ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 414
·期 6
·2275-2284
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IF 4.478
Ge Dianlong,Zhou Jijuan,Chu Yajing,Lu Yan,Zou Xue,Xia Lei,Liu Yawei,Huang Chaoqun,Shen Chengyin,Zhang Liwei,Wang Huanzhong,Chu Yannan
By means of glass bottle sampling followed by solid-phase microextraction gas chromatography-mass spectrometry (SPME-GC-MS) technique, the change characteristics of volatile organic compounds (VOCs) in breaths, between before gargling and after gargling, were investigated, respectively, in 41 healthy subjects and 50 esophageal cancer patients. Using an untargeted strategy, 143 VOC chromatographic peaks were enrolled in the statistical analysis. Based on the orthogonal partial least squares discriminant analysis (OPLS-DA), the VOC variations after gargling for each breath test group were obtained according to the combined criteria of variable importance in projection (VIP > 1.5), Wilcoxon signed-rank test ( P < 0.05), and fold change (FC > 2.0). When gargled, the levels of indole, phenol, 1-propanol, and p-cresol in the breath of healthy people decreased; meanwhile, for esophageal cancer patients, the declined VOCs in breath were indole, phenol, dimethyl disulfide, and p-cresol. Particularly, these substances were previously reported as breath biomarkers in some diseases such as esophageal, gastric, thyroid, breast, oral, and lung cancers, as well as certain non-cancer disorders. The present work indicates that expiratory VOCs involve the prominent oral cavity source, and in the breath biomarkers study, the potential impact that originates from oral volatiles should be considered. In view of the present results, it is also proposed that gargle pretreatment could eliminate possible interference from the oral cavity VOCs that might benefit breath biomarker investigation. Graphical abstract
Gargle pretreatment helps to distinguish oral-source VOCs and control their potential impact on breath biomarkers
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 3
·2115-2130
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IF 4.682
Huang Yingying,Zhao Hongmei,Chen Shaojuan,Wan Gang,Miao Dagang
The waterproof and breathable wound dressings have undergone continuous and substantial evolution over time. Polyethene films have been widely used to fabricate waterproof dressing. Electrospun biopolymers enable rapid and effective wound healing due to the surface-area-to-volume ratio of electrospun nanofibers and their porous structure. In the present study, the waterproof and breathable bandages were prepared with plasma-treated PE films as the waterproof layer and a blend of polyvinyl alcohol–alginic acid by electronic spinning technique. The composited samples were crosslinked with glutaraldehyde to increase their water stability and mechanical properties. The composited pieces were characterized for their structural properties using SEM, FTIR, DSC, TG. Their water vapour transmission rate, air permeability, tensile strength and antibacterial property were also studied. Cytotoxicity of the dressing was evaluated with human dermal fibroblast cells. The results revealed that the composited PVA/PE dressing shown excellent cooling ability, and improved the waterproof and breathable properties, which enhanced wound healing, compared with the traditional dressing material, such as cotton non-woven. Graphical abstract
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BMC Ophthalmology
·
2021
·Vol. 21
·期 1
·1-11
·
IF 2.209
Yu Mengdan,Zhang Lijun,Sun Shasha,Zhang Zhenhua
Background Diabetic retinopathy (DR) is a common and potentially devastating microvascular complication of diabetes mellitus (DM). The main features of DR are inflammation and oxidative damage. Gliquidone (GLI) is confirmed to be a hypoglycemic drug by oral administration. The current study is aimed to investigate the role and mechanism of GLI on the pathogenesis of DR.Methods High glucose (HG)-induced human retinal endothelial cells (HRECs) were used to explore the anti-inflammatory and anti-oxidant effects of GLI on DR in vitro. Streptozotocin (STZ)-induced DM rats were used to investigate the effects of GLI on retinal structures, inflammation, and oxidative stress. The levels of SIRT1/Notch1 pathway-related proteins were determined by western blotting.Results GLI treatment promoted the viability and inhibited the apoptosis of HG-induced HRECs. Meanwhile, the levels of interleukin (IL)-6, IL-1β, tumour necrosis factor alpha and reactive oxygen species were suppressed, while both catalase and superoxide dismutase were elevated after GLI treatment in HG-induced HRECs. Furthermore, we found that Silencing information regulator 2 related enzyme 1 (SIRT1) silencing reversed the inhibiting effects of GLI on the levels of protein Notch1 and effector genes Hes1 and Hey2. Similar anti-inflammatory and anti-oxidant effects of GLI in STZ-induced DM rats were observed. Additionally, GLI administration also repressed vascular hyperpermeability in vivo.Conclusion GLI may be an effective agent to improve DR through repression of inflammation and oxidative stress via SIRT1/Notch1 pathway.
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CELLULOSE
·
2023
·Vol. 30
·期 10
·6601-6619
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IF 5.7
Shan Zhiqiang,Jia Xiaohua,Tian Rui,Yang Jin,Wang Sizhe,Li Yong,Shao Dan,Feng Lei,Song Haojie
Shifting of the preparation strategy of paper-based friction materials from unsustainable to green, environmentally friendly, and recyclable constitutes an important part of low-carbon manufacturing. Herein, a solvent encapsulation strategy involving wood dissolution in a deep eutectic solvent and lignin–cellulose structural reorganization was adopted to obtain a recyclable wood-based slurry from poplar powder. Lignin–cellulose film (LCF) was obtained by vacuum filtration and followed by removal of moisture from slurry. Micro-nanocellulose was used as a reinforcement, which interacted with the lignin binder through hydrogen bonding. The average tensile strength and flexibility of LCF reached 68.7 MPa and 3.06 MJ m −3 respectively. With a minimum coefficient of friction of 0.19 and a minimum wear rate of 6.9 × 10 −3 mm 3 (N m) −1 , LCF could maintain long-lasting frictional stability in a stable condition. Moreover, the wood-based slurry could be easily recycled through convenient experimental treatments, or degraded by microorganisms in the natural environment within 40 days. This sustainable wood-based material obtained via a green and recyclable production strategy provides a promising alternative method to that of traditional paper-based friction materials. Graphical abstract Herein, a solvent encapsulation strategy which involved wood dissolution in deep eutectic solvent (DES) and lignin–cellulose structural reorganization was adopted to obtain recyclable wood-based films from poplar wood, which shows high mechanical strength, excellent flexibility, water stability, and high wear resistance.
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Nano Research
·
2023
·Vol. 16
·期 7
·9116-9124
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IF 9.9
Si Lianxi,Li Hui,Zhang Yu,Zhang Donghao,An Xiaowei,Yao Mengmeng,Shao Yuanyuan,Zhu Jesse,Hu Shi
Ultrathin Pd nanosheets (NSs) have great advantages in catalysis due to their large specific surface area and high percentage of under-coordinated atoms. However, the electrochemical performance still can be improved via composition-controllable growth of their solid solution. Herein, seeded alloying strategy was proposed to synthesize Pd-Cu solid solution from Pd NSs and Pd-Cu nanostructures with tunable molar ratios obtained by changing the amount of Cu precursor. As compared to the pristine Pd NSs, the Pd-Cu solid solution shows significantly enhanced methanol oxidation reaction (MOR) performance over those of Pd NSs and homemade Pd/C as the incorporation of Cu weakens the adsorption of CO intermediate on Pd in the MOR process. The choice of template is pivotal to the growth, as a shape-dependent behavior could be identified in the alloying of Cu with Pd nanosheets enclosed by {111} and {100} facets, Pd nanocubes enclosed by {100} facet, and Pd nano-tetrahedrons enclosed by {111} facet. The Pd-Cu solid solution with tunable composition can only be obtained from Pd NSs and the shape-dependent alloying process is mainly determined by the diffusion barrier and the minimum diffusion depth of the different facets.
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npj Quantum Materials
·
2023
·Vol. 8
·期 1
·1-7
·
IF 5.7
Xu R. Z.,Du X.,Zhou J. S.,Gu X.,Zhang Q. Q.,Li Y. D.,Zhao W. X.,Zheng F. W.,Arita M.,Shimada K.,Kim T. K.,Cacho C.,Guo Y. F.,Liu Z. K.,Chen Y. L.,Yang L. X.
TaTe 4 , a metallic charge-density wave (CDW) material discovered decades ago, has attracted renewed attention due to its rich interesting properties, such as pressure-induced superconductivity and candidate nontrivial topological phase. Here, using high-resolution angle-resolved photoemission spectroscopy and ab initio calculation, we systematically investigate the electronic structure of TaTe 4 . At 26 K, we observe a CDW gap as large as 290 meV, which persists up to 500 K. The CDW-modulated band structure shows a complex reconstruction that closely correlates with the lattice distortion. Inside the CDW gap, there exist highly dispersive energy bands contributing to the remnant Fermi surface and metallic behavior in the CDW state. Interestingly, our ab initio calculation reveals that the large CDW gap mainly opens in the electronic states with out-of-plane orbital components, while the in-gap metallic states originate from in-plane orbitals, suggesting an orbital texture that couples with the CDW order. Our results shed light on the interplay between electron, lattice, and orbital in quasi-one-dimensional CDW materials.
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BIOMETALS
·
2023
·
IF 3.5
Li Ye,Ma Yanxuan,Mu Chunyu,Gu Jiali,Li Zimu
The binding process between three species of chromium and serum albumin (SA) was investigated, as well as the interaction between K 2 Cr 2 O 7 and bovine serum albumin (BSA) under coexistence of different chromium forms. CrCl 3 , K 2 Cr 2 O 7 and Crpic bound to SA spontaneously through Van der Waals force, and their binding constants were 10 3 –10 4 M −1 at 298 K, respectively. K 2 Cr 2 O 7 and Crpic both had strong binding affinity for BSA, and significantly affected the secondary structure of BSA and the microenvironment surrounding amino acid residues. Chromium exhibited a greater fluorescence quenching constant towards HSA than toward BSA, and K 2 Cr 2 O 7 induced greater conformational changes in human serum albumin (HSA) than in BSA. A weak binding of CrCl 3 to BSA had no significant effect on the binding affinity of K 2 Cr 2 O 7 to BSA. K 2 Cr 2 O 7 and BSA have a greater binding affinity when coexisting with Crpic, and K 2 Cr 2 O 7 induces a greater conformational change in BSA.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Ren Suyu,Jin Xiaojie,Bekele Tadiyose Girma,Lv Min,Ding Jing,Tan Feng,Chen Lingxin
4-Methylbenzylidene camphor (4-MBC), a typical organic UV filter (OUVF) in personal care products, is considered to be a potential endocrine disruptor due to its estrogenic activity and bioaccumulation. Although 4-MBC residues have been extensively identified in aquatic waters, little is known about their occurrence, levels, and potential risk in coastal waters. This study developed a reliable sampling approach, based on diffusive gradients in thin films (DGT) with XAD-2 as the binding agent, for monitoring 4-MBC in coastal waters. The diffusion coefficients of 4-MBC in freshwater and artificial seawater were 3.65 × 10 −6 cm 2 /s and 3.83 × 10 −6 cm 2 /s, respectively. XAD-2 binding gel showed rapid adsorption to 4-MBC. The accumulated masses of 4-MBC in XAD-2 DGT increased linearly with deployed time for 7 days in freshwater and seawater, which agreed well with theoretical predictions. The sampling performance was independent of ionic strength (0.0001–0.5 M), pH (4.0–8.5), and dissolved organic matter (0–20 mg/L). Field deployment in the river estuary and bathing beach showed that DGT-measured 4-MBC concentrations were consistent in comparison with grab sampling. Environmental risk assessment showed that 4-MBC may pose a medium risk to aquatic organisms based on computed risk quotient (RQ) values. Sewage discharge is the main source of 4-MBC risk, while the residue in recreation beaches contributes more significantly in summer. The established DGT sampling is suitable for seasonal monitoring, source identification, and risk assessment of 4-MBC in coastal waters. Graphical abstract
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Biomaterials Research
·
2023
·Vol. 27
·期 1
·1-21
·
IF 11.3
Zhang Ying,Lei Hengyu,Wang Pengchong,Zhou Qinyuan,Yu Jie,Leng Xue,Ma Ruirui,Wang Danyang,Dong Kai,Xing Jianfeng,Dong Yalin
Background Reactive oxygen species (ROS) overproduction and excessive hypoxia play pivotal roles in the initiation and progression of ulcerative colitis (UC). Synergistic ROS scavenging and generating O2 could be a promising strategy for UC treatment.Methods Ceria nanozymes (PEG-CNPs) are fabricated using a modified reverse micelle method. We investigate hypoxia attenuating and ROS scavenging of PEG-CNPs in intestinal epithelial cells and RAW 264.7 macrophages and their effects on pro-inflammatory macrophages activation. Subsequently, we investigate the biodistribution, pharmacokinetic properties and long-term toxicity of PEG-CNPs in mice. PEG-CNPs are administered intravenously to mice with 2,4,6-trinitrobenzenesulfonic acid-induced colitis to test their colonic tissue targeting and assess their anti-inflammatory activity and mucosal healing properties in UC.Results PEG-CNPs exhibit multi-enzymatic activity that can scavenge ROS and generate O2, promote intestinal epithelial cell healing and inhibit pro-inflammatory macrophage activation, and have good biocompatibility. After intravenous administration of PEG-CNPs to colitis mice, they can enrich at the site of colonic inflammation, and reduce hypoxia-induced factor-1α expression in intestinal epithelial cells by scavenging ROS to generate O2, thus further promoting disrupted intestinal mucosal barrier restoration. Meanwhile, PEG-CNPs can effectively scavenge ROS in impaired colon tissues and relieve colonic macrophage hypoxia to suppress the pro-inflammatory macrophages activation, thereby preventing UC occurrence and development.Conclusion This study has provided a paradigm to utilize metallic nanozymes, and suggests that further materials engineering investigations could yield a facile method based on the pathological characteristics of UC for clinically managing UC.Graphical Abstract
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 31
·76867-76880
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IF 5.8
Huang Jiaqing,Liu Cenwei,Price Gordon W.,Wang Yixiang
Bacillus cellulasensis Zn-B isolated from vegetable soil was highly adaptable to Zinc (Zn) and Cadmium (Cd). Cd, but not Zn, adversely affected the total protein spectrum and functional groups of Bacillus cellulasensis Zn-B. Up to 31 metabolic pathways and 216 metabolites of Bacillus cellulasensis Zn-B were significantly changed by Zn and Cd (Zn&Cd). Some metabolic pathways and metabolites related to functional groups of sulfhydryl (-SH) and amine (-NH-) metabolism were enhanced by Zn&Cd addition. The cellulase activity of Bacillus cellulasensis Zn-B was up to 8.58 U mL −1 , increased to 10.77 U mL −1 in Bacillus cellulasensis Zn-B + 300 mg L −1 Zn, and maintained at 6.13 U mL −1 in Bacillus cellulasensis Zn-B + 50 mg L −1 Cd. The vegetables’ cellulose content was decreased by 25.05–52.37% and 40.28–70.70% under the action of Bacillus cellulasensis Zn-B and Bacillus cellulasensis Zn-B + 300 mg L −1 Zn. Those results demonstrated that Zn could significantly enhance cellulase activity and biodegradability of Bacillus cellulasensis Zn-B to vegetable cellulose. Bacillus cellulasensis Zn-B can survive in vegetable soil accumulated with Zn&Cd. The tolerance concentration and adsorption capacity of Bacillus cellulasensis Zn-B to Zn were up to 300 mg L −1 and 56.85%, indicating that Bacillus cellulasensis Zn-B acting as a thermostability biological agent had an essential advantage in accelerating the degradation of discarded vegetables by Zn and were beneficial to maintain organic matter content of vegetable soil. Graphical Abstract
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高影响因子
Advanced Composites and Hybrid Materials
·
2023
·Vol. 6
·期 3
·1-13
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IF 20.1
Ye Xin-Yao,Chen Yu,Yang Jing,Yang Hai-Yan,Wang Da-Wei,Xu Ben Bin,Ren Junna,Sridhar Deepak,Guo Zhanhu,Shi Zheng-Jun
The development of modern infrared detection technology has increased the possibility that military targets will be identified. Therefore, the task of protecting these targets is urgent extremely. The infrared stealth materials should be versatile to achieve the performance requirements of different applications and should be sustainable to achieve environmental friendliness. In order to solve this problem, an antimony doped tin oxide/silver/bamboo fibers (ATO-Ag-BFs) composite bamboo fabrics with multi-functional properties including infrared protection and antibacterial and hydrophobic properties were developed by the combination of ATO loading, chemical deposition, and hot press process. The ATO-Ag-BFs fabrics possessed plasmon resonance absorption properties of near-infrared light, which was attributed to the formation of Schottky junction by direct contact between Ag and ATO nanoparticles. The resulting ATO-Ag-BFs shows the infrared emissivity as low as 0.68 in the 8–14 μm thermal imaging band, which allowed the target to be blended adequately into environmental background. In addition, ATO-Ag-BFs treated with n-hexadecyl mercaptan exhibited remarkable hydrophobic properties with a water contact angle (WCA) of 147.7° compared to the non-hydrophobic treated ATO-Ag-BFs, which increased by 273.9%. Especially, the combination of Ag and ATO nanoparticles endowed bamboo fiber fabrics with outstanding antibacterial properties, with 100% inhibition of both Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). Overall, the multi-functional ATO-Ag-BFs based on bamboo fibers developed in this study can be applied in the field of wearable infrared and thermal radiation shielding to meet the requirements for concealment in harsh environments, proving that it is a tremendous potential candidate for infrared stealth materials. Graphical Abstract
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Science China-Chemistry
·
2023
·
IF 9.6
Tang Xianqing,Chen Jinghuang,Zhang Mengqian,Sun Jian,Yang Xiurong
Alkaline phosphatase (ALP) activity and pyrophosphate ion (PPi) levels are remarkable for the human body functions such as signal transduction pathways and metabolism. Current quantitative methods mainly focus on developing complicated organic substrates or employing unstable metal ions as signal-regulated medium. Herein, we have developed a facile hydrothermal method for preparing FeWO 4 nanomaterials with intrinsic peroxidase-like activity and further confirmed that such a catalytic activity could be significantly enhanced by adjusting the size and oxygen vacancy content. More encouragingly, PPi can easily inhibit the catalytic activity of FeWO 4 , whereas orthophosphate ions (Pi) cannot. Therefore, we constructed an FeWO 4 -based colorimetric assay for sensing PPi by means of the classical 3,3′,5,5′-tetramethylbenzidine-peroxidase chromogenic reaction. A facile and reliable ALP activity assay was also designed and developed because of the logical regulation of the peroxidase-like activity of FeWO 4 through the ALP-catalyzed hydrolysis of PPi into Pi. Based on the clear mechanism and mimetic-enzyme FeWO 4 -catalyzed amplification, the sensing system exhibited excellent performance and was able to evaluate ALP activity in real serum samples and screen for potential ALP inhibitors. The proposed mimetic enzyme-involved colorimetric assay provides an alternative pathway, and FeWO 4 nanomaterials with excellent performance have great potential for further biosensing and biomedical applications.
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危险品化学品经营许可证（带存储）