International Journal of Nanomedicine
·
2018
·
IF 4.37
Xiaoming Li,Chao Wang,Shuang Yang,Ping Liu,Bo Zhang
Background An ideal wound dressing should exhibit good biocompatibility, minimize pain and infection, absorb excess exudates, and maintain a moist environment. However, few clinical products meet all these needs. Therefore, the aim of this study was to fabricate a multifunctional double layer nanofibrous scaffolds (DLS) as a potential material for wound dressing. Materials and methods The scaffold was formed from mupirocin and lidocaine hydrochloride homogeneously incorporated into polycaprolactone as the first layer of scaffolds and chitosan as the second layer of scaffolds nanofibers through electrospinning. The fabricated nanofibrous scaffolds were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and measurement of swelling ratio, contact angle, drug release, and mechanical properties. Furthermore, antibacterial assessment, live/dead cell assays, and MTT assays were used to investigate the antibacterial activity and cytotoxicity of the nanofibrous scaffolds. Results The morphology of the nanofibrous scaffolds was studied by scanning electron microscopy, showing successful nanofibrous scaffolds. Fourier transform infrared spectroscopy demonstrated the successful incorporation of the material used to produce the produced nanofibrous scaffolds. Thermal studies with thermogravimetric analysis and differential scanning calorimetry indicated that the DLS had high thermal stability. The DLS also showed good in vitro characteristics in terms of improved swelling ratio and contact angle. The mechanical results revealed that the DLS had an improved tensile strength of 3.88 MPa compared with the second layer of scaffold (2.81 MPa). The release of drugs from the scaffold showed different profiles for the two drugs. Lidocaine hydrochlo ride exhibited an initial burst release (66% release within an hour); however, mupirocin exhibited only a 5% release. Furthermore, the DLS nanofibers displayed highly effective antibacterial activities against Staphylococcus aureus, Escherichia coli , and Pseudomonas aeruginosa and were nontoxic to fibroblasts. Conclusion The fabricated DLS exhibited excellent hydrophilicity, cytocompatibility, sustained drug release, and antibacterial activity, which are favorable qualities for its use as a multifunctional material for wound dressing applications.
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2023
·
IF 8.3
Lucheng Li,Jie Ni,Zehua Zhu,Xiaojun Zuo
A novel Mg-loaded chitosan carbonized microsphere (MCCM) was prepared for simultaneous adsorption of ammonium and phosphate in this study, through the investigation of preparation procedures, addition ratio, and preparation temperature. Pollutants removals by MCCM were more acceptable with 64.71% for ammonium and 99.26% for phosphorus, compared with chitosan carbonized microspheres (CCM), Mg-loaded chitosan hydrogel beads (MCH) and MgCl 2 ·6H 2 O. Addition ratio of 0.6:1 (m chitosan : m MgCl2 ) and preparation temperature of 400 °C in MCCM preparation were responsible for pollutant removal and yield. The effect analysis of MCCM dosage, solution pH, pollutant concentration , adsorption mode and coexisting ions on the removal for both ammonium and phosphate indicated that pollutants removals were increased with increasing MCCM dosages, and achieved the peak at pH 8.5, but presented to be stable with Na + , K + , Ca 2+ , Cl − , NO 3 − , CO 3 2− and SO 4 2− , except for Fe 3+ .Adsorption mechanisms discussion implied that simultaneous ammonium and phosphate removal with MCCM was attributed to struvite precipitation, ion exchange, hydrogen bonding, electrostatic attraction and Mg–P complexation, suggesting that MCCM presents a new way for simultaneous concentrated ammonium and phosphate removal in wastewater treatment .
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2019
·Vol. 11
·期 3
·418-424
·
IF 1.158
Lv Yao,Huang Shifei,Zhao Yufeng
The N-B-F tridoping 3D hierarchical porous graphitized carbon network is produced by a one-step synthesis using chitosan as a precursor. The N-B-F tridoping 3D hierarchical porous graphitized carbon network is rich of nitrogen, boron and fluorine hetero atoms and exhibited relatively
high specific capacitance value of 316 F g–1 in 6 M KOH at a current density of 20.0 A g–1. As well as good cycling stability with capacitance retention of 100% over 10000 cycles, and good rate performance (90.3% capacity retention from 0.5 A g–1
to 20.0 A g–1). When used as supercapacitor electrode, the all carbon symmetric supercapacitor based on N-B-F tridoping 3D hierarchical porous graphitized carbon network delivers a high energy density of 23.87 Wh kg–1, outperforming the state-of-the-art carbon
material.
✓ 已验证
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Guo Shanshan,Li Hua
Diabetes, particularly Type 2 Diabetes Mellitus (T 2 DM), is a chronic metabolic disorder with high and increasing global prevalence, characterized by insulin resistance and inadequate insulin secretion. Despite advancements in novel drug delivery systems, widespread and systematic treatment of advanced glycation end products (AGEs) remains challenging due to issues like drug toxicity, low water solubility, and uncontrolled release. Thus, developing nanoplatforms with controlled release capabilities has become a major research focus. Due to its excellent biocompatibility and drug delivery properties, chitosan has attracted considerable attention as a typical biopolymer. In this study, we designed and synthesized an intelligent fluorescence-pH sensitive nanopolymer material using chitosan. We loaded drug 1 and chromium phthalocyanine (CrPc) into folic acid-conjugated carboxymethyl chitosan (FA-CMCS) nanocarriers, forming FA-CMCS@1-CrPc. Comprehensive characterization of FA-CMCS@1-CrPc was conducted using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), and gas adsorption analysis (BET). The results indicate that the nanomaterial was successfully synthesized and exhibits excellent specific surface area, biocompatibility, and fluorescence response. Further research revealed that FA-CMCS@1-CrPc not only achieved controlled drug release but also could regulate drug release by adjusting pH. Additionally, due to its strong fluorescence performance, the nanomaterial demonstrated higher detection sensitivity, especially for monitoring the release of 5% trace drugs. An in vitro model of insulin-resistant cells was established to evaluate the effects of the drug delivery system on glucose degradation and AGE-RAGE regulation, providing a foundation for the development of new T 2 DM drugs. Graphical Abstract
✓ 已验证
DOI
PubMed
高影响因子
Foods
·
2022
·Vol. 11
·期 9
·1360
·
IF 5.561
Zhiguo Jiang,Jiaolong Wang,Dong Xiang,Zhengke Zhang
In the present study, p-hydroxybenzoic acid-grafted chitosan (PA-g-CS) conjugates with different grafting degrees were synthesized by a free radical-regulated grafting approach. The conjugates were further developed into films by casting, and their characteristics and preservative effects on fresh-cut jackfruit were evaluated. Compared to the CS film, the PA-g-CS film showed comprehensive performance improvements, including enhancements of water solubility, anti-ultraviolet capacity, antioxidation, and antibacterial activity. Moreover, compared with CS film, some appreciable and favorable changes of physical properties were observed in the PA-g-CS films, which included water vapor permeability, oxygen permeability, surface morphology, moisture content, and mechanical intensity. Furthermore, compared to CS alone, the application of PA-g-CS films to fresh-cut jackfruit exerted a beneficial effect on the quality of products, as indicated by the inhibition of weight loss, softening, and membrane damage, the maintenance of soluble solids and ascorbic acids contents, as well as a reduced bacterial count and a higher sensory score. Among these PA-g-CS films, the best preservation effect was achieved with the highest degree of grafting (PA-g-CS III). The results suggested that the PA-g-CS film has the potential to be explored as a new type of packaging material for the preservation of fresh-cut fruits and vegetables.
✓ 已验证
DOI
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2022
·
IF 9.879
Cheng Zhang,Xueqin Zhang,Youquan Ling,Mei Liang,Huawei Zou
The spread-tow thin-ply technology is a development to promote the large-scale production of carbon fiber reinforced polymer (CFRP) composite materials. Commercial CF bundles (width 7 mm) were spread to ultrathin CF (width 24 mm) to explore the effect of spreading CF tow on the properties of the CFRP composites. Next, chitosan (CS) and carbon nanotubes (CNTs) were used to construct a multilayer structure on the surface of the spread CF to improve the mechanical properties of the CFRP composites. The transverse fiber bundle test tensile strength , interlaminar shear strength , and compressive strength of the CS-doped CNT CFRP composites increased by 44.93%, 50.83%, and 36.85%, respectively, compared with the original CFRP composites. Furthermore, the thermal diffusivity of the spreading CFRP composite was increased by 92.59%, showing good thermal conductivity . The resistivity along the fiber direction and the thickness direction of the spreading CFRP composite decreased by 38.32% and 18.39%, respectively. A green and non-destructive method is provided for the surface modification of ultra-thin CF, which can effectively optimize the interface properties of the CFRP composites. This work expands the functional application of ultrathin CF.
✓ 已验证
DOI
高影响因子
Science China-Technological Sciences
·
2024
·
IF 4.4
Zhang YingXin,Liu HanGuang,Jin ShunYu,Li YaJuan,Zhang Wan,Zhou Hang,Nie ZanXiang,Huang Yuan
Wearable pressure sensors made from conductive hydrogels hold significant potential in health monitoring. However, limited pressure range (Pa to hundreds of kPa) and inadequate antibacterial properties restrict their practical applications in diagnostic and health evaluation. Herein, a wearable high-performance pressure sensor was assembled using a facilely prepared porous chitosan-based hydrogel, which was constructed from commercial phenolphthalein particles as a sacrificial template. The relationship between the porosity of hydrogels and sensing performance of sensors was systematically explored. Herein, the wearable pressure sensor, featuring an optimized porosity of hydrogels, exhibits an ultrawide sensing capacity from 4.83 Pa to 250 kPa (range-to-limit ratio of 51,760) and high sensitivity throughout high pressure ranges (0.7 kPa −1 , 120–250 kPa). The presence of chitosan endows these hydrogels with outstanding antibacterial performance against E. coli and S. aureus , making them ideal candidates for use in wearable electronics. These features allow for a practical approach to monitor full-range human motion using a single device with a simple structure.
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Yezhou Jiang,Bingchuan Liu,Jikun Xu,Keliang Pan,Huijie Hou,Jingping Hu,Jiakuan Yang
A complex chitosan/β-cyclodextrin polymer was synthesized by bridging with maleoyl chains followed by cross-linking with glutaraldehyde. The adsorption performance of the synthetic polymer was investigated for selective removal of methyl orange (MO) from aqueous solution. The kinetic behavior was well fitted by the pseudo-second order model, while the adsorption process at equilibrium followed the Langmuir isotherm model. The thermodynamic parameters suggested that the adsorption was exothermic and spontaneous. Under optimal adsorption conditions, the capacity for MO reached 392 mg/g with the dosage of 10 mg/50 mL. Based on the analysis from FTIR, 1 H NMR, TGA and zeta potential, the adsorption mechanism could be explained by the synergistic effect of electrostatic attraction of amino groups from chitosan and host-guest interaction from β-cyclodextrin. This adsorbent also demonstrated high selectivity towards MO due to the unique structure of cross-linked chitosan/β-cyclodextrin polymer that are complementary to that of MO molecule.
✓ 已验证
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2022
·
IF 6.206
Luyao Xu,Xiaojing Fu,Huijuan Su,Huilai Sun,Ruichuan Li,Yong Wan
This study is aimed at the enhancement of the corrosion and tribocorrosion performance of AZ31B magnesium (Mg) alloys after plasma electrolytic oxidization (PEO) treatment. Some PEO-treated Mg samples were coated with chitosan (CS) film by dip-coated method, while others were subjected to hydrothermal treatment (HT) followed by CS film. The microstructure and chemical composition of coatings were investigated via X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy . Corrosion resistance of the specimens was evaluated via electrochemical measurements (open circuit potential and electrochemical impedance spectroscopy) in simulated body fluid. The tribocorrosion performance was determined by simultaneously recording the variation of the friction coefficient and the open circuit potential with the sliding time. The results indicated that better corrosion and tribocorrosion performance were observed when CS layer is applied on hydrothermally treated PEO samples than on the bare PEO samples. Thus, fabrication of hydrothermally treated PEO surface coatings with chitosan is a significant approach to protect the Mg from corrosion and tribocorrosion, thereby increasing the potential application of Mg alloy as biological implants .
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
He Meng,Wenyan Ye,Chunlei Wang,Zeyu Gao,Bingxuan Hu,Caiqi Wang
Hydrogels constructed by traditional polymer networks usually have poor mechanical properties limiting their applications. Here, we proposed a new strategy for ionic interaction modulation of crystalline micro-nanoparticles (CMNPs) to enhance the mechanical properties of polyacrylamide hydrogels. CMNPs were formed via confinement assembly under an aggregated state based on host-guest interactions between chitosan-grafted polyethylene glycol (CS-PEG) and γ-cyclodextrin (γ-CD). Furthermore, the aggregation behavior of the CMNPs was achieved based on the ionic interaction of CS with citrate (Cit 3− ). These Cit 3− -regulated CMNPs were introduced into PAM hydrogels. The modulus (618.44 kPa, 67.6 times), fracture stress (1054.59 kPa, 25.3 times), and toughness (6.23 MJ m −3 , 41.7 times) of the composite hydrogels were greatly improved without affecting the tensile properties (fracture strain, ~1000 %). Finally, we further designed a strain sensor that could monitor human motion, and we verified its potential application in the field of wearable flexible electronics.
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Yi-xin Sun,Jia-hui He,Dan-dan Zhang,Yang Sheng,Defeng Xu,Rong Zhang,Mark Bradley
The rational design of electrochemical methods for chiral recognition is a focus of research in the detection fields of biomolecules and pharmaceuticals. In this work, electrochemical chiral interface based on chitosan (CS) and deoxyribonucleic acid (DNA) was constructed with self-assembly technology, and then characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), cyclic voltammetry, and electrochemical impedance spectroscopy. The FT-IR and SEM results showed the spatial structure of DNA and CS changed significantly and formed superhelix structure during the self-assembly process. Differential pulse voltammetry (DPV) results showed that the oxidation peak current ratio of D -Trp to L -Trp (I D /I L ) was observed to be 4.02 at 25 °C due to the synergistic effects of CS and DNA, obviously higher than that on any individual CS or DNA modified electrode. In addition, there was a linear relationship between the peak current and Trp enantiomer concentration in the range of 0.005–0.15 mM, and the detection limits of D-Trp and L-Trp were 1.33 and 1.67 µM, respectively. More importantly, the chiral interface can also be used to identify the percentage of D-Trp in non-racemic Trp enantiomers mixture solutions, showing its effectiveness and promising potential in practical applications.
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2016
·
IF 4.836
Chunzhen Fan,Kan Li,Juexiu Li,Diwen Ying,Yalin Wang,Jinping Jia
In this paper, tetraethylenepentamine (TEPA) modified chitosan/CoFe 2 O 4 particles were prepared for comparative and competitive adsorption of Cu(II) and Pb(II) in single and bi-component aqueous solutions. The characteristics results of SEM, FTIR and XRD indicated that the adsorbent was successfully fabricated. The magnetic property results manifested that the particles with saturation magnetization value of 63.83 emu g −1 would have a fast magnetic response. The effects of experimental parameters including contact time, pH value, initial metal ions concentration and coexisting ions on single and bi-component adsorption were investigated. The results revealed that the adsorption kinetic was followed pseudo-second-order kinetic model, indicating that chemical adsorption was the rate-limiting step. Sorption isotherms were also determined in single and bi-component solutions with different mass ratio of Cu(II) to Pb(II) (Cu(II)/Pb(II)) and fitted using Langmuir and Freundlich isotherm models. A better fit for Cu(II) and Pb(II) adsorption were obtained with Langmuir model, with a maximum sorption capacity of 168.067 and 228.311 mg g −1 for Cu(II) and Pb(II) in single component solution, 139.860 and 160.256 mg g −1 in bi-component solution (Cu(II)/Pb(II) = 1:1), respectively. The present results suggest that TEPA modified chitosan/CoFe 2 O 4 particles are feasible and satisfactory adsorbent for efficient removal of Cu(II) and Pb(II) ions.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）