INORGANIC CHEMISTRY
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2024
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IF 4.3
Mengzeng Wu,Jingui Xu,Dongzhou Zhang,Yi Zhou,Wei Chen,Shanrong Zhang,Qifa Zhong,Dawei Fan
Layered materials have attracted extensive attention due to their exceptional physical and chemical properties. Understanding the structural evolution of such materials under high pressure is crucial for the development of new functional materials. In this study, the structure evolution of the synthesized layered rare-earth hydroxyhalide YCl(OH)2 under high pressures up to approximately 9.4 GPa was explored by using a diamond anvil cell combined with synchrotron single-crystal X-ray diffraction. Simultaneously, high-pressure Raman spectroscopy experiment was conducted to 10.3 GPa. Our findings indicate that YCl(OH)2 maintains its symmetry within the experimental pressure range. The pressure–volume data of YCl(OH)2 were fitted to the third-order Birch–Murnaghan equation of state (EoS) to derive its EoS parameters including zero-pressure unit-cell volume (VT0), isothermal bulk modulus (KT0), and its pressure derivative (K’T0): VT0 = 142.47 (1) Å3, KT0 = 38.2 (18) GPa, and K’T0 = 9.8 (1). However, the unit-cell parameters a, b, and c exhibit a distinct compressional behavior, with the a-axis being the most compressible and the b-axis being the least. Particularly noteworthy is the observation that YCl(OH)2 displays a negative linear compressibility along the b-axis within the pressure range of 0.4–5.3 GPa. Further detailed structure refinement and Raman spectroscopy analyses indicate that the anomalous behavior of the b-axis could be attributed to the formation of the O–H···O hydrogen bonding chains along the b direction. Moreover, the coordination number of Y3+ increased from 8 to 9 as the pressure reached 5.3 GPa due to the reduction of the interlayer spacing upon compression, ultimately leading to the closure of the interlayer gap.
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JOURNAL OF CELLULAR PHYSIOLOGY
·
2017
·Vol. 233
·期 6
·4919-4925
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IF 4.08
Ji Li,Mincheng Zhang,Yong Mao,Yimao Li,Xiaoxia Zhang,Xuehan Peng,Feng Yu
Aristolochic acid I (AA-I), one of the main active components in Aristolochaia herbs, may induce aristolochic acid nephropathy (AAN). Renal interstitial fibrosis is one of the most typical features of AAN. To investigate the mechanism of Aristolochic acid I (AA-I) −induced renal epithelial-mesenchymal transition (EMT) and determine the role of aquaporin-1 (AQP1) in this process, we established an AA-I-induced EMT model in human proximal tubular epithelial cells (HK-2 cells). Morphological examination, MTT assay, and Western blot analysis were performed. Aquaporin 1 (AQP1) and several EMT-related proteins were detected, thereby suggesting the occurrence of AA-I-induced EMT. Two main pathways of transforming growth factor-β (TGF-β) signaling, namely, Smad-dependent and Smad-independent signaling pathways, were also detected. The results showed that the TGF-β / Smad-independent signaling pathways (β-catenin, Ras-Raf-Erk1/2 signaling pathways) were activated, and AQP1 expression was decreased during the AA-I induced EMT on HK-2 cells. With the presence of TGF-β1 receptor inhibitor (LY364947) and Erk1/2 inhibitor (PD98059), AQP1 expression was altered by PD98059, suggested that AQP1 could be adjusted by Erk1/2 signaling. Moreover, the inhibitory effect of AA-I on AQP1 was stronger than that of TGF-β1, suggested that AQP1 may be an important target on AAN clinical therapy.
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FOOD AND AGRICULTURAL IMMUNOLOGY
·
2018
·
IF 2.568
Fengyin Liu,Zijian Chen,Yudong Shen,Yuanming Sun,Jinyi Yang,Hong Wang,Hongtao Lei,Zhenlin Xu
Immunoassay direct for 3-amino-5-morpholinomethyl-2-oxazolidone (AMOZ), the metabolite of furaltadone, based on a specific antibody was usually unavailable due to its small molecule weight. In this work, a hapten with a double bond and an active carboxyl group was designed and then conjugated to peptide dendrimer to obtain novel multiple haptens. The haptens and multiple haptens were coupled to bovine serum albumin as immunogens. Polyclonal antibodies showed binding to free AMOZ in a heterologous competitive indirect enzyme-linked immunosorbent assay were obtained. The assay showed IC50 (half maximal inhibitory concentration) of 4.1 μg/kg and limit of detection of 0.2 μg/kg for AMOZ. Recoveries of AMOZ from grass carp were tested from 83.1% to 117.0%, with the coefficient of variation below 12%. As no laborious derivatisation procedure was employed, the proposed assay should be useful for the screening of AMOZ for a large number of samples.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2018
·
IF 5.018
Qiangqiang Xiao,Wenhui Yuan,Li Li,Tao Xu
Latent thermal energy storage using phase change material (PCM) is an effective way to store and transport energy. In this work, expanded graphite was modified using octylphenol polyoxyethylene ether to generate modified expanded graphite (MEG), and then a novel shape-stabilized Ba(OH) 2 ·8H 2 O/MEG composite PCM was synthesized by incorporating Ba(OH) 2 ·8H 2 O into MEG matrix. Mass fractions of Ba(OH) 2 ·8H 2 O in composite PCM were calculated from 74% to 93%. The effects of MEG on properties of PCM were investigated using scanning electron microscopy, X-ray diffraction, differential scanning calorimetry and thermal constant analyzer. The results indicated that MEG had the desired compatibility with Ba(OH) 2 ·8H 2 O. The phase separation of Ba(OH) 2 ·8H 2 O was effectively inhibited by the MEG matrix and the supercooling temperature decreased from 13 °C for Ba(OH) 2 ·8H 2 O to 2.4 °C for composite PCM with a MEG matrix density of 200 g/L. At the same matrix density, the thermal conductivity of composite PCM reached 3.58 W/(m K), 1.84 times higher than that of Ba(OH) 2 ·8H 2 O. The latent heat was approximately equal to the product of the latent heat of Ba(OH) 2 ·8H 2 O and its mass fraction. Moreover, the enthalpy loss of the composite PCM was negligible after 400 cycles, showing good thermal reliability.
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ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Lu Qin,Peng She,Panlong Si,Suqin Liu,Gaopeng Dai,Cong Pan
Photocatalytic production of H 2 O 2 is indeed a safe, sustainable and cost-effective technology, offering an environmentally friendly solution to the energy crisis through solar photocatalysis. However, it still faces challenges such as reliance on organic electron donors and pure O 2 , as well as inefficiencies in hole utilization. To overcome these limitations, a dual-channel photocatalytic system has been developed. In this study, we showcase the efficiency of the CuO/Cu(OH) 2 @g-C 3 N 4 composite, derived from CuBTC/g-C 3 N 4 via NaOH treatment, as a high-performance dual-channel photocatalyst for H 2 O 2 production. Under visible light (λ ≥ 420 nm), this composite achieves a H 2 O 2 yield of 1354 μmol/L in 120 min without any sacrificial agent, outperforming g-C 3 N 4 by 8.4 times, CuO by 13.6 times and CuO@g-C 3 N 4 by 1.9 times. Quenching experiments and electron paramagnetic resonance spectra confirmed that HO • and O 2 •− are intermediate products in the photocatalytic process, following a two-step single-electron reaction pathway. The superior activity of CuO/Cu(OH) 2 @g-C 3 N 4 in H 2 O 2 generation can be attributed to the synergistic effects of OH bonds on the CuO@g-C 3 N 4 Z-type heterojunction and Cu(OH) 2 . This research presents a straightforward and promising approach for developing highly efficient photocatalysts for energy conversion.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Wei Liu,Ming Yang,Shuang Wang,Yan-Sai Bao,Yong-He Cui,Ling-Xu Meng,Liang-Cheng Li,Yang Wu,Yu-Yang Zhang
Solid-phase microextraction (SPME) has been widely used for the analyzing trace organic pollutants in environmental samples. The properties of coatings have a significant effect on the application range, selectivity and sensitivity of existing analytical methods. Therefore, the development of SPME technology depends on fibers with a stable, efficient, and selective coating. In this study, metal-organic frameworks (MOFs) were used to fabricate porous carbon membranes in situ for SPME. The composite material (UIO66-NH 2 @PAC) was directly carbonized to prepare a derivative porous carbon material (C-UIO66-NH 2 @PAC), which was applied to the extraction of off-odour organic pollutants for the first time. The Zr-N co-doping in the material was not only beneficial to the formation of derivatized porous carbon, but also endowed it with a certain hydrophilicity, which was highly advantageous for capturing weakly polar compounds. By optimizing the extraction and desorption conditions, a highly selective and sensitive analytical method was developed, which exhibited a detection limit of 0.61 and 0.78 ng L −1 for 2-methylisoborneol (2-MIB) and geosmin (GSM), respectively, along with a linear range from 10 to 3000 ng L −1 . Both intra-fiber repeatability (RSD 5.5 % and 3.7 %) and inter-fiber repeatability (RSD 9.7 % and 8.8 %) were satisfactory. The fiber coated with C-UIO66-NH 2 @PAC exhibited high extraction efficiency (the extraction efficiency of the analytes was 4.6–8.3 times higher than that of commercial fibers), and had excellent thermal and chemical stability. Finally, the C-UIO66-NH 2 @PAC-coated fibers were successfully applied to the SPME analysis of off-odour organic pollutants in real water samples, and these results highlighted the broad prospect for the detection of natural/drinking water.
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Frontiers in Pharmacology
·
2024
·
IF 4.4
Wang Mengting,Mao Haiguang,Ke Zhijian,Wang Jinbo
Background: The hypoglycemic effects of Chinese bayberry leaves proanthocyanidins (BLPs) have been demonstrated. It is unclear, nevertheless, whether BLPs reduced postprandial blood glucose levels by regulating glucose uptake and glucose transport.
Method: This study investigated the effect of BLPs (25, 50 and 100 μg/mL) on glucose uptake and glucose transport in human intestinal epithelial cells (Caco-2 cells). The uptake of 2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl) amino]-D-glucose (2-NBDG) and disaccharidases activity in Caco-2 cells were measured. The glucose transport ability across the cell membrane was determined using the established Caco-2 monolayer model. The transcript and protein levels of key glucose transporters were analyzed using real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting, respectively.
Results: The results showed that BLPs significantly decreased glucose uptake and disaccharidases activity (p<0.05). Otherwise, BLPs treatment obviously inhibited glucose transport across the Caco-2 monolayer in both simulated-fast (5 mM glucose) and simulated-fed (25 mM glucose) conditions. It was attributed to the suppression of glucose transporter2 (GLUT2) and sodium-dependent glucose cotransporter 1 (SGLT1) by BLPs. BLPs were found to significantly downregulated the transcript level and protein expression of glucose transporters (p<0.05). Meanwhile, the mRNA expression of phospholipase C (PLC) and protein kinase C (PKC) involved in the signaling pathway associated with glucose transport were decreased by BLPs.
Conclusion: These results suggested that BLPs inhibited intestinal glucose transport via inhibiting the expression of glucose transporters. It indicated that BLPs could be potentially used as a functional food in the diet to modulate postprandial hyperglycemia.
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Catalysts
·
2024
·Vol. 14
·期 12
·929
·
IF 3.8
Jingxin Tan,Mengqi Li,Lingtao Liu,Lijian Wang,Haocun Wang,Junjie Bian,Chunhu Li
Biomass platform compound 5-Hydroxymethylfurfural (HMF), with its low price and abundant source, can be used as a renewable resource to replace traditional petrochemicals. MOF-808(Zr) has tunable active sites and excellent stability under high temperatures and acidic as well as basic environments, and the unsaturated coordination of metal ions within its framework structure can exhibit Lewis acidity, facilitating catalytic transfer hydrogenation from HMF to 2, 5-Furandimethanol (BHMF). The hydrothermal–impregnation–reduction method was used to prepare Cu/MOF-808 catalysts with high catalytic performance. Formic acid was chosen as the hydrogen donor solvent. The selectivity and yield of BHMF were 75.65% and 71%, respectively, at 150 °C for 4 h. A reaction pathway for the catalytic hydrogen transfer of HMF to BHMF was proposed. The high activity and stability of the Cu/MOF-808 catalyst with dual active sites provide a viable method for feasible hydrogenation of HMF to high value-added compounds.
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TALANTA
·
2024
·
IF 5.6
Qiang Tang,Xiaoling Huang,Guangxing Liu,Hongran Huang,Jiayi Zhang,Jihua Wei,Yuanxun Gong,Qianli Tang,Kai Zhang,Xianjiu Liao
This study introduces a novel electrochemical biosensor for detecting Matrix Metalloproteinase-2 (MMP-2), a key biomarker in cancer diagnostics and tissue remodeling. The biosensor is based on a dual-amplification strategy utilizing T7 RNA polymerase isothermal amplification and CRISPR-Cas12a technology. The principle involves the release of a DNA template in the presence of MMP-2, leading to RNA synthesis by T7 RNA polymerase. This RNA activates CRISPR-Cas12a, which cleaves a DNA probe on the electrode surface, resulting in a measurable electrochemical signal.The biosensor demonstrated exceptional sensitivity, with a detection limit of 2.62 fM for MMP-2. This high sensitivity was achieved through the combination of transcriptional amplification and the collateral cleavage activity of CRISPR-Cas12a, which amplifies the signal. The sensor was able to detect MMP-2 across a wide dynamic range from 2 fM to 1 nM, showing a strong linear correlation between MMP-2 concentration and the electrochemical signal. In practical applications, the biosensor accurately detected elevated levels of MMP-2 in cell culture supernatants from HepG2 liver cancer cells, distinguishing them from normal LO2 liver cells. The use of an MMP-2 inhibitor confirmed the specificity of the detection. These results underscore the biosensor's potential for clinical diagnostics, particularly in early cancer detection and monitoring of tissue remodeling activities. The biosensor's design allows for rapid, point-of-care testing without the need for complex laboratory equipment, making it a promising tool for personalized healthcare and diagnostic applications.
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JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Tao Wu,Shiyu Zhang,Miaomiao Zhang,Mengying Long,Guangzhe Wang,Tianrun Gu,Hao Deng,Cuiting Ding,Runnan Zhang,Zhongyi Jiang
When introducing acid groups in the diamine monomer for the fabrication of polyamide (PA) membranes through interfacial polymerization (IP), the acid groups not only reduce the diffusion flux of diamine monomer for the polymerization to prepare ultrathin membrane but also provide the negative charges on the membrane surface . However, the introduction of acid groups often weakens the reactivity of diamine monomers, resulting in the formation of thick and loose PA membranes with low rejection of ions. This study proposes a strategy of modulating the IP process of piperazine-2-carboxylic acid (CPIP) by employing an acid acceptor (NaOH) to prepare thin nanofiltration membranes . The acid acceptor can neutralize the HCl to prevent CPIP from being protonated during the IP process, thereby facilitating the cross-linking reaction rate. The thickness of the resulting membrane decreases from 180 nm to 30 nm, accompanied by the fortification of the negative charge, an increase in cross-linking density, and a reduction in pore size. The resulting PA-AA/CPIP_1.0 membrane exhibits a water permeance of 44.6 L m −2 h −1 bar −1 , with a significantly increased Na 2 SO 4 rejection of 98.4 % compared with 50.4 % of the PA-AA/CPIP_0 membrane fabricated without acid acceptor. This work may open a new avenue to fabricating high-performance PA membranes for nanofiltration .
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ANALYST
·
2011
·Vol. 136
·期 22
·4770-4773
·
IF 3.913
Ling Chen,Tingting Lou,Chunwei Yu,Qi Kang,Lingxin Chen
An approach for mercury ions (Hg2+) sensing based on the Hg2+-induced aggregation of thymine (T)–SH-functionalized gold nanoparticles (AuNPs) has been reported. The T–SH ligands that we synthesized can easily be coupled to the surface of AuNPs through the Au–S bond and can recognize Hg2+ with high selectivity by forming a T–Hg–T complex with strong affinity. For the T–SH-functionalized AuNPs (T–S-AuNPs) sensor, upon addition of Hg2+, the formation of the T–Hg–T complex induces aggregation of T–S-AuNPs and results in a significant change of color and UV-Vis absorption spectra. Thus, our method can be used for the rapid, easy and reliable screening of Hg2+ in aqueous solution, with high sensitivity (2.8 nM) and selectivity over competing analytes. The developed method is successfully applied to the sensing of Hg2+ in real environmental samples.
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DALTON TRANSACTIONS
·
2024
·
IF 3.5
Cengceng Du,Zhenyu Wang,Yiming Wang,Wenjuan Xu,Yuqiu Huo,Hongbin Sun,Guangwen Xu
Constructing an environmentally friendly and efficient electrocatalyst holds important and profound significance for energy-efficient hydrogen production. Replacing the oxygen evolution reaction with a lower potential urea oxidation reaction (UOR) may save energy in water electrolysis to produce hydrogen. The UOR is characterized by its high energy barrier, which results in slow reaction kinetics. In this study, we introduced Ba(OH)2 into Ni(OH)2 to form uniform nanosheets. Due to the introduction of Ba2+, the lattice expansion of Ni(OH)2 was triggered, leading to significant improvement in UOR activity. The catalyst achieved a current density of 100 mA cm−2 at only 1.316 V and exhibited remarkable stability over time. Density functional theory (DFT) calculations demonstrate that the Ba–Ni(OH)2 site significantly reduces the energy barrier for urea adsorption, intermediate steps, and desorption. This work provides a novel and environmentally friendly strategy for constructing energy-efficient and highly efficient catalysts through the doping of alkaline earth metals.
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