ANALYTICA CHIMICA ACTA
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2019
·
IF 5.256
Feng Zhang,Mengke Wang,Lili Zhang,Xingguang Su
Herein, we developed a novel and sensitive ratiometric fluorescence strategy for pH sensing and urea detection based on MoS 2 quantum dots (MQDs) and 2, 3-diaminophenazine (DAP). The DAP was pH-sensitive and can be used as pH indicator while MQDs was pH-insensitive and acted as a reference fluorescent signal. The fluorescence intensity of DAP at 568 nm exhibited increases gradually while the fluorescence intensity of MQDs at 420 nm kept unchanged as the pH changed from 3.0 to 9.0. So the ratio of the two fluorescence intensities at 568 nm and 420 nm can be used to monitor the change of pH. The pH-sensing system showed a linear and reversible respond to pH in the range of 3.8–6.0 with an interval of 0.2 pH unit. Furthermore, the enzymatic reaction of urea in the presence of urease can lead to the pH increase of the solution, which can be used to detect urea by using the above-mentioned pH-sensing system. There exhibited a good linear relationship between the ratiometric fluorescence intensity of I 568 /I 420 and urea concentrations ranging from 5 to 700 μM. And a low detection limit of 1.8 μM was obtained. The proposed strategy exhibited excellent selectivity and sensitivity. Additionally, the developed ratiometric fluorescence strategy was successfully applied to detect urea in water samples.
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BIOCHEMICAL PHARMACOLOGY
·
2020
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IF 4.96
Hongwei Yao,Jingkai Gu,Yuqin Shan,Yani Wang,Xue Chen,Dong Sun,Yingjie Guo
Patients with diabetic mellitus tend to have a poor response to clopidogrel (Clop) due to reduced generation of active metabolite (Clop-AM). However, the underlying mechanism is not elucidated. A type 2 diabetic mellitus (T2DM) rat model was established by combining high-fat diet feeding and low-dose streptozotocin (STZ) injection. The reduced Clop-AM exposure was observed in T2DM rats after oral administration of Clop. However, in vitro liver microsomes incubated with Clop exhibited increased Clop-AM levels in T2DM rats due to a significant decrease in carboxylesterase (CES)1 expression and activity and a significant increase in the expression or activity of CYP1A2 and CYP3A . Interestingly, different from oral administration, the significantly increased C max of Clop-AM was observed in T2DM rats after intravenous injection, with no difference in AUC 0-t and t 1/2 values between the two strains. Meanwhile, in situ single -pass intestinal perfusion study showed lower absorption rate constant ( K a) and effective apparent permeability values ( P eff ) of Clop in T2DM rats than in control rats. It is explained by the increased expression or function of P-glycoprotein (P-gp) and pregnane X receptor (PXR) in duodenum and jejunum of T2DM rats. Moreover, the decreased Clop-AM level in T2DM rats was eliminated by the pretreatment of cyclosporin A , a P-gp inhibitor. It suggests that intestinal absorption, not hepatic metabolism is responsible for the reduced Clop-AM exposure in T2DM rats. P-gp might be the key factor causing the reduction of Clop absorption, consequently making less Clop available for Clop-AM formation.
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高影响因子
Nanoscale
·
2019
·Vol. 11
·期 39
·18426-18435
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IF 6.97
Meng Duan,Fangfang Xia,Tianliang Li,Joseph G. Shapter,Sheng Yang,Yongying Li,Guo Gao,Daxiang Cui
This work explored the application of matrix metalloproteinase 2-targeted superparamagnetic nanoprobes for magnetic resonance imaging (MRI), near infrared (NIR) fluorescence imaging and photodynamic therapy of tumors. PEG, PAMAM (G5) and matrix metalloproteinase 2 (MMP2) were attached to the surface of carboxylated Fe3O4 nanoparticles (NPs) using a chemical coupling method and then finally loaded with the photosensitizer chlorin e6 (Ce6). In vitro and in vivo experiments demonstrated that the Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes exhibited excellent stability, precise tumor targeting and biocompatibility. Furthermore, the fluorescence properties of Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes were analogous to Ce6 and could be employed for fluorescence imaging. Meanwhile, the Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes have also been shown to be effective as contrast agents for T2-weighted MRI. The target molecule MMP2 enhanced the tumor targeting ability of Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes. Additionally, the Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes significantly inhibited tumor growth compared with PBS and free Ce6. This work will inspire greater enthusiasm for the construction of multifunctional magnetic nanoplatforms for biomedical applications.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
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IF 5.7
Ya-wei Lu,Li-ya Xie,Meng-han Qi,Shen Ren,Yue-qi Wang,Jun-nan Hu,Zi Wang,Shan Tang,Jing-tian Zhang,Wei Li
Objectives: The aim of this study was to investigate the ameliorative effect of platycodin D (PD) on cognitive dysfunction in type 2 diabetes mellitus (T2DM) and its potential molecular mechanisms of action in vivo and in vitro. Materials and methods: An animal model of cognitive impairment in T2DM was established using a single intraperitoneal injection of streptozotocin (100 mg/kg) after 8 weeks of feeding a high-fat diet to C57BL/6 mice. In vitro, immunofluorescence staining and Western blot were employed to analyze the effects of PD on glucose-induced neurotoxicity in mouse hippocampal neuronal cells (HT22). Results: PD (2.5 mg/kg) treatment for 4 weeks significantly suppressed the rise in fasting blood glucose in T2DM mice, improved insulin secretion deficiency, and reversed abnormalities in serum triglyceride, cholesterol, low-density lipoprotein, and high-density lipoprotein levels. Meanwhile, PD ameliorated choline dysfunction in T2DM mice and inhibited the production of oxidative stress and apoptosis-related proteins of the caspase family. Notably, PD dose-dependently prevents the loss of mitochondrial membrane potential, promotes phosphorylation of phosphatidylinositol 3 kinase and protein kinase B (Akt) in vitro, activates glycogen synthase kinase 3β (GSK3β) expression at the Ser9 site, and inhibits Tau protein hyperphosphorylation. Conclusions: These findings clearly indicated that PD could alleviate the neurological damage caused by T2DM, and the phosphorylation of Akt at Ser473 may be the key to its effect.
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JOURNAL OF MOLECULAR STRUCTURE
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2024
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IF 4
Qianqian Xing,Xiaoliang Jia,Shiyu Jia,Yongqin Qi,Yuqi Wang,Yingxiong Wang,Xianglin Hou
The traditional synthesis methods of cyclopropyl methyl ketone (CPMK) have some disadvantages such as low yield, slow reaction rate and unclear catalytic mechanism. To solve these problems, a new strategy is developed to synthesize CPMK from 5‑chloro-2-pentanone (CPE) using 1,8-diazabicyclo[5.4.0]undec‑7-ene (DBU). Experiment results show that the yield of CPMK reached a maximum of 96.5 % in DBU at 40 °C for 30min. The mechanism study shows that the hydrogen bond between DBU and CPE is the key to drive the deprotonation and cyclization of CPE. The hydrogen bond is formed between the N atom on C = N of DBU and the α-H on the methylene group associated with the carbonyl group on CPE. The catalyst DBU is converted into [DBUH] + Cl − , which can be reclaimed and recycled completely. The density functional theory (DFT) calculation confirmed the existence of molecular hydrogen bonds and proved that the hydrogen bond driving force is the key to the reaction. The hydrogen bond driven mechanism provides a new idea for the basic research of cyclization reaction.
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高影响因子
FUEL
·
2024
·
IF 6.7
Yangshuo Liu,Keke Huang,Yao Meng,Chubo Wang,Liang Qiao,Wei Cai,Yaotian Yan,Xiaohang Zheng
Searching for highly efficient electrocatalysts for the hydrogen evolution reaction (HER) is principal to the development electrolytic water production industry. Experimental screening of highly active electrocatalysts is time-consuming and complicated. In this work, an Artificial Neural Network model is proposed to accelerate the screening for Ag(M) catalysts (M = Al, Si, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Mo, Ru, Rh, Pd, In, Sn, Sb, W, Re, Os, Ir, Pt, Au and Hg), which is used to predict the Gibbs free energy of hydrogen. The Ag(Ni) catalyst is identified as a potential electrocatalyst with the nearly ideal (ΔG H ), which affords the relatively low overpotentials of 159 mV for HER at 10 mA cm −2 . According to the prediction of our ANN model, we synthesized Ag(Mn), Ag(Co), and Ag(Cu) catalysts. The Ag(Ni) catalyst exhibits the best HER activity, which is 120 mV smaller than Ag(Mn), Ag(Co), and Ag(Cu) catalysts. The incorporation of Ni effectively optimizes the electronic environment of the materials, which drives the upshift of d-band center and drastically reduces the Gibbs free energy of hydrogen (ΔG H ). Our method is significantly more efficient, running 1184 times faster than the traditional DFT method. Our work paves an efficient way to design and develop potential HER catalysts.
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Energy Storage Materials
·
2024
·
IF 18.9
Zhilin Zheng,Xiaoqiao Li,Yong Wang,Yunlong Zhang,Yufeng Jiang,Yu-Shi He,Chao Niu,Haiying Che,Linsen Li,Zi-Feng Ma
Air stability is a crucial factor in the practical application of a battery material, as it profoundly affects the material's preparation, storage, and electrode fabrication processes. Sodium iron sulfate cathodes, despite their attractive attributes in cost and electrochemical performance, are widely believed to be unstable upon air exposure because of the sulfate group. Here we report remarkable air-stability of the Na 2 Fe(SO 4 ) 2 -based (NFS) cathodes (minimal decay in 20 % RH air for 60 days, 91.9 % capacity retention after 3500 cycles in half cells) and their outstanding cycle performance in practically relevant pouch-type full cells (∼100 Wh kg -1 specific energy, >1000 cycle-life). Although the NFS cathodes do react with moisture H 2 O to produce Na 2 Fe(SO 4 ) 2 ⋅4H 2 O but the hydration is spatially confined at the NFS particles’ surface and not propagating into their bulk. Further, the structural changes are reversible when the surface-hydrated NFS particles are heated in the typical electrode vacuum-drying process, avoiding extra treatment and additional cost. This work reveals the promising properties of the NFS cathode materials towards high-performance and sustainable Na-ion batteries.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2024
·
IF 10.8
Yuwen Wang,Lingdong Kong,Jie Tan,Beibei Liu,Yixuan An,Lianghai Xia,Yu Lu,Qing Li,Lin Wang
Hydrogen peroxide (H2O2) plays a crucial role as an oxidizing agent within the tropospheric environment, making a substantial contribution to sulfate formation in hydrated aerosols and cloud and fog droplets. Field observations show that high levels of H2O2 are often observed in heavy haze events and polluted air. However, the source of H2O2 remains unclear. Here, using the droplets formed in situ by the deliquescence of hygroscopic compounds under a high relative humidity (RH), the formation of H2O2 by the photochemistry of imidazole-2-carbaldehyde (2-IC) under ultraviolet irradiation was explored. The results indicate that 2-IC produces IM–C•–OH and IM–C•═O radicals via H transfer itself to its excited triplet state and generates H2O2 and organic peroxides in the presence of O2, which has an evident oxidizing effect on SO2, suggesting the potential involvement of this pathway in the formation of atmospheric sulfate. H2O2 formation is limited in acidic droplets or droplets containing ammonium ions, and no H2O2 is detected in droplets containing nitrate, whereas droplets containing citric acid have an obvious promotion effect on H2O2 formation. These findings provide valuable insights into the behaviors of atmospheric photosensitizers, the source of H2O2, and the formation of sulfate in atmospheric droplets.
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BIORESOURCE TECHNOLOGY
·
2025
·
IF 9
Yuan Li,Danchen Zhu,Linmeng Hong,Jixiang Dai,Lijun Wu
This study systematically investigated the effect of interfering with autoinducer-2 (AI-2) signaling system on controlling initial fouling attachment and irreversible components. Exposure of bacteria to the inhibitor significantly reduced the expression of the luxS gene, which resulted in a 37.3% reduction of AI-2 signaling molecule synthesis. Expression of flagellin and kinesin, which determine bacteria adhesion properties, and virulence genes was significantly down-regulated. AI-2 quorum quenching (QQ) significantly suppressed the initial biofilm growth and inhibition efficiency was positively correlated with bacteria concentration. Extracellular polymeric substances accumulation decreased by 40.8% in QQ experiment relative to the control, thus mitigating the flux decline. Polysaccharides, which constitute irreversible components, were significantly reduced by 69.3% with presence of inhibitor. AI-2 QQ altered protein and peptide structure of fouling layer, which converted irreversible fouling into reversible fouling. These findings contributed to the understanding of QQ susceptibility to initial fouling, providing a theoretical basis for engineering applications.
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PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Qiang Liu,Hao Li,Ling Kong,Yiming Du,Yunsheng Da,Zhouping Sun,Yong Dong,Yanyan Liu,Xingyou Tian,Hua Wang
Waterborne epoxy (EP) is considered a promising environmentally friendly anticorrosive technology with extensive potential applications. However, its limited anticorrosive ability poses significant challenges in practical usage. In this study, we use dopamine (DA) polymerization to load 2-mercaptobenzimidazole (MBI) onto the surface of g-C 3 N 4 (CN) nanosheets, resulting in the synthesis of MBI-PDA@g-C 3 N 4 (MBI-PDA@CN) nanosheet composites. The MBI-PDA@CN composite exhibits favorable hydrophilicity and high loading capacity of 35.8 %, enabling the formation of compact bonding layer at the interface with the EP. Simultaneously, the MBI-PDA@CN nanosheets exhibit a fully lamellar structure, thereby effectively impeding the infiltration of corrosive agents. Electrochemical tests show that the coating resistance ( R p ) of MBI-PDA@CN/EP coating (8.5 × 10 7 Ω cm 2 ) exhibited a significantly higher magnitude compared to that of the EP (2.6 × 10 6 Ω cm 2 ) after being immersed in 3.5 wt% NaCl solution for 30 days. It is worth mentioning that the MBI-PDA@CN nanosheets possess the capability to gradually release MBI-PDA molecules in acidic environments. Given that MBI and PDA function as outstanding metal corrosion inhibitors, they substantially augment the corrosion resistance of the coating in acidic conditions. This study presents an intriguing approach to fabricating robust corrosion-resistant composite coatings.
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NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Shuling Liu,Ruirui Teng,Xiangyang Wei,Yupei Li,Zixiang Zhou,Xiaoqiang Shi,Jiebing Li,Jianbo Tong
Manganese dioxide nanorods (Na0.4MnO2) with a typical 2 × 4 tunnel structure are successfully synthesized by the simple hydrothermal method in the presence of 5 M NaCl. The nanorods are about 30 nm in diameter. ZIBs (zinc-ion batteries) with Na0.4MnO2 display a specific capacity of 274.6 mA h g−1 at 0.2 A g−1 and have a high reversible capacity of 182.6 mA h g−1 after 1400 charge–discharge cycles at 1 A g−1 with a capacity retention of 96.5%. The unique morphology endows abundant electrochemical active sites and facile ion diffusion kinetics, which contributes to high specific capacity and stability. Both Zn2+ and H+ are inserted/extracted during the discharging/charging processes, and the crystalline structure and morphology of the nanorods do not change after repetitive cycling. The Na0.4MnO2 with the 2 × 4 tunnel structure is a promising candidate as the electrode material for ZIBs.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Wenlin Zhang,Di Jiao,Lu-Hua Zhang,Fengshou Yu
Iron phthalocyanine (FePc) is a promising non-noble metal catalyst for oxygen reduction reaction (ORR). While, with the plane-symmetric FeN 4 site, the ORR activity of FePc is generally low due to its low ability to adsorb and activate O 2 . Herein, we anchor FePc on Mg(OH) 2 / N -doped carbon nanosheets building the ternary plate-like catalyst FePc/Mg(OH) 2 /NC. Theoretical and experimental results show that due to the formation of FePc/Mg(OH) 2 heterojunction, the electron spin state of the monodisperse iron active site ranges from medium spin (MS, t 2g 5 e g 1 ) to low spin (LS, t 2g 6 e g 0 ), enhancing the adsorption with oxygen-containing intermediates, thereby improving the dynamics of the oxygen reduction reaction. As a result, FePc/Mg(OH) 2 /NC catalyst exhibits an outstanding performance (E 0 = 1.02 V, E 1/2 = 0.91 V) for ORR, superior to the commercial Pt/C electrode (E 0 = 1.01 V, E 1/2 = 0.85 V) and FePc/NC (E 0 = 0.97 V, E 1/2 = 0.87 V) under the alkaline conditions. This work offers a new way for the rational design of effective Fe N C catalysts with the support of metal oxides/hydroxides.
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