Nature Communications
·
2026
·
IF 18.1
Yuan Lingjie,Huang Wei-Hsiang,Tang Zheng,Hsu Su-Yang,Fan Yalei,Wang Beibei,Xu Mingkai,Chen Tsung-Yi,Yeh Min-Hsin,Chen Jin-Ming,Hu Zhiwei,Zhu Yinlong
Exploiting cost-effective trifunctional electrocatalysts toward oxygen evolution reaction, hydrogen evolution reaction and oxygen reduction reaction is important for sustainable energy conversion and storage devices yet challenging. Here, we report a single-phase trifunctional electrocatalyst Sr 2 CoRuO 6-δ with well-defined super-exchange double perovskite structure, which can efficiently catalyze oxygen evolution, hydrogen evolution and oxygen reduction under alkaline conditions. As an air electrode, Sr 2 CoRuO 6-δ delivers high peak power density of 216 mW cm −2 , high specific capacity of 748 mAh g −1 and long lifespan up to 1000 h for liquid rechargeable zinc-air batteries, as well as broad temperature and deformation adaptability for solid-state flexible zinc-air batteries. Furthermore, an anion exchange membrane water electrolyzer employing Sr 2 CoRuO 6-δ as both cathode and anode requires a cell voltage of 1.90 V at the current density of 1 A cm −2 and shows a stable and rapid response when coupled with fluctuating solar electricity. Combining complementary in-situ and microscopic techniques, spatiotemporal surface reconstruction behavior of Sr 2 CoRuO 6-δ under varied reactions is comprehensively investigated and true active components are identified.
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PubMed
高影响因子
NEUROCHEMICAL RESEARCH
·
2026
·Vol. 51
·期 4
·207
·
IF 4.5
Fu Jie,Zhang Shaotao,Chu Yifei,Li Jinglun,Chen Xiu
Microglia-mediated neuroinflammation is closely associated with the pathogenesis of epilepsy. Mammalian sterile-20-like kinase 4 (MST4) has been suggested a regulator of inflammation. However, the effect of MST4 on microglia neuroinflammation in epilepsy remains unclear. A pilocarpine-induced rat epilepsy model was constructed and a lipopolysaccharide (LPS)-stimulated microglia cell model was applied in the current research. Knockdown or overexpression of MST4 was established using lentivirus transfection. Electroencephalograph (EEG) was employed to measure brain activities of rats. The protein and mRNA expressions were detected using western blot and qRT-PCR, respectively. Immunofluorescent staining was conducted to detect the distribution of the proteins. TUNEL staining was performed to evaluate cell apoptosis. The protein interaction was evaluated with Co-IP assay. Our results showed that MST4 and nuclear PKM2 expressions were increased in epileptic rats compared to control and colocalized with microglia. MST4 overexpression inhibited microglia activation, the release of TNF-α and IL-1β, and improved neuronal apoptosis in epileptic rats. Furthermore, MST4 interacted with PKM2 and regulated PKM2 nuclear translocation. Inhibiting PKM2 nuclear translocation by TEPP-46 reversed the promoting effect of MST4 knockdown on microglia neuroinflammation. In summary, our study demonstrated that MST4 alleviated microglia-mediated neuroinflammation in epilepsy, and the mechanism of MST4-mediated anti-neuroinflammatory effects may be associated with the inhibition of PKM2 nuclear translocation.
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DOI
PubMed
高影响因子
Nature Plants
·
2026
·
IF 15
Liu Zunyong,Chen Xin,Xu Zishu,Zhang Guiping,Chen Mingyu,Chen Yun,Ma Zhonghua
In both plant and animal innate immunity, rapid biosynthesis of cytokine-like peptides is essential for activating immune responses through plasma membrane receptor kinases. Peptide homeostasis is tightly controlled at multiple regulatory levels to avoid adverse effects caused by excessive phytocytokine production. However, the mechanisms underlying the rapid transition between transcriptional activation and repression of phytocytokine genes in response to immune stimuli remain largely unknown. Here we identify previously uncharacterized phytocytokine clusters in wheat, termed TaFIPs, which are rapidly induced by Fusarium infection. TaFIP genes are epigenetically regulated by H3K4me3 and H3K27me3 bivalent histone marks enabling rapid transcriptional shifts. Functionally, the leucine-rich repeat receptor kinase TaFIPR directly recognizes and binds TaFIPs to activate multiple immune responses, thereby enhancing wheat resistance to Fusarium infection. Our findings reveal an epigenetic mechanism that fine-tunes phytocytokine-mediated immunity in wheat.
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PubMed
高影响因子
CELL DEATH AND DIFFERENTIATION
·
2026
·
IF 13.6
Li Yue,Zhang Zuo,Yao Ran,Jin Xiying,Yong Zan,Song Xuguang,Sun Cai,Xu Zhengqing,Huang Yujin,Ju Wen,He Yuan,Qiao Jianlin,Zeng Lingyu
Myeloablative treatments before bone marrow (BM) transplantation severely disrupt the microvasculature of the BM, and its regeneration precedes and supports hematopoietic regeneration after BM transplantation. Thus, the identification of factors that regulate BM vascular regeneration after an injury could offer a significant therapeutic opportunity to improve hematopoietic regeneration. After myeloablation, the BM cavity is filled with various dying cell-derived products. Here, we show that after transplantation, dying cell-derived products educate macrophages into a proangiogenic state and enhance vascular regeneration in the BM. Mechanistically, dying cell-derived sphingosine-1-phosphate (S1P) primes hypoxia-inducible factor-1α (HIF-1α) gene expression in macrophages. Importantly, our results revealed that the degradation of apoptotic bodies (ApoBDs) elevates intracellular cholesterol levels and activates their sensor, liver X receptor α (LXRα), in macrophages. Activated LXRα physically binds to the HIF-1α protein and inhibits its ubiquitylation, further potentiating VEGFA expression in macrophages. In vivo studies using transgenic mouse models and liposome-mediated delivery confirm that the LXRα/HIF-1α axis is required for macrophage-driven vascular repair following transplantation. These data not only uncover a new role for macrophages in BM vascular regeneration, but also provide novel evidence demonstrating the unexpected beneficial effect of efferocytosis in eliciting the pro-healing functions of macrophages in the context of injury.
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PubMed
高影响因子
Nature Metabolism
·
2026
·
IF 27.5
Yao Tao,Tian Xin,Rao Linbin,Ni Jinling,Yu Jiayong,Yang Hongguo,Tang Yuexiao,Huang Xingxiao,Xia Xintong,Zhao Lin,Diao Bowen,Ping Yan,Wei Danni,Li Siqi,Chai Hui,Hu Zhiming,Ruan Xiongzhong,Feng Suihan,Shao Mengle,Shan Bo,Wu Ying
Tissue regeneration is essential for maintaining tissue homoeostasis and influences disease progression. In the liver, injury evokes a complex regenerative response with robust immune activation and metabolic rewiring, yet how these processes coordinate hepatocyte proliferation remains unclear. Here we show the presence of an injury-induced, lipid-dependent accrual of a distinct monocyte-derived macrophage (MDM) subset characterized by abundant cytosolic lipid content and heightened inflammatory response. Multi-omic analyses, spanning both single-cell transcriptomics and quantitative lipidomics, unveil substantial cellular diversity and heterogeneity between these ‘lipo-inflammatory MDMs’ (termed LIMMs) and other hepatic macrophages, including Kupffer cells. Blocking CD36-dependent LIMM induction markedly impairs hepatocyte proliferation and liver regeneration in injured livers. Mechanistically, CD36-mediated increase in ceramide biosynthesis activates IRE1α–XBP1 signalling pathway in LIMMs, driving production of the regenerative cytokine interleukin-6. Disrupting CD36-dependent IRE1α activation in LIMMs compromises liver repair. These findings identify a lipid-laden MDM subcluster as a key regulator of regenerative inflammation in injured livers.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
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2026
·
IF 4.6
Zhang Qiao-Ran,Wang Xin-Fei,Chen Ya-Nan,Zhou Bo-Yuan,Wei Hong-Liang,Cao Xiao-Yu,Wang Jin
Passive thermal regulation materials offer a promising route toward energy-efficient building and smart devices. However, achieving both passive radiative cooling and solar-driven heating within a single polymeric system remains a significant challenge due to trade-offs in optical transparency, solar reflectivity, and environmental durability. Herein, we report a molecularly engineered polyimide (PI) film platform with switchable cavitation (realized through controlled cross-linking) that enables bidirectional thermal regulation. By tuning the molecular architecture, the PI films can be fabricated into either a highly porous, white reflective film for passive cooling (about 90% solar reflectivity, Δ T is about −6 °C) or a transparent solid film for passive heating (about 88.7% solar transmittance, Δ T is about +8 °C). The films exhibit excellent flame retardancy (PHRR is about 7.98 W·g −1 ), thermal stability ( T max > 500 °C), and environmental resistance to UV and acidic conditions. Comprehensive outdoor and simulated tests confirm their dual-mode thermal regulation capabilities. This work presents a versatile strategy for designing robust, multifunctional PI materials for year-round thermal management in extreme environments, paving the way for next-generation energy-saving polymers.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2026
·
IF 4.4
Yan Zhuoxi,Zhang Jixiang,Zhang Han,Zhou Keyu,Zhang Jingjing
Polyvinyl alcohol (PVA) hydrogels are promising materials for soft robotics, biomimetic devices and wearable sensors, yet their practical applications are often hindered by low tensile strength and insufficient surface friction. Herein, a high-friction and tough PVA/polyisobutylene (PIB) hydrogel was successfully fabricated via a one-pot method combined with a solvent exchange strategy. Fourier transform infrared spectroscopy, X-ray diffraction and differential scanning calorimetry were employed to characterize the chemical interactions and crystalline behaviors of the hydrogels, while the water content, swelling ratio, microcosmic observation, tensile strength and tribological performance were tested to investigate the combination properties of hydrogels. The results revealed that glycerol was optimal for enhancing mechanical properties by promoting PVA crystallization and forming a dense network. The incorporation of PIB serving as a filler significantly improved the friction coefficient while maintaining adequate tensile strength. The PVA/PIB hydrogel with a PVA/PIB mass ratio of 17:3 exhibited the balanced performance, with a tensile strength of 1.5 MPa, an elongation at break of 545%, a high friction coefficient of 0.83 (which was higher than that of other hydrogels, up to 0.1191) and a low specific wear rate of 7.27 10 –4 mm 3 /Nm. Mechanistic studies indicated that the increase of friction resulted from the synergistic effects of PIB film formation, obstruction of water spillage under compression and the optimal material strength. Graphical abstract
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高影响因子
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
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2026
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IF 2.6
Huang Shizhong,Ma Jin,Shi Xiaoliang
Improving the tribological performance of gear surfaces is of great significance for extending service life and reducing energy consumption. In this study, inspired by the semi-ring structure of loach scales, semicircular surface textures were designed and further optimized using a topology optimization approach. Five types of textures with different geometries and arrangements were fabricated by laser marking, including semi-ring textures (BS), topologically optimized unidirectional parallel textures (TUP), topologically optimized unidirectional staggered textures (TUS), topologically optimized opposed parallel textures (TOP), and topologically optimized opposed staggered textures (TOC). SnAgCu solid lubricant was subsequently filled into these textures to prepare five self-lubricating samples, and their tribological performance was systematically investigated under both dry friction and oil-lubricated conditions. The results show that under dry friction conditions, the TUS sample exhibits reductions of 4.56% in the coefficient of friction (COF) and 64.77% in the wear rate compared to the smooth sample (SS). Under oil-lubricated conditions, the TUS sample demonstrates decreases of 19.2% in COF and 78.78% in wear rate relative to the SS sample. Overall, the topologically optimized textured surfaces exhibit superior tribological performance under different operating conditions, and appropriate texture arrangements are found to be more effective in mitigating wear of the AISI 4140 steel substrate.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 10
·693
·
IF 5.4
Li Sirui,Wang Shanshan,Chang Guorui,Yang Yaoxing,Feng Hui,Xue Haoqian,Zhang Li,Luo Manlin,Liu Jing,Li Bowen,Xu Shuxia
To enable rapid and reliable on-site monitoring of organophosphorus pesticides a novel portable dual-mode biosensor has been developed which integrates electrochemical and colorimetric detection into a single freeze-dried bioactive capsule. This innovative design supports instrument-free operation and provides dual-signal cross-validation. The sensor is based on a newly synthesized Mn/Ce bimetallic metal-organic framework (MOF) nanozyme with high oxidase-like activity, co-immobilized with acid phosphatase (ACP) within a mannitol- and sucrose-stabilized lyophilized capsule to ensure long-term stability and field readiness. In the presence of malathion, the pesticide selectively inhibits ACP, thereby restoring the MOF's catalytic activity and enabling the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB). The resulting signal is detected both visually and through chronoamperometry after conversion to a yellow diimine product. This approach achieves a wide linear detection range of 1–2000 nM and an exceptionally low detection limit of 0.06 nM for malathion, along with high accuracy evidenced by recoveries of 93.31%-104.03% in real water samples. This work establishes a field-deployable and user-friendly sensing platform that combines innovative material design with integrated dual-mode detection, offering a robust and practical strategy for on-site environmental monitoring. Graphical
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高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Xie Yuxin,Ding Zhiwei,Zeb Shakeel,Xiang Liangyin,Yu Rongpeng,Liu Zhanchao,Jiang Yinhua,Liu Yan
A novel surface molecularly imprinted electrochemical sensor for myricetin detection was developed. This sensor employs deep eutectic solvent (DES) as a green multifunctional electrolyte to suppress template oxidation, improve solubility, and assist the electropolymerization of a dual-monomer ( p -aminobenzoic acid, p -ABA; pyrrole, Py). The sensor with DES as the electrolyte exhibited a 1.3-fold higher response current than the aqueous system, owing to enhanced myricetin solubility and reduced template oxidation. Meanwhile, it was incorporated with a well-dispersed few-layer MXene to construct an optimal sensitized interface. The dual-monomer system is capable of two types of interactions with myricetin: p -ABA forms hydrogen bonds with its hydroxyl group, while Py undergoes π–π stacking with the aromatic a-ring. This synergistic binding generates an imprinted cavity with high specificity. The amount of sorbent, pH, and voltammetric parameters were all optimized during the experiment. Differential pulse voltammetry (DPV) showed that the sensor exhibited acceptable stability, a wide linear detection range of 2.0–160 µmol/L, and a low limit of detection (LOD) of 0.5 µmol/L (signal-to-noise ratio [S/N] = 3), with an imprinting factor of 3.4. The electrochemical investigation of myricetin in real fruit juice samples showed potential for the proposed sensor, which could have applications in food safety. Graphical abstract Deep eutectic solvent-assisted dual-monomer molecularly imprinted polymer (MIP) sensor for selective voltammetric determination of myricetin (MYR) with enhanced molecular recognition. A novel molecularly imprinted electrochemical sensor for myricetin detection is fabricated by immobilizing a dual-monomer surface molecularly imprinted polymer (SMIP) layer coupled with few-layer MXene on a glassy carbon electrode (GCE). The sensor was prepared using deep eutectic solvent (DES) as the electrolyte to maintain the stability of the target molecular structure and to facilitate interactions such as hydrogen bonding and π–π stacking, thereby enhancing the selectivity of the sensor. The developed analytical approach provides valuable insights for the design and development of other electrochemical sensing systems.
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高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2026
·
IF 3.1
Ye Sifei,Li Yingnan,Liu Peng,Deng Jianghao,Tang Qiuhua,Lei Xiaoting,Zeng Xiangrong,Wen Yangping
The abnormal accumulation of purine metabolites, such as adenine (A) and hypoxanthine (Hx), is closely associated with the pathogenesis of hyperuricemia and gout, underscoring the urgent need for precise methodologies enabling their simultaneous detection. To overcome the inherent limitations of conventional analytical techniques and resolve the challenge of overlapping voltammetric signatures in electrochemical sensing, this study presents an integrated analytical strategy encompassing an advanced sensing platform, sophisticated signal processing, and intelligent data analytics. A glassy carbon electrode modified with carboxymethyl cellulose-functionalized multi-walled carbon nanotubes (CMC-fMWCNTs/GCE) serves as the foundation for highly sensitive detection. Crucially, the application of half-order derivative voltammetry effectively resolves the overlapping oxidation peaks of A and Hx, thereby enhancing analytical selectivity. Complementing this, a K -means clustering algorithm is employed to enable automated, data-driven assessment of sensing stability. These components are integrated into a web-based intelligent system that automates the complete analytical workflow, from raw data ingestion to quantitative concentration readout. The proposed system exhibits a broad linear dynamic range (0.08–80 μM), low limits of detection (0.062 μM for A and 0.075 μM for Hx), and high analytical reproducibility (relative standard deviation < 5%), while streamlining the analytical process. Collectively, this work not only achieves the precise synchronous quantification of A and Hx but also establishes a transferable analytical framework for the intelligent analysis of small molecules with analogous structural features.
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高影响因子
Nature Chemical Biology
·
2026
·
IF 15.8
Liu Jiapeng,Han Jian,Wang Yupu,Song Mengjiao,Zhu Jianbei,Liang Yu,Chen Fangyi,Liu Zhike,Yan Xinwen,Wang Ziyuan,Peng Weicheng,Tu Ruibo,Zhang Zihan,Zhong Binglin,Sun Hao,Yin Junyi,Chang Jingbo,Long Yuying,Men Yinghui,Tsai Shang-Jui,Wang Shanshan,Susanto Teodorus Theo,Qiang Albert,Chen Yong,Pan Weijun,Lin Yizhu,Wu Wei,Shen Yidong,Li Jiefu,Wan Yue,Han Shuo
Understanding the spatial organization of biomolecules in living organisms is a central but challenging goal in biology. Here, we introduce peroxidase reactions activated by D -amino acids (PRADA), which uses an engineered oxidase to convert nonproteinogenic D -amino acids into H 2 O 2 for in situ activation of a genetically fused peroxidase. PRADA enables versatile proximity-based chemistries, including protein labeling, RNA labeling and functional polymer assembly, with minimal toxicity and background. We demonstrate that PRADA is broadly applicable inside living organisms, including flies, worms, fish and mice. By further leveraging the unique RNA reactivity of PRADA, we developed a mutational profiling sequencing strategy for spatiotemporally resolved mapping of RNA secondary structure. Application of this multifaceted PRADA platform in a mouse xenograft model offered insights into its mitochondrial proteome, transcriptome and RNA structurome, revealing RNA folding as a regulatory mechanism in mitochondrial gene expression. Collectively, PRADA holds promise to uncover the intricate organization of biomolecules in vivo.
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高影响因子
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