Theranostics
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2016
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IF 8.854
Yunkun Li,Yachao Li,Xiao Zhang,Xianghui Xu,Zhijun Zhang,Cheng Hu,Yiyan He,Zhongwei Gu
Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications. We herein report a dual-responsive supramolecular PEGylated dendritic system for efficient platinum-based drug delivery and near-infrared (NIR) tracking. With a refined molecular/supramolecular engineering, supramolecular dendritic systems were stabilized by bioreducible disulfide bonds and endowed with NIR fluorescence probes, and PEGylated platinum derivatives coordinated onto the abundant peripheral groups of supramolecular dendritic templates to generate pH/redox dual-responsive theranostic supramolecular PEGylated dendritic systems (TSPDSs). TSPDSs markedly improved the pharmacokinetics and biodistribution of platinum-based drugs, owing to their stable nanostructures and PEGylated shells during the blood circulation. Tumor intracellular environment (low pH value and high glutathione concentration) could trigger the rapid disintegration of TSPDSs due to acid-labile coordination bonds and redox-cleavable disulfide linkages, and then platinum-based drugs were delivered into the nuclei to exert antitumor activity. In vivo antitumor treatments indicated TSPDSs not only provided high antitumor efficiency which was comparable to clinical cisplatin, but also reduced renal toxicity of platinum-based drugs. Moreover, NIR fluorescence of TSPDSs successfully visualized in vitro and in vivo fate of nanoplatforms and disclosed the intracellular platinum delivery and pharmacokinetics. These results confirm tailor-made supramolecular dendritic system with sophisticated nanostructure and excellent performance is a promising candidate as smart theranostic nanoplatforms.
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CARBOHYDRATE POLYMERS
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2016
·
IF 4.219
Huizhen Zheng,Meng Gao,Ying Ren,Ruyun Lou,Hongguo Xie,Weiting Yu,Xiudong Liu,Xiaojun Ma
A pH-responsive carrier based on an ethylenediaminetetraacetic-calcium-alginate (EDTA-Ca-Alg) system was developed by controlling the release of Ca 2+ . The system remained in the solution state at neutral pH since EDTA completely chelated the Ca 2+ . In contrast, a hydrogel immediately formed when the pH was below 4.0, which triggered the in situ release of Ca 2+ from the EDTA-Ca compound and led to alginate-Ca binding. Taking advantage of the pH sensitivity, we prepared hydrogel microspheres with uniform size to entrap Lactobacillus rhamnosus ATCC 53103 through emulsification. In an acidic environment, the hydrogel structure remained compact with negligible pores to protect L. rhamnosus ATCC 53103. However, in a neutral intestinal environment, the hydrogel structure gradually disassembled because of the Ca 2+ release from the hydrogel, which caused cell release. Therefore, a pH-responsive carrier was developed for the protection and the controlled release of cells in gastrointestinal tract, thus providing potential for oral delivery of probiotics.
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CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Xinyu Hu,Yongmei Wang,Liangliang Zhang,Man Xu,Wei Dong,Jianfa Zhang
Salecan is a novel water-soluble extracellular β-glucan and possesses excellent physicochemical and biological properties. Here, redox/pH dual stimuli-responsive hydrogel based on Salecan grafted with itaconic acid (IA) and 2-hydroxyethyl methacrylate (HEMA) were prepared using disulfide-functionalized crosslinker N,N - bis (acryloyl)cystamine (BAC) for controlled drug delivery. The introduction of carboxylic groups endows the system with pH-sensitive character, swelling behavior of the hydrogel was conducted by changing the pH and Salecan content. It was demonstrated that DOX was efficiently loaded into the hydrogels and released in a controlled fashion via pH-control and swelling-shrinking mechanism. More importantly, DOX-loaded hydrogels showed dose dependent cytotoxicity toward A549 cell, and efficient cell killing was observed. Furthermore, a key point of this study was that the presence of disulfide linkage in system favored the degradation of hydrogels in the reductive environment. These results highlight the potential of Salecan- g -SS-poly(IA- co -HEMA) hydrogel as a novel system for the controlled release of anti-cancer drugs.
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Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Juan Wu,Wei Jiang,Yewen Shen,Wei Jiang,Renbing Tian
Multifunctional nanocarriers based on the Fe 3 O 4 nanoparticles core and mesoporous silica shell (mSiO 2 ) were synthesized for controlled drug release through magnetic targeting and pH-sensitive performances. The developed Fe 3 O 4 @mSiO 2 nanocarriers exhibited a suitable size (63 nm) and good magnetic responsibility, doxorubicin (DOX) could be successfully loaded into the mesoporous of Fe 3 O 4 @mSiO 2 via electrostatic interaction, and the drug loading content and loading efficiency are 29.3% and 93.6%, respectively. The chitosan (CS) was employed to wrap the Fe 3 O 4 @mSiO 2 -DOX as the blocking agent to inhibit premature drug release, and the final CS/Fe 3 O 4 @mSiO 2 -DOX exhibited excellent pH-sensitivity, 86.1% DOX was released within 48 h at pH 4.0. Furthermore, all the release behaviors fit the Higuchi model very well and a purely diffusion-controlled process played a major role on DOX release from CS/Fe 3 O 4 @mSiO 2 -DOX. In addition, MTT assays in human liver hepatocellular carcinoma cells (HepG2) demonstrated that the CS/Fe 3 O 4 @mSiO 2 -DOX had high anti-tumor activity, while the Fe 3 O 4 @mSiO 2 nanocarriers were practically non-toxic. Thus, our results revealed that the CS/Fe 3 O 4 @mSiO 2 -DOX could play an important role in the development of intracellular delivery nanodevices for cancer therapy.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2016
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IF 8.328
Jianqing Ma,Qunfeng Yang,Yuezhong Wen,Weiping Liu
Heterogeneous Fe-N complexes are a kind of promising catalysts for the Fenton-like reaction. The present study selected a stable and inexpensive g-C 3 N 4 as the chelating agent and combined with the graphitized mesoporous carbon (GMC). The fabricated Fe-g-C 3 N 4 /GMC composite was characterized by several techniques including FTIR, XRD, XPS, TEM and STXM. Results showed clear sheets of g-C 3 N 4 and graphite with Fe evenly distributed mostly in the Fe-N coordination form. The catalyst expressed high activity in the Fenton-like reaction in a wide pH range of 4–10. 99.2% removal of Acid Red 73 was obtained in 40 min, and the degradation data well fitted with the pseudo-first-order kinetics model. By correlating the constant of reaction rates calculated from the model and the Fe speciation contents of the samples prepared at different conditions, we deduced that Fe-N species are the most important active sites for the Fenton-like reaction. More importantly, hydroxyl radicals played a great role in the whole reaction yet their generation was independent of visible light. Cyclic voltammetry results confirmed that the GMC can accelerate the Fe(III)/Fe(II) redox cycle by enhancing electron transfer, and thus enable this Fenton-like catalyst to perform well in a wide pH range.
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Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Juan Wu,Aipeng Deng,Wei Jiang,Renbing Tian,Yewen Shen
This study focuses on the synthesis and in vitro evaluation of magnetic nanocomposites (Fe 3 O 4 @LDH) as methotrexate (MTX) delivery system for targeted anticancer therapy. In which, the Fe 3 O 4 nanoparticles acted as magnetically responsive carriers; the coating layer of layered double hydroxide (LDH) was used as a storehouse for MTX. The prepared Fe 3 O 4 @LDH nanocomposites exhibited a suitable size, good stability and magnetic responsibility (M s 36.66 emu/g); MTX successfully intercalated into the LDH of Fe 3 O 4 @LDH at an entrapment rate (%) of 91.78% (the drug loading was 18.36%) by host-guest exchange process. Moreover, the release studies in vitro showed that the drug delivery system (Fe 3 O 4 @LDH-MTX) had excellent pH-sensitivity, 84.94% of MTX was released within 48 h at pH 3.5 via the co-effect of dissolution of LDH layer and ion-exchange. WST-1 assays in cancer cells (MCF-7 and HepG2) and normal cells (HUVEC) demonstrated that Fe 3 O 4 @LDH-MTX exhibited high anticancer activity while low toxicity to normal cells, and also the Fe 3 O 4 @LDH composites were practically non-toxic. Thus, our results revealed that Fe 3 O 4 @LDH-MTX would be a competitive candidate for targeted delivery and sustained and controlled release of MTX.
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PROCESS BIOCHEMISTRY
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2017
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IF 2.497
Hongxia Pan,Ting Yang,Jialing Chen,Xuejun Cao
Cefprozil, a semi-synthetic antibiotic, has been used in pediatric therapy. The purpose of this study was to improve the yield of cefprozil and obtain purer product in an aqueous two-phase system composed of P ADB and P MDB . P ADB and P MDB were synthesized using acrylic acid, methacrylic acid, 2-dimethylaminoethyl methacrylate, and butyl methacrylate. Cefprozil was synthesized with 7-amino-3-(1-propenyl)-4-cephalosporanic acid (7-APRA) as the main ring, ( R )-amino-(4-hydroxyphenyl) acetic acid methyl ester hydrochloride (D-HPGME-HCl) as the acyl donor and the immobilized penicillin acylase as the catalyst. 7-APRA and D-HPGME-HCl were concentrated in the P MDB -rich phase, while cefprozil was in the P ADB -rich phase. The optimal partitiona coefficient of cefprozil was 1.84 with 40 mM KSCN, while the enzyme reaction yield of cefprozil reached 99.39% compared with 77.61% in the aqueous-phase system. The recovery of the two copolymers was up to 96.01% at pH 3.54. After crystallization, the purity of the product reached 88.02%, and no copolymer remained in the product. The combination of cefprozil∙DMF was detected by gas chromatography-mass spectrometry, FT-IR spectroscopy, thermogravimetric analysis, and electrospray ionization mass spectrometry. The results showed that no chemical bond existed between cefprozil and DMF.
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ELECTROCHIMICA ACTA
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2016
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IF 4.803
Li Shao,Xing Qian,Xiaoying Wang,Hongmei Li,Rucai Yan,Linxi Hou
Highly efficient and low-cost electrocatalysts are essential for producing hydrogen through water electrolysis. Here ternary compounds CoMoS 4 and NiMoS 4 were synthesized by a one-step reaction, and further CoMoS 4 -H and NiMoS 4 -H were obtained by heating the above two samples under Ar atmosphere. The above four materials both show uniformly small irregular nanoparticles. Each element of the four materials exhibits semblable valence without distinct difference of which S was −2, Mo was +6, Ni and Co were +2. We firstly use the above ternary materials as advanced electrocatalysts for HER over a wide pH range, of which CoMoS 4 -H displays the best performance with a low onset overpotential at 8 mV in 1.0 M KOH and 83 mV in 0.5 M H 2 SO 4 . NiMoS 4 -H also shows excellent performance with a low onset overpotential at 26 mV in 1.0 M KOH and 160 mV in 0.5 M H 2 SO 4 . In 1 M phosphate buffer solution, CoMoS 4 -H and NiMoS 4 -H exhibit onset overpotential at overpotential of 122 mV and 152 mV, respectively. These results indicate that the combination of earth-abundant sulfur, cobalt (or nickel) and molybdenum elements can provide highly active electrocatalysts for HER over a wide pH range.
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RSC Advances
·
2016
·Vol. 7
·期 1
·248-255
·
IF 3.289
Huajian Chen,Yan Ma,Xianwen Wang,Xiaoyi Wu,Zhengbao Zha
Due to their clinical use approved by US Food and Drug Administration (FDA), Prussian blue nanoparticles (PB NPs) have been explored as a new generation of photothermal agents for cancer photothermal therapy (PTT). However, PTT treatment alone has limited therapeutic efficiency since it can not eliminate tumor cells completely. Herein we developed a facile method for the synthesis of PB NPs through a combined ligand exchange and thin film hydration process, modified the PB NPs by lipid-PEG conjugation, producing PEGylated PB NPs, and encapsulated doxorubicin (DOX) in the PEGylated PB NPs via hydrophobic interactions, creating PEGylated PB-DOX NPs. Obtained from the results of fluorescence intensity measurements, the loading efficiency and content of DOX in PEGylated PB-DOX NPs was as high as 98.0% and 9.2%, respectively. The DOX release from the PEGylated PB-DOX NPs was significantly enhanced at acidic pH, likely due to the protonation of the amine group, and a three-parameter simulation model was used to gain insight into the pH effect on DOX release. Moreover, a cell cytotoxicity study in vitro shows that PEGylated PB-DOX NPs exhibits a remarkable photothermal-chemo synergistic effect to HeLa cells, attributed to both photothermal ablation mediated by the PEGylated PB NPs and enhanced cellular uptake of DOX. Therefore, our study may open a new path for the production of PB NPs as drug delivery vehicles for combined photothermal-chemo cancer treatment.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2016
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IF 2.857
Huayao Chen,Yueshun Lin,Hongjun Zhou,Xinhua Zhou,Sheng Gong,Hua Xu
The salicylaldehyde-modified mesoporous silica (SA–MCM-41) was prepared through a co-condensation method. Through the bridge effect from the copper ion, which also acts as the nutrition of the plant, the model drug chlorpyrifos (CH) was supported on the copper(II) Schiff base mesoporous silica (Cu–MCM-41) to form a highly efficient sustained-release system (CH–Cu–MCM-41) for pesticide delivery. The experimental results showed that the larger the concentration of the copper ion, the more adsorption capacity (AC) of Cu–MCM-41 for chlorpyrifos and the smaller its release rate. The results confirmed the existence of a coordination bond between SA–MCM-41 and copper ions as well as a coordination bond between Cu–MCM-41 and chlorpyrifos. The AC of SA–MCM-41 is 106 mg/g, while that of Cu–MCM-41 is 295 mg/g. The as-synthesized system showed significant pH sensitivity. Under the condition of pH ≤ 7, the release rate of chlorpyrifos decreased with increasing pH, whereas its release rate in weak base conditions was slightly larger than that in weak acid conditions. Meanwhile, the drug release rate of the as-synthesized system was also affected by the temperature. Their sustained-release curves can be described by the Korsmeyer–Peppas equation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xiaowei Xu,Jie Yong,Lin Wang,Su Chen,Jie Pang
The aim of this study was to utilize pH-responsive hydrogel skin scaffolds to achieve the sustained release of bioactive compounds (BCs) to promote wound healing. ZIF-8@flavanone nanoparticles were successfully synthesized through microfluidic channels and integrated into a hydrogel scaffold consisting of carrageenan (KC) and konjac glucomannan (KGM) to create a pH-responsive composite hydrogel scaffold. The unique pore structure of ZIF-8 efficiently loaded the active material, and the coordination bonds were disrupted in a slightly acidic environment, allowing the release of flavonoids. The natural macromolecular polysaccharides KC and KGM have good biocompatibility, and as a moist but not wet hydrogel scaffold substrate, they more closely resemble the growth environment of cells and are more favorable for wound healing. The hydrogel scaffolds developed in this study had a tensile strength of 1.15 MPa, an elongation at break of 320 %, good biocompatibility, a relative cell viability of 99.6 %, relative antimicrobial rate of 96.3 % ( E. coli ) and 95.8 % ( S. aureus ), respectively, and a release rate of 43.3 % at a pH of 5.0, and a wound closure rate at 15 d of 90.5 %, contributing to the improvement of wound healing performance and providing new possibilities for customized antimicrobial wound dressings.
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PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Bingyan Yu,Keru Hou,Zhuizhui Fan,Kaili Jin,Zaisheng Cai
pH-responsive materials are an important choice for the preparation of smart membranes due to their simplicity of operation, but their substrate requirements are high and most of the existing materials are slow to respond. Cotton fabrics with three-dimensional structures have high strength and resistance to acid and alkali, enabling rapid penetration of acid and alkali solutions with fast response time. In this paper, hexadecyltrimethoxysilane (HDTMS) was used to hydrophobically modify the surface of polydopamine (PDA)-modified CF, and novel CF with pH-adjustable wetting properties were designed by the Michael addition reaction and the Schiff base reaction among 12-aminodododecanedioic acid (NH 2 (CH 2 ) 11 COOH) and PDA. In neutral and acidic aqueous solutions (pH ≤ 7), the coated cotton fabric showed hydrophobicity and lipophilicity, with a separation efficiency of 97.3 % and a separation flux of 3.8 × 10 4 L·m −2 ·h −1 . On the contrary, in alkaline aqueous solutions (pH > 7), the coated cotton fabric had a fast conversion time (within 20s), exhibited oleophobicity and hydrophilicity, with a separation efficiency of 99.9 % and a separation flux of 2.8 × 10 4 L·m −2 ·h −1 . In addition, the cycling and durability tests showed that the cotton fabric had excellent cyclability and durability. This simple, green, intelligent wetting material can be ideal for controllable on-demand oil-water separation.
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