Communications Chemistry
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2026
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IF 6.9
Xu Yiming,Zou Yun,Zhang Junfei,Li Fujun,Tao Shengyang
Calorimetry data for continuous-flow photochemistry are scarce, hindering kinetic model development and safe scale-up. Here we show that in situ calorimetry combined with designed experiments enables a quantitative, heat-consistent kinetic description for the continuous-flow photobromination of ( E )-methyl 2-(methoxyimino)-2-( o -tolyl) acetate (EMMA). We record total heat release, conversion, and selectivity over defined windows of residence time and light intensity, and fit a two-step kinetic scheme constrained by the calorimetric heat-release data. The model predicts total heat with R 2 = 0.957 and conversion with R 2 = 0.894, while the second bromination step shows negligible dependence on light intensity within the explored window, indicating thermally driven behaviour. We translate these parameters into a real-time visual digital model that maps the spatial distributions of conversion, selectivity, and heat-release rate and provides thermal-management guidance in real time. This approach extends the calorimetric dimension of process analytics for photochemistry and supports safer, more efficient process development.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·325
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IF 38.5
Ali Muhammad,Ali Moazzam,Hussain Hamid,Aman Samia,Naseer Ufra,Mahmood Asif,Ahsan Muhammad Tayyab,Jiang Yinzhu,Yousaf Muhammad
A multifunctional melamine cyanurate hydrogen-bonded framework separator provides intrinsic flame retardancy, high-temperature dimensional stability, and dendrite suppression, offering a practical alternative to commercial polyolefin separators for sodium metal batteries.
Polar N–H/C=O motifs preferentially interact with PF 6 − , suppressing anion migration and boosting Na + transference number, enabling uniform Na + flux and lower polarization.
Separator-driven interphase regulation forms an inorganic, NaF-rich solid electrolyte interphase confirmed by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry 3D mapping, improving Na plating/stripping reversibility and long-term full-cell durability at elevated temperature.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 5
·301
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IF 5.4
Wang Junbo,Holman Joseph Benjamin,Chen Xiangyu,Sun Jiaying,Qiu Bensheng,Zhang Anqing,Ding Weiping,Li Chengpan
In gout progression, uric acid (UA) accumulation triggers crystal deposition, while interleukin-6 (IL-6) drives the subsequent inflammatory flares. Therefore, monitoring both UA and IL-6 is important for gout management. In this study, for the first time a microfluidic electrochemical system (MES) has been developed to simultaneously detect UA and IL-6 levels in blood. The MES consists of a multilayer microfluidic chip that incorporates a plasma separation module and two screen-printed electrochemical (SPE) sensors, integrated with a wireless potentiostat for real-time data analysis. The working electrode (WE) of one SPE was modified with uricase and hydrophilic fumed nano-silica (FSiO₂) for UA sensing, and the WE of the other SPE was modified with gold nanoparticle-reduced graphene oxide (Au NPs/rGO) composites and antibodies for IL-6 sensing. The MES demonstrated excellent analytical performance for the simultaneous detection of UA and IL-6 in human blood, featuring high selectivity, broad linear ranges (10-1000 µM for UA and 0.001-100 ng/mL for IL-6), robust stability, and strong concordance with reference methods (R² > 0.95). This study provides a proof-of-concept platform for gout-related biomarker determination and offers a new strategy for the development of multi-biomarker electroanalytical devices.
Section
Graphical
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JOURNAL OF SOLUTION CHEMISTRY
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2026
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IF 1.3
Zhuo Chen,He Zhu,Junlei Shi,Chengxin Shen,Shun Yan,Huanxin Li,Xueguo Liu
The dissolution behavior of 6-methylcoumarin in eleven mono-solvents, namely methanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, isobutanol, 2-methyl-2-butanol, methyl acetate, ethyl acetate, n-propyl acetate and isopropyl acetate, was investigated with the static equilibrium method. The studied temperature ranged from 278.15 to 318.15 K at p = 100 kPa. The results demonstrated that the solubility of 6-methylcoumarin increased with the temperature increasing. Among the selected solvents, methyl acetate exhibited the highest solubility for 6-methylcoumarin, whereas 2-propanol had the lowest. At the same time, the experimental solubility data were fitted with van’t Hoff, λh , Wilson, and NRTL models, with the NRTL model providing the most accurate predicted results. Additionally, the mixing thermodynamics were calculated by using the NRTL model, which revealed that the mixing process is spontaneous, endothermic and entropy-driven. Finally, the dissolution mechanism of 6-methylcoumarin in the selected solvents was preliminarily analyzed from the perspectives of the molecular structural characteristics of the solute, the solute–solvent intermolecular interactions, and the physicochemical properties of the solvent.
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npj Science of Food
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2026
·
IF 9.7
Peng Ya-lin,Wang Yong-zhan,Li Yu-cong,Zeng Li-ting,Song Xin-yi,Li Xue-qing,Lv Ao-jing,Dong Rui-ling,Gao Wen-hao,Feng Lu,Li He-shuai,Qi Jun,Xiong Guo-yuan,Zhang Chun-hui
This study developed a novel gelatin-stabilized nano-silver particle/agar hydrogel (AgNP hydrogel) and investigated its color rendering mechanism for monitoring the freshness of braised chicken. The results showed that the color of AgNP hydrogel shifted from brown to gray-white within 3 days of storage of braised chicken, and its application extended the shelf life of unpackaged braised chicken meat from 4 d to 6 d at 4 °C ( P < 0.05). The results of circular dichroism (CD), particle size, zeta potential, and UV indicated that Cl - on the surface of braised chicken could react with Ag + on the surface of AgNP, resulting in the formation of AgCl particles during storage. These AgCl particles were subsequently transformed into black Ag 2 S particles, causing the visual color shift of AgNP to gray-white. Overall, the AgNP hydrogel could provide a new method for the freshness assessment of cooked meat products.
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ANALYTICAL SCIENCES
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2026
·
IF 2
Zheng Diantao,Li Qiuyan,Hu Ran,Zhang Baoliang
Serum C-terminal telopeptide of type I collagen (CTX-I) is a key bone turnover biomarker in osteoporosis, and its elevated levels are indicative of increased bone resorption. Current techniques for CTX-I measurement suffer from high operational requirements, complex procedures, and high costs. This study focuses on a novel strategy for detecting serum CTX-I concentration to predict the occurrence and severity of osteoporosis. Using silver-capped Fe 3 O 4 (Fe 3 O 4 @Ag) as the substrate material, an artificial antibody for CTX-I was prepared via magnetic core-shell molecularly imprinted polymers (MIPs), and surface-enhanced Raman scattering (SERS) was used as a signal output device. With crystal violet (CV) at 10 −4 M as the reporter molecule, the proposed biosensor exhibited a good linear response over the range of 10 pg/mL to 2 ng/mL (R 2 = 0.986, LOQ = 4.79 pg/mL), covering the normal reference range required for identifying bone turnover. Moreover, the biosensing platform demonstrated resistance to matrix interference in real serum and urine samples. After six reuse cycles, the SERS intensity of CV decreased by only 10.5%, and after 15 days of storage at 4 °C, it decreased by 15.7%. The Fe 3 O 4 @Ag-MIPs were used to detect CTX-I with excellent uniformity (RSD = 4.1%) and repeatability (RSD = 2.7%), and the overall analysis time was 30 min. The proposed biosensing platform was applied to analyze known real serum samples obtained from human. The proposed biosensor was validated using enzyme-linked immunosorbent assay (ELISA), and the developed biosensor showed good correlation with ELISA. The experimental results indicate that the proposed novel biosensing platform is a fast, low-cost, and reliable tool for the rapid detection of the bone biomarker CTX-I in serum or urine. Graphical abstract
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Scientific Reports
·
2026
·
IF 4.9
He Jinjin,Wang Baoyan,Sun Hongwei,Liu Yucan,Wang Gang,Yang Xiaoyong,Zhang Yanxiang
Imidacloprid (IMI) is a highly toxic organic pollutant. Therefore, effective IMI treatment methods must be developed. This study synthesized iron-modified rape straw biochar (Fe-RSB) to activate peracetic acid (PAA) for IMI removal from water. At the optimal concentrations of 0.55 g∙L − 1 for Fe-RSB and 0.25 mM for PAA, the removal of IMI reached 81.6% after 60 min. Additionally, the IMI removal was minimally affected over a broad pH range (3–11). CH 3 C(O)O· and CH 3 C(O)OO· played crucial roles in the IMI degradation. The degradation pathway of IMI consisted of three pathways, and the ecological hazards of most intermediates were lower than those of IMI. The effect of Cl⁻ on IMI removal was concentration dependent, 2 mM Cl⁻ showed slight inhibition, while 10 mM Cl⁻ promoted the degradation. In contrast, both HA and HCO 3 ⁻ exhibited inhibitory effects across the tested concentration ranges. After five cycles, the removal of IMI reached 61.9%, indicating the stability of Fe-RSB. Overall, a new Fe-RSB/PAA process is proposed for the degradation of IMI.
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Journal of Coatings Technology and Research
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2026
·
IF 3.4
Yao Hongrui,Wang Xinwei,Li Wanshen,Wang Na
The combination of waterborne epoxy coatings (WECs) and two-dimensional nanofillers is a major method to improve the coating’s anticorrosion performance. In this paper, polyaniline (PANI) is deposited on the surface of hexagonal boron nitride (h-BN) through in situ polymerization to enhance the compatibility between h-BN and WEC. Then, the two oxides (TiO 2 and CeO 2 ) are loaded on the h-BN-PANI by in situ hydrolysis, obtaining two composite nanofillers (h-BN-PANI@TiO 2 and h-BN-PANI@CeO 2 ). The structures of composite nanofillers are investigated by FTIR, XRD, and SEM. The anticorrosion performances of WECs with h-BN-PANI, h-BN-PANI@TiO 2 , and h-BN-PANI@CeO 2 are evaluated by EIS and salt spray test. The EIS results show that h-BN-PANI@TiO 2 /WEC and h-BN-PANI@CeO 2 /WEC exhibit the best corrosion resistance, and its low-frequency impedance ( Z f =0.01 Hz ) is one order of magnitude higher than those of pure WEC and h-BN/WEC. In salt spray test, h-BN-PANI@TiO 2 /WEC and h-BN-PANI@CeO 2 /WEC also show excellent long-term corrosion resistance with few corrosion products even after 600 h. Besides, h-BN-PANI@TiO 2 /WEC and h-BN-PANI@CeO 2 /WEC reflect fantastic adhesion strength. Generally, the excellent protection properties of h-BN-PANI@TiO 2 /WEC and h-BN-PANI@CeO 2 /WEC are attributed to the presence of PANI and oxides (TiO 2 or CeO 2 ) on h-BN, which increase the compatibility and surface interactions between two-dimensional nanofillers and waterborne epoxy resin.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·Vol. 24
·期 1
·258
·
IF 15
Jiang Junbo,Zhang Cailing,Gao Chen,Zhang Haiyang,Cai Guiyuan,Zheng Yunsheng,Kuang Yuxing,Xu Guangqing,Lan Yue
Conductive nerve scaffolds have emerged as a promising alternative to autologous grafts for promoting nerve regeneration. However, optimizing the electroactive properties of scaffold materials and elucidating their regulatory mechanisms on neural stem cell (NSC) differentiation remain critical challenges. Magnetic graphene oxide (MGO), an innovative nanomaterial integrating magnetic responsiveness with two-dimensional carbon-based conductivity, exhibits potential for modulating neural regeneration. Nevertheless, its application in guiding NSC fate within nanofibrous scaffolds is still limited. In this study, a multifunctional MGO-gelatin–polycaprolactone (PCL) composite nanofibrous scaffold—termed the MGO Functionalized Nanofibrous Neural Scaffold—was developed via electrospinning technology, functionalized with superparamagnetic Fe₃O₄ nanoparticles and graphene oxide nanosheets. This design enhanced the scaffold’s mechanical properties, electroactivity, biocompatibility, and structural stability. In vitro experiments demonstrated that the MGO Nanofibrous Scaffold not only supported NSC adhesion and proliferation but also significantly promoted differentiation toward excitatory neuronal phenotypes, suppressed excessive astrocyte activation, and maintained synaptic plasticity and functional maturity. RNA-Seq analysis revealed that the scaffold was associated with the enrichment of key neurogenesis-related pathways, including neurotrophic factor and Wnt-related pathways, which correlated with directed neuronal differentiation and functional maturation of NSCs. Further validation using dorsal root ganglion (DRG) models confirmed its efficacy in accelerating axonal regeneration. Collectively, the MGO Nanofibrous Neural Scaffold constructs an optimized electrophysiological microenvironment conducive to neuronal commitment and nerve fiber regeneration. These findings underscore its significant potential in regulating NSC differentiation and neuronal growth, highlighting the value of multifunctional graphene-based composites in neural tissue engineering. Graphical abstract
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npj Science of Food
·
2026
·
IF 9.7
Wu Tong,Dong Yuhe,Zhu Wanying,Xie Zesen,Jiang Tao,Yu Xi,Xiao Ying,Sui Siyao,Zhong Tian
To prevent the rapid microbial growth caused by unintended temperature abuse during the handling of cooked meat, such as malfunctioning hot-holding equipment or improper storage, this study developed a smart formulation that can be triggered by high temperature to release antibacterial agents on demand. A mixture of lauric acid and stearic acid was employed as the phase change material (PCM), and cinnamaldehyde (CA) was used as the active substance to fabricate this composite (CA/PCM). At 42 °C, CA/PCM can transit from a solid phase to a molten state, leading to the rapid release of embedded CA. In vitro experiments showed that, compared with the 25 °C group, the CA/PCM-42°C group reduced the colony counts of E. coli and S. aureus by 74.5% and 74.0%, respectively, and also decreased the biofilm absorbance by 92.75% and 82.08%, respectively. Compared with the samples stored at 25 °C, the inoculated meat stored at 42 °C for 24 h exhibited smaller changes in colour (∆ E * < 3.5), hardness, pH, TVB-N, and MDA values. Moreover, the microbial counts remained below 5 log CFU·g -1 . The results demonstrate that CA/PCM serves as an effective fail-safe strategy, providing targeted antimicrobial protection specifically under temperature-abuse conditions for the preservation of cooked meat.
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Advanced Composites and Hybrid Materials
·
2026
·
IF 15.5
Bai Tian,Qin Xionghai,Wu Zhenguo,Su Junjie,Li Lin,Yao Hang,Niu Zhaoxuan,Yue Chengbin,Wang Dong,Yue Yiying,Cheng Wanli,Zeng Chengjun,Zhao Wei,Han Guangping
Commercial airway stents often slip and deform, leading to severe complications such as mucosal injury, granulation tissue formation, and stent migration, which can cause recurrent airway obstruction and necessitate repeated interventions. Here, we introduce a 3D-printed tracheal stent composed of continuous bamboo fiber reinforced shape memory polylactic acid (BF/SMP). These naturally derived fibers (tensile strength ~ 1.90 GPa, modulus ~ 91.30 GPa) exhibit excellent mechanical resilience. Following an instantaneous thermal treatment, their interfacial compatibility with SMP is notably improved. The 30% BF/SMP stent can undergo over 1,000 three-point bending cycles under a 20 N load, with a bending deflection of 30.85%. In vitro, it promotes bronchial epithelial cell proliferation. Preliminary animal studies suggest that the biomass-based stent provides airway support without causing significant inflammation or organ abnormalities. Overall, this work demonstrates a biomass-reinforced, thermally deployable airway stent concept and provides a foundation for future studies on catheter-compatible delivery and long-term in vivo performance.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Zhao Rui,Ni Shiwen,Yang Mei,Gu Zhifeng,Zhu Yujuan
Endometrial injury is a major cause of female infertility and recurrent miscarriage. Conventional treatments often fail to dynamically regulate the local immune microenvironment or effectively promote angiogenesis and functional regeneration. Here, we developed an ultrasound-responsive microneedle (MN) patch for wireless endometrial repair, integrating the natural compound curcumin and piezoelectric potassium sodium niobate (KNN) nanoparticles into a photopolymerized hydrogel. This design enables spatiotemporally controlled drug release, antioxidant activity, and piezoelectric stimulation under ultrasound activation. In vitro, the Cur@KNN MN exhibited excellent biocompatibility, potent reactive oxygen species scavenging, anti-inflammatory effects, and pro-angiogenic capacity, as validated in macrophage and vascular-on-a-chip models. In a rat endometrial injury model, implantation of the patch combined with ultrasound exposure promoted KNN-mediated microcurrent generation, which synergistically enhanced curcumin release and significantly improved regeneration of smooth muscle and microvessels. Notably, the treated endometrium showed increased thickness, reduced fibrosis, and restored fertility, with a marked increase in embryo implantation rates. These results demonstrate that the traditional Chinese medicine-based piezoelectric MN system not only supports structural reconstruction of the injured uterus but also effectively restores reproductive function, offering an innovative and minimally invasive strategy for in situ tissue regeneration. Graphical
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