⅰ, Ⅱ, Ⅲ) and aldosterone. Adsorption experiments and model fitting revealed that Py-BPy 2+ -COF exhibited adsorption capacities ranging from 5.02 to 26.12 μg g −1 for the four target analytes. The Hirshfeld partition analysis elucidated that the interaction forces of angiotensin and aldosterone with Py-BPy 2+ -COF originated from electrostatic interactions, π-π stacking and hydrophobic interactions. Py-BPy 2+ -COF was employed as the sorbent packing in a 96-well plate coupled with liquid chromatography-tandem mass spectrometry, achieving high sensitivity, excellent reproducibility, high recoveries (80.1%-94.9%), low limits of detection (5–50 pg mL −1 ), and cost-effectiveness, while maintaining high extraction efficiency even after 10 repeated uses. This study provides a novel approach for the detection of angiotensin (Ⅰ, Ⅱ, Ⅲ) and aldosterone in plasma, and demonstrates the potential of cationic COFs as functional materials in biomedical analysis. Graphical
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IONICS
·
2026
·
IF 3.4
Liu Zhuangzhuang,Yang Xiaobo,Li Shengting,Lu Guimin,Sun Ze
Iron impurities are among the most detrimental impurities in magnesium electrolysis because they can promote cathode passivation, reduce current efficiency, and contribute to Mg loss. This study systematically investigated the electrochemical reduction of Fe(Ⅲ) and the corresponding cathode passivation mechanism in an anhydrous carnallite melt composed of MgCl₂ and KCl with a molar ratio of 1:1 at 973 K. Based on cyclic voltammetry (CV), square wave voltammetry (SWV), chronoamperometry (CA), chronopotentiometry (CP), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS), the results show that Fe(Ⅲ) reduction is a single-step, diffusion-controlled, quasi-reversible process. Current reversal chronopotentiometry (CR-CP) measurements based on representative curves suggested a decrease in apparent current efficiency from 92.5% to 79.1% after 10 min of electrolysis. Morphological and electrochemical analyses further suggest the underlying passivation mechanism. During the initial stage of electrolysis, Fe(Ⅲ) is preferentially reduced and deposited on the cathode surface as a porous, sponge-like structure. The newly formed porous Fe deposits may adsorb MgO-containing species from the molten salt, suggesting the possible presence of an Fe/Mg/O-rich passivation layer on the cathode surface. Such a surface layer may reduce the wettability of the cathode toward liquid Mg and hinder the spreading and coalescence of Mg droplets, thereby promoting the deposition of Mg as fine, discrete, caviar-like particles with diameters below 1 mm. This process may contribute to Mg loss and the decrease in current efficiency during electrolysis. These findings provide fundamental insight into the role of Fe(Ⅲ) in cathode passivation during magnesium electrolysis.
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Nature Communications
·
2026
·
IF 18.1
Feng Doudou,Xie Yanchun,Shen Yinlin,Zhang Hao,Chen Xuan,Wang Peng-Fei,Qin Jiaqian,Jiao Yucong,Xu Jijian
Interfacial instability from polyiodide shuttling and zinc electrode degradation critically limits the reversibility of aqueous zinc–iodine batteries. Existing mono-valent organic cation strategies offer insufficient charge density and pose challenges in maintaining interfacial protection under dynamic electric field conditions. Here, we present an electrolyte design incorporating a high-valent organic cation (HVOC) —a tetravalent cation derived from 1,1,4,4,7,7,10,10-octaallyltetraazacyclodecane trifluoromethanesulfonate—that enables electrostatically engineered bipolar interfaces. The HVOC establishes a durable cationic positive electrode–electrolyte interphase on the iodine electrode that not only effectively immobilizes polyiodide species through strong electrostatic interactions under dynamic field reversals, but also facilitates iodine redox kinetics. Simultaneously, the HVOC drives the formation of a hybrid organic–inorganic solid electrolyte interphase on the zinc electrode that homogenizes zinc deposition and mitigates side reactions. This bipolar interfacial regulation enables zinc–iodine batteries with an N/P ratio of 2.43 to achieve 40.7% of zinc utilization and 95.4% of iodine utilization, with minimal capacity decay of 0.016% per cycle over 1,000 cycles at 0.4 A g –1 , and stable performance across a wide temperature range from –40 to 60 o C. This work presents a viable electrolyte design paradigm using HVOC chemistry for advanced aqueous battery systems.
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INTERNATIONAL UROLOGY AND NEPHROLOGY
·
2026
·
IF 2.2
Chen Huihui,Zhang Guolei,Jin Jingjing,Cheng Mei Juan,Zhang Dongxue,Niu Zhezhe,Zhu Rongfang,Qian Yuetong,Liang Xiangnan,He Lei,Zhou Wei,Zhang Shenglei,Bai Yaling,Xu Jin Sheng
Purpose Vascular calcification (VC) is highly prevalent and a significant cardiovascular risk factor in patients with chronic kidney disease (CKD). Secreted frizzled-related protein 1 (SFRP1) is a secreted glycoprotein closely associated with the Wnt/β-catenin pathway which plays a crucial role in bone formation, but its function and mechanism in VC remain unknown. Methods Serum and radial artery tissues were collected from CKD patients with or without VC. The cellular model of VSMCs’ calcification was established under high-phosphate conditions in vitro. Western blot, qRT-PCR, and immunofluorescence were used to detect SFRP1 expression. The function of SFRP1 was identified by transfection with sh-SFRP1 and pCMV3-SFRP1 plasmid. Results Initially, bioinformatics analysis showed that SFRP1 expression was significantly elevated in high-phosphate-stimulated rat VSMCs. Subsequently, we discovered that the expression of SFRP1 was dramatically increased in the calcified arteries of CKD patients. Functionally, when SFRP1 was knocked down, the calcification process and the expression of Runx2 were attenuated. In contrast, SFRP1 overexpression exacerbated the β-GP-induced VSMCs’ calcification. Mechanistically, we confirmed the activation of Wnt/β-catenin signaling in the in vitro calcification model and this activation was inhibited by SFRP1 knockdown. Furthermore, when the Wnt/β-catenin signaling was enhanced with LiCl, the suppressing effect of SFRP1 knockdown on β-GP-induced osteogenic transdifferentiation of VSMCs was reversed, and calcification was promoted. Conclusion We identified that SFRP1 promoted vascular calcification in CKD partly by regulating the Wnt/β-catenin/Runx2 axis, suggesting that SFRP1 may be a potential biomarker and therapeutic target for VC in CKD.
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Nature Communications
·
2026
·Vol. 17
·期 1
·3422
·
IF 18.1
Cao Hongxuan,Tu Jie,Chen Jiahui,Chen Bingzhang,Huang Zeyue,Wang Yingjie,Shen Jing,Hu Xiuqi,Bo Jialin,Rao Li,Liu Zheng,Makunga Nokwanda P.,Hameed Muhammad Salman,Su Chen,Wan Jian,Chang Wenqiang,Sheng Chunquan,Ren Yanliang
The rise of drug resistance and limitations of current antifungal treatments highlight the urgent need for innovative antifungal strategies. Here we present the development of cis -fumaramidmycin-derived analogs inhibiting the interactions of ribosome assembly factor Mrt4 with rRNA to combat fungal infections. Through antifungal screening, we identified a promising lead 20 with strong efficacy against various drug-resistant fungi, including notorious super-fungus Candida auris . A comprehensive approach combining active-and-inactive-based protein profiling (AIBPP), chemical-genetic profiling, and fluorescence polarization revealed that the antifungal activity of 20 is primarily due to selectively inhibiting essential Ca Mrt4-rRNA interaction by conjointly covalent engaging C96&C189 on Ca Mrt4 but inactive for Hu Mrt4-rRNA interaction, thereby disrupting fungal ribosomal assembly. Therapeutic efficacy of 20 in both Galleria mellonella larvae and murine candidiasis models validate this antifungal strategy. Collectively, our studies provide a potential and much needed therapeutic strategy to address the rapidly rising burden of drug-resistant fungal infections.
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npj Heritage Science
·
2026
·
IF 0
Yang Guan,Yang Ruofan,Guo Ning,Guo Jingyang,Chen Jiawei,Ma Haomeng,Qi Yunpeng,Li Yuhu,Zhou Yajun,Luo Yujia
Lead white blackening is a common deterioration in traditional Chinese paintings that severely undermines their artistic and cultural value. This study proposes a two-step preventive treatment involving sequential application of phosphotungstic acid-phosphoric acid-acetone (PPA) and barium hydroxide-ethyl cellulose-methanol (BCM) solutions. Accelerated H₂S aging tests showed that the treated lead white only exhibited localized blackening after 20 days of aging, whereas the untreated control turned completely black within 1 day. Comprehensive characterizations (EDS, SEM, XRD, XPS, FTIR) demonstrated that phosphotungstic acid chelates Pb(II) to inhibit H₂S-induced blackening, while barium hydroxide neutralizes residual acid and forms a protective barrier. Mechanical tests confirmed no adverse impact on paper substrates. This method offers a promising reference for lead white blackening prevention, though its on-site applicability and long-term stability require further validation.
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npj Science of Food
·
2026
·
IF 9.7
Xu Jingyi,Luo Peida,Xie Mingji,Liu Cheng,Li Xin,Zhao Jianping,Zheng Murong,Chen Changhui,Sun Bo,He Chunlei,Bian Jinlin,Du Xiao
Mengding bud yellow tea (MDBYT) is a renowned Chinese yellow tea characterized by its mellow, umami, and sweet taste. This study integrated flavoromics and metabolomics to investigate dynamic changes in non-volatile metabolites and sensory attributes during traditional “three yellowings and three fryings” processing. Sensory evaluation revealed progressive quality improvement, with the yellowing critical for enhancing umami and sweetness. Untargeted metabolomics identified 156 differentially abundant compounds. Theanine glucoside emerged as a potential contributor to the characteristic taste. KEGG pathway analysis highlighted amino acid biosynthesis and flavonoid metabolism as significantly enriched. Comparative metabolomic analysis with green tea identified 19 potential biomarkers, prominently including N-ethyl-2-pyrrolidinone-substituted flavan-3-ols (EPSFs), which were the most prominent. Correlation analysis between biomarkers and sensory attributes revealed distinct patterns in yellow and green teas, supporting their potential functional roles. These findings provide systematic and novel insights into the taste characteristics and underlying formation mechanisms of yellow tea.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 7
·480
·
IF 5.4
Yang LingFeng,Fu Zuyao,Shuaibu Abubakar,Xie Jing,Ding Zhaoyang
A zirconium-based MOF-on-MOF hybrid nanostructure (AIE-MOF@PCN-222, average size 3860 nm) was synthesized and characterized by SEM, TEM, XRD, XPS, FTIR, BET and TGA, which displays excellent peroxidase-like activity and stable aggregation-induced emission (AIE) properties. The dual-mode colorimetric-fluorescent sensing of formaldehyde relies on the synergistic mechanism of specific Schiff-base condensation, nanozyme catalysis and fluorescence resonance energy transfer (FRET). After parameter optimization, the sensor presents a linear response of 4–40 µM, with detection limits of 14.5 nM (colorimetric) and 1.78 nM (fluorescent). A 3D-printed portable device integrated with PDMS microfluidics was developed for on-site detection. In spiked shrimp and fish samples, the sensor achieves recoveries of 97.60-103.50% (colorimetric, RSD ≤ 2.95%) and 98.20-102.40% (fluorescent, RSD ≤ 3.12%), with relative errors below 1.51% relative to HPLC. This strategy provides a promising dual-mode platform with potential for portable HCHO screening in food matrices for HCHO detection in food matrices. Graphical The alternative text for this image may have been generated using AI.
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