PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2014
·Vol. 17
·期 4
·2550-2559
·
IF 4.198
Zhifeng Jiang,Deli Jiang,A. M. Showkot Hossain,Kun Qian,Jimin Xie
Ag nanoparticles (NPs) are successfully grown in situ on nanoporous Fe2O3 microboxes (Ag/Fe2O3) simply by annealing Prussian blue (PB) in the presence of silver nitrate for the first time. The catalytic activity of the Ag/Fe2O3 microboxes for the reduction of p-nitrophenol (PNP) with NaBH4 is measured by UV-vis spectroscopy. It is found that the composites exhibit bifunctional properties with high magnetization and excellent catalytic activity toward PNP reduction. The high catalytic activity of the catalyst might be attributed to its high surface area and the synergistic effect on the delivery of electrons between Ag NPs and Fe2O3 microboxes. In addition, efficient reduction is observed and found to depend upon the content of Ag in the Ag/Fe2O3 microboxes. The dosage of the catalyst and the reaction temperature were investigated. Furthermore, the catalysts can be easily recycled by applying an external magnetic field while maintaining the catalytic activity without significant decrease even after running six times. The unique properties provide an ideal platform to study various metal/Fe2O3 catalysts which can be potentially applied in a wide variety of fields of catalysis and green chemistry.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2014
·Vol. 2
·期 13
·1825-1837
·
IF 0
Changcan Shi,Fanglian Yao,Jiawen Huang,Guoliang Han,Qian Li,Musammir Khan,Yakai Feng,Wencheng Zhang
Herein, we developed a novel biodegradable gene carrier for rapid endothelialization of endothelial cells (ECs) in vitro. Three triblock amphiphilic copolymers, methoxy-poly(ethylene glycol)-block-poly(3(S)-methyl-2,5-morpholinedione-co-glycolide)-graft-polyethyleneimine (mPEG-b-P(MMD-co-GA)-g-PEI) with different 3(S)-methyl-2,5-morpholinedione and glycolide contents were synthesized. Microparticles (MPs) were obtained via self-assembly of these copolymers. The hydrophobic core composed of P(MMD-co-GA) segments provide crosslinking points for numbers of PEG and short PEI chains to form a highly hydrophilic and positively charged corona/shell of MPs. Using these MPs, potential genes (ZNF580) for rapid endothelialization were efficiently transported into EA.hy926 cells. Because of the hydrophilic PEG chains and low molecular weight PEI in the triblock copolymers, the cytotoxicity of these MPs and their complexes with pEGFP–ZNF580 was decreased significantly. The transfection efficacy of MPs/pEGFP–ZNF580 complexes was as high as Lipofectamine™ 2000 reagent to EA.hy926 cells in vitro. The proliferation and migration of EA.hy926 cells were improved greatly by the expression of pEGFP–ZNF580 after 60 hours. Our results indicated that the mPEG-b-P(MMD-co-GA)-g-PEI based MPs could be a suitable non-viral gene carrier for ZNF580 gene to enhance rapid endothelialization.
✓ 已验证
产品关联
DOI
PubMed
Polymer Chemistry
·
2015
·Vol. 6
·期 13
·2445-2456
·
IF 5.52
Minghui Xu,Junmin Qian,Aili Suo,Ting Liu,Xuefeng Liu,Hongjie Wang
To enhance the therapeutic efficacy of doxorubicin (DOX) to breast cancer cells, a multifunctional triblock copolymer, poly(ethylene glycol)-block-poly(L-glutamic acid γ-hydrazide)-block-polyethylenimine (PEG-b-PGAH-b-PEI) having a cleavable disulfide linkage between blocks, was developed as a vehicle for targeted co-delivery of DOX and P-glycoprotein (P-gp) siRNA into MCF-7/ADR cells. The PGAH blocks were used to chemically conjugate DOX molecules via hydrazone bonds, while the PEI blocks could complex siRNA through electrostatic interactions. A tumor-targeting agent, folic acid (FA), was attached to the distal ends of the PEG blocks to specifically bind to the folate receptors overexpressed in MCF-7/ADR cells. The DOX-conjugated copolymer would self-assemble in aqueous solutions into cationic nanomicelles, which could condense siRNA to form nanomicelleplexes with an average particle size of ∼194 nm and a positive zeta potential of >+10 mV. The nanomicelleplexes exhibited sustained drug release profiles, and the release rates of DOX and siRNA from the nanomicelleplexes in a reductive acidic environment (pH 5.0 + 10 mM glutathione) were much faster than those under physiological conditions (pH 7.4). FA-decorated nanomicelleplexes were more efficiently internalized by MCF-7/ADR cells via folate-receptor-mediated endocytosis and exhibited a higher cytotoxic effect on MCF-7/ADR cells in comparison with FA-undecorated nanomicelleplexes. Furthermore, the synergistic effects of DOX and P-gp siRNA in inhibiting cell proliferation and inducing apoptosis in MCF-7/ADR cells were achieved by the FA-targeted co-delivery system. The triblock copolymer itself had a low cytotoxicity. These results indicate that the triblock copolymer could serve as an ideal tumor-targeting vehicle for simultaneous delivery of drugs and siRNA in breast cancer therapy.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 77
·62519-62526
·
IF 3.84
Wen Wang,Hua-Bin Fang,Yan-Zhen Zheng,Yanke Che,Xia Tao,Jian-Feng Chen
A novel 3D p–n heteroarchitecture Ag3PO4/Ta3N5 composite photocatalyst with double visible-light-response characteristics has been prepared using an in situ template-free precipitation method. It is found that the fascinating Ag3PO4/Ta3N5 exhibited high superior photoactivity and photostability compared to bare Ag3PO4 and Ta3N5 for the degradation of RhB under visible light irradiation. The improved performance of the composite is primarily attributable to sufficient visible-light harvesting, efficient charge separation and transfer of photogenerated electrons and holes resulting from matched energy bandgaps and sufficient p–n hetero-interfaces between Ag3PO4 and Ta3N5. The quenching effects of different scavengers demonstrate that the reactive h+ and O2−˙ species played a major role in the photodegradation process. It is expected that the 3D p–n heterostructure composite fabricated via a facile precipitation method, may be a promising candidate for organic pollutant degradation.
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2015
·
IF 5.75
Zhao Wang,Ting Luo,Ruilong Sheng,Hui Li,Jingjing Sun,Amin Cao
In this work, a series of diblock terpolymer poly(6-O-methacryloyl-d-galactopyranose)-b-poly(methacrylic acid-co-6-cholesteryloxy hexyl methacrylate) amphiphiles bearing attached galactose and cholesterol grafts denoted as the PMAgala-b-P(MAA-co-MAChol)s were designed and prepared, and these terpolymer amphiphiles were further exploited as a platform for intracellular doxorubicin (DOX) delivery. First, employing a sequential RAFT strategy with preliminarily synthesized poly(6-O-methacryloyl-1,2:3,4-di-O-isopropylidene-d-galactopyranose) (PMAIpGP) macro-RAFT initiator and a successive trifluoroacetic acid (TFA)-mediated deprotection, a series of amphiphilic diblock terpolymer PMAgala-b-P(MAA-co-MAChol)s were prepared, and were further characterized by NMR, Fourier transform infrared spectrometer (FTIR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and a dynamic contact angle testing instrument (DCAT). In aqueous media, spontaneous micellization of the synthesized diblock terpolymer amphiphiles were continuously examined by critical micellization concentration assay, dynamic light scattering (DLS), and transmission electron microscopy (TEM), and the efficacies of DOX loading by these copolymer micelles were investigated along with the complexed nanoparticle stability. Furthermore, in vitro DOX release of the drug-loaded terpolymer micelles were studied at 37 °C in buffer under various pH conditions, and cell toxicities of as-synthesized diblock amphiphiles were examined by MTT assay. Finally, with H1299 cells, intracellular DOX delivery and localization by the block amphiphile vectors were investigated by invert fluorescence microscopy. As a result, it was revealed that the random copolymerization of MAA and MAChol comonomers in the second block limited the formation of cholesterol liquid-crystal phase and enhanced DOX loading efficiency and complex nanoparticle stability, that ionic interactions between the DOX and MAA comonomer could be exploited to trigger efficient DOX release under acidic condition, and that the diblock terpolymer micellular vector could alter the DOX trafficking in cells. Hence, these suggest the pH-sensitive PMAgala-b-P(MAA-co-MAChol)s might be further exploited as a smart nanoplatform toward efficient antitumor drug delivery.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2014
·
IF 5.211
Yaoming Xiao,Gaoyi Han,Yunzhen Chang,Haihan Zhou,Miaoyu Li,Yanping Li
High performance dual function of polyaniline (PANI) with brachyplast structure is synthesized by using a two-step cyclic voltammetry (CV) approach onto the fluorinated tin oxide (FTO) glass substrate, which acts as the sensitizer and p-type hole-transporting material (p-HTM) for the all-solid-state perovskite-sensitized solar cell (ass-PSSC) due to its π–π* transition and the localized polaron . The ass-PSSC based on the PANI delivers a photovoltaic conversion efficiency of 7.34%, and reduces from 7.34% to 6.71% after 1000 h, thereby 91.42% of the energy conversion efficiency is kept, indicating the device has a good long-term stability.
✓ 已验证
产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2025
·
IF 6.1
Yue Zhang,Hui Zhao,Qianxi Feng,Rui Guo,Li Zhong,Shengxian Liang
Benzotriazole ultraviolet stabilizers (BUVSs) are pervasive environmental contaminants that pose significant risks to human health. This study evaluated the effects of three typical BUVSs (UV-328, UV-329, and UV-P) on human mesenchymal stem cells (hMSCs), which play crucial roles in tissue maintenance and repair. hMSCs were exposed to BUVSs across a range of concentrations, and their maintenance and differentiation capacities were assessed. At concentrations below 50 μM, no significant cytotoxicity was observed. However, at non-cytotoxic doses, UV-P exhibited stronger effects on the differentiation of hMSCs compared to UV-328 and UV-329, significantly inhibiting adipogenesis and enhancing osteogenesis. Mechanistically, UV-P was found to significantly enrich the PPAR signaling pathway during both differentiation processes. Dual-luciferase reporter assays confirmed UV-P's interaction with PPARγ_LBD at an alternate binding site outside the canonical pocket. These findings raise concerns about the health impacts of BUVSs, particularly UV-P, and underscore the need for further investigation into their toxicological profiles.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 5
·1-13
·
IF 5.3
Hu Anqi,Chen Guoqing,Li Lei,Ma Chaoqun,Yang Taiqun,Gao Hui,Gu Jiao,Zhu Chun,Wu Yamin
Nitrogen, boron co-doped carbon quantum dots (gCQDs), and a coloration probe (PPD-NPs) with response to cobalt ions (Co 2+ ) were prepared by using 4-hydroxyphenylboric acid as the common precursor, with ethylenediamine and p-phenylenediamine (PPD) adopted as nitrogen-doped reagents, respectively. A noticeable brown-to-purple color change can be observed with the addition of Co 2+ , and a broad absorption band emerges at 535 nm. At the same time, gCQDs, which is introduced as the fluorescence signal source, will be significantly quenched due to the enhanced inner filtration effect, induced by the overlap between the emission spectrum of gCQDs and the emerging absorption band. Therefore, a colorimetric/fluorescent dual-mode sensing probe for Co 2+ is constructed by combining the recognition unit PPD-NPs and the fluorescent gCQDs into PPD-NP/gCQD. Under the optimized experimental conditions, the calculated limits of detection are 1.51 × 10 −7 M and 3.75 × 10 −7 M for the colorimetric mode and the fluorescence mode, respectively, well qualified for the determination of Co 2+ maximum permitted level in drinking water. The feasibility of the proposed method has been verified in tap water, lake water, and black tea samples. Graphical Abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2025
·
IF 3.1
Gu Weiwen,Bing Linhan,Jin Gaoling,Sun Qianhe,Fan Yu,Liu Botong,Huang Hanjiang,Wei Jianfei,Wang Rui
As the most widely utilized thermoplastic polyester with the largest production volume, PET is primarily used in clothing, curtains, plastic films, and electronic appliances, all of which have high safety performance requirements, particularly in terms of fire resistance. In this study, a bio-based integrated phosphorus-containing flame retardant (PCDs) was efficiently prepared using phosphoric acid and biomass material gelatin as raw materials, employing a rapid microwave-assisted method. Subsequently, PCDs was copolymerized into the PET matrix (PET-PCDs) through in situ polymerization, achieving enhanced flame retardancy. The combustion properties and flame retardancy mechanisms were analyzed using CONE, TG-IR, and py-GCMS. The results showed that the peak heat release rate of PET-PCDs decreased by 54.02% when the PCDs content was only 1.0 mass%. Additionally, the yield of CO and CO 2 decreased by 9.00% and 16.67%, respectively. In terms of fire risk, compared to PET, the fire growth index of PET-PCDs decreased by 64.07%, and the fire performance index increased by 51.61%. Furthermore, the tensile strength of PET-PCDs was not significantly affected, and the elongation was improved. This study offers a promising solution for the development of eco-friendly and integrated flame retardants for PET.
✓ 已验证
产品关联
DOI
高影响因子
Asian Journal of Pharmaceutical Sciences
·
2024
·
IF 10.7
Dawei Jiang,Chao Chen,Peng Dai,Caiyan Li,Zhiyi Feng,Na Dong,Fenzan Wu,Junpeng Xu,Ping Wu,Liuxi Chu,Shengcun Li,Xiaokun Li,Youjun Yang,Weian Zhang,Zhouguang Wang
The cyanine dyes represented by IR780 can achieve synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) under the stimulation of near-infrared (NIR) light (commonly 808 nm). Unfortunately, the stability of NIR-excited cyanine dyes is not satisfactory. These cyanine dyes can be attacked by self-generated reactive oxygen species (ROS) during PDT processes, resulting in structural damage and rapid degradation, which is fatal for phototherapy. To address this issue, a novel non-cyanine dye (IR890) was elaborately designed and synthesized by our team. The maximum absorption wavelength of IR890 was located in the deep NIR region ( ca. 890 nm), which was beneficial for further improving tissue penetration depth. Importantly, IR890 exhibited good stability when continuously illuminated by deep NIR light. To improve the hydrophilicity and biocompatibility, the hydrophobic IR890 dye was grafted onto the side chain of hydrophilic polymer (POEGMA-b-PGMA-g-C CH) via click chemistry. Then, the synthesized POEGMA- b -PGMA- g -IR890 amphiphilic polymer was utilized to prepare P-IR890 nano-photosensitizer via self-assembly method. Under irradiation with deep NIR light (850 nm, 0.5 W/cm 2 , 10 min), the dye degradation rate of P-IR890 was less than 5%. However, IR780 was almost completely degraded with the same light output power density and irradiation duration. In addition, P-IR890 could stably generate a large number of ROS and heat at the same time. It was rarely reported that the stable synergistic combination therapy of PDT and PTT could be efficiently performed by a single photosensitizer via irradiation with deep NIR light. P-IR890 exhibited favorable anti-tumor outcomes through apoptosis pathway. Therefore, the P-IR890 could provide a new insight into the design of photosensitizers and new opportunities for synergistic combination therapy of PDT and PTT.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Xin Cao,Zhiyang Zhang,Jiadong Chen,Ji Qi,Yanzhou Wu,Zhenyu Liu,Yan Chen,Xiaobo Xie,Shuang Su,Chunlei Xia,Lingxin Chen,Xiaoyan Wang
Gold nanorods (AuNRs), as versatile sensing materials, have wide analytical applications due to their unique optical properties. Cetyltrimethylammonium bromide (C16TAB), a conventional reagent in AuNR synthesis, also often acts as a stabilizer of AuNRs in applications. However, C16TAB-stabilized AuNRs undergo severe spontaneous aggregation and etching under extreme pH conditions, greatly limiting their optical sensing applications. Herein, we accidentally discovered that octadecyl trimethylammonium bromide (C18TAB), a rarely used surfactant for AuNRs, has a substantially higher stabilizing ability than C16TAB in preventing spontaneous aggregation and etching of AuNRs, which enables C18TAB-stabilized AuNRs as a superior sensing platform, demonstrating a 100-fold higher sensitivity than C16TAB-stabilized AuNRs for detection of model analytes. The excellent stability of C18TAB-stabilized AuNRs can be attributed to the higher surfactant coverage density on the gold surface, evidenced by the red-shifted longitudinal band (5 nm), which is tuned by the metal surface refraction index. The experimental results show that C18TAB-stabilized AuNRs can keep monodispersed and unchanged optical properties at very acidic and alkaline conditions with a low concentration of surfactant (0.05 mM). Moreover, the C18TAB-stabilized AuNRs can prevent spontaneous etching in the acidic sensing system and maintain their unchanged plasmon band, therefore decreasing the intensity of the noise signal. Benefiting from these findings, we established a reliable and ultrasensitive C18TAB-stabilized AuNR sensing platform and achieved the ultrasensitive detection of the model biomarker p-aminophenol (pAP), with a visual detection limit of 8 nM. This sensitivity represents at least a 100-fold improvement over the existing method using C16TAB-stabilized AuNRs. Moreover, C18TAB-stabilized AuNRs were successfully applied to detect pAP in urine samples with satisfactory recovery rates of 99.84–114.91%, further validating its reliability in practical applications. In summary, C18TAB-stabilized AuNRs provide a powerful tool for trace-level visual detection in chemo- and biosensing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DIAMOND AND RELATED MATERIALS
·
2025
·
IF 5.1
Jinjing Du,Yuehao Guo,JianGuo Zhang,Dongbo Wang,Tao Zhang,Yu Zhou,Yuxiang Yangxuan,Xun Liu,Bin Wang,Qian Li
In this paper, with the goal of developing a high-performance silicon-based negative electrode through a reasonable green design using simple magnesium thermal reduction and pickling combined methods. Specifically, we utilize inexpensive photovoltaic waste silicon mud as the silicon source to synthesize porous silicon. Subsequently, we utilized self-produced porous silicon as the raw material and graphene as the coating material to fabricate a graphene-coated porous silicon-based negative electrode material with excellent cycling stability. We employ the PW91 method, which is based on density functional theory (DFT) using the generalized gradient approximation (GGA), to compute the first principles of both silicon-based materials and graphene-coated silicon/graphene composites. The study revealed that the P-Si@RGO composite exhibited excellent electrochemical properties. When adding 150 mL of graphene oxide with a concentration of 0.2 mg/mL. Even after the 100th cycle at a current density of 100 mA·g −1 , the specific discharge capacity of the P-Si@RGO electrode remains high at 1167.6 mAh·g −1 . At the same time, the results of DFT calculations also show that graphene can improve the conductivity of silicon materials. In summary, the experimental results are consistent with the results of the first-principal calculation, indicating that the computer simulation can predict the accuracy of the experiment, verify the empirical conclusions, and indicate the direction for designing the experimental scheme.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）