JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 8
·5177-5197
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IF 4.682
Wang Shuangshou,Ding Yuwen,Wang Haili,Li Wenzhi,Xu Wenjing,Sun Panwen,Huang Wei,Chen Yang,Gu Jing,Lin Peng,Ma Liang,Liu Zi,Ling Qiang,Zhang Qi,Chen Hongmei,Yan Tingxuan
Actively tumor-targeted photothermal therapy (PTT) has been regarded as an attractive strategy for tumor treatment. Unfortunately, invasive damage caused by hyperthermia, irrepressible heating transfer and self-heating from in-organism water is always a real ‘hot potato’ in existing PTT modes. Herein, molecularly imprinted upconversion nanoparticles (UCPs@MIPs) were innovatively reported as an artificial antibody for active tumor targeting and microinvasive PTT. UCPs@MIPs were prepared using boronic acid-functionalized upconversion nanoparticles as a substrate, in-water polymerizable dopamine and m -aminophenylboronic acid as a functional co-monomer and photothermal couplant, and sialic acid, a monosaccharide overexpressed on most cancer cells, as a template to create tumor-targeted imprinting cavities. Uniquely, the as-designed UCPs@MIPs were of three-in-one traits, i.e., active tumor targetability, bright upconversion luminescence and superb photothermal properties, enabling to achieve tumor-targeted microinvasive PTT by virtue of semi-accurate hyperthermia tumor ablation while protecting the normal tissue from overheating. Finally, as a proof of concept, such a molecular imprinting technique (MIT)-based PTT mode was successfully applied to real biosystems using HepG2 tumor-bearing mice as tumor models. Since MIT has good versatility in the selection of imprinting methods, substrate materials and template molecules, it will find its wider applications in the fields of biosensing and nanomedicine.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 414
·期 7
·2355-2362
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IF 4.478
Zhao Xueqi,Zhang Yue,Wang Xinghua,Ma Pinyi,Song Daqian,Sun Ying
Long-range surface plasmon resonance (LRSPR) has demonstrated excellent performance in sensing and detection, due to its higher accuracy and sensitivity compared with conventional surface plasmon resonance (cSPR). In this work, we establish an LRSPR biosensor which employs PDA/Ti 3 C 2 -MXene/PDA-gold film as a sensing substrate and gold nanoparticles (AuNPs) as enhancers. Ti 3 C 2 -MXene is an emerging two-dimensional (2D) layered material which is used extensively in immunoassay and biosensing. The sensing substrate comprises two polydopamine (PDA) films between which is sandwiched a Ti 3 C 2 -MXene film based on a gold film, which provides a large surface area and abundant binding sites to rabbit anti-human IgG (Ab 1 ). Sandwich amplification is adopted to enhance the sensitivity of the LRSPR biosensor, and AuNPs/staphylococcal protein A (SPA)/mouse anti-human IgG (Ab 2 ) composites are introduced into the flow cell as enhancers after the immune binding of human IgG to Ab 1 . The antigen (human IgG) detection range is 0.075 μg mL −1 to 40 μg mL −1 , and the limit of detection is almost 20 times lower than that for cSPR biosensors. This novel LRSPR biosensor demonstrates excellent performance in immune sensing over a broad detection range and a low limit of detection. Subsequent modification of the LRSPR sensing platform could be made for extensive application in various biological detection fields. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 7
·4876-4894
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IF 4.682
Liu Hongxu,Xie Junhao,Zhao Jingxuan,Xue Peng,Lv Xue,Sun Shulin
With the rapid development of industrial technology, wastewater pollution has gradually become an important social issue and severely affects sustainable development. Polymer membranes separation technology provides an effective way for industrial wastewater treatment. Herein, 1-butyl-3-vinylimidazole bromide ionic-liquid grafted poly(vinylidene fluoride) (PVDF-g-IL) were prepared by irradiation-induced radical grafting method. The corresponding PVDF-g-IL films were prepared by non-solvent-induced phase separation method and were used to separate dye and emulsion wastewater for the first time. The results indicated that the grafted IL improved the hydrophilicity, porosity and average pore size, water flux, oil resistance, and anti-pollution ability of PVDF films. The PVDF-g-IL membranes exhibit splendid filtration performance for cationic dyes and emulsion wastewater, and the best one can achieve over 98% rejection and nearly 100% flow recovery. This research provides a simple and effective membrane preparation strategy for PVDF-based functional membranes and which behave as potential application prospects in dyes wastewater and oil–water emulsions purification field.
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Biomass Conversion and Biorefinery
·
2022
·
IF 4.05
Chen Lulu,Liu Shima,Pan Hu,Song Ke,Zhou Xianwu,Guo Jie,Zhuo Ou,He Jian
Exploitation of natural biopolymers as heterogeneous catalysts for biomass valorization is highly attractive as it renders the production processes to be sustainable and increases the economic competitiveness of bio-refinery. Herein, sodium alginate was for the first time developed as heterogeneous base catalyst for Knoevenagel condensation of furfural and acetylacetone to produce high-quality fuel precursor. A furfural conversion rate as high as 89.58% along with 86.47% yield of 3-(furan-2-ylmethylene)pentane-2,4-dione was obtained in ethanol at 140 °C with 10 h. The excellent catalytic performance of sodium alginate in Knoevenagel condensation of furfural with acetylacetone was confirmed by the low value (10.8 kJ/mol) of as-obtained activation energy. In addition, a plausible reaction mechanism for Knoevenagel condensation of furfural with acetylacetone over sodium alginate was proposed. Moreover, sodium alginate almost sustained its original activity in consecutive six reuse experiments and the durability of sodium alginate was characterized by several techniques. Furthermore, other bio-based aldehydes such as 5-hydroxymethylfurfural and 5-methylfurfural were also applicable in the as-established system with producing the corresponding fuel precursor in excellent yields.
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JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 10
·5805-5824
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IF 4.682
Sheng Mingming,Yang Rongkun,Gong Hongyu,Zhang Yujun,Lin Xiao,Jing Jie
With the extensive use of high-power electronic appliances, polymer-based thermal insulation composites with excellent thermal properties are utilized in the field of heat management with the aim of improving heat dissipation. Due to the high thermal conductivity and good electrical insulation, boron nitride (BN) is rendered as a superior candidate material for thermally conductive fillers. However, the thermal conduction of the composites is inevitably hampered by the interfacial resistance between BN and the polymer matrix. In this work, BN surface was modified by dopamine hydrochloride (PDA) and phenyltrimethoxysilane to enhance its interface compatibility with the polymer matrix. Meanwhile, by applying pressure to the composites during processing, BN grains inside the composite were well aligned to the direction parallel to the heat flow, thereby improving the through-plane thermal conductivity. When the filler content is fixed at 31 vol%, the thermal conductivity of the phenyl silicone rubber (PVMQ)-based composite prepared from modified BN (mark as M-BN/PVMQ) reaches 1.642 W/(m·K), nearly equal to nine times the value for the pure PVMQ matrix (0.18 W/(m·K)). Furthermore, in a nitrogen atmosphere, the initial decomposition temperature (T5%) reaches 512 °C, 172 °C higher than that of pure PVMQ (340 °C). The improved thermal stability of the composites prepared from modified BN resulted from the enhanced interfacial effect, which was analyzed by thermogravimetric infrared gas mass spectrometry system (TG-IR-GC/MS). The high thermal conductivity and stability enable the M-BN/PVMQ composite a promising material for thermal management.
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Probiotics and Antimicrobial Proteins
·
2022
·Vol. 15
·期 4
·941-954
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IF 5.265
He Xi,Zhou Meiling,Chen Xuemei,Wang Jing,Zhao Xiaoli,Zhu Yanxia,Liu Tao
Overcoming the bacterial infection and promoting angiogenesis are challenge and imperious demands in wound healing and skin regeneration. Hereby, we developed a multifunctional AMP/S1P@PLA/gelatin wound dressing fabricated by electrospinning poly ( l -lactic acid) (PLA)/gelatin with antimicrobial polypeptides (AMPs) and sphingosine-1-phosphate (S1P) in order to inhibit the bacteria growth and induce angiogenesis. In our work, AMP/S1P@PLA/gelatin wound dressing was obtained by two-step method of electrospinning and dopamine adsorption. Our results showed that incorporating AMP into PLA/gelatin nanofibrous membranes significantly improved antibacterial properties against both Escherichia coli and Staphylococcus aureus . S1P releasing from AMP/S1P@PLA/gelatin nanofibrous membranes could significantly enhance tube formation. Simultaneously, we found that the AMP/S1P@PLA/gelatin nanofibrous membranes facilitated the adhesion, proliferation, and migration of human umbilical vein endothelial cells (HUVECs) and murine fibroblast (L929). AMP/S1P@PLA/gelatin membranes could also accelerate infected wound healing and skin regeneration by antibacterial and pro-angiogenesis effects. In summary, our developed AMP/S1P@PLA/gelatin nanofibrous membranes could be multifunctional dressing for infected wound healing and skin regeneration. Graphical Abstract Schematic figure to describe the characterizations and preparation of AMP/S1P@PLA/gelatin nanofibrous membranes.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 28
·43169-43178
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IF 5.19
Piao Mingyue,Du Hongxue,Sun Yuwei,Teng Honghui
Hybrid hydrogel was synthesized by immobilizing TiO 2 in polyethylene glycol diacrylate (TiO 2 @PEGDA) as an efficient adsorbent with photocatalysis property for bisphenol A (BPA) elimination. TiO 2 @PEGDA exhibited spherical and rough structure with limited crystallinity and abundant functional groups. The contact angle increased to 61.96° (TiO 2 @PEGDA) from 46.73° (pristine PEGDA), indicating that hydrogel hydrophilicity decreased due to the presence of TiO 2 . The swelling capacity of TiO 2 @PEGDA (9.0%) was decreased compared with pristine PEGDA (15.6%). Adsorption results demonstrated that the maximum adsorption capacity of TiO 2 @PEGDA (101.4 mg/g) for BPA was slightly higher than that of pristine PEGDA (97.68 mg/g). The adsorption capacity was independent with pH below 8 and decreased obviously when the value of pH was higher than 8. The adsorption behavior was fitted well with the pseudo-second-order kinetic and the Langmuir isotherm model. Both ΔG 0 and ΔH 0 were negative, indicating that BPA adsorbed on TiO 2 @PEGDA was an exothermic and spontaneous process. Regeneration study was performed by photocatalysis, and the adsorption capacity was 85.6% compared with the initial capacity after four-cycle use, indicating that TiO 2 @PEGDA could be recycled without significant adsorption capacity loss. Consequently, TiO 2 @PEGDA can serve as an eco-friendly and promising material for efficiently adsorbing BPA with self-clean property.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-14
·
IF 17.694
He Huaying,Zhou Weikang,Gao Jing,Wang Fan,Wang Shaobing,Fang Yan,Gao Yang,Chen Wei,Zhang Wen,Weng Yunxiang,Wang Zhengchao,Liu Haiqing
Cotton gauze is a widely used topical hemostatic material for bleeding control, but its high blood absorption capacity tends to cause extra blood loss. Therefore, development of rapid hemostatic cotton gauze with less blood loss is of great significance. Here, we develop an efficient hemostatic cotton gauze whose surface is slightly modified with a catechol compound which features a flexible long hydrophobic alkyl chain terminated with a catechol group. Its hemostatic performance in animal injuries is superior to standard cotton gauze and Combat Gauze TM . Its biosafety is similar to cotton gauze and rebleeding hardly occurs when the gauze is removed. Here, we show its hemostatic capability is attributable to the rapid formation of big and thick primary erythrocyte clots, due to its effective controlling of blood movement through blocking effect from tissue adhesion by catechol, blood wicking in cotton, and the hydrophobic effect from long alkyl chains.
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CELLULOSE
·
2022
·Vol. 29
·期 3
·1419-1433
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IF 6.123
Huang Ting,Zhou Yaohong,Zhang Xiaohua,Peng Dayong,Nie Xuliang,Chen Jing,Xiong WanMing
A furfuryl alcohol resin-based solid acid (SC-FAR-800) was prepared and applied in the conversion of carbohydrates into furan platform compounds in microwave. The results showed that SC-FAR-800 was an irregular mesoporous material containing sulfonic acid groups with an acid density of 3.43 mmol/g, which was quite stable below 200 °C. SC-FAR-800 showed good catalytic activity, and the yield of furfural from xylose could reach 60.46%; the yield of 5-HMF from fructose, glucose, cellobiose and cellulose macromolecules could reach 89.35%, 38.17%, 42.6%, 14.73%, respectively. However, the effect of reaction temperature, reaction time, catalyst dosage and water content on various carbohydrate’s conversion was different. SC-FAR-800 could be reused more than 6 times in fructose conversion, and could be regenerated after a re-sulfonation process. Moreover, the catalytic activity of SC-FAR-800 was super to some biomass-based solid acid. Therefore, this catalyst may be an attractive alternative in the conversion of biomass to prepare furan compounds. Graphical abstract Furfuryl alcohol resin-based solid acid (SC-FAR-800), which has a high acidity of 3.43 mmol/g, was applied in the conversion of carbohydrates in a microwave oven. The peak yield of furfural from d -xylose could reach 60.46%; the yield of 5-HMF from d -fructose, glucose, cellobiose and cellulose macromolecules could reach 89.35%, 38.17%, 42.6%, 14.73%, respectively.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-22
·
IF 9.429
Zhang Yu,Wang Xiaowei,Chen Jian,Qian Dingfei,Gao Peng,Qin Tao,Jiang Tao,Yi Jiang,Xu Tao,Huang Yifan,Wang Qian,Zhou Zheng,Bao Tianyi,Zhao Xuan,Liu Hao,Zheng Ziyang,Fan Jin,Zhao Shujie,Li Qingqing,Yin Guoyong
Subtalar osteoarthritis (STOA) is often secondary to chronic ankle sprains, which seriously affects the quality of life of patients. Due to its etiology and pathogenesis was not studied equivocally yet, there is currently a lack of effective conservative treatments. Although they have been used for tissue repair, platelet-rich plasma-derived exosomes (PRP-Exo) have the disadvantage of low retention and short-lived therapeutic effects. This study aimed to determine whether incorporation of PRP-Exo in thermosensitive hydrogel (Gel) increased their retention in the joint and thereby playing a therapeutic role on STOA due to chronic mechanical instability established by transecting lateral ligaments (anterior talofibular ligament (ATFL)/calcaneal fibular ligament (CFL)). PRP-Exo incorporated Gel (Exo-Gel) system, composed of Poloxamer-407 and 188 mixture-based thermoresponsive hydrogel matrix in an optimal ratio, was determined by its release ability of Exo and rheology of Gel response to different temperature. The biological activity of Exo-Gel was evaluated in vitro, and the therapeutic effect of Exo-Gel on STOA was evaluated in vivo. Exo released from Exo-Gel continuously for 28 days could promote the proliferation and migration of mouse bone mesenchymal stem cells (mBMSCs) and chondrocytes, at the same time enhance the chondrogenic differentiation of mBMSCs, and inhibit inflammation-induced chondrocyte degeneration. In vivo experiments confirmed that Exo-Gel increased the local retention of Exo, inhibited the apoptosis and hypertrophy of chondrocytes, enhanced their proliferation, and potentially played the role in stem cell recruitment to delay the development of STOA. Thus, Delivery of PRP-Exo incorporated in thermosensitive Gel provides a novel approach of cell-free therapy and has therapeutic effect on STOA.Graphical Abstract
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npj Science of Food
·
2022
·Vol. 6
·期 1
·1-8
·
IF 7
Chen Yu-Hong,Zhang Yan-Hong,Chen Gen-Sheng,Yin Jun-Feng,Chen Jian-Xin,Wang Fang,Xu Yong-Quan
Phenolic acids are important taste components in green tea. The aim of this study was to analyze the taste characteristics of phenolic acids and their influence on the bitterness and astringency of green tea by sensory evaluation and chemical determination. The major tea phenolic acids and quercetin-3- O -rutinoside (Que-rut) were significantly positively correlated with the bitterness ( r = 0.757, p < 0.01; r = 0.605, p < 0.05) and astringency ( r = 0.870, p < 0.01; r = 0.576, p < 0.05) of green tea infusion. The phenolic acids have a sour and astringent taste, whereas Que-rut has a mild astringent taste. Phenolic acids and Que-rut can increase the bitterness of epigallocatechin gallate (EGCG). However, these components behaved differently for astringency on EGCG. Gallic acid (GA) enhances the astringency throughout all the concentrations in this study. While it seemed to be double effects of caffeic acid (CA), chlorogenic acid (CGA), and Que-rut on that, i.e., the inhibition at lower concentrations (CA: 0–0.2 mM; CGA: 0–0.2 mM; Que-rut: 0–0.05 mM) but enhancement at higher ones. The phenolic acids and Que-rut interacted synergistically with tea infusion and as their concentration increased, the synergistic enhancement of the bitterness and astringency of tea infusion increased. These findings help provide a theoretical basis for improving the taste of middle and green tea.
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Food Analytical Methods
·
2022
·Vol. 15
·期 6
·1471-1481
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IF 3.498
Qiu Daoyang,Wang Xiaoqiang,Wen Yangping,Zeng Yifang,Li Weiqiang,Zhao Li,Chen Lili,Xiong Jianhua,Tang Kaijie
We explored a low-cost wireless smart portable sensor based on a disposable laser-induced porous graphene (LIPG) flexible substrate electrode decorated by gold nanoshells (AuNSs) for a simple and rapid electrochemical detection of sulfonamides (SAs). The LIPG was prepared by the one-step computer-controlled laser direct-writing patterning techniques on polyimide (PI) substrate, and the AuNSs were facilely modified onto the surface of LIPG substrate electrode by the drop-coating. The electrode displayed an excellent electrochemical response towards sulfanilamide (SN) in a linear range from 0.4 to 100 μM with a low limit of detection of 0.035 μM; recovery ranges from 96.04 to 105.00% in fish and shrimp samples using the traditional large electrochemical workstation. Other three SAs were also detected, and their results were similar with SN. The portable mini electrochemical workstation with the wireless bluetooth transmission displayed better feasibility, practicability, and superiority in the rapid on-site supervision of SAs in food safety in comparison with the traditional large electrochemical workstation with the wire transmission.
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危险品化学品经营许可证（带存储）