LASER PHYSICS LETTERS
·
2016
·Vol. 13
·期 9
·095602
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IF 2.391
Jing Wang,Xiongwei Wang,Shimiao Wang,Zheng Huang,Jun Liu
Chlorin e6 (Ce6), a large heterocyclic aromatic molecule, is a promising photosensitizer for photodynamic therapy (PDT). We propose an efficient nano-photosensitizer delivery system based on covalent interactions between Ce6 and polyethylenimine (PEI) coated carbon nanodots (CDots). We observed >50% Ce6 drug loading content for PEI, due to this compound's unique 'proton sponge effect.' We found that the covalently incorporated Ce6 molecules retained their functional properties for near-infrared (NIR) fluorescence imaging and PDT. The chemical characteristics of CDot-PEI-Ce6 and Ce6 were evaluated using different analytical methods, including transmission electron microscopy and UV–Visible absorption spectra. Time-correlated single photon counting (TCSPC) and fluorescence spectra were used to demonstrate that Ce6 successfully conjugated to the CDots. The high cellular uptake of CDots-PEI-Ce6 was confirmed using flow cytometry and confocal laser scanning microscopy. According to the MTT assay, the CDots-PEI-Ce6 exhibited low dark toxicity and efficient PDT efficacy to HeLa cancer cells. These results indicate that CDot-PEI-Ce6 conjugates are potential photosensitizer delivery systems for PDT.
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高影响因子
NEW CARBON MATERIALS
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2017
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IF 1.02
Shu-zhang Niu,Si-da Wu,Wei Lu,Quan-hong Yang,Fei-yu Kang
Porous carbon materials can increase the conductivity of sulfur and restrain the shuttling of polysulfides in the electrolyte. A hierarchical microporous-mesoporous carbon (HMMC) with a large surface area and pore volume was prepared by the simple one-step carbonization of a mixture of magnesium gluconate (MG) and phenolic resin. The MG was transformed into nanosize magnesium oxide that acted as a hard template during carbonization to create mesopores. The HMMC has a high surface area (∼1 560 m 2 g −1 ) and large pore volume (∼2.6 cm 3 g −1 ), which provides abundant space for sulfur loading and accommodates volume changes during charge/discharge. The interconnected pore structure and carbon framework ensure fast electron and Li ion transfer. As the cathode of a Li-S battery the sulfur-loaded HMMC has a high discharge capacity of 939 mAh g −1 at 0.3 C and a reversible capacity of 731 mAh g −1 after 150 cycles with only a 0.15% capacity fade per cycle. Even at a high rate of 2 C, it still delivers a high discharge capacity of 626 mAh g −1 , showing an excellent rate performance.
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Journal of Bionic Engineering
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2016
·
IF 1.466
Si Zhang,Yanting Lv,Long Zheng,Jiayi Li,Song Liang,Zhenning Liu,Luquan Ren
Natural composites have inspired the fabrication of various biomimetic composites that have achieved enhancement on certain mechanical performance. Herein, a facial approach enabled by recent advances in polyimine chemistry has been developed to fabricate bio-inspired hard-soft-integrated copolymers from two polyimines (i.e. PI-H and PI-S) with hardness differential. Subsequent evaluations of multiple mechanical properties on the bio-inspired copolymers with PI-S contents of full-range variability (0 wt%–100 wt%) have revealed extremal transitions for friction coefficients, impact strengths and tensile moduli. More interestingly, the minimum points of friction coefficients show a deformation-resisting response toward the change of applied loads, but not for the altered sliding speeds, suggesting a more significant role of load in determining the optimal anti-friction composition of the hard-soft integrated copolymers. These trends have been further corroborated by scanning electron microscopy of the worn specimens. Together these results have demonstrated that full-range extremal transitions exist on multiple mechanical properties for hard-soft-integrated copolymers, providing valuable insights to the design and fabrication of composite polymers for many applications. The polyimine-based approach outlined here also affords a convenient method to tune the ratio of two components in the copolymers within the full range of 0 wt%–100 wt%, enabling quick integration with high content variability.
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CHINESE JOURNAL OF CATALYSIS
·
2015
·
IF 1.964
Bing Cai,Wen-Hua Zhang,Jieshan Qiu
Control of the morphology and coverage of high-quality perovskite films is the main issue affecting planar-structured perovskite solar cells fabricated by solution processing. In this work, the solvent engineering of mixed solutions for spin-coating uniform perovskite thin films was investigated in detail by adding different ratios of N,N -dimethylformamide (DMF) or γ-butyrolactone (GBL) to dimethyl sulfoxide (DMSO). The morphology and film thickness of the resulting perovskite films were found to be significantly altered. At 20%~40% (volume fraction) of N , N -dimethylformamide mixed with DMSO, micrometer scale grains and reduced grain boundaries were observed on the highly uniform perovskite thin films. The optimized planar-structured perovskite solar cells showed power conversion efficiency as high as 16.5% and a stabilized efficiency of 14.4% at a fixed forward bias of 0.88 V.
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Biomedical Materials
·
2014
·Vol. 9
·期 1
·015007
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IF 2.922
Qi Wang,Pei Liu,Peifeng Liu,Tao Gong,Suming Li,Yourong Duan,Zhirong Zhang
Biodegradable chitosan-graft-polylactide (PLA–CS) copolymers were prepared by the grafting of a poly(L-lactide) (PLLA) or poly(D-lactide) (PDLA) precursor to the backbone of chitosan using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC ⋅ HCl) and N-hydroxysuccinimide (NHS) as a coupling agent. The blood and cell compatibility of the graft copolymers were investigated in comparison to PLLA and PDLA homopolymers. The coagulation properties of PLA–CS were evaluated by hemolysis, plasma recalcification, dynamic blood clotting and protein absorption assays. PLA–CS copolymers present similar hemolysis ratio and plasma recalcification time as PLA, but slower dynamic blood clotting and lower protein absorption. The cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), agar diffusion and lactate dehydrogenase (LDH) experiments. All the samples presented no effect on the viability to cells. Inflammatory cytokine analysis using sandwich ELISAs revealed that PLA–CS would not stimulate inflammatory activity.
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PubMed
高影响因子
CHINESE JOURNAL OF CATALYSIS
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2014
·
IF 1.552
Li Meng,Fangzhong Wang,Ao Wang,Jian Pu,Bo Chi,Jian Li
La 0.8 Sr 0.2 MnO 3 (LSM)-coated Ba 0.5 Sr 0.5 Co 0.8 Fe 0.2 O 3 (BSCF) composite powder (LSM-BSCF) was synthesized by a novel solid-solution method and investigated electrochemically as a cathode material for intermediate temperature solid oxide fuel cells. The cathode combined the merits of LSM and BSCF cathodes through an extended triple phase boundary and stabilized microstructure and demonstrated a polarization resistance between 0.61 and 0.09 Ω cm 2 at 600 to 750 °C. Compared with high performance cathodes prepared by solution impregnation, this LSM-BSCF cathode greatly improved performance stability.
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JOURNAL OF RARE EARTHS
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2014
·
IF 1.342
Xiaodong WU,Haining YU,Duan WENG,Shuang LIU,Jun FAN
MnO and CeO 2 powders were mechanically mixed by a spatula and by milling to obtain loose-contact and tight-contact mixed oxides, respectively. The monoxides and their physical mixtures were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), X-ray photoelectron spectroscopy (XPS), Raman, O 2 temperature-programmed desorption (O 2 -TPD), H 2 temperature-programmed reduction (H 2 -TPR) and NO temperature-programmed oxidation (NO-TPO). The MnO x -CeO 2 solid solutions did not form without any calcination process. The oxidation state of manganese tended to increase while the ionic valence of cerium decreased in the mixed oxides, accompanied with the formation of oxygen vacancies. This long-ranged electronic interaction occured more significantly in the tight-contact mixture of MnO and CeO 2 . The formation of more Mn 4+ and oxygen vacancies promoted the catalytic oxidation of NO in an oxygen-rich atmosphere.
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CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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2013
·
IF 0.769
Xi CUI,Qi-Rong XIONG,Yong-Hua XIONG,Shan SHAN,Wei-Hua LAI
In this study, immunomagnetic beads were prepared by coupling anti- Escherichia. coli O157:H7 monoclonal antibodies with magnetic beads. A colloidal gold test strip was composited with anti- E. coli O157:H7 monoclonal antibody marked by colloidal gold as the detection antibody, anti- E. coli O157:H7 polyclonal antibody as the test line, and donkey anti-mouse IgG secondary antibody as the control line. Immunomagnetic separation was coupled with colloidal gold lateral flow assay to detect E. coli O157:H7 rapidly. Results showed that 1 mL 7.6 × 10 3 colony-forming unit (CFU) mL 1 E. coli O157:H7 exhibited a positive outcome when colloidal gold lateral flow assay was performed after immunomagnetic separation. A food sample inoculated with 10 CFU/g E. coli O157:H7 after 6 h of enrichment could be detected within 72 min of immunomagnetic separation and colloidal gold lateral flow assay. The method proposed in this study could be used to on-site detect harmful substances in food significantly and rapidly.
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Biomedical Materials
·
2014
·Vol. 9
·期 3
·035008
·
IF 2.922
Hongjie Huang,Xin Zhang,Xiaoqing Hu,Linghui Dai,Jingxian Zhu,Zhentao Man,Haifeng Chen,Chunyan Zhou,Yingfang Ao
Hydrogels are attractive for cartilage tissue engineering because of their high plasticity and similarity with the native cartilage matrix. However, one critical drawback of hydrogels for osteochondral repair is their inadequate mechanical strength. To address this limitation, we constructed a solid-supported thermogel comprising a chitosan hydrogel system and demineralized bone matrix. Scanning electron microscopy, the equilibrium scanning ratio, the biodegradation rate, biomechanical tests, biochemical assays, metabolic activity tests, immunostaining and cartilage-specific gene expression analysis were used to evaluate the solid-supported thermogel. Compared with pure hydrogel or demineralized matrix, the hybrid biomaterial showed superior porosity, equilibrium swelling and degradation rate. The hybrid scaffolds exhibited an increased mechanical strength: 75% and 30% higher compared with pure hydrogels and demineralized matrix, respectively. After three days culture, bone-derived mesenchymal stem cells (BMSCs) maintained viability above 90% in all three materials; however, the cell retention of the hybrid scaffolds was more efficient and uniform than the other materials. Matrix production and chondrogenic differentiation of BMSCs in the hybrid scaffolds were superior to its precursors, based on glycosaminoglycan quantification and hyaline cartilage marker expression after three weeks in culture. Its easy preparation, favourable biophysical properties and chondrogenic capacity indicated that this solid-supported thermogel could be an attractive biomaterial framework for cartilage tissue engineering.
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PubMed
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2013
·
IF 0.769
Wei ZHANG,Fan-Jun MENG,Mei-Juan ZHOU,Peng LI,Jing-Jing ZHAO,Huai-Sheng WANG,Ji-Feng LIU,Chong ZHANG
3-Mercaptopropionic acid, Mg 2+ and nucleotide monophosphate (NTMP) including guanosine monophosphate (GMP), adenosine monophosphate (AMP), cytidine monophosphate (CMP) and uridine-5′-monophosphate (UMP) were adsorbed onto Au substrates stepwise to form nucleobases terminated surface. Electron transfer (ET) process across the NTMP/Mg 2+ /MPA/Au multilayer self-assembled film was studied and the ET kinetics were determined using electrochemical methods including cyclic voltammetry (CV), chronoamperometry (CA) and electrochemical impedance spectroscopy (EIS). The experimental results showed that the rate of ET kinetics decreased in the following order: GMP/Mg 2+ /MPA/Au > AMP/Mg 2+ /MPA/Au > UMP/Mg 2+ /MPA/Au > CMP/Mg 2+ /MPA/Au. The calculated energy gaps (Δ E gap = E LUMO - E HOMO ) of their corresponding Mg-NTMP complexes motif increased in the order: Δ E Mg-GMP (0.89 eV) < Δ E Mg-AMP (1.40 eV) < Δ E Mg-UMP (1.57 eV) < Δ E Mg-CMP (1.64 eV). The results suggest that the complexation of Mg with the NTMP, and their corresponding Δ E gap may play important role in their ET process across the nucleobases terminated multilayer self-assembled film.
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CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2014
·
IF 0.7
Ren-Dan ZHOU,Lai-Sheng LI,Biao-Ping CHENG,Gui-Zhen NIE,Hong-Fu ZHANG
A 6-azido-β-cyclodextrin was synthesized and derivatized with p -nitrophenyl isocyanate as chiral ligand. Then the ligand was chemically bonded to mesoporous SBA-15 via a ‘Click Chemistry’ reaction of the azido group with alkynyl group. A new p -nitrophenylcarbamoylated β-cyclodextrin bonded SBA-15 chiral stationary phase (NPCSP) for HPLC was thus obtained. The new stationary phase was first used for enantioseparation of propranolol in human plasma under the polar organic solvent mode. The effects of methanol content, concentration of glacial acetic acid/triethylamine in mobile phase and the temperature on the enantioseparation were studied in detail. The optimized chromatographic conditions were as follows: mobile phase was acetonitrile/methanol/glacial acetic acid/triethylamine (90/10/1.25/2.25, V/V ) at 288 K, with a flow rate of 0.5 mL min −1 , an injection volume of 20 μL and detection wavelength at 290 nm. The resolution was 2.04 with a short run time (< 15 min) under the optimal conditions. The content of propranolol in plasma was quantitatively measured by HPLC-MS under selected ion monitoring mode ([M + H] + m/z 260.10) with hydrochlorothiazide as an internal standard. The good linear relationship was observed in the range of 2.5−50 μg L −1 . The detection limits were 1 μg L −1 according to S/N = 3 for both enantiomers. The experimental results showed that the chiral stationary phase exhibited excellent chiral separation ability to propranolol. The analytical method for propranolol enantiomers was sensitive, accurate, simple and fast, which was can be for the determination of propranolol in plasma and related pharmacokinetic studies.
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Materials Research Express
·
2015
·Vol. 2
·期 9
·095021
·
IF 0
Chuhang Zhang,Yuanxin Feng
A gold (Au) nanoparticle (NP) supported photocatalyst is synthesized by vapor-depositing Au atoms onto SrTiO3 (100) and the photocatalytic water oxidation efficiency is investigated by measuring the photocurrent. Loading of Au NPs onto SrTiO3 dramatically improves the photocurrent and induces a visible-light response of SrTiO3. Small-sized NPs with plateau shape and larger NPs with spherical shape are more reactive under UV and visible irradiation, respectively. The maximum photocurrents under UV and visible-light illumination approach 7.0 mA cm−2 and 32.0 μA cm−2. The onset of visible light response is attributed to the localized surface plasmon resonance of the Au NPs.
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