NANOTECHNOLOGY
·
2018
·Vol. 29
·期 20
·205705
·
IF 3.404
X X Cui,Q Fan,S J Shi,W H Wen,D F Chen,H T Guo,Y T Xu,F Gao,R Z Nie,Harold D Ford,Gordon H Tang,C Q Hou,B Peng
Fluorescence imaging signal is severely limited by the quantum efficiency and emission wavelength. To overcome these challenges, novel NIR-emitting K5NdLi2F10 nanoparticles under NIR excitation was introduced as fluorescence imaging probe for the first time. The photostability of K5NdLi2F10 nanoparticles in the water, phosphate buffer saline, fetal bovine serum and living mice was investigated. The fluorescence signal was detected with depths of 3.5 and 2.0 cm in phantom and pork tissue, respectively. Fluorescence spectrum with a significant signal-to-background ratio of 10:1 was captured in living mice. Moreover, clear NIR images were virtualized for the living mice after intravenous injection. The imaging ability of nanoparticles in tumor-beard mice were evaluated, the enrichment of K5NdLi2F10 nanoparticles in tumor site due to the enhanced permeability and retention effect was confirmed. The systematic studies of toxicity, bio-distribution and in-vivo dynamic imaging suggest that these materials give high biocompatibility and low toxicity. These NIR-emitting nanoparticles with high quantum efficiency, high penetration and low toxicity might facilitate tumor identification in deep tissues more sensitively.
✓ 已验证
DOI
高影响因子
JOURNAL OF EXPERIMENTAL BIOLOGY
·
2018
·Vol. 221
·期 5
·
IF 3.179
Zhang Junjun,Wang Zhengwei,Wen Ping,Qu Yufeng,Tan Ken,Nieh James C.
The nectar of the thunder god vine, Tripterygium hypoglaucum , contains a terpenoid, triptolide (TRP), that may be toxic to the sympatric Asian honey bee, Apis cerana , because honey produced from this nectar is toxic to bees. However, these bees will forage on, recruit for, and pollinate this plant during a seasonal dearth of preferred food sources. Olfactory learning plays a key role in forager constancy and pollination, and we therefore tested the effects of acute and chronic TRP feeding on forager olfactory learning, using proboscis extension reflex conditioning. At concentrations of 0.5–10 µg TRP ml −1 , there were no learning effects of acute exposure. However, memory retention (1 h after the last learning trial) significantly decreased by 56% following acute consumption of 0.5 µg TRP ml −1 . Chronic exposure did not alter learning or memory, except at high concentrations (5 and 10 µg TRP ml −1 ). TRP concentrations in nectar may therefore not significantly harm plant pollination. Surprisingly, TRP slightly increased bee survival, and thus other components in T. hypoglaucum honey may be toxic. Long-term exposure to TRP could have colony effects but these may be ameliorated by the bees’ aversion to T. hypoglaucum nectar when other food sources are available and, perhaps, by detoxification mechanisms. The co-evolution of this plant and its reluctant visitor may therefore likely illustrate a classic compromise between the interests of both actors.
✓ 已验证
DOI
高影响因子
JOURNAL OF CRYSTAL GROWTH
·
2022
·
IF 1.83
ShuTian XuanYuan,Hongxun Hao,Cuihong Hu,Jinqi Lan,Tong Song,Chuang Xie
Quantitative analysis of crystallization processes remains challenging due to the complicated relationships among the multiple phases and their spectra. In this work, in situ Raman spectroscopy was chosen to quantitatively analyze the solution concentration and suspension density simultaneously in a crystallization process . A model based on support vector regression (SVR) was developed to separate the information of solution and solid from the Raman spectra. The simultaneous correlations of the spectra with solution concentration and suspension density were achieved and the results were evaluated. It demonstrated that the SVR-based method proposed in this work gave satisfactory fitting and prediction performance. Furthermore, the model was validated in the reactive crystallization of the ternary NaHCO 3 -Na 2 CO 3 -H 2 O system. It suggested that baseline removal is not necessary when using this model. The effect of bubbles should be included for the clear solution but could be neglected in solid suspensions. The results of this work provide a simple and rapid option for the quantitative analysis of crystallization processes and similar suspension systems.
✓ 已验证
DOI
高影响因子
Exploration
·
2024
·
IF 0
Heng Guo,Linlin Shi,Zengliang Shi,Yue He,Yizhi Zhu
Yellow light-emitting diodes (LEDs) with a wavelength of 570–590 nm can reduce the excitability of peripheral nerves and the sensitivity of the skin, stimulate collagen synthesis, and tighten the skin, which plays an important role in skin rejuvenation. In general, commercial LEDs are made of phosphor excited by ultraviolet chips. It is very important for the development of yellow light emitters with high luminous efficiency, good stability, and environmental protection. For the first time, a simple organic structural unit (2-methylimidazole, 2-MIM) was used to collect a mixture of two metal precursors (CsI and CuI) and successfully synthesized an all-inorganic lead-free yellow light CsCu 2 I 3 powder in water. The prepared CsCu 2 I 3 powder exhibited excellent optical properties and considerable stability. Finally, a phosphor-converted LED (pc-LED) device was fabricated via the CsCu 2 I 3 phosphor coated on a 310 nm ultraviolet chip. The pc-LED device's electroluminescence spectra may be a good fit for the blood's absorption regions. Therefore, this work provides a facile method for the synthesis of novel lead-free metal halide CsCu 2 I 3 powder in eco-friendly solvents. In addition, the stable and efficient CsCu 2 I 3 powder shows promising exciting potential applications in photoluminescence and phototherapy fields.
✓ 已验证
DOI
Cell Reports Physical Science
·
2022
·
IF 7.832
Han Man,Jingjing Feng,Shaofei Wang,Shuyang Li,Peng Li,Huiwen He,Wioletta Raróg-Pilecka,Jie Zhao,Jichao Zhang,Fang Fang,Dalin Sun,Yongtao Li,Yun Song
Transition-metal chalcogenides (TMCs) show great potential as highly efficient and cost-effective electrocatalysts for oxygen evolution reaction (OER). Yet the electrochemical conversion into oxides/hydroxides remains poorly understood. In this work, we develop a built-in, electric-field-induced surface reconstruction strategy for ultra-fast self-activation of transition metal sites in self-supporting CoS 2 /CuS heterostructures. The activated CoS 2 /CuS grown on carbon cloth with oxygenated surface species displays an outstanding OER electrocatalytic activity with ultra-low overpotentials of only 136 mV at the current density of 10 mA cm −2 and 266 mV at 100 mA cm −2 in 1.0 M KOH. Comparative studies via synchrotron radiation X-ray absorption spectroscopy and theoretical calculations are employed to elucidate that the built-in electric field within heterointerfaces significantly promotes the reconstruction efficiency by decreasing the formation energy of (oxy)hydroxide species. We believe this work provides new perspectives to conceive catalysts with ultra-low overpotentials and complements the fundamental comprehension of TMCs’ self-reconstruction mechanism.
✓ 已验证
DOI
高影响因子
Heliyon
·
2022
·
IF 3.776
Wenjun Zhu,Qianqian Gu,Boyan Liu,Yanhong Si,Huirong Sun,Jingjie Zhong,Yi Lu,Dan Wang,Junli Xue,Shucun Qin
As an antioxidant, anti-inflammatory and anti-apoptotic agent, hydrogen (H 2 ) shows a promising potential in basic and clinical research against various diseases owing to its safety and efficacy. However, knowledge involving its underlying mechanisms of action, dosage effects, and dose duration remains limited. Previously, the dynamics of H 2 concentrations in different tissues of rats after exogenous H 2 inhalation had been detected by our team. Here, sequential changes of H 2 concentrations in different tissues of another most commonly used experimental rodent mice were monitored in real time with an electrochemical H 2 gas sensor during continuous different concentrations of H 2 inhalation targeting on five tissues including brain, liver, spleen, kidney, and gastrocnemius. The results showed that the H 2 saturation concentrations varied among tissues significantly regardless of the concentration of H 2 inhaled, and they were detected the highest in the kidney but the lowest in the gastrocnemius. Meantime, it required a significant longer time to saturate in the thigh muscle. By comparing the H 2 saturation concentrations of mice and rats, we found that there were no differences detected in most tissues except the kidney and spleen. Both gas diffusion and bloodstream transport could help the H 2 reach to most organs. The results provide data reference for dosage selection, dose duration determination to ensure optimal therapeutic effects of H 2 for mice experiments.
✓ 已验证
DOI
高影响因子
Journal of the American Chemical Society
·
2019
·
IF 14.695
Fangfang Wei,Shiu-Lun Lai,Shunan Zhao,Maggie Ng,Mei-Yee Chan,Vivian Wing-Wah Yam,Keith Man-Chung Wong
A series of luminescent cyclometalated rhodium(III) complexes have been designed and prepared. The improved luminescence property is realized by the judicious choice of a strong σ-donor cyclometalating ligand with a lower-lying intraligand (IL) state that would raise the d–d excited state and introduction of a lower-lying emissive IL excited state. These complexes exhibit high thermal stability and considerable luminescence quantum yields as high as up to 0.65 in thin film, offering themselves as promising light-emitting materials in OLEDs. Respectable external quantum efficiencies of up to 12.2% and operational half-lifetimes of over 3000 h at 100 cd m–2 have been achieved. This work demonstrates a breakthrough as the first example of an efficient rhodium(III) emitter for OLED application and opens up a new avenue for diversifying the development of OLED materials with rhodium metal being utilized as phosphors.
✓ 已验证
DOI
高影响因子
ChemElectroChem
·
2022
·Vol. 9
·期 24
·e202200884
·
IF 4.782
Li Zhang,Ziqiang Liu,Gaowei Wang,Wangjun Feng,Xiaoyun Wang,Jianze Feng,Xiaqing Zhang,Hongyun Ma,Xu Zhang,Yongtai Xu,Siyuan Yao,Yunxia Ding,Kailimai Su,Xingbin Yan
Graphical Dual Graphite Batteries : Based on the decomposability of potassium oxalate monohydrate (K 2 C 2 O 4 ⋅H 2 O) as positive additive, it can provide extra cations to support a stable negative interface and suppress the anion-cation crosstalk. The as-constructed DGBs with K 2 C 2 O 4 ⋅H 2 O deliver high-rate capability (31.8 mAh g –1 at 3.0 C) and excellent cyclic stability (∼84.1 % capacity retention after 180 cycles). Due to their merits of affordability, safety, and environmental friendliness, dual graphite batteries (DGBs) have drawn widespread interest as novel energy storage devices. Nevertheless, the development of DGBs is plagued by inferior cyclic stability that arise from the irreversible loss of cations and the anion-cation crosstalk during the formation of an negative interface. We proposed an in-situ sacrificial positive additive strategy to enhance the electrochemical performances, based on the decomposability of potassium oxalate monohydrate (K 2 C 2 O 4 ⋅H 2 O). The experimental and computational results show that the positive additive can add cations to support a stable negative interface and suppress the anion-cation crosstalk. The as-constructed DGBs with K 2 C 2 O 4 ⋅H 2 O deliver high-rate capability (31.8 mAh g −1 at 3.0 C) and excellent cyclic stability (∼84.1 % capacity retention after 180 cycles). This work provides a new opportunity of negative interface construction for propelling the commercial evolution of the advanced DGBs.
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Yanyan Wu,Zijuan Xie,Ying Li,Zhe Lv,Lingling Xu,Bo Wei
Developing efficient oxygen evolution reaction (OER) electrocatalysts with earth-abundant elements is very important for sustainable H 2 generation via electrochemical water splitting. Here we design a crystalline-amorphous Ni–Fe–Al hybrid phosphides nanosheet arrays grown on NiFe foam for efficient OER application. Dynamic surface reorganization of phosphides at anodic/cathodic polarizations is probed by in situ Raman spectroscopy . The reconstructed amorphous Ni(Fe)OOH species are determined as the active phases that facilitate the OER process. This unique electrode shows highly catalytic activity toward water oxidation , achieving the current densities of 10 and 100 mA cm −2 at 181 and 214 mV in 1 M KOH, respectively. Meanwhile, it also exhibits excellent stability at a large current density of 100 mA cm −2 for over 60 h. This work reveals the dynamic structural transformation of pre-catalyst in realistic conditions and highlights the important role of oxyhydroxides as real reactive species in OER process with high activity.
✓ 已验证
DOI
高影响因子
ACS Sensors
·
2024
·
IF 8.2
Fang-Kun Yang,Jie Cao,Ting Zhang,Hao-Xiang Jiang,Han-Bin Cui,Kai Wang
Cardiovascular disease (CVD) is a chronic disease characterized by the accumulation of lipids and fibrous tissue within the arterial walls, potentially leading to vascular obstruction and an increased risk of heart disease and stroke. Hydroxyl radicals play a significant role in the formation and progression of CVD as they can instigate lipid peroxidation, resulting in cellular damage and inflammatory responses. However, precisely detecting hydroxyl radicals in CVD lesions presents significant challenges due to their high reactivity and short lifespan. Herein, we present the development and application of a novel activatable optical probe, Cy-OH-LP, designed to detect hydroxyl radicals in lipid-rich environments specifically. Built on the Cy7 molecular skeleton, Cy-OH-LP exhibits near-infrared absorption and fluorescence characteristics, and its specific response to hydroxyl radicals enables a turn-on signal in both photoacoustic and fluorescence spectra. The probe demonstrated excellent selectivity and stability in various tests. Furthermore, Cy-OH-LP was successfully applied in an in vivo model to detect hydroxyl radicals in mouse models, providing a potential tool for diagnosing and monitoring AS. The biosafety of Cy-OH-LP was also verified, showing low cytotoxicity and no significant organ damage in mice. The findings suggest that Cy-OH-LP is a promising tool for the specific detection of hydroxyl radicals in lipid-rich environments, providing new possibilities for research and clinical applications in the field of oxidative stress-related diseases.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Applied Spectroscopy
·
2025
·
IF 1
Wu H.,Meng L.
Nitrogen-doped carbon quantum dots (N-CQDs) were prepared by a one-step hydrothermal method using urea, aniline, and ethylenediamine as raw materials and nitrogen sources which exhibited good fluorescence performance. Spectral characteristics of the samples were analyzed using UV spectrophotometry, fluorescence spectrophotometry, and Fourier transform infrared spectroscopy. Optimal conditions, such as pH, reaction time, and ion concentration were investigated for N-CQDs. Under the optimal conditions (40 μL N-CQDs, buffer solution at pH 6 with a reaction time of 30 min), it was observed that cobalt ions caused a significant fluorescence quenching effect on the prepared N-CQDs, as determined by fluorescence spectrophotometry. The spiked recovery rates ranged from 95.8 to 104.6%, indicating that the N-CQDs could serve as a fluorescent probe for detecting the content of Co(II) in the actual environment. This method could be applied to the monitoring of heavy metal pollution in mine groundwater, the detection results of Co(II) using this method were very similar to ICP-MS, indicating that this method had good application prospects.
✓ 已验证
DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2018
·
IF 4.556
Zhengwei Huang,Ying Huang,Cheng Ma,Xiangyu Ma,Xuejuan Zhang,Ling Lin,Ziyu Zhao,Xin Pan,Chuanbin Wu
The objective of this study was to perform the in vitro and in vivo validation of an endotracheal aerosolization (ETA) device (HRH MAG-4, HM). Solid lipid nanoparticle suspension (SLNS) formulations with particle sizes of approximately 120, 240, 360, and 480 nm were selected as model nanoparticle suspensions for the validation. The emission rate (ER) of the in vitro aerosolization and the influence of aerosolization on the physicochemical properties were investigated. A high ER of up to 90% was obtained, and no significant alterations in physicochemical properties were observed after the aerosolization. The pulmonary deposition of model drug budesonide in Sprague–Dawley rats was determined to be approximately 80%, which was satisfactory for pulmonary delivery. Additionally, a fluorescent probe with aggregation-caused quenching property was encapsulated in SLNS formulations for in vivo bioimaging, after excluding the effect of aerosolization on its fluorescence spectrum. It was verified that SLNS formulations were deposited in the lung region. The results demonstrated the feasibility and reliability of the HM device for ETA in laboratory investigation.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）