ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2021
·Vol. 29
·期 13
·19273-19282
·
IF 4.223
Lu Jiarui,Wu Jie,Gong Lulin,Cheng Yuan,Yuan Qingbin,He Yide
Despite extensive investigation on the toxicity of microplastics (MPs), an emerging global concern, little is known about the combined toxicity of MPs and co-occurring pollutants in aquatic environments. In this study, the combined toxicity of polystyrene MPs and sulfamethoxazole (SMZ) antibiotics was explored in zebrafish embryos in terms of the developmental, physiological, and endocrine toxicities. Exposure to PS and SMZ induced mortality (rate: 25.0 ± 7.5%) and malformation (rate: 20~35%) at multiple regions and stages of zebrafish development. Physiological toxicity was also induced as shown by the significant decrease in fetal movement (by 31.1~37.0%) and swimming frequency (by 26.9~36.8%) and the increase in heartbeat rate (by 19.0~20.9%). Finally, PS and SMZ exposure also induced extensive endocrine toxicities in zebrafish as confirmed by increases in various biomarkers including vitellogenin, 17β-estradiol, testosterone, and triiodothyronine. The combination index showed that antagonistic effects were present between PS and SMZ toxicity, which slightly decreased their combined toxicity. This study aims to further understand the combined toxicity of MPs and co-occurring pollutants in aquatic environments.
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FOOD SCIENCE AND BIOTECHNOLOGY
·
2023
·
IF 2.9
Hou Tianmeng,Wang Feijie,Wang Liqiang
Intelligent controlled release technologies that rely on environmental changes to control the release rate of antimicrobial agents have attracted attention in the field of food preservation. In this paper, cinnamaldehyde (CN) was grafted onto chitosan (CS) to form a pH-responsive controlled-release complex, CS–CN, via the Schiff base reaction. Then, tempo oxidized cellulose nanofibers (CNF) and PVA were prepared as aerogels loaded with CS–CN with different pore parameters (PCNF@CN). Release experiments showed that acid triggered the release of CN and increased the release from 10.3 to 68.4% with increasing pH. In addition, PCNF@CN showed significant pH-responsive antimicrobial properties against Escherichia coli and Staphylococcus aureus . Utilizing the water absorption of the aerogel and triggering the release of CN, the shelf life of fresh meat could be delayed for 4 days. This study demonstrated the potential application of PCNF@CN aerogel in functional food preservation packaging.
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MICROCHIMICA ACTA
·
2023
·Vol. 191
·期 1
·1-14
·
IF 5.7
Sun Wang,Liu Junyan,Chu Huacong,Wang Yang
Abstract The synergistic armor-etching (SAE) approach was proposed using natural organic weak acid (tannic acid, i.e., TA) for the controllable assembly of hollow and interpenetrated HZIF-8@MWCNTs hybrid nanomaterial (ZIF-8, zeolitic imidazolate framework-8; MWCNTs, multi-walled carbon nanotubes), which exhibited highly ordered crystal structure and unique morphological characteristics. The SAE strategy not only can rapidly etch solid ZIF- material into a hollow structure (~ 10 min), but also form the TA shell (~ 33 nm) on its surface. Then, the HZIF-8@MWCNTs electrochemical sensor was constructed for selective and sensitive detection of the target molecule (dopamine, DA). A sequence of studies indicated that the fabricated TA coating was capable of promoting the spread of DA into the reactive centers of hollow MOF and MWCNTs, which exhibited outstanding electroanalytical characteristics through the synergistic effect. The DPV oxidation peak of DA was strongest at 50 mV vs. Ag/AgCl reference electrode. Under the optimal conditions, there are two linear dynamic ranges of current response of 0.01 ~ 10 and 10 ~ 550 µmol L − 1 with a detection limit of 0.003 µmol·L − 1 (S/N = 3). Simultaneously, the HZIF-8@MWCNTs electrochemical sensor could detect low levels of DA in real products. The recoveries of the actual sample tests were between 98.2% and 102%, and the relative standard deviation (R.S.D.) of all studies was less than 3.0%. The statistical analyses (F-test and t-test) were employed to demonstrate the accuracy of method developed. This work will enlighten researchers operating in the domain of MOFs composites, accelerating the advancement of electrochemical sensing on the basis of hollow MOFs materials. Graphical Abstract
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MICROCHIMICA ACTA
·
2023
·Vol. 191
·期 1
·1-11
·
IF 5.7
Lu Yuyang,Shen Nuotong,Xi Yachao,Zhu Tao,Peng Hao,Zhong Lihao,Li Fang
Mn 3 O 4 nanozyme with good oxidase-like activity was successfully synthesized. The prepared Mn 3 O 4 nanozyme can directly and effectively catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to generate green–blue-colored ox-TMB. Creatinine exhibits distinct inhibition effect on Mn 3 O 4 nanozyme-catalyzed TMB colorimetric reaction system, leading to obvious color fading and absorbance intensity decrease of the reaction system. Furthermore, interference from uric acid can be effectively eliminated by regulating the pH of TMB-Mn 3 O 4 colorimetric reaction system to pH 2.0. Then, a simple and bioenzyme-free colorimetric assay for the determination of creatinine was developed based on TMB-Mn 3 O 4 colorimetric reaction. The linear detection range is from 100 to 800 μM and from 1 to 20 mM. The lowest limit of detection is 35.3 μM. Satisfied results are obtained for the determination of creatinine in real urine and sweat samples. This work provides the synthesis of a good oxidase-like nanozyme Mn 3 O 4 and presents the fabrication of an effective nanozyme-based bioenzyme-free colorimetric assay for the determination of creatinine. Graphical Abstract
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-10
·
IF 16.6
Xue Tiantian,Zhu Chenyu,Yu Dingyi,Zhang Xu,Lai Feili,Zhang Longsheng,Zhang Chao,Fan Wei,Liu Tianxi
Polyimide aerogel fibers hold promise for intelligent thermal management fabrics, but their scalable production faces challenges due to the sluggish gelation kinetics and the weak backbone strength. Herein, a strategy is developed for fast and scalable fabrication of crosslinked polyimide (CPI) aerogel fibers by wet-spinning and ambient pressure drying via UV-enhanced dynamic gelation strategy. This strategy enables fast sol-gel transition of photosensitive polyimide, resulting in a strongly-crosslinked gel skeleton that effectively maintains the fiber shape and porous nanostructure. Continuous production of CPI aerogel fibers (length of hundreds of meters) with high specific modulus (390.9 kN m kg −1 ) can be achieved within 7 h, more efficiently than previous methods (>48 h). Moreover, the CPI aerogel fabric demonstrates almost the same thermal insulating performance as down, but is about 1/8 the thickness of down. The strategy opens a promisingly wide-space for fast and scalable fabrication of ultrathin fabrics for personal thermal management.
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Nano Research
·
2023
·
IF 9.9
Tong Zongwei,Yan Xiangjie,Wang Yuexiang,Li Kexun,Ma Weihai
Increasing porosity is one of the most direct ways to improve the thermal insulation and dielectric properties of materials. Until now, many wet methods for preparing Si 3 N 4 ceramic foams usually face the problems of complex rheology, long period, and expensive cost, and the reported pore sizes of Si 3 N 4 ceramic foams are typically micron-grade, resulting in a lack of competitiveness in thermal insulation and wave-transparent applications. In this paper, the Si 3 N 4 @SiO 2 ceramic foams were prepared using an efficient dry-method, which combined three processes of low temperature chemical vapor deposition (LTCVD), template, and isostatic pressing. The method has the advantages of simple operation and short preparation period, and can realize near-net size molding and mass production. In addition, the evolution mechanisms of honeycomb microstructure and composition of Si 3 N 4 @SiO 2 ceramic foam during sintering were studied by chemical reaction thermodynamics. The as-prepared Si 3 N 4 @SiO 2 ceramic foam possesses low density (0.377 g·cm −3 ), high compressive strength (7.5 MPa), low thermal conductivity (0.0808 W·m −1 ·K −1 ), and excellent dielectric properties ( ε < 1.32, tan δ < 0.009) in the frequency range of 8–18 GHz, and its maximum working temperature in air can reach up to 1100 °C. It will be recommended to be applied in the interlayer of Si 3 N 4 ceramic radome to improve its thermal insulation and electromagnetic wave transparency performances.
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Frontiers of Optoelectronics
·
2023
·Vol. 16
·期 1
·1-12
·
IF 5.4
Li Dongyu,Lin Hao,Sun Silin,Liu Shaojun,Liu Zhang,He Yuening,Zhu Jingtan,Xu Jianyi,Semyachkina-Glushkovskaya Oxana,Yu Tingting,Zhu Dan
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder that poses a significant burden on socio-economic and healthcare systems worldwide. However, the currently available therapy of AD is limited, and new strategies are needed to enhance the clearance of β-amyloid (Aβ) protein and improve cognitive function. Photobiomodulation (PBM) is a non-invasive and effective therapeutic method that has shown promise in treating various brain diseases. Here, we demonstrate that 1267-nm PBM significantly alleviates cognitive decline in the 5xFAD mouse model of AD and is safe as it does not induce a significant increase in cortical temperature. Moreover, with the combination of 3D tissue optical clearing imaging and automatic brain region segmentation, we show that PBM-mediated reductions of Aβ plaques in different subregions of prefrontal cortex and the hippocampus are different. The PBM-induced lymphatic clearance of Aβ from the brain is associated with improvement of memory and cognitive functions in 5xFAD mice. Our results suggest that the modulation of meningeal lymphatic vessels (MLVs) should play an important role in promoting Aβ clearance. Collectively, this pilot study demonstrates that PBM can safely accelerate lymphatic clearance of Aβ from the brain of 5xFAD mice, promoting improvement of neurocognitive status of AD animals suggesting that PBM can be an effective and bedside therapy for AD. Graphical Abstract
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Bao Siqi,Yu Xiaotong,Li Xiaolin
Antibiotic contamination has a significant negative impact on China, one of the largest producers and consumers of antibiotics worldwide. In this study, a three-dimensional flower-like structure of CoFe-LDHs was used to efficiently degrade tetracycline (TC) in a system triggered by peroxymonosulfate (PMS) and exposed to visible light. After exploring the effects of different metal ratios, catalyst dosage, initial TC concentrations, and pH, the optimal reaction conditions were determined. In comparison to pure CoFe-LDHs, the TC elimination rate was dramatically increased by the addition of the PMS. The strong environmental resistance, excellent stability and reusability, and universal flexibility were shown. The quenching experiments and electron spin resonance detection showed that the creation of reactive oxygen species was facilitated by the synergistic transmission of electrons between the active bimetallic components. Further, photogenerated holes was the dominant oxidizing species, which contributed more to the degradation of TC. The potential degradation pathways and intermediate toxicity of TC were suggested. This work offers a new method dominated by photogenerated holes for efficiently removing TC effluent.
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Chemistry Central Journal
·
2016
·Vol. 10
·期 1
·1-11
·
IF 2.552
Guo Wenbo,Yan Mengmeng,Xu Bing,Chu Fuhao,Wang Wei,Zhang Chenze,Jia Xiaohui,Han Yaotian,Xiang Hongjun,Zhang Yuzhong,Wang Penglong,Lei Haimin
Background Glycyrrhetinic acid (GA) derivatives had shown not only cytotoxicity but also could trigger apoptosis in various human cancer cell lines. Moreover, cinnamic acid (CA) and its phenolic analogues as potent antitumor agents were employed in the design of anti-tumor drugs. To further improve the anti-tumor activity of GA and CA derivatives, a series of novel compounds were designed and synthesized using GA and CA derivatives fragments.Results The result showed that all the novel glycyrrhetinic acid-cinnamoyl (GA–CA) hybrids presented higher antitumor activity on the tumor cell lines of HepG2, HT-29, Hela and lower cytotoxicity on three non-tumor cells lines MDCK, HY926, H9C2 than the parent compounds (IC50 > 50 μM). It was worth noting that 8a had a superior cytotoxicity effect on Hela cells (IC50 = 8.54 μM) than on other cancer cell lines (IC50 > 15 μM). And it also indicated that 8a showed lower cytotoxicity (IC50 > 27 μM) towards MDCK, HY926 and H9C2 cells than cisplatin (DDP, IC50 < 10 μM). Moreover, according to the acute toxicity, it could be indicated that the LD50 of 8a exceeded 3.0 g/kg by oral administration in mice. The further research using Giemsa, H33342 staining, flow cytometric analysis and caspase-3 assay showed that 8a could cause Hela cell damage, nuclei lysis and apoptosis. In addition, the structure–activity relationships of these hybrids were briefly discussed.Conclusion sCompared with GA, target compounds demonstrated better anti-tumor activity, among which 8a was the most active one. What’s more, structure–activity relationship analysis also revealed that hybrids with trans olefinic bond group show higher antitumor activity than those without olefinic bond, such as 1a > 1b, 6a > 2b, 8a > 3b, 9a > 4b. In addition, it was found that the methoxy substituent might enhance selectivity of GA–CA hybrids towards regular non-cancerous cells MDCK, HY926 and H9C2, such as 4a, 6a, 7a, 8a. However, there might be less relationship between the cytotoxicity and the quantity, position of methoxy moiety. Hence, it is urgent need to synthesize efficient, low toxicity and multi-target anti-tumor compounds based on the structure combination principle.
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JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 54
·期 7
·5695-5711
·
IF 3.442
Qin Jiejie,Huang Yan,Yan Guoqing,Wang Jun,Hu Liefeng,Zhang Panpan,Tang Rupei
In this work, the tumor-targeted ultra-pH-responsive conjugates (PBA/Dex-g-OE) and nontargeted conjugates (Dex-g-OE) were successfully prepared and could easily self-assemble into stable micelles with lower CMC values in neutral aqueous solution. Transmission electron microscopy and dynamic light scattering measurement indicated that the resulting micelles have desirable size distribution and regular spherical shape. The PBA/Dex-g-OE micelles possessed high stability in physiological condition and were pH sensitive to both extracellular and intracellular acidic conditions. Doxorubicin (DOX) was efficiently loaded to give the DOX-loaded micelles (PBA/Dex-g-OE-DOX and Dex-g-OE-DOX) with the desirable drug loading contents. In vitro cellular uptake and growth inhibition assays suggested that PBA/Dex-g-OE-DOX micelles were more efficiently internalized by monolayer tumor cells and three-dimensional multicellular tumor spheroids (MCTS) than nontargeted micelles (Dex-g-OE-DOX), leading to the fast and complete destruction of MCTS in vitro.
研究领域:
药剂学
·
肿瘤学
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ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
·
2019
·Vol. 41
·期 3
·1545-1557
·
IF 3.252
Ye Bin,Cang Yan,Li Ji,Zhang Xiaolei
Chlorine dioxide (ClO 2 ) has been widely used in the process of preoxidation and disinfection as an excellent water treatment reagent. However, the inorganic by-products produced by ClO 2 , such as chlorite (ClO 2 − ) and chlorate (ClO 3 − ) are harmful to human health, and this has become a potential problem when using ClO 2 in drinking water treatment. In this study, ClO 2 alone and a ClO 2 /NaClO combination process were carried out to evaluate the algae removal efficiency of the treatment and the formation of disinfection by-products (DBPs: chlorite, chlorate, trihalomethanes and haloacetic acids) for high algae-laden water with 124.16 µg L −1 chlorophyll a (Chl.a) content. The results show that disinfection with 1.5 mg L −1 ClO 2 alone results in a ClO 2 − concentration exceeding 0.7 mg L −1 . ClO 2 preoxidation/ClO 2 disinfection is applicable for the control of effluent quality, but the ClO 2 − concentration still has an excessive risk when using 0.8 mg L −1 and 0.6 mg L −1 ClO 2 for the two process, respectively. In the ClO 2 /NaClO combination process, the ClO 2 − concentration is below 0.6 mg L −1 , and trihalomethane (THM) and haloacetic acid (HAA) concentrations are lower than 60% of the maximum contaminant levels (MCLs) set by the World Health Organization (WHO). Further, the formation of ClO 2 − is more effectively controlled by NaClO preoxidation/ClO 2 disinfection than ClO 2 preoxidation/NaClO disinfection.
研究领域:
环境科学
·
水处理工程
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 13
·9845-9857
·
IF 2.779
Hu Ke,Wang Ruoheng,Maimaitituersun Mieralimu,Sun Huajun,Liu Xiaofang,Zhang Yong
In this work, ultrathin Bi 2 WO 6 nanosheets (BWO NS) was synthesized by two-step hydrothermal process, which exhibited a lamellar structure with a thickness of about 10 nm and a transverse length of 100–400 nm. The piezoelectric properties and photocatalytic properties of BWO NS were coupled successfully, and the piezo-photocatalytic activity was studied through the decomposition of 10 mg L − 1 Rhodamine B (Rh B). The results showed that the degradation ratio of BWO NS for Rh B was about 98.39% within 70 min, which was higher than that of sole piezocatalysis (48.98%) and photocatalysis (61.84%). There was no significant degradation of the catalytic performance observed after being recycled four times. Moreover, piezo-photocatalysis of BWO NS efficiently produced active radicals that the major reactive oxidative species (ROS) such as superoxide radicals (·O 2 − ) and hydroxyl radicals (·OH) were confirmed by radical capture experiment. The excellent piezo-photocatalysis of BWO NS endows it the potential application for decomposing organic dye via making full advantage of the vibration and solar energy present in natural environments.
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