NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 21
·9702-9708
·
IF 2.7
An-Xu Ma,Cai-Fang Liu,Yu-Lan Zhu,Zong-Hong Luo,Hong-Mei Zhou,Yue Zhang,Bang-Jin Wang,Jun-Hui Zhang,Sheng-Ming Xie,Li-Ming Yuan
In this work, a chiral core–shell microspheres composite, L-his-MIL-53-NH2@SiO2, was prepared through in situ growth and chiral post-modification strategies. The core–shell microspheres were applied as a novel chiral stationary phase for HPLC enantiomeric separation. Various racemates were separated on the L-his-MIL-53-NH2@SiO2 packed column using n-hexane/isopropanol as the mobile phase. The chiral column showed excellent separation efficiency for fourteen chiral compounds, including alcohols, alkanes, esters, phenols, ketones, and organic acids. The influence of injection mass and temperature on the separation performance of the chiral column were investigated. The relative standard deviations (n = 5) of the retention time and peak area by repeated separation of benzoin are 0.28% and 0.63%, respectively. The results show that the L-his-MIL-53-NH2@SiO2 packed column exhibited good reproducibility and stability. In addition, the chiral resolution ability of the L-his-MIL-53-NH2@SiO2 packed column was compared with that of a commercial chiral column (Chiralpak AD-H). The L-his-MIL-53-NH2@SiO2 packed column exhibits unique advantages in chiral separations that can be complementary to the commercial chiral column. It was demonstrated that the chiral core–shell microspheres composite L-his-MIL-53-NH2@SiO2 prepared based on in situ growth and chiral post-modification strategies has great potential for enantiomeric separation by HPLC.
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BIOTECHNOLOGY AND BIOENGINEERING
·
2024
·
IF 3.5
Han-Yu Liu,Pan Ning,Feng Qian,Yao-Wu Wang,Hai-Min Zhang,Pu Wang
Flavin-dependent halogenase (FDH) is highly prized in pharmaceutical and chemical industries for its exceptional capacity to produce halogenated aromatic compounds with precise regioselectivity. This study has devised a multi-enzyme self-assembly strategy to construct an effective and reliable in vitro coenzyme cycling system tailored for FDHs. Initially, tri-enzyme self-assembling nanoclusters (TESNCs) were developed, comprising glucose dehydrogenase (GDH), flavin reductase (FR) and FDH. The TESNCs exhibited enhanced thermal stability and conversion efficiency compared to free triple enzyme mixtures during the conversion of L -Trp to 6-Cl- L -Trp, resulting in a 2.1-fold increase in yield. Subsequently, an ordered co-immobilization of GDH, FR, and FDH was established, further amplifying the stability and catalytic efficiency of the FDH coenzyme cycle system. Compared to the free TESNCs, the immobilized TESNCs demonstrated a 4.2-fold increase in catalytic efficiency in a 5 mL reaction system. This research provides an effective strategy for developing a robust and efficient coenzyme recycling system for FDHs.
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PubMed
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SOUTH AFRICAN JOURNAL OF BOTANY
·
2025
·
IF 2.7
Jingxin Chen,Jian Shi,Wenting Gu,Weiye Li,Ruiyin Lyu,Xueping Wu,Junming Wang,Chunhong Liu
Depression is a worldwide affliction that seriously compromises social adaptation and physical well-being. Citrus medica L. var. sarcodactylis Swingle (also known as Bergamot) is a citrus plant in the Rutanceae family. Bergamot essential oil, a naturally derived product, has been reported to possess neuroprotective effects. The present study aimed to reveal the neuroprotective mechanisms of bergamot essential oil in PC12 cells, and compare its efficacy with that of its predominant constituent, D-limonene. To confirm the target of action, this study sought to use PI3K inhibitor LY294002 to validate the mechanism in modulating autophagy and apoptosis of bergamot essential oil. By constructing a corticosterone-induced PC12 cell model of depression in vitro , we observed that bergamot essential oil stimulated the PI3K/AKT/mTOR signaling cascade, reducing autophagy markers LC3-II and p62 approximately by 22 % and 37 % respectively, and decreasing apoptosis rates by 37 %. Bergamot essential oil intervention also upregulated 5-HT levels and played a positive role in the BDNF/TrkB pathway which associated with synaptic plasticity. D-limonene (56.6 % of bergamot essential oil) was demonstrated to be a key contributor to these mechanisms. It exhibited protective effects comparable to bergamot essential oil against autophagy and BDNF/5-HT signaling activation, however, bergamot essential oil showed better efficacy in alleviating apoptosis. This study provides in vitro mechanistic evidence supporting the potential application of bergamot essential oil in the treatment of depression.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Yina Guan,Xiaojia Li,Tian Gao,Kai Zheng,Yukun Wang,Zelian Yu,Chunguang Liu
Engineered nanomaterials (NMs) have emerged as promising tools for improving agricultural sustainability. However, their dual capacity to restrict pollutant bioaccumulation while enhancing environmental remediation remains a challenge. In this study, we developed a novel Fe-Mo nanocomplex (Fe@Mo-5) that concurrently addresses both critical challenges in agro-environmental systems. Comprehensive characterization indicated that Fe@Mo-5 exhibited strong stability, high redox activity and excellent nanozyme-mimetic properties, formed protective film on the surface of lettuce ( Lactuca sativa L. ) roots. This barrier effectively reduced the uptake of multiple pollutants, including atrazine (ATZ), ibuprofen and bisphenol A. Notably, the accumulation of ATZ was decreased 60.7 % in roots and 65.7 % in edible leaves, while decreasing its translocation factor from 0.177 to 0.111, significantly lowering dietary exposure risks. Parallelly, Fe@Mo-5 actively participated in ATZ degradation by increasing removal efficiency by 42.5 %, with a safe concentration and sustained ROS generation that balanced efficient ATZ removal with minimal phytotoxicity. Additionally, the application of Fe@Mo-5 significantly improved lettuce growth parameters, including promoting biomass accumulation, photosynthesis and nitrogen metabolism without inducing oxidative damage. This work establishes a breakthrough nano-enabled strategy that synergistically combines crop protection with environmental remediation, offering a viable solution for sustainable agriculture and food safety in contaminated environments.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Tingting Li,Yuanqing Huo,Huifang Ji,Wenjie Yan,Mengni Jia,Changming Xiong,Yunlan Li,Ruiping Zhang
Liver fibrosis, a pivotal pathological stage in the progression of chronic liver diseases to cirrhosis and hepatocellular carcinoma is characterized by liver sinusoidal endothelial cell (LSEC) capillarization, oxidative stress imbalance, and cell pyroptosis. Current clinical interventions show limited efficacy in reversing fibrosis, highlighting the urgent need for novel therapeutic strategies. In this study, we developed an L-arginine-loaded melanin-like nanozyme (L-Arg@MeNPs) that targets liver fibrosis through a triple-action mechanism: (1) sustained nitric oxiderelease from L-Arg restores LSEC fenestration, improving sinusoidal permeability; (2) the MeNPs exhibit catalase/superoxide dismutase-mimicking activity to scavenge reactive oxygen species, thereby blocking the NOD-like receptor pyrin domain-containing 3/caspase-1-mediated pyroptosis pathway; and (3) intrinsic photoacoustic/magnetic resonance dual-modal imaging enables real-time therapeutic monitoring. Overcoming the biosafety limitations of conventional metal-based nanozymes, this system demonstrates superior pH stability and metabolic degradability. In vivo studies confirm that L-Arg@MeNPs effectively ameliorate the fibrotic microenvironment and reduce excessive extracellular matrixdeposition, offering a targeted, safe, and theranostic solution for clinical liver fibrosis treatment.
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FOOD CONTROL
·
2025
·
IF 6.3
Meiyu Zheng,Jin Zhang,Siya Zhao,Yong Yang,Shu Wang,Bin Li,Zhigang Hu,Sihong Zhang,Dongping He,Fenfen Lei,Li Zhou
The thermal roasting process, indispensable for the development of sesame oil's characteristic organoleptic properties, is concurrently responsible for the generation of hazardous chemical compounds. Given that the influence of alternative processing techniques, specifically dehulling and microwave treatment, on this formation remains inadequately characterized, this study systematically evaluated their impacts on physicochemical properties, contaminant levels, and flavor profiles. Analytical results demonstrated that dehulling significantly increased the concentrations of hazardous compounds, specifically benzo[a]pyrene (from 6.52 μg/kg in seeds with hull to 9.56 μg/kg in dehulled seeds), 3-monochloropropane-1,2-diol esters (from 64.43 μg/kg in seeds with hull to 90.47 μg/kg in dehulled seeds), and glycidyl esters (from 9.23 μg/kg in seeds with hull to 16.07 μg/kg in dehulled seeds). Conversely, microwave treatment effectively suppressed their formation. More intensive processing parameters, for both roasting and microwave applications, correlated with a reduced acid value, decreasing from 0.78 (180 °C and 10 min) to 0.19 mg KOH/g oil (260 °C and 40 min). Furthermore, these treatments induced significant alterations in the fatty acid profile, evidenced by a reduction in unsaturated fatty acids of up to 5.5 % under extreme thermal conditions. Volatile compound analysis via electronic-nose and HS-SPME-GC-MS indicated a progressive increase in both the diversity and total concentration of volatiles (e.g., from 884.55 mg/kg at 180 °C and 10 min to 1298.42 mg/kg at 260 °C and 40 min) with treatment intensity. This study provides critical insights for mitigating contaminants while modulating oil quality, offering valuable strategies for industrial optimization and regulatory oversight.
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Food & Function
·
2019
·Vol. 10
·期 5
·2906-2913
·
IF 3.241
Yanlong Li,Xudong Tian,Shengcai Li,Lijun Chang,Ping Sun,Yubei Lu,Xiaoyan Yu,Shiwang Chen,Zhengquan Wu,Zhong Xu,Wanrong Kang
Dysfunction of the intestinal epithelial barrier plays an important role in the pathogenesis of several intestinal diseases, including celiac disease, inflammatory bowel disease, and irritable bowel syndrome. The present research was carried out to investigate the protective effect of total polysaccharides of adlay bran (TPA) on TNF-α-evoked epithelial barrier dysfunction in Caco-2 cells. Caco-2 cells were treated with or without TPA in the absence or presence of TNF-α, and transepithelial electrical resistance (TEER) and Phenol Red flux were assayed to evaluate the intestinal epithelial barrier function. The results indicated that TPA suppressed the TNF-α-induced release of pro-inflammatory factors. Furthermore, TPA obviously assuaged both the increased paracellular permeability and the decrease of TEER in TNF-α-challenged Caco-2 cells. Furthermore, TPA obviously assuaged TNF-α-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-κB p65. Our results indicated that TPA assuages the TNF-α-evoked dysfunction of the intestinal epithelial barrier by inhibiting the NF-κB p65-mediated inflammatory response.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2023
·Vol. 32
·期 2
·536-547
·
IF 5.3
Chen Weishuo,Zhong Channa,Li Shuangcheng,Wen Die,Zhou Dongdong,Shao Jun,Chen Shuiliang,Hou Haoqing,Xiang Sheng
The blends of poly(D-lactic acid) and poly(L-lactic acid) (PDLA/PLLA) produce the stereocomplex crystals (SC) with a melting temperature of ~ 250 °C, which exhibits higher crystallization rate and mechanical strength than PDLA or PLLA. The SC was also reported as an effective nucleator for PLA homochiral crystals (HC). In the PDLA/PLLA blends, the SC would develop at first in most of cases. However, the morphology of SC in the asymmetric blends were rarely reported, and the effect of the SC morphology on the subsequently crystallization of HC was not clear yet. In this study, the PDLA/PLLA blends with dissimilar weight ratios were prepared by three methods, i.e. , electrostatic spinning, solution casting, and melted-cooling, and the SC with different morphologies were achieved. Then, the crystallization behavior of HC under the existence of SC was studied. Results indicated that the SC morphology exerted diverse effects on the formation of HC. The SC with fibrous and banded morphology produced by electrostatic spinning presented great limitation for the formation of HC. The SC with spherical morphology developed in the solution casting films enhanced the formation of HC. The SC with network structure produced in the melted-cooling specimens accelerated the crystallization rate of HC significantly. This investigation indicated that not only the content of SC, but also the morphology of SC would influence the crystallization behavior of HC, which would make a deep understanding for the crystallization behavior of PDLA/PLLA specimens.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Chao Zhang,Chunhe Gu,Fan Su,Mengrui Wang,Junxia Chen,Ziqing Chang,Junping Zhou,Mingzhe Yue,Fei Liu,Zhen Feng
Iridoid glycosides (IGs) are secondary metabolites found in plants such as the noni plant ( Morinda citrifolia L.), known for their diverse biological activities and potential health benefits. Herein, we screened fifteen natural deep eutectic solvents (NADES) and two conventional solvents (CS, 70% (V/V) methanol and 70% (V/V) ethanol) for extraction of IGs from noni fruit pomace. Our findings indicate that non-acidic NADES promote IG extraction. Glycerol/glycine combined with β-cyclodextrin was selected, and a molecular simulation was performed to elucidate the interaction between NADES components and IGs. Further, the structure-activity relationship and interaction mechanisms of IGs with α-glucosidase were investigated using multispectral and molecular docking tools. The results demonstrated that deacetylation of the B-ring's C-10 improved the inhibitory potential of IGs. Deacetylation produces hydrophobic contacts, which enhance the inhibitory effect of deacetylasperulosidic acid on α-glucosides. Additionally, hydrogen bonds and van der Waals forces drive the formation of non-covalent complexes between IGs and enzymes.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Bingyao Zhou,Hong Wang,Shui Hu,Qi Yan,Pudun Zhang
Effects of montmorillonite (MMT) on the crystallization behavior of poly(L-lactic acid) (PLLA) were investigated by variable-temperature FTIR spectroscopy. The variations of carbonyl band (1800–1720 cm −1 ) of different PLLA/MMT nanocomposites were focused due to its strong intensity and the involved abundant structure information. Difference spectrometry was used to evaluate the structural variations of PLLA after introducing MMT, and perturbation correlation moving window two-dimensional analysis (PCMW2D) split the temperature range into two sub-regions, i.e., 32–116 ℃ and 116–152 ℃, on the basis of the spectral variation. Two-dimensional correlation spectroscopy (2DCOS) was further applied to such sub-regions in order to find the change order between varied PLLA polymorphs. The results showed that less addition of MMT (≤3%) would lead to a well-exfoliated structure, which not only had no nucleation effect for PLLA, but also delayed the cold crystallization to a higher temperature compared with the one of pure PLLA. However, a higher addition of MMT (≥5%) would lead to an intercalated structure, which acted as a nucleating agent and thus advanced the cold crystallization to a lower temperature. Nevertheless, the introduction of MMT cannot affect the phase transition order between the amorphous, the intermediate, the α′- and the α′-PLLAs based on 2DCOS results.
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ULTRASONICS SONOCHEMISTRY
·
2024
·
IF 8.7
Junping Wang,Hongyi Zhao,Xuexue Xue,Yutong Han,Xin Wang,Zunlai Sheng
Lycopene-rich guava ( Psidium guajava L.) exhibits significant economic potential as a functional food ingredient, making it highly valuable for the pharmaceutical and agro-food industries. However, there is a need to enhance the extraction methods of lycopene to fully exploit its beneficial uses. In this study, we evaluated various ionic liquids to identify the most effective one for extracting lycopene from guava. Among thirteen ionic liquids with varying carbon chains or anions, 1-butyl-3-methylimidazolium chloride demonstrated the highest productivity. Subsequently, a single-factor experiment was employed to test the impact of several parameters on the efficiency of lycopene extraction using this selected ionic liquid. These parameters included extraction time, ultrasonic power, liquid-solid ratio, concentration of the ionic liquid, as well as material particle size. Moreover, models of artificial neural networks using genetic algorithms (ANN-GA) and response surface methodology (RSM) were employed to comprehensively assess the first four key parameters. The optimized conditions for ionic liquid ultrasound-assisted extraction (IL-UAE) were determined as follows: 33 min of extraction time, 225 W of ultrasonic power, 22 mL/g of liquid-solid ratio, 3.0 mol/L of IL concentration, and extraction cycles of three. Under these conditions, lycopene production reached an impressive yield of 9.35 ± 0.36 mg/g while offering advantages such as high efficiency, time savings, preservation benefits, and most importantly environmental friendliness.
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Sustainable Chemistry and Pharmacy
·
2025
·
IF 5.8
Qingfen Zhang,Dan Ge,Shengcheng Mi,Qi Lu
The bioactive properties of essential oil are strongly associated with their chemical composition. In this work, a novel method of salt-enhanced homogenization pretreatment coupled with solvent-free microwave extraction (HP-SSFME) was developed for extracting essential oil (KGEO) from fresh Kaempferia galanga rhizomes, which significantly improved the extraction efficiency. Gas chromatography was employed to measure the contents of the main active components, ethyl p -methoxycinnamate (EPMC) and ethyl cinnamate (EC) in the essential oil. The extraction process was optimized by the Box-Behnken Design using the comprehensive scores of the yields of EPMC, EC, and KGEO obtained by the entropy weight method. The optimal parameters were determined as follows: amount of sodium chloride was 1.60 %, homogenization speed of 15000 r/min, homogenization time of 4 min, microwave irradiation power of 300 W, microwave irradiation time of 23 min. Under these conditions, the KGEO yield was 5.10 %, EPMC yield was 3.81 %, EC yield was 0.89 %. Compared with the conventional methods, the HP-SSFME method not only significantly increased the extraction yield of KGEO but also remarkably enhanced the yields of EPMC and EC. Additionally, the HP-SSFME method has low CO 2 emission and energy consumption, highlighting its environmental friendliness. Moreover, in terms of antibacterial activity, the HP-SSFME outperformed other methods, demonstrating a more powerful and extensive inhibitory effect against a range of bacteria. This study provides a valuable reference for the efficient extraction and quality control of essential oils from Kaempferia galanga rhizomes.
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