CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Feng Gao,Yifang Mi,Xinlei Wu,Jun Yao,Qi Qi,Wei Chen,Zhihai Cao
It is an urgent task to exploit effective antimicrobial agents due to the rise of drug-resistant pathogens. Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH 2 -Ag nanoparticles (NPs). The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS. Furthermore, the NH 2 -Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics. Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics. Our study provides a facile and controllable method to construct polymer/inorganic CNGs to address the urgent need for antibacterial agents/fabrics.
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高影响因子
PROCESS BIOCHEMISTRY
·
2022
·
IF 4.885
Lele Chen,Zhao Liu,Jipeng Shi,Chengbo Wang,Ling Ding,Xu Ding,Guixiang Teng,Jianping Wu,Ji Zhang
In this paper, three kinds of environmentally friendly chitosan (CS)/polyvinyl alcohol (PVA) nanofibrous mats were prepared by electrospinning using low concentrations of acetic acid (AA), succinic acid (SA) and citric acid (CA) as solvents. For the first time, a systematic study on the effect of different organic acids on the properties of CS/PVA nanofibres was performed, which avoided the disadvantages of the use of strong acids or toxic organic acids as solvents. This study aimed to prepare CS/PVA nanofibrous mats to improve the antibacterial effect and biocompatibility. The results showed that the water stability of the prepared CS/PVA/CA nanofibrous mat was higher than that of pure PVA nanofibre mats, and CS/PVA/CA displayed optimal antibacterial activity and biocompatibility. Therefore, the CS/PVA/CA nanofibrous mat offers great potential for antibacterial applications.
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ACS Applied Bio Materials
·
2025
·
IF 4.7
Baoer Fan,Jia Guo,Siqi Zhang,Yingying Wang,Yaqi Tao,Wei Zheng,Kun Chen,Wen Tang
Wound infection causes excessive inflammation, delays healing, and may lead to severe complications. An ideal dressing should release antibacterial agents on demand to eradicate pathogens locally. Enzyme-responsive drug release systems are highly biocompatible and specific, yet their application in chitosan hydrogels has been limited by imprecise control over release profiles, mechanical properties, and potential drug resistance from premature leakage. Herein, we developed a dual-enzymatically responsive chitosan hydrogel for the on-demand release of antibacterial nanoparticles (ANPs). By synthesizing a series of hydroxyphenyl- and N-acetyl-modified glycol chitosan (HPPA-GC), we tuned the hydrogel stiffness and lysozyme degradation kinetics. Broad-spectrum ANPs were encapsulated via photo-cross-linking. Lysozyme, abundant in infected wounds, triggered hydrogel degradation and ANP release in vitro. When applied to S. aureus-infected full-thickness wounds in mice, the ANP-loaded hydrogel effectively combated infection and accelerated healing. This study demonstrates a robust and biocompatible platform for enzyme-triggered antimicrobial delivery, showing promise for the future development of smart wound dressings.
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高影响因子
Burns & Trauma
·
2022
·
IF 5.711
Xu Na,Yuan Yucheng,Ding Liangping,Li Jiangfeng,Jia Jiezhi,Li Zheng,He Dengfeng,Yu Yunlong
BackgroundMost traditional wound dressings only partially meet the needs of wound healing because of their single function. Patients usually suffer from the increasing cost of treatment and pain resulting from the frequent changing of wound dressings. Herein, we have developed a mutifunctional cryogel to promote bacterial infected wound healing based on a biocompatible polysaccharide.MethodsThe multifunctional cryogel is made up of a compositive scaffold of chitosan (CS), gelatin (Gel) and tannic acid (TA) and in situ formed silver nanoparticles (Ag NPs). A liver bleeding rat model was used to evaluate the dynamic hemostasis performance of the various cryogels. In order to evaluate the antibacterial properties of the prepared cryogels, gram-positive bacterium Staphylococcus aureus (S. aureus) and gram-negative bacterium Escherichia coli (E. coli) were cultured with the cryogels for 12 h. Meanwhile, S. aureus was introduced to cause bacterial infection in vivo. After treatment for 2 days, the exudates from wound sites were dipped for bacterial colony culture. Subsequently, the anti-inflammatory effect of the various cryogels was evaluated by western blotting and enzyme-linked immunosorbent assay. Finally, full-thickness skin defect models on the back of SD rats were established to assess the wound healing performances of the cryogels.ResultsDue to its porous structure, the multifunctional cryogel showed fast liver hemostasis. The introduced Ag NPs endowed the cryogel with an antibacterial efficiency of >99.9% against both S. aureus and E. coli. Benefited from the polyphenol groups of TA, the cryogel could inhibit nuclear factor-κB nuclear translocation and down-regulate inflammatory cytokines for an anti-inflammatory effect. Meanwhile, excessive reactive oxygen species could also be scavenged effectively. Despite the presence of Ag NPs, the cryogel did not show cytotoxicity and hemolysis. Moreover, in vivo experiments demonstrated that the biocompatible cryogel displayed effective bacterial disinfection and accelerated wound healing.ConclusionsThe multifunctional cryogel, with fast hemostasis, antibacterial and anti-inflammation properties and the ability to promote cell proliferation could be widely applied as a wound dressing for bacterial infected wound healing.
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高影响因子
Gels
·
2025
·Vol. 11
·期 12
·950
·
IF 5.3
Xinyue Gai,Yinghao Bi,Wen Zhao,Changlong Ren,Ming Chang,Miansong Zhang,Tingting Cui,Xue Liu,Airong Jia
Wound healing is a complicated process that involves hemostasis, antibacterial defense, and tissue regeneration. Conventional treatment methods, such as surgical suturing, have inherent limitations, necessitating the exploration of new ones. Hydrogels can create a moist environment that facilitates wound healing, making them an ideal material for wound healing. In this study, a procoagulant polysaccharide mixture (carboxymethyl chitosan/sodium alginate/fucoidan; CAF) was designed. Hydrogels were prepared using CAF and an oxidized starch/tannic acid blend (OT) at different ratios. Through comprehensive evaluations, such as gelation time, swelling capacity, and antibacterial efficacy, an optimal hydrogel (COT) was identified. This COT hydrogel was formed by mixing 3% CAF and OT solutions at a ratio of 2:1 (v/v). The associated gelation process occurred rapidly within 13 s. COT hydrogel exhibited self-healing properties, and a high swelling rate (~3109 ± 74%). It also demonstrated high antibacterial activity, facilitating enhanced protection against infection. Additionally, COT hydrogel exhibited biocompatibility and biosafety. COT hydrogel demonstrated low cytotoxicity on mice fibroblast cells (L929) and good hemocompatibility in vitro. Moreover, in vivo evaluations revealed that it did not cause skin irritation or allergic reactions. Importantly, COT hydrogel significantly outperformed the commercially available hydrogel with its hemostatic and wound healing performance (p< 0.001,p< 0.01).
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Frontiers in Bioengineering and Biotechnology
·
2019
·
IF 5.122
Wang Xinlu,Xu Pengcheng,Yao Zexin,Fang Qi,Feng Longbao,Guo Rui,Cheng Biao
Wound immersion in seawater with high salt, high sodium, and a high abundance of pathogenic bacteria, especially gram-negative bacteria, can cause serious infections and difficulties in wound repair. The present study aimed to prepare a composite hydrogel composed of hyaluronic acid (HA) and quaternized chitosan (QCS) that may promote wound healing of seawater-immersed wounds and prevent bacterial infection. Based on dynamic Schiff base linkage, hydrogel was prepared by mixing oxidized hyaluronic acid (OHA) and hyaluronic acid-hydrazide (HA-ADH) under physiological conditions. With the addition of quaternized chitosan, oxidized hyaluronic acid/hyaluronic acid-hydrazide/quaternized chitosan (OHA/HA-ADH/O-HACC and OHA/HA-ADH/N-HACC) composite hydrogels with good swelling properties and mechanical properties, appropriate water vapor transmission rates (WVTR), and excellent stability were prepared. The biocompatibility of the hydrogels was demonstrated by in vitro fibroblast L929 cell culture study. The results of in vitro and in vivo studies revealed that the prepared antibacterial hydrogels could largely inhibit bacterial growth. The in vivo study further demonstrated that the antibacterial hydrogels exhibited high repair efficiencies in a seawater-immersed wound defect model. In addition, the antibacterial hydrogels decreased pro-inflammatory factors (TNF-α, IL-1β, and IL-6) but enhanced anti-inflammatory factors (TGF-β1) in wound. This work indicates that the prepared antibacterial composite hydrogels have great potential in chronic wound healing applications, such as severe wound cure and treatment of open trauma infections.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2021
·Vol. 36
·期 6
·934-941
·
IF 0.957
Yan Chunchao,Xiao Feng,Qiu Tong,Zhang Xueqiong,Zhan Siwen,Lu Mengli,Yang Mengjia,Zhang Juan
To synthesize three different grafting ratios of gallic acid (GA)-chitosan (CS) copolymer by a free radical mediated grafting method, which is further applied to the field of antibacterial materials, crosslinking structures of the compound GA-CS copolymer were characterized, fully indicating that gallic acid is resoundingly grafted onto chitosan. The grafting ratios of three copolymers GA-CS are 45.71% (I), 36.12% (II), and 18.96% (III) were determined by UV-Vis spectrophotometer. The minimum inhibitory concentrations of three GA-CS copolymers are 30 µg/mL against Escherichia coli and are ranged from 250 to 550 µg/mL against Staphylococcus aureus. By counting viable bacterial colonies, it can be found that antibacterial property is preferable by increasing the grafting ratio of GA-CS copolymers. Findings of investigation on aforementioned bacteria experiment indicate that the CFU/mL values of GA-CS (I, II, III) are 2.04×10 6 , 7.56×10 6 , 1.48×10 7 to Staphylococcus aureus , and 2.96×10 6 , 1.01×10 7 , 2.14×10 7 to Escherichia coli after 12 h treatment. In addition, the interaction process between GA-CS copolymer and bacteria can be observed through a transmission electron microscope. The specific manifestation is that the bacterial cell membranes are ruptured after being treated with the copolymer, which causes the cell contents to flow out, and the cell morphology is shrunk and out of shape.
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Food & Function
·
2022
·Vol. 13
·期 11
·6129-6138
·
IF 6.317
Weiwei Li,Di Liu,Laicui Song,Hao Li,Shijie Dai,Ya Su,Qianjin Li,Jianlin Li,Tiesong Zheng
Surface modified pH-responsive porous silicon (PSi) carriers were developed for efficient delivery of lutein. PSi particles were prepared by the electrochemical etching method and modified with two chemical groups: hydroxyl and octadecyl silane, respectively. Chitosan (CS) was used for coating of PSi to ensure pH-responsive release. The loading conditions, release properties, cytotoxicity and toxicity were investigated. The highest loading percentage of lutein could be obtained with oxidized PSi and the structure of the microparticles was characterized by Fourier transform-infrared spectroscopy. The surface area and pore size of the microparticles were obtained from the N2 adsorption–desorption isotherm. The CS–PSi–Lut microparticles showed the minimum surface area of 220.30 m2 g−1 and a relatively larger average pore width of 179.00 Å. In vitro release experiments showed a pH-responsive and controlled release of lutein, with the fastest release rate and highest cumulative release rate of 97% under acidic conditions (pH 5.0) within 7 h. PSi, chitosan and lutein showed synergistic toxic effects, and the CS–PSi–Lut microparticles could effectively inhibit the proliferation of HT-29 cells in a dose-dependent manner, with an inhibition rate of 77% when the lutein concentration reached 40 μg mL−1. The in vivo toxicological evaluation of CS–PSi–Lut microparticles indicated good biocompatibility in the range of experimental doses. The chitosan-coated oxidized PSi capable of delivering bioactive compounds in a targeted and controlled manner provides a novel platform for the development and application of lutein.
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CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Qiang Li,Yulan Hu,Bingjian Zhang
ABSTRACT Historical monuments are increasingly being threatened by unexpected microbial colonizers, leading to their subsequent deterioration. Here, two tetraalkylphosphonium polyoxometalate ionic liquids (Q14-IL and Q16-IL) were successfully synthesized, which showed excellent antibacterial activity against four bacteria colonising wall paintings. Notably, Q14-IL exhibited superior antibacterial efficacy compared to longer alkyl Q16-IL. Additionally, polyvinyl alcohol/chitosan (PVA-CS) hydrogels containing two ILs were prepared, and the morphology, thermal stability, swelling ratio and antibacterial activity were systematically evaluated. The results suggest that higher CS content resulted in more uniform micropores and increased the swelling ratio. However, fewer antibacterial ILs were released and diffused over time from the matrix. Hydrogels with 5% CS content exhibited the highest antibacterial activity, which was mainly attributed to the synergetic antibacterial activity of positively charged ammonium (−NH 3 + ) groups of CS and quaternary phosphonium cation of ILs. This study may provide an alternative strategy for fighting against bacterial communities colonising ancient artworks.
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ACS Biomaterials Science & Engineering
·
2022
·
IF 5.395
Yang Wang,Wenbo Zhang,Xinhu Gong,Caimei Zhao,Yiying Liu,Chaoqun Zhang
On the basis of the original hydrogen bonding interaction and physical entanglement, covalent cross-linking and ionic cross-linking were additionally introduced to construct a carboxymethyl chitosan/allyl glycidyl ether conductive hydrogel (CCH) through a one pot method by a graft reaction, an addition reaction, and simple immersion, successively. The multiple cross-linking networks significantly increased the strength of CCHs and endowed them with ionic conductivity and an antifreezing property at −40 °C, which showed stable, durable, and reversible sensitivity to finger bending activity at subzero temperature. The CCHs could even be assembled into a triboelectric nanogenerator (TENG) to provide electric energy, which demonstrated stability against temperature variation, multiple drawing, long-term storage, or large quantities of contact-separation motion cycles. CCH-TENG can also be used as a tactile sensor within the pressure range from 0.4 kPa to higher than 8000 kPa. This work provided a simple route to fabricate antifreezing conductive hydrogels based on carboxymethyl chitosan and to find potential applications in soft sensor devices under a low temperature environment.
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SOLAR ENERGY
·
2024
·
IF 6
Kefan Chen,Lijing Ma,Jinwen Shi,Dengwei Jing
Solar-driven interfacial evaporation (SIE) receives much attention nowadays. At present, efficient thermal management and salt resistance during operation are still the difficulties of SIE technology. In this work, a new composite hydrogel for SIE has been reported. This composite hydrogel uses polyvinyl acetate (PVA) and chitosan (CS) as the framework, carbon nanoparticles (CB) as the photothermal material, modified with hydrophilic/hydrophobic fumed nano-silica. The addition of fumed nano-silica reduces the thermal conductivity and effectively immobilizes heat energy on the evaporator’s top surface, which reduces heat loss and improves the evaporation rate. The CSPC (CB/Nano-silica PVA-CS) evaporator modified with hydrophobic nano-silica exhibits Janus structure with transition from a hydrophobic top to a hydrophilic bottom. The Janus-structured CSPC evaporator has the characteristics of excellent salt resistance, simple preparation process, low heat loss with self-floating property. The CSPC evaporator containing 0.5 g hydrophobic fumed nano-silica has a maximum evaporation rate of 1.58 kg/(m 2 ·h), about 1.6 times higher than the evaporator without fumed nano-silica, which proves that the introduction of fumed nano-silica can effectively improve the evaporation performance of hydrogel. The overall efficiency of CSPC evaporator in simulated seawater is 88.63 %. The evaporation rate of CSPC evaporator has reached a high level in the evaporators using carbon black as photothermal material which was prepared by simple and low-cost method. It should be a promising category of material to be employed for solar desalination.
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npj Flexible Electronics
·
2024
·Vol. 8
·期 1
·1-12
·
IF 12.3
Shi Wei,Li Hui,Xu Chengsheng,Wu Gaoyi,Chen Jing,Zhang Jinyong,Liang Lixin,Wu Qingyang,Liang Yongsheng,Li Guanglin,Tang Wei
Flexible sensors are promising candidates in personalized healthcare, while desired sensors that allow implantation for biomedical applications with optimal sensing and favorable biological properties remain challenges. Here, a multifunctional hydrogel sensor was developed with gallic acid-modified chitosan (CSGA) and 3-carboxyphenylboronic acid-modified chitosan (CSPBA) by encapsulating Ag-decorated polydopamine (Ag@PDA) nanoparticles, namely Ag@PDA-(CSPBA/CSGA). The optimized hydrogel sensor showed desired sensitivity (gauge factor = 2.49), a rapid response/recovery time of 263 ms and good durability. Due to the presence of abundant reactive groups within Ag@PDA-(CSPBA/CSGA), the hydrogel sensor exhibited a comprehensive performance of self-healing, tissue adhesiveness, antioxidative activity, and antibacterial effects against Escherichia coli (92.76%) and Staphylococcus aureus (98.08%). Moreover, the hydrogel sensor could be utilized as a wound dressing, facilitating accelerated wound closure and tissue regeneration. Both subtle activities and large-scale movements could be monitored and distinguished by the hydrogel sensor. This study provides a promising epidermal sensor that offers multifunctionality for health monitoring and wound management.
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