Nature Communications
·
2026
·
IF 18.1
Xu Weicong,Xu Xiaomin,Liu Chao,Huang Feifan,Wang Bin,Li Peijun,Ke Xiaofeng,Kong Xiangchen,Chen Qingwen,Aerxin Wulejiasi,Ning Anze,Hai Guangtong,Zhang Huiyan,Li Tao,Xiao Rui,Shao Zongping
The electrocatalytic reduction of carbon dioxide (CO 2 ) offers a pathway to transform greenhouse gas emissions into fuels and chemicals using renewable electricity. Among possible products, methane (CH 4 ) is particularly attractive due to its high energy density and seamless integration with existing natural gas infrastructure, yet its electrosynthesis is hindered by demanding multi-electron kinetics and mass-transport constraints. Here, we report a four-channel copper tubular penetration electrode (TPE) with a honeycomb-like architecture that fundamentally reshapes the reaction environment for CO 2 electroreduction. By precisely controlling electrode cross-sectional thickness, this multi-channel design regulates gas, electron, and electrolyte transport, stabilizing the three-phase interface required for efficient CH 4 formation. The optimized TPE achieves a CH 4 Faradaic efficiency of 87.5%, a half-cell energy efficiency of 43.46%, and stable operation for 100 hours. Combined experimental and theoretical analyses reveal that rational design of electrode architecture enables precise control over the CO 2 adsorption configurations and reaction intermediates, thereby fine-tuning the reaction pathway toward CH 4 . These findings establish multi-channel TPEs as a powerful platform for efficient CO 2 electromethanation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Materials
·
2026
·
IF 7.7
Zhang Yingzhen,Han Shibo,Huang Jianying,Cai Weilong,Ng Yun Hau,Chen I-Wen Peter,Lai Yuekun
The practical deployment of alkaline water electrolysis (AWE) is fundamentally limited by the instability of oxygen evolution reaction (OER) catalysts caused by continuous dissolution of active metal sites under harsh operating conditions. Herein, we report a strategy for stabilizing NiFe layered double hydroxides (NiFe-LDH) via weak Brönsted base intercalation, which tunes the interlayer spacing and interfacial electronic structure. Through the intercalation of weakly basic nitrate anions (NO 3 − ), a nitrate-modified NiFe-LDH (NiFe-NO 3 ) is constructed, which effectively suppresses Fe dissolution by stabilizing high-valence Ni/Fe species during operation. As a result, NiFe-NO 3 exhibits exceptional durability, maintaining stable operation at 1000 mA cm −2 in 30 wt% KOH at 80 °C for over 500 h with an ultralow degradation rate of 0.04 mV·h −1 (retention rate of electrochemical activity was 99.1%), representing a ∼12-fold lifetime improvement over pristine NiFe-LDH. Mechanistic studies reveal that NO 3 − intercalation induces synergistic effects including slight interlayer expansion, electronic redistribution, and regulation of interlayer Brönsted basicity, which collectively stabilize high-valence Ni/Fe species and preserve the oxyhydroxide active phase during OER. This work demonstrates that Brönsted base intercalation provides an effective strategy to suppress active-site dissolution and offers new insights for the design of durable OER catalysts for industrial alkaline water electrolysis (AWE).
✓ 已验证
产品关联
DOI
高影响因子
Journal of Bionic Engineering
·
2026
·
IF 4.4
Hao Jingbin,Shen Ding,Liu Siyu,Wang Shuaihang,Shi Xi,Qiao Yuehua,Naveena Konduru,Zhang Gaorong,Sun He,Zhang Zuoli
Given the poor efficacy of conventional oral medications in treating inner ear disorders due to the presence of the Blood-Labyrinth Barrier (BLB) in the inner ear, we designed an inner ear injectable Andro@GelMA hydrogel for the repair of Diabetic Hearing Loss (DHL). Natural protein-derived materials, such as collagen and gelatin, hold broad prospects in tissue engineering and regenerative medicine. Specifically, Gelatin Methacryloyl Acetate (GelMA), a photosensitive polymer obtained by modifying gelatin with methacrylic anhydride, inherits the high biocompatibility of collagen, making it an ideal drug delivery carrier. In this study, FTIR, XRD, SEM, and rheological tests demonstrated that hydrogen-bonding linkages formed between Andrographolide (Andro) and GelMA, thereby enhancing cross-linking degree and structural stability. Additionally, in vitro and in vivo tests confirmed that the Andro@GelMA hydrogel could achieve controllable sustained release by adjusting the cross-linking degree. Furthermore, in vitro cellular experiments showed strong protective effects on auditory cells, while animal experiments verified that this local delivery system significantly improved the therapeutic efficacy of DHL and promoted the regeneration of damaged inner ear hair cells compared to the control group.
✓ 已验证
产品关联
DOI
高影响因子
WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 18
·1052
·
IF 3.5
Su Zhaoxin,Xiong Yankai,Wang Zhijie,Wang Xiufen,Li jiayi,Wang Mujie
Antibiotic contamination in rivers threatens ecosystem integrity and promotes the dissemination of antimicrobial resistance. Dissolved organic matter (DOM) regulates antibiotic photodegradation via photosensitization, light screening, and complexation. This study examined the occurrence of representative antibiotics in the mainstream of the Xiaoqing River and evaluated the role of DOM composition in regulating their photodegradation under simulated sunlight conditions. Target compounds included macrolides (erythromycin [ETM], roxithromycin [RTM], and tilmicosin), fluoroquinolones (norfloxacin [NOR] and ofloxacin), and a sulfonamide (sulfamethoxazole [SMX]). Field monitoring combined with laboratory irradiation experiments was conducted to characterize DOM fluorescence components (C1–C3) and quantify their effects on antibiotic photodegradation. Most target antibiotics in the Xiaoqing River mainstream occurred at concentrations below global average levels reported for surface waters. However, SMX exhibited a high detection frequency, and RTM was detected in all samples with the highest mean concentration, longitudinal analysis showed that total antibiotic concentrations increased downstream into the urban center, indicating a substantial municipal wastewater influence. EEM–PARAFAC analysis identified three prevalent DOM components: C1 (visible-region fulvic-like), C2 (UV-region fulvic-like), and C3 (tyrosine-like protein-like), with C2 dominating the DOM pool. Photodegradation experiments revealed pronounced DOM-specific effects. Humic acid (HA) generally enhanced degradation (e.g., ETM, k obs = 0.2628 h −1 , R 2 = 0.81), whereas fulvic acid (FA) strongly inhibited NOR photodegradation ( k obs = 0.0006 h −1 ). Tryptone alone suppressed photodegradation but produced synergistic enhancement when combined with HA and FA (NOR, k obs = 0.0671 h −1 ). In contrast, SMX exhibited limited photoreactivity under simulated sunlight in all DOM treatments. Overall, these results demonstrate that DOM composition is a key regulator of antibiotic photochemical fate in anthropogenically impacted rivers, and that interactions among DOM components and antibiotic molecular structures govern photodegradation behavior.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Zhang Guiru,Ji Ning,Luo Liuxuan,Li Xiangrui,Shen Peng,Xue Rui,Yuan Shu,Huang Junyi,Zhao Congfan,Bi Tianzi,Cheng Xiaojing,Guo Yangge,Yan Xiaohui,Su Xiaozhi,Shen Shuiyun,Zhang Junliang
Single-atom catalysts (SACs) are favored owing to their well-defined motifs and notable CO selectivity in electrochemical CO 2 reduction. However, the dynamic coordination evolution under working conditions and the structure-activity relationships remain highly puzzling. Herein, we suggest that flexible Zn–P 3 nanodomains with weak-bond interactions may exhibit a potential-dependent structural modulation under working conditions compared to Zn–N 4 configurations. A possible metastable state with reduced Zn–P x -like coordination may be formed from the Zn–P 3 structure under CO 2 reduction working conditions. Based on in situ spectroscopy analysis, deuterium isotope kinetic analysis, and theoretical calculations, the low-coordination Zn and the possibly perturbed P sites may serve as efficient active sites for the first step of sequential proton–electron transfer in the CO 2 electroreduction. The collaborative assignments within this dynamic catalytic nanodomain, rather than at individual metal site, may contribute to the improved the intrinsic activity, which delivers a high turnover frequency (47,690 h −1 ) and a CO production rate (213 mL h −1 cm −2 ) at 500 mA cm −2 for 100 h. Our work elucidates the dynamic coordination-governed mechanisms of SACs and underscores the necessity of probing their structural basis under operating conditions.
✓ 已验证
产品关联
DOI
高影响因子
Science China-Materials
·
2026
·
IF 7.7
Yan Sai,Zhang Han,Zhang Yue,Shang Xiaohong,Li Peng,Cao Ran,Zhu Meifang
Fluorination has been demonstrated as an effective strategy to enhance triboelectric output. However, a systematic investigation into the role of fluorine content and substitution effect remains lacking. In this study, by in-situ embedding fluorine-functionalized hydrogen-bonded organic frameworks (HOFs) into poly(vinylidene fluoride-hexa-fluoropropylene) (PVDF-HFP) nanofibers via electrospinning, we explored the fluorine content and substitution effect on tribo-sensor performance. Owing to the enhanced dielectric constant and surface charge polarization, the resulting PVDF-HFP/HOF nanofibers exhibited significantly improved triboelectric performance. Notably, tribo-sensors based on fluorine-functionalized HOF-doped nanofibers delivered a maximum open-circuit voltage of 210.7 V, far surpassing that of pristine PVDF-HFP (66.9 V). Theoretical simulations further revealed that this superior performance originates from the increased molecular dipole moments and local electrostatic potentials induced by fluorine substitution, with ortho -substitution offering stronger polarization than para -substitution. In addition, the gait monitoring experiment further demonstrated the application potential of PVDF-HFP/HOF nanofibers as a high-performance tribo-sensor. This work demonstrates a structure–property-guided approach to designing engineered fluorine-functionalized HOFs as tunable nanofillers, offering new insights into the development of high-performance triboelectric materials for next-generation electronics.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Shen Yu,Pan Ting,Cheng Xiaoya,Zhang Senyu,Yan Pu,Li Jiaxing,Chen Tangzhe,Ding Meijuan,Liu Xiangmei,Zhao Qiang,An Zhongfu,Lai Wen-Yong
Flexible X-ray scintillators are critical for next-generation conformal imaging and wearable radiation monitoring, yet their development is hindered by the persistent trade-offs among particle dispersion, scintillation efficiency, and mechanical robustness in conventional composite designs. Here, we overcome these limitations via a ligand-matrix interface engineering strategy, integrating highly soluble copper-iodide clusters with a self-healing fluorinated block copolymer to produce highly stretchable and autonomously self-healing scintillator films. Interfacial coordination and ion-dipole interactions guide the in situ self-assembly of uniformly dispersed, aggregation-induced emission-active clusters within the polymer matrix, while dynamic dipole-dipole interactions between fluorinated segments confer high stretchability (up to 2000% strain) and room-temperature self-healing capability. The resulting films achieve a high spatial resolution of 16.4 lp mm −1 , enabling distortion-free conformal imaging of curved objects and maintaining high-fidelity imaging under severe mechanical deformation or in aqueous environments. Furthermore, dip-coated textiles functionalized with the composite serve as wearable radiation-alert systems that synergize real-time visual detection with passive X-ray shielding. This work provides a versatile materials platform that reconciles long-standing performance conflicts, paving the way for advanced conformal diagnostics and scalable personal radiation protection technologies.
✓ 已验证
产品关联
DOI
高影响因子
Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·438
·
IF 38.5
Zhang Jun,Chen Xiaoyu,Wu Bin,Guo Xiangyang,Qu Xianlin,Ma Qunzhi,Wang Ying,Li Jiayi,Liu Wei,Li Xu,Cao Liyun,Wang Yi,Huang Jianfeng,Zhao Jingxiang,Zhang Fuxiang,Feng Yongqiang
Phase engineering of ZrO 2 regulates the electronic metal–support interactions and work function difference between Ru and ZrO 2 , resulting in reverse hydrogen spillover, therefore enhancing electrocatalytic hydrogen evolution reaction in alkaline medium.
The Ru@ m -ZrO 2 /C catalyst demonstrated a low overpotential and high mass activity (45 times that of commercial 20% Pt/C), and when integrated into an anion-exchange membrane water electrolyzer, it exhibited stable operation for over 300 hours.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Materials
·
2026
·
IF 7.7
Li Zhao,A. Hubao,Dong Huanhuan,Lu Zhimin,Wu Changming,Zheng Shuang,Chu Zonglin,Xie Ganhua,Xu Yang,Peng Shan,Zhao Yuanyuan
The precise control and manipulation of microdroplets (diameter < 20 µm) on solid substrates holds critical importance across diverse applications, such as environmental air quality assessment, targeted pharmaceutical delivery, clinical diagnostics, and public health initiatives. A key challenge in this field is contact angle hysteresis, caused by interfacial adhesion and frictional forces, which pin droplets and impede their mobility. To overcome this, we introduced a crack-mediated capillary bridging strategy that enables the efficient capture and directional transport of microdroplets. This approach utilizes a stretchable elastomeric substrate engineered with precision to incorporate island-like microstructures. Upon application of longitudinal tensile stress, the substrate undergoes controlled fracture, yielding densely packed, directionally oriented surface cracks. These fissures induce localized capillary forces of significant magnitude, effectively counteracting adhesion-induced resistance and facilitating programmable droplet motion. To validate the practical utility of this platform, experiments were conducted to capture airborne pathogenic agents, demonstrating a 14.2-fold enhancement in enrichment efficiency relative to conventional flat surfaces. These findings highlight the versatility of the proposed mechanism, offering promising avenues for advancing technologies in biosensing, pollutant analysis, and related interdisciplinary fields. The integration of fracture mechanics with capillary-driven fluid dynamics presented herein establishes a foundational framework for next-generation microfluidic systems.
✓ 已验证
DOI
高影响因子
INFLAMMOPHARMACOLOGY
·
2026
·
IF 6.3
Yang Xiaoxiao,Yang Nengjie,Wang Yunan,Xiao Jun,Gu Zhifeng,Dong Chen
Background Sjogren’s Syndrome (SS) is an autoimmune disease characterized mainly by xerostomia (dry mouth), xerophthalmia (dry eyes) and damage of immune system. Recent studies have found that SS patients frequently experience neuropsychiatric symptoms such as depression and fatigue, suggesting potential underlying mechanisms involving complex immune-neural interactions. However, current therapeutic strategies targeting this immune-neuropsychiatric axis remain limited. Agomelatine (AGO), a novel antidepressant classified as a melatonin (MLT) receptor agonist and a 5-HT2C receptor antagonist, has yet to be fully investigated for its immunomodulatory potential and therapeutic application in SS. Objectives This study explores the immune–neuropsychiatric interaction in SS using Non-Obese Diabetic (NOD) mice, and investigates the therapeutic potential of AGO, highlighting its anti-inflammatory and immunomodulatory effects. Methods NOD mice were divided into blank control, hydroxychloroquine (HCQ, a basic immune regulatory drug), MLT, and AGO groups; ICR mice served as healthy controls. All received intraperitoneal injections for 4 weeks. Behavioral tests (open field and tail suspension) were conducted. Flow cytometric analysis was performed to systematically evaluate splenic T cell and B cell subsets. The results showed that only the proportions of T helper 1 (Th1) and T helper 17 (Th17) cells exhibited significant differences, whereas no obvious changes were observed in B cells or regulatory T cells (Tregs).Salivary gland tissues were assessed by Hematoxylin–Eosin (HE) staining for inflammation and damage, and by immunofluorescence for Th1-epithelial cell co-localization. Results AGO-treated mice showed significantly shorter immobility time in the tail suspension test versus untreated NOD controls, indicating reduced despair. AGO intervention also reduced splenic Th1 and Th17 cell proportions, alleviated salivary gland lymphocyte infiltration, and decreased Th1-epithelial cell co-localization, suggesting inhibition of Th1 cell migration to target tissues. Conclusion AGO significantly improved behavioral performance, reduced the proportion of Th1 cells in the spleen, and alleviated inflammatory infiltration in the salivary glands of NOD mice. These findings suggest that the drug may exert therapeutic effects by modulating immune responses and neurobehavioral functions, positioning it as a promising candidate for the treatment of SS.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Zhang Jiacheng,Cao Xuewen,Zhang Jun,Tian Xuefeng,Du Jianfei,Huang Rui,Yuan Yihui,Wang Ning
Photocatalytic uranium extraction can surpass the intrinsic capacity limits of adsorption by converting soluble uranyl into insoluble uranium peroxides via H 2 O 2 generation. However, this process requires simultaneous local enrichment of H 2 O 2 and UO 2 2+ beyond the solubility product constant, which is difficult to achieve in continuously flowing and ultra-dilute seawater. Here we report a hollow hierarchical covalent organic framework (COF) microcavity reactor, HH-COF-(CN/AO) x , that spatially decouples H 2 O 2 generation from uranyl capture to overcome this thermodynamic barrier via a bidirectional reactant flux coupling strategy. A cyano-functionalized inner layer produces and stores H 2 O 2 in a central cavity, whereas an amidoxime-rich outer layer selectively enriches uranyl ions. The convergence of outward H 2 O 2 flux and inward uranyl adsorption establishes a persistent high-concentration interface that supports continuous formation of insoluble uranium peroxide. The optimized HH-COF-(CN/AO) 0.35 achieves 25.1 mg g −1 uranium uptake in natural seawater, 3.9 times that of the non-hollow analog, which demonstrates a generalizable strategy for manipulating reactant fluxes in ultra-dilute environments for realizing effective resource extraction from water environment.
✓ 已验证
DOI
PubMed
高影响因子
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
·
2026
·Vol. 42
·期 7
·398
·
IF 4.7
Lequan Qiu,Mengyuan Bao,Zhongqing Yu,Longkuan Wang,Tongtong Li,Shijin Wu
Phthalic acid (PA) is a key intermediate in the biodegradation of phthalate esters (PAEs), and its aerobic degradation pathways exhibit considerable diversity. In this study, a novel aerobic PA degradation bypass was discovered in Klebsiella variicola SY1. After blocking the classical 4,5-dioxygenase pathway, the strain retained the ability to utilize PA, and gene 5193 encoding a UbiD family decarboxylase was significantly upregulated. Further knockout of gene 5193 caused the loss of PA utilization ability. Metabolomic and LC-MS analysis revealed that this bypass is initiated by 4-monooxygenation of PA to 4-hydroxyphthalic acid, followed by decarboxylation to 4-hydroxybenzoic acid, which then enters protocatechuic acid or phenol metabolism. Heterologous expression of gene 5193 did not confer the ability to convert PA or 4-hydroxyphthalic acid (4-HP), indicating that its product is not directly responsible for substrate conversion. Furthermore, by constructing a constitutive expression vector and introducing the esterase gene pehA , the recombinant strain achieved degradation rates exceeding 90% for dimethyl phthalate, diethyl phthalate, and dibutyl phthalate, effectively broadening the substrate spectrum. This finding enriches the understanding of the diversity of aerobic PA metabolism and provides both a strain resource and theoretical support for the bioremediation of phthalate ester pollution.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）