Scientific Reports
·
2025
·Vol. 15
·期 1
·1-11
·
IF 3.9
Li Wenlan,Zhang Zijie,Jiang Zixiao,Barasarathi Jayanthi,Zhou Ying,Liu Sui,Lee Shiou Yih,Liu Yangyang
Psychotria rubra Herbal Tea (PRHT) is a traditional Chinese folk medicine used to treat in-flammation induced by respiratory infections. Its specific mechanisms of action, however, remain unclear. The study combined ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS), network pharmacology, and in vitro cell experiments to systematically analyze the chemical composition and validate the biological activity of PRHT. Protein-protein interaction (PPI) network analysis and molecular docking were used to identify key targets and mechanisms. PRHT was found to contain 128 active compounds, including alkaloids, amino acids and their derivatives, and flavonoids. Key targets such as STAT3, IL-6, and TP53 were identified through PPI network analysis. PRHT exhibited significant anti-inflammatory effects by modulating the STAT3/IL-6/TNF-α signaling pathway. Experimental results demonstrated that PRHT inhibited the release of inflammatory cytokines in a dose-dependent manner. Molecular docking confirmed strong interactions between PRHT components and core targets. The study reveals that PRHT exerts anti-inflammatory effects by regulating the STAT3/IL-6/TNF-α signaling pathway, contributing to inflammation balance and tis-sue repair. These findings provide scientific evidence for the development of PRHT as a functional anti-inflammatory agent and offer new insights into treatment strategies for respiratory infections.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Guo Qiubo,Han Shuai,Lu Yaxiang,Xiao Ruijuan,Li Jin,Hao Qingli,Rong Xiaohui,Weng Suting,Niu Yaoshen,Ding Feixiang,Yang Yang,Xia Hui,Wang Xuefeng,Xie Fei,Zhou Lin,Hou Xueyan,Li Hong,Huang Xuejie,Chen Liquan,Hu Yong-Sheng
Prussian blue analogues (PBAs) are promising electrode candidates for aqueous batteries because the inevitable interstitial water is generally thought to have little impact on battery performance. Currently, mounting researches have focused on optimizing PBA properties by varying transition metal composition, but less attention has been paid to interstitial water, especially in alkali metal-ion deficient PBAs with large cavities. Here, we employ the water-rich K 0.01 Mn[Cr(CN) 6 ] 0.74 ·4.75H 2 O as the negative electrode to study the effect of interstitial water. It is found that during de-potassiation, the electrode undergoes dehydration, which negatively impacts kinetics, distorts structure, and raises charging potential. A cation-self-shielding strategy involving Dihydroxyacetone (DHA) in the electrolyte to secure the water-rich state is then proposed. The built 1.82 V all-Prussian blue aqueous K-ion battery delivers a high practical specific energy of ~76 Wh kg −1 over 1.5 V (based on the total mass of active materials in both electrodes). This study reveals the significance of interstitial water on the kinetics of PBA negative electrodes and promotes the exploration of water-containing electrodes to develop high-voltage aqueous rechargeable batteries for energy storage applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Chang Linhui,Cheng Hongwei,Li Jiamin,Zhang Lei,Zhang Bomian,Zheng Liheng,Sun Qiangchao,Li Jiantao,Lu Xionggang,Zhao Kangning
Aqueous zinc-ion batteries offer sustainable large-scale storage potential with inherent safety and low cost, yet suffer from limited energy density and cycle life due to aqueous electrolyte constraints. Here, we introduce affordable, stable electrolyte (0.33 $·kg −1 ) incorporating minimal multi-halogen anions (Cl − , Br − , and I − ) to create a high-entropy solvation structure enabling high-performance zinc batteries. Despite the small amount, the diversified mono-halogenated contact ion pair and multi-halogenated aggregate solvation structures create the unique high-entropy solvation structure, to form the lean-water halogenated interfacial environment, suppressing the hydrogen evolution reaction, while facilitating cascade desolvation. Multi-halogen additives generate diverse contact ion pairs (Zn-X, X = Cl/Br/I) with compact solvation shells accelerating ion transport. In this way, the high-entropy solvation structure breaks the trade-off between plating overpotential (energy efficiency) and plating/stripping reversibility (Coulombic efficiency). As a result, the high-entropy solvation-based electrolyte enables practical zinc metal battery with 152.2 Wh kg − 1 electrode for 120 cycles at lean electrolyte of 2.4 μL mg − 1 and an Ah-level pouch cell is validated with high Coulombic efficiency of over 99.90% for over 250 cycles. Our findings emphasize the importance of electrolyte design for the precise control of anion-cation interactions for stable Zn/electrolyte interface and enable practical zinc metal battery with high energy and low cost.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2025
·Vol. 43
·期 4
·588-596
·
IF 4
Yuan Ling-Xin,Liu Chang-Yue,Yang Ji-Ping,Wang Zhi-Jian
Soft robots have shown great advantages with simple structure, high degree of freedom, continuous deformation, and benign human-machine interaction. In the past decades, a variety of soft robots, including crawling, jumping, swimming, and climbing robots, have been developed inspired by living creatures. However, most of the reported bionic soft robots have only a single mode of motion, which limits their practical application. Herein, we report a fully 3D printed crawling and flipping soft robot using liquid metal incorporated liquid crystal elastomer (LM-LCE) composite as the actuator. With the application of voltage, liquid metal works as the conductive Joule heating material to induce the contraction of the LCE layer. The bending angle of the LM-LCE composite actuator highly depends on the applied voltage. We further demonstrate that the soft robot can exhibit distinct moving behaviors, such as crawling or flipping, by applying different voltages. The fully 3D printed LM-LCE composite structure provides a strategy for the fast construction of soft robots with diverse motion modes.
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2025
·Vol. 43
·期 9
·1671-1680
·
IF 4
Wu Zi-Shuo,Deng Jia-Ying,Chen Wei
The deformation mechanism of glycerol plasticized poly(vinyl alcohol) (PVA) with different hydrolyses (88%, 92%, 98%) at elevated temperatures (60–100 °C) was elucidated by in situ synchrotron radiation X-ray scattering. The vinyl acetate (VAc) in PVA acts as a non-crystalline chain defect, which significantly influences the plastic deformation and stretching-induced crystallization behavior of PVA. The key microstructural parameters of PVA during deformation, such as crystallinity ( χ c ), lateral crystallite size ( L ), and long period ( l ), in combination with the stress-strain curves, were obtained. The experimental results show that the deformation process of the plasticized PVA film present a three-stage evolution: (i) a plastic deformation zone. The plastic deformation of the crystallite occurs as evidenced by the apparent decrease in crystallinity and lamellar reorientation induced by stretching; (ii) the stress softening zone. The decreasing trend of crystallinity becomes slow, and the long period becomes smaller, which indicates that PVA crystallization is induced by stretching; and (iii) the strain-hardening zone. There is a synergistic effect between the crystallite destruction and formation. Further research reveals that a high temperature and low degree of alcoholysis favor the stretching-induced crystallization of PVA, while the system with a high degree of alcoholysis shows significant characteristics of preferred crystal growth.
✓ 已验证
产品关联
DOI
高影响因子
Electrocatalysis
·
2025
·
IF 2.8
Gao Hongmin,Deng Jiahe,Zhang Hehua,Chen Hua,Zhou Yang,Qu Pu,Zhu Huan,Chang Dong,Pan Hongzhi
Developing portable, accurate, cost-effective hydrogen peroxide (H 2 O 2 ) detection platforms is essential for industrial applications and early disease diagnosis. Metal–organic frameworks (MOFs) based composites integrated with metal nanoparticles have been intensively investigated in electrochemical sensing, attributable to their unique architecture and performance characteristics. Herein, PdNPs@NH 2 -MIL-101(Fe) nanocomposites were synthesized via a green reduction process using tannic acid and applied in the development of an enzyme-free electrochemical sensor for H 2 O 2 detection. The synergistic effect of the Pd nanoparticles and the MOFs matrix provided abundant active sites and enhanced electron transfer capability, enabling the sensor to exhibit excellent electrocatalytic performance. Under optimal conditions, the sensing platform exhibited a wide linear response from 10 μM to 15 mM, with a detection threshold of 3.6 μM (S/N = 3). Furthermore, the sensor achieved reliable detection of exogenous H 2 O 2 in commercial mouthwash samples and intracellularly generated H 2 O 2 by cancer cells (HepG2), underscoring its effectiveness in practical scenarios. This work presents a novel strategy for synthesizing high-performance composite nanomaterials and offers valuable insights into the large-scale application of electrochemical sensors for H 2 O 2 detection. Graphical
✓ 已验证
产品关联
DOI
高影响因子
CARDIOVASCULAR DRUGS AND THERAPY
·
2025
·
IF 3.1
Li Yuanbin,Feng Chuanping,Lin Hui,Li Hui,Zeng Wei,Dong Xiaoyan,Chen Zhuang
Purpose While reperfusion is essential for restoring blood flow, it can paradoxically exacerbate myocardial injury by disrupting energy metabolism, leading to cell necrosis, apoptosis, and structural damage. Despite the significance of ischemia–reperfusion (I/R) injury, effective treatments remain scarce, highlighting the need for a deeper understanding of its underlying mechanisms to develop targeted therapies. Methods A rat model of myocardial I/R injury and a H9c2 cell-based hypoxia/reoxygenation (H/R) model were utilized for primary validation. HOXB5 was overexpressed several days prior to I/R or H/R induction. Gene and protein expression were assessed by RT-qPCR, Western blotting, immunohistochemistry, and immunofluorescence. Cell viability and apoptosis were evaluated using CCK-8 and flow cytometry. Mitochondrial function and ferroptosis were analyzed by commercial kits. The regulatory relationship among Lin28a, HOXB5, and Sirt5 was examined using RIP, ChIP-PCR, and dual-luciferase assays. Results HOXB5 expression was significantly reduced in infarcted myocardial tissue following I/R injury, of which overexpression attenuated H/R-trigged apoptosis to motivate H9c2 cell survival. Meanwhile, HOXB5 overexpression decreased mitochondrial ROS production, improved mitochondrial respiration, mitochondrial complexes (I, II, III, and V) activity, and reduced mitophagy under H/R conditions in H9c2 cells. Mechanistically, Lin28A was identified as a regulator of HOXB5, which in turn transcriptionally activated Sirt5. Furthermore, the protective effects of HOXB5 overexpression on myocardial histological damage and cardiac function through modulating ferroptosis in rats' I/R injury was abrogated by Sirt5 knockdown. Conclusion Our study reveals the crucial role of HOXB5 in maintaining mitochondrial homeostasis and regulating mitophagy, which in turn protects cardiomyocytes from I/R injury through Sirt5. These findings underscore the HOXB5-Sirt5 pathway as a promising therapeutic target for mitigating I/R injury.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Yin Shijie,Li Jianguo,Lai Zhuozhi,Meng Qing-Wei,Xian Weipeng,Dai Zhifeng,Wang Sai,Zhang Li,Xiong Yubing,Ma Shengqian,Sun Qi
Efficient energy conversion using ions as carriers necessitates membranes that sustain high permselectivity in high salinity conditions, which presents a significant challenge. This study addresses the issue by manipulating the linkages in covalent-organic-framework membranes, altering the distribution of electrostatic potentials and thereby influencing the short-range interactions between ions and membranes. We show that a charge-neutral covalent-organic-framework membrane with β-ketoenamine linkages achieves record permselectivity in high salinity environments. Additionally, the membrane retains its permselectivity under temperature gradients, providing a method for converting low-grade waste heat into electrical energy. Experiments reveal that with a 3 M KCl solution and a 50 K temperature difference, the membrane generates an output power density of 5.70 W m −2 . Furthermore, guided by a short-range ionic screening mechanism, the membrane exhibits adaptable permselectivity, allowing reversible and controllable operations by finely adjusting charge polarity and magnitude on the membrane’s channel surfaces via ion adsorption. Notably, treatment with K 3 PO 4 solutions significantly enhances permselectivity, resulting in a giant output power density of 20.22 W m −2 , a 3.6-fold increase over the untreated membrane, setting a benchmark for converting low-grade heat into electrical energy.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2024
·
IF 1.5
Lei Sijie,Lin Xiaoyan,Han Qiang
In this study, polyacrylonitrile was modified to polyamidoxime to enhance foam stabilization and decontamination rate. Polyamidoxime was combined with graphene oxide, 1 wt% of saponins, and 1 wt% of alkyl glycosides to formulate the PAO/GO foam decontaminant. The outcomes demonstrated resulted in the half-life of the foam extending from 32 to 308 min. The PAO/GO foam decontaminant displayed α-ray decontamination rates of 93.30%, 98.34%, and 99.81% on stainless steel, tile, and glass surfaces. Hence, the dual functional PAO/GO in stabilizing foam while enhancing decontamination rates underscores its potential for radioactive decontamination.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 11
·1-11
·
IF 5.3
Zhu Guancheng,Zou Jiahui,Lin Xueer,Zhong Huimin,Jiang Cong,Huang Yanyan
By self-assembly of MnCl 2 and arginine under alkaline conditions, ultra-small MnArg nanoparticles were successfully constructed as oxidase (OXD) mimics for intelligent detection of the Ginkgo toxin 4′- O -methylpyridoxal (MPN). The obtained MnArg nanozymes possessed excellent OXD-like activity and thermal stability. Based on the inhibitory effect of MPN for the catalytic activity of MnArg, this system was utilized for the colorimetric sensing of MPN with a low limit of detection (LOD) of 2.16 µg mL −1 . The detection system exhibited good selectivity against other potential interferents. FTIR data showed that the presence of MPN binds with MnArg and shields the active sites, thereby interfering with the oxidase-like activity. Combined with a smartphone and the ColorMax software, this nanozyme-based intelligent detection platform could effectively detect MPN with a LOD of 2.1 µg mL −1 . Our MnArg nanozyme–based system was applied to detect real ginkgo nut samples with recoveries of 92.4–108.7%, and the relative standard deviations were less than 0.7%. This work may promote the development of novel nanozymes and expand their applications in the field of food safety detection. Graphical Abstract
✓ 已验证
DOI
PubMed
高影响因子
Beni-Suef University Journal of Basic and Applied Sciences
·
2025
·Vol. 14
·期 1
·1-33
·
IF 2.6
Abd El-Kaream Samir Ali,Ahmed Yara Ahmed Mohamed Elsaid Mohamed,Mohamed Mohamed Hagar,Soliman Amal Saleh Mohamed,Hussein Nabila Gaber Ali,El Kholey Sohier Mahmoud
There is no doubt that one of the most considerable researcher dilemmas is cancer. Radiofrequency-photodynamic therapy (RFPDT) offers novel approaches to cancer treatment by combining radiofrequency-dynamic therapy and photodynamic therapy with sensitizers. While novel sensitizers for RFPDT have been synthesized successfully, their effective application is still limited. Their limited ability to transfer sensitizer's deeper intratumorally, low tumor-targeting selectivity, and failing tumor microenvironment all restrict their anti-tumor activity. The goal of the current work was to examine the most recent advancement in activated cancer treatment using radiofrequency assisted drug delivery of conjugated activated carbon nanoparticles of broccoli, cabbage, and kale (BCK-ACNP) to treat colorectal cancer (CRCA) using both in vivo and in vitro RFPDT.The current study included human CRCA cells (SW-620) and Swiss albino induce CRCA mice [treated with 1,2-dimethylhydrazine (DMH) and dextran sulphate sodium (DSS) only] were used in the in vitro and in vivo study. The study treatment protocol started only after CRCA induction, and involved daily administration of BCK-ACNP as RFPDT sensitizer whether or not to be exposed to laser (IRL) or radiofrequency (RF) or a combination of them for 3 min for a period of 2 weeks.Demonstrated that ACNP is a useful BCK delivery mechanism that targets CRCA cells directly. Furthermore, BCK-ACNP is a promising RFPS that, when used in conjunction with RFPDT, can be very effective in in vitro treating CRCA-SW-620 (in a dose-dependent manner cell viability declined, an increase in the population of cells during the S and G2/M phases indicates that the cell cycle was arrested, and an increase in the Pre-G cell population, autophagic cell death, as well as early and late apoptosis and necrosis, indicate that cell death was induced) and DMH/DSS-CRCA-induced mice in vivo (induced antiproliferative genes, p53, Bax, TNFalpha, caspase 3,9, repressed antiangiogenic and antiapoptotic genes, VEGF and Bcl2 respectively), successfully slowing the growth of tumors and even killing cancer cells, as well as lowering oxidative stress (MDA), improving the functions of the kidneys (urea, creatinine), liver (ALT, AST), and antioxidants (GPx, GR, GST, GSH, CAT, SOD, TAC). RFPDT, the photochemical or radiofrequency BCK activation mechanism, and the antioxidant capacity of non-activated BCK can all be linked to this process.Based on the findings, BCK-ACNP shows a great promise as a cutting-edge, efficient selective delivery system for localized RFPDT-activated colorectal cancer treatment.
✓ 已验证
DOI
高影响因子
Cell Discovery
·
2025
·Vol. 11
·期 1
·1-14
·
IF 12.5
Wang Jinrui,Niu Shenghui,Hu Xiao,Li Tianxing,Liu Shengduo,Tu Yingfeng,Shang Zehua,Zhao Lin,Xu Pinglong,Lin Jingwen,Chen Lu,Billadeau Daniel D.,Jia Da
The cGAS-STING pathway mediates the innate immune response to cytosolic DNA, contributing to surveillance against microbial invasion or cellular damage. Once activated, STING recruits TBK1 at the trans-Golgi network (TGN), which in turn phosphorylates IRF3 to induce type I interferon (IFN-I) expression. In contrast to STING, little is known about how TBK1 is transported to the TGN for activation. Here, we show that multiple TGN tethering factors, a group of proteins involved in vesicle capturing, are indispensable for STING-IFN-I signaling. Deletion of TBC1D23, a recently reported tethering factor, in mice impairs the STING-IFN-I signaling, but with insignificant effect on STING-NF-κB signaling. Mechanistically, TBC1D23 interacts with TBK1 via the WASH complex subunit FAM21 and promotes its endosome-to-TGN translocation. Furthermore, multiple TGN tethering factors were reduced in aged mice and senescent fibroblasts. In summary, our study uncovers that TGN tethering factors are key regulators of the STING-IFN-I signaling and suggests that their reduction in senescence may produce aberrant STING signaling.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）