COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Fan Li,Yimeng Liu,Jun Wang,Yu Zhou,Junjie Tan,Hongxiang Chen,Hongye Yan,Xinghua Liao
To increase the water solubility of chitosan and enhance the mechanical strength of chitosan-based in-situ hydrogel, poly(ethylene glycol) monomethyl ether-grafted chitosan (PCS) was fabricated by a simple and efficient modification method with hexamethylene diisocyanate (HDI) as bridging agent, and then a series of poly(ethylene glycol)/chitosan-based in situ hydrogels (PCS@gel) were prepared from PCS and aldehyde-terminated poly(ethylene glycol) (DF-PEG) as cross-linking agent. The resultant PCS shows good water solubility in the absence of acid and its solid content is up to 8 wt%. By studying the effects of the mass ratio of PCS to DF-PEG and their solid content on the gel time and properties of PCS@gel, the results demonstrate that increasing the solid content of precursor solution can significantly shorten the gel time and improve its mechanical properties and adhesion strength. When the mass ratio of PCS to DF-PEG is 1:1, PCS@gel has a shorter gel time and higher mechanical strength. While the mass ratio of PCS to DF-PEG is 5:1, PCS@gel has better adhesion properties. Besides, PCS@gel also has good self-healing ability, antibacterial effect, low cytotoxicity and the ability to promote cell migration. Therefore, PCS@gel will have a promising application as a wound dressing.
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NEW JOURNAL OF CHEMISTRY
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2025
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IF 2.5
Ming Huang,Yingfeng Wang,Yuhan Zhu,Maoli Yin,Zhipeng Ma,Xiaojuan Li
To address the challenge of antibiotic resistance and cross-infection from microorganisms, chitosan (CS) was covalently bound with rose bengal (RB) and blended with polyethylene oxide (PEO) to prepare nanofiber membranes with good antibacterial properties. Morphological and structural characteristics confirmed successful integration of RB-modified CS (CS-RB) without compromising the fiber morphology or stability of PEO/CS-RB nanofiber membranes. FT-IR and TG analyses were employed to characterize the chemical structure and thermal stability of PEO-based membranes. With visible light irradiation, PEO/CS-RB nanofiber membranes efficiently generated reactive oxygen species (ROS), enabling rapid inactivation of all Escherichia coli (E. coli), Staphylococcus aureus (S. aureus) and Candida albicans (C. albicans) within 30 min. The PEO-based membranes exhibited well-balanced hydrophilicity and water stability, along with low hemolytic activity, indicating good biocompatibility. This strategy creates PEO-based membrane materials that exhibit good biocompatibility, hydrophilicity, and photodynamic antibacterial properties, making them suitable for use in the biomedical and healthcare fields.
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Food Bioscience
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2025
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IF 5.9
Mingyang Yuan,Yuehao Song,Jie Mi,Yiwen Guo,Qidong Xue,Xiaoyu He,Yazhen Xing,Ruijie Liu,Ming Chang
Phytosterols (PS) are natural steroidal compounds with multiple physiological functions, but their poor solubility, high crystallinity, and low bioavailability hinder effective utilization. In this study, PS-loaded nanostructured lipid carriers modified with cross-linked chitosan (CLCS-PS-NLCs) developed via emulsification-evaporation combined with high-pressure homogenization. The optimal formulation was achieved with 0.5 % (w/w) chitosan and a tripolyphosphate (TPP):chitosan (CS) mass ratio of 2:1 to enhance carrier stability and PS absorption. Structural characterization using dynamic light scattering (DLS) and transmission electron microscopy (TEM), along with fourier transform infrared (FTIR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC), confirmed efficient PS encapsulation and successful chitosan modification. CLCS-PS-NLCs demonstrated excellent stability under varying pH, ionic strength, and storage conditions. In vitro and in vivo studies showed improved digestion and absorption of PS, achieving a bioaccessibility of 36.65 % compared to only 13.28 % for PS-NLCs, and enhancing its uptake in rats. This study provides a promising delivery system for PS with potential applications in functional foods and pharmaceuticals.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Zhiyue Feng,Shiqi Chen,Ke Han,Qiang Ma,Boyan Sun,Chujun Liu,Qiqi Wang,Hao Zhao,Zimo Liu,Junying He,Zhimeng Zhang,Haiyang Jiang
Infections caused by multidrug-resistant bacteria significantly hinder wound healing, highlighting the need for non-antibiotic alternatives. Here, we developed a multifunctional hydrogel platform, LAMC@PCN-224@BBR, by incorporating photodynamic PCN-224 and the natural product berberine (BBR) into lipoic acid-modified chitosan (LAMC). This design combines photo-crosslinking for enhanced tissue adhesion with photodynamic therapy (PDT) for antimicrobial activity. Upon light irradiation, the hydrogel generates reactive oxygen species (ROS), effectively eradicating methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli ( E. coli ) with an efficiency exceeding 99 %. Its excellent biocompatibility and adaptive adhesion allow conformal coverage of irregular wounds. In a full-thickness skin defect model, the hydrogel accelerated healing by suppressing inflammation, promoting collagen deposition, enhancing angiogenesis, and polarizing macrophages toward the pro-regenerative M2 phenotype. These findings demonstrate that the LAMC@PCN-224@BBR hydrogel is a promising clinical strategy for controlling resistant infections and promoting tissue regeneration.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Xiaolei Zhang,Dongjun Lv,Zhongmin Liu,Fan Yang,Qi Tang,Nan Gao,Zong Tan,Peng Du,Jinyang Li,Jiahao Wang
Microplastics and dye pollutants threaten aquatic ecosystems and human health, prompting the need for sustainable solutions. Converting industrial solid waste into value-added adsorbents provides an effective remediation pathway. In this work, industrial solid waste—fly ash cenospheres—was transformed into a value-added adsorbent (PMFL) by coating with polydopamine (PDA) and Fe 3 O 4 , imparting magnetic recoverability and high adsorption capacity for polystyrene (PS) microplastics (312.00 mg/g). To further improve practical applicability and broaden pollutant removal capacity, PMFL was immobilized within a chitosan matrix to form a monolithic CS@PMFL composite. This structure not only enables facile recovery but also exhibits strong adsorption affinity toward both PS microplastics and Congo red dye. Mechanistic investigations indicated that adsorption involved a combination of electrostatic, chemical, and physical interactions, including π–π stacking, hydrogen bonding, hydrophobic effects, surface complexation and physical entrapment. The materials maintained high adsorption performance across a wide range of pH and ionic conditions, demonstrating robust environmental adaptability. Overall, this study presents a scalable approach for converting industrial waste into multifunctional adsorbents capable of simultaneously removing diverse pollutants.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Man-Fang Cheng,Dong-Hua Xie,Rui Hu,Nuzahat Habibul,Guo-Ping Sheng
The Fenton catalytic process represents a promising advanced oxidation technology for the degradation of recalcitrant organic pollutants; however, its practical application is limited by issues such as catalyst agglomeration and restricted pH tolerance. In this study, a chitosan-derived Schiff base iron aerogel (CS-C=N-Fe) was synthesized via a cost-effective and environmentally friendly method at ambient temperature. The coordination between the Schiff base ligand and iron effectively dispersed the active sites and mitigated Fe agglomeration. The obtained aerogel exhibited a high sulfamethoxazole (SMX) removal efficiency of 96.2 % within 210 min under near-neutral conditions, with an apparent rate constant of 0.0951 min −1 . The catalyst maintained more than 70 % degradation efficiency after six consecutive cycles, and 91 % SMX removal during 24 h of continuous operation in a flow system, showing excellent structural stability and resistance to coexisting ions. The total organic carbon removal reached 29 % within 60 min, indicating effective oxidative mineralization of SMX intermediates. Mechanistic studies confirmed that hydroxyl radicals were the dominant reactive species. Density functional theory calculations further revealed that H 2 O 2 adsorption and decomposition on the CS-C=N-Fe surface occur with favorable energies (−0.987 eV and −0.747 eV, respectively), supporting efficient H 2 O 2 activation. These results highlight the CS-C=N-Fe aerogel as a robust, recyclable, and scalable Fenton-like catalyst capable of operating efficiently across a broad pH range (3.0–9.0), offering practical potential for the treatment of antibiotic-contaminated wastewater.
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
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2025
·Vol. 113
·期 12
·e70006
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IF 3.9
Jing Dai,Xuechun Wang,Siyu Li,Shaoqing Chen,Xinye Ni,Min Lin
Severe acute pancreatitis (SAP) is a prevalent gastrointestinal disease with no effective treatment to control inflammation currently. Macrophages, particularly peritoneal macrophages (PMOs), play a pivotal role in SAP inflammation by polarizing into M1 or M2 phenotypes, which exhibit distinct functional properties and cytokine expression profiles. Galectin-9 (Gal-9) modulates macrophage polarization, but its specific effect on PMOs in SAP remains unclear. In this study, hyaluronic acid-chitosan nanoparticles encapsulating Gal-9 (HA-CS-Gal-9 NPs) were developed for delivery. In vitro, HA-CS-Gal-9 NPs enhanced M2 marker expression and suppressed M1 markers in both naive (M0) and LPS-induced M1 macrophages. In vivo, HA-CS-Gal-9 NPs effectively delivered Gal-9, showing effective uptake by PMOs without notable toxicity, resulting in reduced IL-6, and increased IL-10 expression in PMOs. Treatment with these nanoparticles (NPs) decreased systemic pro-inflammatory cytokines, thereby alleviating pancreatitis severity. These findings demonstrate that Gal-9-loaded NPs robustly promoted M2 macrophage polarization, highlighting a promising therapeutic strategy for SAP.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Lei Nie,Xiaoyue Ding,Yingsong Zhao,Peng Ding,Meili Zhao,Yuanna Sun,Yanfang Sun,Guohua Jiang
Multifunctional hydrogel dressings, with their robust antibacterial and anti-inflammatory properties, represent a great potential in biomaterials for wound care. Injectable and self-healing hydrogels that mimic the natural extracellular matrix of tissues offer a promising strategy for effective wound repair. This study designs a hydrogel based on the formation of a dynamic cross-linking network within the hydrogel matrix through the Schiff base reaction between the synthesized polymers L-hydroxyproline-conjugated chitosan (LHCS) and oxidized pullulan (OPL). The fabricated LP hydrogels preserve the porous interconnected microstructure, excellent self-healing capacity, and injectability, suitable swelling capability, robust mechanical strength, and outstanding tissue adhesion. Moreover, curcumin was encapsulated in Polyether F127 (Pluronic F127) micelles to obtain curcumin loaded PF127 (Cur-PF127) micelles and then incorporated into LP hydrogel to fabricate the composite hydrogels. The composite hydrogels exhibit effective antibacterial properties and antioxidant abilities, admired hemostatic effect and hemocompatibility, excellent cytocompatibility and cell pro-migration ability. In addition, in vivo evaluation confirmed that curcumin loaded hydrogels could facilitate the regeneration of epithelial and hair follicles, increase the collagen production, alleviate the inflammatory response via the downregulation of the tumor necrosis factor-α (TNF-α), and reduce the fibrosis, thus promote the wound repair process. This work offers a promising facile approach for the development of the composite hydrogel as wound dressing in wound healing applications.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Siyuan Yu,Boxuan Peng,Pengfei Wu,Jiahui Li,Qingyun Liu,Shuo Li,Yuanyuan Gu,Ying Liu,Zichang Lu,Jingbao Wang,Jinfeng Xing
To achieve effective adsorptive removal of Congo red (CR) from wastewater, magnetic chitosan microspheres CTS-Fe 3 O 4 were initially synthesized through emulsion crosslinking, followed by the preparation of polydopamine-coated microspheres PDA-CTS-Fe 3 O 4 via deposition of polydopamine (PDA) onto CTS-Fe 3 O 4. The physicochemical properties of synthesized microspheres were systematically characterized. The influence of adsorbent dosage, contact time, pH, ionic strength, and temperature was investigated, and the results demonstrated that PDA-CTS-Fe 3 O 4 (679.99 mg·g −1 ) exhibited superior adsorption performance compared with CTS-Fe 3 O 4 (595.21 mg·g −1 ) towards CR. The adsorption processes of both microspheres adhered to the pseudo-first-order kinetic model and Langmuir isotherm model, and were determined to be spontaneous and endothermic. The adsorption energy between PDA-CTS-Fe 3 O 4 and CR was higher than that between CTS-Fe 3 O 4 and CR, and the enhanced adsorption capacity of CR onto PDA-CTS-Fe 3 O 4 was attributed to the synergistic effect of π-π stacking interaction, hydrogen bonding, and electrostatic attractive force.
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Food Bioscience
·
2025
·
IF 5.9
Yi Liu,Jihong Qu,Haibo Zhao,Jianpeng Li,Die Dong,Chao Yuan,Meng Zhao,Bo Cui
Starch complexation with non-starch components can reduce starch digestibility, which is crucial for increasing resistant starch (RS) content. However, the accompanying decrease in starch viscosity limits its application in food products. Annealing is a safe and environmentally friendly physical modification method. In this study, we systematically investigated the effects of adding different concentrations (1.0%, 2.0%, and 3.0%) of ε-polylysine (ε-PL), type-A gelatin (GA), chitosan (CS), and chitooligosaccharides (COS) combined with annealing treatment on the digestibility and viscosity of natural corn starch (NS). The results showed that the addition of these positively charged components (PCC) decreased the digestibility of NS, while exerting varying effects on the viscosity. Turbidity and Fourier transform infrared (FTIR) spectroscopy results showed that electrostatic attraction and hydrogen bonds were involved in the interaction between the PCC and NS during the annealing treatment. Furthermore, the formation of complexes was confirmed by the results of laser particle sizing, fluorescence microscopy, and scanning electron microscopy. Among the tested PCC, only CS effectively increased the viscosity of the complexes; moreover, CS increased the RS content more effectively than other PCC. The results may provide new insights into how NS/PCC interactions affect the digestibility and viscosity of NS.
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International Journal of Nanomedicine
·
2023
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IF 8
Tingting Xu,Xiaoyue Xu,Yan Gu,Lei Fang,Feng Cao
Background To enhance ocular bioavailability, the traditional strategies have focused on prolonging precorneal retention and improving corneal permeability by nano-carriers with positive charge, thiolated polymer, absorption enhancer and so on. Glycylsarcosine (GS) as an active target ligand of the peptide tranpsporter-1 (PepT-1), could specific interact with the PepT-1 on the cornea and guide the nanoparticles to the treating site.Purpose The objective of the study was to explore the active targeting intercalated nanocomposites based on chitosan-glutathione-glycylsarcosine (CG-GS) and layered double hydroxides (LDH) as novel carriers for the treatment of mid-posterior diseases.Materials and methods CG-GS-LDH intercalated nanocomposites were prepared by the coprecipitation hydrothermal method. In vivo precorneal retention study, ex vivo fluorescence images, in vivo experiment for distribution and irritation were studied in rabbits. The cytotoxicity and cellular uptake were studied in human corneal epithelial primary cells (HCEpiC).Results CG-GS-LDH nanocomposites were prepared successfully and characterized by FTIR and XRD. Experiments with rabbits showed longer precorneal retention and higher distribution of fluorescence probe/model drug. In vitro cytological study, CG-GS-LDH nanocomposites exhibited enhanced cellular uptake compared to pure drug solution. Furthermore, the investigation of cellular uptake mechanisms demonstrated that both the active transport by PepT-1 and clathrin-mediated endocytosis were involved in the internalization of CG-GS-LDH intercalated nanocomposites. An ocular irritation study and a cytotoxicity test indicated that these nanocomposites produced no significant irritant effects.Conclusions The active targeting intercalated nanocomposites could have great potential for topical ocular drug delivery due to the capacity for prolonging the retention on the ocular surface, enhancing the drug permeability through the cornea, and efficiently delivering the drug to the targeted site.
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American Journal of Translational Research
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2018
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IF 3.061
Xionglin Chen,Wenxue Fu,Xiaoming Cao,He Jiang,Xiangxin Che,Xiaoyuan Xu,Baicheng Ma,Jie Zhang
Skin wound healing is complex and involves the processes of many factors, among which angiogenesis and inflammatory responses play important roles. New blood vessels provide nutrition and oxygen for skin wound repair. Cytokines in skin wounds, which include pro-inflammatory and anti-inflammatory factors, can modulate the inflammatory response. Therefore, treatment strategies that promote angiogenesis and modulate the inflammatory response in skin wounds can accelerate skin wound healing. This study explored the effects of peptide Ser-Ile-Lys-Val-Ala-Val (SIKVAV)-modified chitosan hydrogels in skin wound healing. General observation demonstrated that SIKVAV-modified chitosan hydrogels promoted the contraction of skin wounds compared with the negative and positive controls. Masson’s trichrome staining indicated that peptide-modified chitosan hydrogels accelerated the deposition of more collagen fibers in the skin wounds compared with the negative and positive controls. Immunohistochemistry assays showed that more myofibroblasts were deposited and more angiogenesis was found in skin wounds treated with peptide-modified chitosan hydrogels compared with the negative and positive controls. In addition, qRT-PCR assays showed that peptide-modified chitosan hydrogels promoted the expression of TGF-β1 (transforming growth factor-β1) mRNA and inhibited the expression of TNF-α (tumor necrosis factor-α) mRNA and IL-1β (Interleukin-1β) mRNA and IL-6 (Interleukin-6) mRNA in skin wounds. Taken together, these results indicate the potential of SIKVAV-modified chitosan hydrogels in skin wound healing as complex biomaterials.
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