BMC Oral Health
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2026
·Vol. 26
·期 1
·1227
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IF 3.8
Zhang Qian,Zhang Hengwei,Wei Linting,Yang Bin,Bai Xiaofan,Ruan Jianping,Dong Ning
Objective This study explored the effects of inflammatory microenvironment on stem cells from the apical papilla (SCAP) for cell homing strategy-based pulp regeneration. Methods Dental pulp stem cells (DPSCs) were treated with lipopolysaccharide (LPS) for 48 h, creating a conditioned medium (LPS-CM). The influence of LPS-CM on SCAP proliferation, migration, odontogenic and neurogenic differentiation, pro-angiogenetic effects, cell apoptosis and senescence were assessed. Following construction of the ectopic pulp regeneration model, treated dentin matrix (TDM) specimens were harvested after a 2-month implantation period and subjected to histological examination to assess changes in the regenerated tissues. Results We found that a moderate inflammatory microenvironment (LPS-5 CM) significantly enhanced SCAP proliferation, migration, odontogenic differentiation, and the formation of neuron-like cells. In contrast, a high-inflammatory microenvironment (LPS-10 CM) exerted inhibitory effects on these processes and concurrently induced cellular apoptosis and senescence. All LPS-CM groups promoted angiogenesis in vitro. Critically, only the LPS-5 CM group successfully facilitated the regeneration of well-vascularized pulp-like tissue in vivo. Conclusions Inflammatory microenvironment performed a dual role in pulp regeneration. A moderate inflammatory stimulus enhances the regenerative functions of SCAP, while excessive inflammation is detrimental. This underscores the importance of inflammatory signals for successful cell homing-based pulp regeneration. Graphical abstract
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JOURNAL OF FLUORESCENCE
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2026
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IF 3.4
Liang Tianmi,Liu Shijian,Ma Wenjin,Tao Xiaoqi
Colla Corii Asini ( CCA ), a traditional food-medicine product, is vulnerable to food safety and market integrity due to frequent adulteration. This study developed a lateral flow assay based on polyethylenimine-functionalized europium metal-organic frameworks (PEI-Eu-MOFs-LFA) for quantitatively detecting donkey DNA to assess the authenticity of CCA , without the need for knowing the types of adulterants. The protonated amino groups on the PEI‑Eu-MOFs surface formed stable complexes with negatively charged single‑stranded DNA (ssDNA) probes. Electrostatic attraction and hydrogen bonding facilitated conjugate formation, leading to fluorescence quenching of the PEI-Eu-MOFs via the inner-filter effect (IFE). This method enables direct analysis after DNA extraction, eliminating the need for additional nucleic acid amplification steps, and completes the entire process in just 60 min. Furthermore, a calibration curve was established between the T/C ratio and the logarithmic value of donkey hide content (2% to 100%). The PEI-Eu-MOFs-LFA exhibited excellent sensitivity and accuracy, with a detection limit of 1.86%, recoveries ranging from 85.70% to 114.63%, and relative standard deviations from 2.48% to 12.59%. Consequently, PEI-Eu-MOFs-LFA demonstrates high sensitivity and accuracy, significantly improving detection efficiency and providing an innovative approach for quality control and market regulation of CCA .
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CYTOTECHNOLOGY
·
2026
·Vol. 78
·期 4
·156
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IF 2.2
Zhang Yougen,Gu Li,Zhang Xiaoyang,Ran Wei,Yan Yanfeng,Gu Hongwei
Pulmonary inflammation is a key feature of chronic obstructive pulmonary disease (COPD), contributing to disease progression and morbidity. However, the molecular mechanisms underlying therapeutic interventions remain to be fully elucidated. This study aimed to investigate the mechanisms of naringenin in modulating COPD-related pulmonary inflammation. Using an integrated approach combining network pharmacology, molecular docking, and in vitro/in vivo models, we systematically explored the effects of naringenin. Network pharmacology analysis identified NF-κB as a central target, which was validated through molecular docking and dynamics simulations showing stable binding between naringenin and NF-κB. In vitro, cigarette smoke extract-challenged lung epithelial cells treated with naringenin exhibited reduced cytotoxicity, downregulated TNF-α, phospho-NF-κB p65, and NLRP3 expression, inhibited Caspase-1 activation, and attenuated IL-1β maturation, and suppressed Gasdermin D cleavage. In vivo, naringenin-treated COPD mice displayed diminished pulmonary inflammatory cell infiltration, milder histopathological lung damage, decreased serum TNF-α/IL-1β levels, and inhibited activation of the NF-κB/NLRP3/Caspase-1 axis in lung tissue. Collectively, these findings reveal that naringenin alleviates COPD pulmonary inflammation and pyroptosis by targeting the NF-κB/NLRP3/Caspase-1 signaling cascade, providing mechanistic insights for traditional Chinese medicine-based COPD therapies. Graphical abstract
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JOURNAL OF ELECTRONIC MATERIALS
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2026
·
IF 2.8
Bai Guangzhu,Guo Sujia,Chen Zhi,Chang Rui,Wang Fang
The performance of the anode foil for aluminum electrolytic capacitors is primarily determined by its microstructure and dielectric properties. However, traditional electrochemical etching techniques face difficulties in meeting the increasing demand for high-capacity capacitors due to the inherent limitations of two-dimensional pore structures. This study investigates the impact of modulating the particle size of aluminum powder in additive manufacturing on the performance of anode foils. A comprehensive analysis is carried out on the correlation between the microstructure formed after stacking and sintering aluminum powders with different particle sizes and the resulting performance characteristics. The research shows that when the aluminum powder particle size is 4–5 μm, the anode foil forms a three-dimensional through-pore structure, with a specific capacitance of 1.022 μF/cm 2 , which is higher than that obtained by traditional etching methods. In contrast, when smaller particles (< 3–4 μm) are utilized, the specific capacitance drops significantly to below 0.3 μF/cm 2 . This decrease is attributed to pore blockage caused by sintering-induced melting and a substantial reduction in the total available surface area. On the other hand, larger particle sizes (> 4–5 μm) lead to a gradual decrease in specific capacitance, reaching 0.631 μF/cm 2 , mainly due to loose packing and reduced surface area. These findings confirm that the particle size of aluminum powder plays a decisive role in determining the performance of anode foils by influencing pore topology and the total available surface area. This study offers both theoretical support and practical guidance for optimizing particle size parameters in additive manufacturing processes for the production of high-performance anode foils. Graphical
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ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
·
2026
·Vol. 48
·期 10
·422
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IF 4.3
Wen Kunyu,Wang Mengjie,Wang Bin,Yin Yiwen,Ma Yanbin,Lu Taotao,Miao Renhui,Qi Zhichong
Silica-based nanomaterials have shown promise for remediating heavy metal-contaminated soils. However, their remediation stability may be compromised by natural and anthropogenic activities such as rainfall and irrigation. This work systematically investigates the leaching behavior of Cd from soils amended with unmodified SiO 2 and thiol-functionalized SiO 2 (SH-SiO 2 ) nanoparticles, along with nanoparticle-mediated Cd release and transport through soil porous media. The results demonstrated that the leaching concentrations of Cd 2+ from the soil remediated by SH-SiO 2 were the least and followed the order of SH-SiO 2 < SiO 2 ≈ control (untreated Cd-contaminated soil) under simulated acid rain conditions (pH 5.6). This confirms that thiol-functionalized silica effectively immobilizes Cd due to its strong chelating ability. However, co-transport experiments revealed that both SiO 2 and SH-SiO 2 nanoparticles could act as carriers that enhanced Cd 2+ transport, governed by their Cd-binding capacity and intrinsic mobility over a pH range of 5.0–8.0, with greater facilitation at higher pH levels. Notably, SH-SiO 2 exhibited a much stronger facilitation effect, attributable to its higher affinity for Cd 2+ , greater mobility in porous media, and resistance to desorption of SH-SiO 2 -bound Cd 2+ . At a nanoparticle concentration of 50 mg/L, the maximum breakthrough of Cd 2+ reached 10.1% for SiO 2 and 75.2% for SH-SiO 2 . While SH-SiO 2 demonstrates excellent Cd immobilization capacity and acid-rain resistance, any disturbance that remobilizes these nanoparticles may facilitate the mobility of Cd 2+ , potentially expanding the scope of heavy metal contamination. Therefore, when applying remediation agents for soil rehabilitation, it is crucial to consider their long-term effectiveness and stability.
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Nature Communications
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2026
·
IF 18.1
Xing Kun,Han Qi-Ze,Wang Jian-Tao,Huang Lei,Ran Zhaoyu,Yin Li-Juan,Zhong Shao-Long,Lu Jingtong,Wan Baoquan,Wang Xin-Jie,Guo Limin,Bi Ke,Dang Zhi-Min
Polymer-based dielectrics are widely employed in electrostatic energy storage capacitors serving as pulse power supply owing to their lightweight nature and rapid charge-discharge capability. However, their intrinsically low dielectric constant severely limits energy storage density. Although high-dielectric-constant nanofillers are commonly incorporated to enhance permittivity, organic-inorganic interfacial incompatibility often induces particle agglomeration and structural defects. In this work, we propose a confined co-doping strategy for structured polymer dielectrics, wherein BaTiO 3 and Al 2 O 3 nanoparticles are co-doed within the ferroelectric core P(VDF-HFP) of coaxial fibers and undergo self-assembly. This approach simultaneously enhances both energy density and charge-discharge efficiency. As a result, the 1 wt% BaTiO 3 /1 wt% Al 2 O 3 core co-doping composite dielectric achieves a discharged energy density of 19.2 J/cm 3 and a charge-discharge efficiency of 81.0%, and maintains stable performance over 1 × 10 5 cycles under an electric field of 400 kV/mm. This confined co-doping strategy thus provides an effective and scalable route for developing polymer-based dielectrics with high energy density and high reliability.
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Food and Bioprocess Technology
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2026
·Vol. 19
·期 7
·367
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IF 5.6
Xiong Xuefeng,Su Jingkai,Wang Yuanyuan,Wang Ziyi,Cao Xuehui,Zhu Danshi
To investigate the improving effect of magnetic field-assisted osmotic dehydration pretreatment on the quality of frozen strawberries, this study evaluated its influence on the color, key enzyme activities, and antioxidant properties of the fruit. The results showed that magnetic field-assisted pretreatment significantly increased the a * value of frozen strawberries and effectively inhibited the activities of peroxidase, catalase, and superoxide dismutase. Compared with direct freezing treatment, magnetic field-assisted permeation dehydration method resulted in a 52.47% increase in the retention of total phenolic substances, 42.10% increase in total flavonoid substances, and 57.65% increase in total anthocyanin substances in frozen strawberries. The correlation analysis indicates that the color ( a * value) is positively correlated with the activities of polyphenol oxidase, catalase, and superoxide dismutase enzymes and the antioxidant capacity. Principal component analysis further confirmed that magnetic field-assisted osmotic dehydration pretreatment helps to better preserve the nutritional quality of strawberries. Therefore, magnetic field-assisted osmotic dehydration pretreatment is an effective method for improving the quality of frozen strawberries.
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Science China-Chemistry
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2026
·
IF 9.8
Zhang Jiaying,Feng Jiakai,Li Zhihui,Cao Mengzhu,Lin Wenjing,Li Jiaxin,Lu Jianhong,Shi Jincan,Pan Guoyi,Yi Guobin,Qin Yanlin
Conductive hydrogel-based wearable flexible electronics are of growing interest for smart health monitoring, data transmission, and human-machine interfaces. However, achieving multifunctional flexible electronics with lignin-derived, long-term adhesion, self-healing, wide-temperature threshold stability and embedded therapeutics remain unresolved bottleneck. Herein, a novel lignin sulfonate@silver eutectic hydrogel (LS@Ag-GA-DES) was synthesized via a one-step ultrafast free radical polymerization completed within 20 s. The eutectic hydrogel exhibited remarkable stretchability (1470%), strong skin adhesion (9.11 kPa), high ionic conductivity (0.57 S m −1 ), high gauge factor (15.22), along with excellent self-healing capabilities. DES endowed eutectic hydrogel with high sensitivity, rapid response (75 ms) and recovery times (84 ms), excellent wide-temperature adaptability (−40 °C to 60 °C) and long-term stable sensing performance. This eutectic hydrogel not only enabled real-time detection of subtle muscle strains and joint movements, but also adapted to a nine-grid coded information transmission interface for non-verbal fast communication (about 3 s per letter) in patients with hearing or speech impairments. Integrating AI, electronic communication and photothermal conversion module, the closed-loop management of cervical spine “monitoring-photothermal therapy-rehabilitation assessment” and abnormal posture alarm system has been achieved for the first time, suggesting the promising potential of lignin-derived eutectic hydrogel for applications in smart healthcare and information transmission.
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NATURE GENETICS
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2026
·
IF 25.5
Zhang Liyuan,Wang Yahui,Wei Kai,Nie Wen,Feng Yayuan,Shi Zhiwen,Xiao Hongmei,Xie Weifen,Lin Yong,Zeng Xin,Shi Yongquan,Tang Wei,Li Tuo,Yang Fu,Zhou Ye,Wang Minjun,Liu Yanfang,Liu Shanrong,Hou Jin
Metabolic dysfunction-associated steatotic liver disease (MASLD), especially its severe form, metabolic dysfunction-associated steatohepatitis (MASH), progresses to liver fibrosis, leading to cirrhosis and liver cancer. The cross-talk between spleen and liver in MASLD/MASH progression remains poorly understood. Here we found enlarged spleens in patients with MASLD and identified induced TRNP1 hi CD8 + T cells in spleens of MASLD/MASH mouse models and patients. These cells exhibited pro-fibrotic properties through secretion of INSR-α. Mechanistically, demethylated DNA and H3K27me3, increased H3K27ac and bolstered enhancer-promoter contact synergistically reorganized chromatin topologically associating domains spatially to initiate the expression of transcription factor TRNP1 in splenic CD8 + T cells. TRNP1 then transcriptionally activated the expression of FURIN and CTSD, promoting the maturation and ectodomain shedding of INSR-α and facilitating its secretion to activate hepatic stellate cells. In vivo blockade of INSR-α using neutralizing antibodies alleviated MASLD/MASH-induced liver fibrosis. This study reveals splenic TRNP1 hi CD8 + T cells with pro-fibrotic properties and suggests a potential anti-fibrotic strategy.
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Science China-Technological Sciences
·
2026
·Vol. 69
·期 9
·1920106
·
IF 5.1
Li Haorong,Zhang Huixin,Wu Xinlong,Niu Xiaojuan,Hong Wenpeng,Li Haoran
Solar-driven interfacial evaporation, with its zero carbon emissions, low cost, and off-grid characteristics, has become a core solution for seawater desalination and wastewater purification. However, its practical application is still limited by the insufficient freshwater productivity due to the low vapor condensation rate. This study introduces a copper foam (CF)-based bidirectional solar water production (CF-BSWP) device. Utilizing the interconnected networks of CF, the available surface area and nucleation sites for vapor condensation are increased. Furthermore, the CF undergoes hydrophobic modification to suppress the formation of a liquid film, which constitutes a major barrier for continuous vapor condensation. Under 1 sun illumination, the hydrophobic CF-BSWP device achieves a water productivity of 1.20 kg m −2 h −1 and a solar-water efficiency of 80%. Importantly, a 10-hour real-world operation demonstrates an outstanding water yield of 11.07 kg m −2 , suggesting sustainable water production under natural sunlight and fluctuating weather conditions. This work provides an effective and viable solution to harvest the vapor generated in solar-driven interfacial evaporation devices.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 8
·522
·
IF 5.4
Qiao Yuchun,Wu Yiying,He Jiahui,Chen Wen,Fan Jiaqi,Zhang Zhicong,Shen Jialu,Su Mengping,Wang Qidong,Li Shuai,Shen Yingjie,Shang Jizhen,Wang Hua
Glucose is a vital energy source, and its accurate monitoring is crucial for the diagnosis and management of metabolic diseases. Herein, we report a simple colorimetric sensing platform for glucose detection based on MnO 2 /Au-Ag nanozymes, glucose oxidase (GOx), and 3,3′,5,5′-tetramethylbenzidine (TMB). In this cascade system, GOx catalyzes the oxidation of glucose to generate H 2 O 2 , which is subsequently decomposed by MnO 2 /Au-Ag to produce reactive species that oxidize TMB, yielding a visible blue signal. The incorporation of Au-Ag nanoparticles provides additional catalytic sites and promotes interfacial electron transfer, thereby enhancing the catalytic performance of MnO 2 . The platform exhibits a linear response over 0.025-0.20 mM with a detection limit of 0.012 mM. It enables reliable glucose detection in artificial sweat and 80-fold diluted serum samples. In addition, portable nitrocellulose test strips were developed for visual and smartphone-assisted glucose detection. This strategy provides a simple and portable approach for low-concentration glucose analysis and offers potential for point-of-care applications after further validation. Graphical
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Nature Communications
·
2026
·
IF 18.1
Wu Jiawei,Guo Yongshi,Hong Soon Hyung,Zhang Hongti,Kan Wang Hay,Ma Yanyan,Bai Tanglong,Yang Zheng,Zhang Xiaohua,Dong Kai,Sun Jie,Yan Jianhua
Ceramics are prized for exceptional strength, but their inherent brittleness has long been a fundamental bottleneck. Here, we report tensile plastic Al 2 O 3 meta-fibers that achieve a combination of high tensile strength (1.94 GPa) and large plastic strain (10.01%), with micro-strain reaching 194%. This is enabled via a phase-regulation strategy that constructs high-purity unsaturated [AlO 5 ] coordination with disordered oxygen lattices in Al 2 O 3 fibers. The metastable [AlO 5 ] fundamentally alters the deformation mechanics by reducing the energy barrier for bond breaking and reformation, while the disordered oxygen lattice facilitates extensive atomic displacement, collectively enabling intrinsic plastic behavior. This local plasticity accumulates in high-purity networks, ultimately achieving macroscopic tensile plasticity of fibers, challenging conventional understanding of ceramic deformation. These plastic fibers can be twisted and woven into high-strength, stretchable refractory ceramic fabrics. Our work establishes metastable phase customization as a universal paradigm, opening a promising pathway for designing superplastic ceramics.
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