Results in Engineering
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2024
·
IF 6
Wei Li,Shengxian Chen,Yongqi Lu,Jiangjie Yu,Shiguang Zhao
The co-immobilized laccase-mediator system (LMS) has broad development prospects in the fields of biocatalysis, biochemistry, and environmental remediation. In this study, laccase and mediator molecules were co-immobilized in functionally modified calcium alginate microspheres to improve their catalytic activity and stability and to systematically characterize the physicochemical properties and evaluate the catalytic performance of the co-immobilized laccase-mediator system. The co-immobilized LMS was used to catalyze the synthesis of theaflavins (TFs) from tea polyphenols, improve the catalytic efficiency, realize the recycling of the system, and explore the safety of the catalytic products. The results showed that the catalytic efficiency of the co-immobilized LMS was significantly improved and the relative activity remained above 50% after 10 cycles. The in vitro safety of the catalytic product was verified by Human hepatocellular carcinoma (HepG2) cell-related indexes. The results show that the co-immobilized laccase mediator system has great development potential in the industrial application of theaflavins.
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CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Jianing Wang,Hongcai Yu,Yunhui Min,Shulin Chen,Xiaotian Li,Ruihong Liang,Zhiyong Zhou,Bin Yang
Calcium bismuth niobate (CBN), known for its high Curie temperature ( T C ), has been investigated as a potential material for vibration sensor due to its ability to operate at elevated temperatures. However, the inherent weakness in piezoresponse of CBN has limited its sensing performance. In this study, a pseudo-tetragonal distortion in CBN was successfully induced by incorporating Ce 3+ ions into the (Bi 2 O 2 ) 2+ layers of CBN. This modification led to a change in the interaction between the perovskite and bismuth layers, resulting in enhanced piezoelectric and ferroelectric properties. Further enhancement was achieved by introducing Mn 4+ ions into the Ce 3+ -doped CBN. The co-doped CaBi 1.96 Ce 0.04 Nb 1.985 Mn 0.015 O 9 demonstrated a significantly improved piezoelectric coefficient ( d 33 ) of 15.9 pC/N, compared to 6.8 pC/N for pure CBN ceramics, and an increased remnant polarization ( P r ) of 20.78 μC/cm 2 , compared to the 3.83 μC/cm 2 of the pure material. This work not only deepens the understanding of bismuth-layer-structured ferroelectrics (BLSFs) but also presents a viable co-doping strategy to enhance the piezoresponse in CBN ceramics. This strategy could pave the way for the development of high-performance, high-temperature vibration sensors and potentially lead to the discovery of more novel BLSFs with superior performance.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Long Chen,Wen Xu,Zhongyu Yang,David Julian McClements,Xinwen Peng,Zhenlin Xu,Man Meng,Yidong Zou,Guanxiong Chen,Zhengyu Jin
Three nanoparticles were fabricated for the co-delivery of quercetin and resveratrol. Nanoparticles consisted of a zein and carboxymethyl cellulose assembled using antisolvent precipitation/layer-by-layer deposition method. Nanoparticles contained quercetin in the core and resveratrol in the shell, resveratrol in the core and quercetin in the shell or both quercetin and resveratrol in the core. The particle sizes of nanoparticles were 280.4, 214.8, and 181.8 nm, respectively. Zeta-potential was about −50 mV and PDI was about 0.3. The different positions of polyphenol distribution nanoparticles could reduce the competition between the two polyphenols, the encapsulation rate, loading rate and storage stability reached up to 91.7 %, 5.37 % and 97.1 %, respectively. FT-IR showed that hydrophobic and electrostatic interactions were the main driving forces of nanoparticle assembly. XRD showed that two polyphenols were successfully encapsulated in nanoparticles. TGA showed that distributing the nanoparticles in different layers would enhance thermal stability. TEM and SEM showed that polysaccharides attached to the surface of nanoparticles formed a core-shell structure with uniform particle size. All three nanoparticles could release two polyphenols slowly in simulated gastrointestinal digestion, Korsmeyer-Peppas was the most suitable kinetic release model. Therefore, biopolymer-based nanocarriers can be created to enhance the loading, stability, and bioaccessibility of co-encapsulated nutraceuticals.
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JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2024
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IF 11.2
Binrui Xu,Guangbin Wang,Yong Liu,Quanan Li,Fengzhang Ren,Jianmin Ma
The poor reversibility and stability of Zn anodes greatly restrict the practical application of aqueous Zn-ion batteries (AZIBs), resulting from the uncontrollable dendrite growth and H 2 O-induced side reactions during cycling. Electrolyte additive modification is considered one of the most effective and simplest methods for solving the aforementioned problems. Herein, the pyridine derivatives (PD) including 2,4-dihydroxypyridine (2,4-DHP), 2,3-dihydroxypyridine (2,3-DHP), and 2-hydroxypyrdine (2-DHP), were employed as novel electrolyte additives in ZnSO 4 electrolyte. Both density functional theory calculation and experimental findings demonstrated that the incorporation of PD additives into the electrolyte effectively modulates the solvation structure of hydrated Zn ions, thereby suppressing side reactions in AZIBs. Additionally, the adsorption of PD molecules on the zinc anode surface contributed to uniform Zn deposition and dendrite growth inhibition. Consequently, a 2,4-DHP-modified Zn/Zn symmetrical cell achieved an extremely long cyclic stability up to 5650 h at 1 mA cm –2 . Furthermore, the Zn/NH 4 V 4 O 10 full cell with 2,4-DHP-containing electrolyte exhibited an outstanding initial capacity of 204 mAh g –1 , with a notable capacity retention of 79% after 1000 cycles at 5 A g –1 . Hence, this study expands the selection of electrolyte additives for AZIBs, and the working mechanism of PD additives provides new insights for electrolyte modification enabling highly reversible zinc anode.
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SAUDI PHARMACEUTICAL JOURNAL
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2024
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IF 3
Yao Yao,Qian Zhao,Feng Xu,Tingting Yao
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. Sorafenib (Sf) is currently the first-line treatment for HCC. However, due to the side effects and unsatisfied efficiency of Sf, it is urgent to combine different therapeutic agents to inhibit HCC progression and increase the therapeutic efficacy. Here, our study constructed a Sf and KIAA1199-siRNA co-loaded liposome Sf-Lp-KIAA, which was prepared by electrostatic interaction of KIAA1199-siRNA and Sf loaded liposome (Sf-Lp). The particle size, zeta potential, the in vitro cumulative release was investigated. The physical and chemical properties were characterized, and the inhibition of HepG2 growth and metastasis in vitro was investigated. The cellular uptake of the co-loaded liposome was significantly higher than that of free siRNA, and the drug/siRNA could be co-delivered to the target cells. Sf-Lp-KIAA could significantly inhibit the growth, migration, invasion and down-regulate KIAA1199 expression of HepG2 cells in vitro than that of single Sf treated group. In addition, the co-delivery liposome accumulated in the HepG2 subcutaneous tumor model and suppress tumor growth after systemic administration without induce obvious toxicity. The present study implied that the co-delivery of Sf and KIAA1199-siRNA through the co-loaded liposomes exerted synergistic antitumor effects on HCC, which would lay a foundation for HCC therapy in the future.
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Journal of Materials Chemistry A
·
2024
·Vol. 12
·期 48
·33917-33925
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IF 10.7
Yi Ma,Luming Li,Jialing Tang,Zongkun Hu,Yong Zhang,Huan Ge,Ning Jian,Jun Zhao,Andreu Cabot,Junshan Li
Plastics have become an integral part of modern society due to their excellent mechanical properties, light weight, chemical stability and low cost. However, their continuous production and use worldwide have resulted in a major environmental problem. In this context, the green degradation and upcycling of waste plastics using electrochemical oxidation present a promising solution. To make this solution practical, the development of cost-effective catalysts optimized for this reaction is essential. In this study, we propose a new catalyst for the electrocatalytic reforming of ethylene glycol (EG) derived from polyethylene terephthalate (PET) to formic acid. The catalyst comprises layered Ni–Co9S8 nanosheet arrays (NSAs) grown on nickel foam (NF) via the hydrothermal method. Under EG oxidation reaction (EGOR) conditions, the Ni–Co9S8 NSAs/NF catalyst achieves Faraday efficiencies (FEs) of up to 92%. Additionally, the direct use of commercial PET plastic powder hydrolysate still enables formate FEs to exceed 90%. These outstanding results are rationalized using density functional theory (DFT) calculations providing insights into the role of the different elements in the EGOR. Overall, this study demonstrates both a synthetic strategy for transition metal sulfides and an efficient and sustainable strategy for the upgraded recycling of PET plastics.
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Journal of Energy Chemistry
·
2024
·
IF 14
Wenkang Miao,Ronghui Hao,Lu Gan,Wanyin Xu,Zihan Wang,Wenxin Lin,Heguang Liu,Yinchun Lyu,Qianqian Li,Jinyang Xi,Anmin Nie,Jinsong Wu,Hongtao Wang
Platinum-based (Pt) catalysts are notoriously susceptible to deactivation in industrial chemical processes due to carbon monoxide (CO) poisoning. Overcoming this poisoning deactivation of Pt-based catalysts while enhancing their catalytic activity, selectivity, and durability remains a major challenge. Herein, we propose a strategy to enhance the CO tolerance of Pt clusters (Pt n ) by introducing neighboring functionalized guest single atoms (such as Fe, Co, Ni, Cu, Sb, and Bi). Among them, antimony (Sb) single atoms (SAs) exhibit significant performance enhancement, achieving 99% CO selectivity and 33.6% CO 2 conversion at 450 °C. Experimental results and density functional theory (DFT) calculations indicate the optimization arises from the electronic interaction between neighboring functionalized Sb SAs and Pt clusters, leading to optimal 5 d electron redistribution in Pt clusters compared to other functionalized guest single atoms. The redistribution of 5 d electrons weaken both the σ donation and π backdonation interactions, resulting in a weakened bond strength with CO and enhancing catalyst activity and selectivity. In situ environmental transmission electron microscopy (ETEM) further demonstrates the exception thermal stability of the catalyst, even under H 2 at 700 °C. Notably, the functionalized Sb SAs also improve CO tolerance in various heterogenous catalysts, including Co/CeO 2 , Ni/CeO 2 , Pt/Al 2 O 3 , and Pt/CeO 2 -C. This finding provides an effective approach to overcome the primary challenge of CO poisoning in Pt-based catalysts, making their broader applications in various industrial catalysts.
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MOLECULES
·
2024
·Vol. 29
·期 21
·4994
·
IF 4.2
Fan Ma,Hong-Wei Lin,Zizi Li,Wen-Jing Li,Jia-Wei Wang,Gangfeng Ouyang
Noble-metal-free CO2reduction systems based on cobalt phthalocyanine (CoPc) and its derivatives have demonstrated remarkable photocatalytic performances; however, their structure-activity relationship with electronic tuning remains unexplored. Herein, we now provide a systematic study to investigate the electron effects of substituents on theCoPcfamily in photocatalytic CO2reduction, where a Cu(I) heteroleptic photosensitizer is utilized. The highest performance can be achieved using cobalt tetracarboxylphthalocyanine in light-driven CO2-to-CO reduction, with a maximum turnover number of 2950 at 450 nm and an outstanding apparent quantum yield of 63.5% at 425 nm, over ten times the activity with the tetra-dimethylamino-substitutedCoPcderivative. The favorable electron-withdrawing effects have been further verified by DFT calculations and cyclic voltammetry, which reduces the overpotential required for CO2reduction and decreases the Gibbs free energy of the catalyst active intermediates, particularly the CO-desorption energetics.
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FUEL
·
2024
·
IF 6.7
Yuhang Jing,Feng Gong,Sijun Wang,Wenbin Wang,Peng Yang,Enkang Fu,Rui Xiao
Plasma-assisted ammonia synthesis (PAAS) can produce ammonia using highly energetic, electronically excited nitrogen and Hydrogen radicals at low temperatures and atmospheric pressure, which has been regarded as a prospective alternative to the Haber − Bosch process. PAAS can exclusively use renewable power (solar, wind, etc.) to achieve green, decentralized and efficient ammonia synthesis. However, current catalysts for PAAS are suffering from low efficiency, poor stability and cyclability. Herein, we demonstrate a one-step hydrothermal synthesis of Ni-Co bimetallic metal–organic frameworks (MOFs) for PAAS. Attributed to the amplified gas transport capability and bimetallic coupling, the Ni-Co-MOF exhibits significantly improved PAAS performance: 88.21 μmol g −1 ·min −1 , above 30 % increase over 5 wt% Ni/Al 2 O 3 . The high stability of Ni-Co-MOF under the harsh electric field enables its durable performance (36 h) and excellent cyclability (24 cycles). Finally, to determine the viability of PAAS for industrial applications, we construct a hypothetical zero-carbon ammonia plant using only renewable energy sources, and the outcomes indicate that PAAS has significant competitiveness for future ammonia production.
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JOURNAL OF HAZARDOUS MATERIALS
·
2024
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IF 12.2
Zhi Mei,Fang Wang,Yuhao Fu,Yu Liu,Syed A. Hashsham,Yu Wang,Jean Damascene Harindintwali,Qingyuan Dou,Marko Virta,Xin Jiang,Yu Deng,Tong Zhang,James M. Tiedje
Reducing antibiotic levels in soil ecosystems is vital to curb the dissemination of antimicrobial resistance genes (ARGs) and mitigate global health threats. However, gaps persist in understanding how antibiotic resistome can be suppressed during antibiotic degradation. Herein, we investigate the efficacy of a biochar biofilm incorporating antibiotics-degrading bacterial strain ( Arthrobacter sp. D2) to mitigate antibiotic resistome in non-manured and manure-amended soils with sulfadiazine (SDZ) and trimethoprim (TMP) contamination. Results show that biofilm enhanced SDZ degradation by 83.0% within three days and increased TMP attenuation by 55.4% over 60 days in non-manured soils. In the non-manured black soil, the relative abundance of ARGs increased initially after biofilm inoculation. However, by day 30, it decreased by 20.5% compared to the controls. Moreover, after 7 days, biofilm reduced TMP by 38.5% in manured soils and decreased the total ARG abundance by 19.0%. Thus, while SDZ degradation did not increase sulfonamide resistance genes, TMP dissipation led to a proliferation of insertion sequences and related TMP resistance genes. This study underscores the importance of antibiotic degradation in reducing related ARGs while cautioning against the potential proliferation and various ARGs transfer by resistant microorganisms.
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Polymers
·
2024
·Vol. 16
·期 6
·805
·
IF 4.7
Xinyuan Wan,Xiaojian Xia,Yunxiang Chen,Deyuan Lin,Yi Zhou,Rui Xiong
Thermal conductive coating materials with combination of mechanical robustness, good adhesion and electrical insulation are in high demand in the electronics industry. However, very few progresses have been achieved in constructing a highly thermal conductive composites coating that can conformably coat on desired subjects for efficient thermal dissipation, due to their lack of materials design and structure control. Herein, we report a bioinspired thermal conductive coating material from cellulose nanofibers (CNFs), boron nitride (BN), and polydopamine (PDA) by mimicking the layered structure of nacre. Owing to the strong interfacial strength, mechanical robustness, and high thermal conductivity of CNFs, they do not only enhance the exfoliation and dispersion of BN nanoplates, but also bridge BN nanoplates to achieve superior thermal and mechanical performance. The resulting composites coating exhibits a high thermal conductivity of 13.8 W/(m·K) that surpasses most of the reported thermal conductive composites coating owing to the formation of an efficient thermal conductive pathway in the layered structure. Additionally, the coating material has good interface adhesion to conformably wrap around various substrates by scalable spray coating, combined with good mechanical robustness, sustainability, electrical insulation, low-cost, and easy processability, which makes our materials attractive for electronic packaging applications.
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Acta Biomaterialia
·
2024
·
IF 9.4
Pinxin Lv,Zhanfeng Wang,Xinghui Si,Jing Su,Zhifei Yu,Hongquan Yu,Guofeng Ji,Wantong Song
Glioblastoma (GBM), a prevalent and aggressive brain tumor, poses significant treatment challenges due to its rapid progression and the difficulty in achieving complete surgical resection. The current treatment regime, primarily surgery followed by radiotherapy and chemotherapy, offers limited success, with a five-year survival rate of less than 10%. For addressing the challenges faced in the treatment of GBM, an approach using a biopolymer implant constructed with dynamic reversible covalent bonds, was designed to achieve controlled and constant-rate release of chemotherapy drug (Temozolomide, TMZ), immune adjuvant (Resiquimod, R848) and checkpoint inhibitor (5-carboxy-8-hydroxyquinoline, IOX1). The safety evaluation demonstrated the biocompatibility of the implants, with no significant inflammatory response or adverse effects on various systemic organs. In vivo antitumor study showed that the local delivery of drug combination via this implant significantly inhibited tumor recurrence of orthotopic GBM. Immune analysis revealed that the combination of the three drugs effectively activated systemic antitumor immune responses and induced memory effects. The synergistic mechanism of the drug combination was further validated by RNA whole sequencing. The innovative approach of combining chemotherapy and immunotherapy in biopolymer immune implants for GBM treatment showed promising and opens new avenues for treating GBM, particularly in addressing postoperative recurrence. Statement of Significance Our research introduces a pioneering approach in treating orthotopic brain glioblastoma (GBM), characterized by inevitable tumor recurrence, poor immune infiltration and the restrictive nature of the blood-brain barrier. To break the impasse of ineffective treatment for GBM, the innovative use of dynamically reversible covalent bonds in polymer matrix ensures the controlled, stable and sustained release of drug combinations of the chemotherapeutic agent temozolomide, immune adjuvants and checkpoint inhibitors, which maintains the optimal concentration in the tumor, overcoming problems associated with conventional chemotherapy such as systemic toxicity and low tumor targeting. Empirical evidence from in vivo experiments on the rat GBM model demonstrates significant outcomes: 90% tumor size reduction and prolonged survival with over 70% tumor cure rate.
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