Cancer Nanotechnology
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2022
·Vol. 13
·期 1
·1-16
·
IF 7.917
Chen Xiaoxiao,Wang Lulu,Liu Sijia,Luo Xuezhen,Wang Kai,He Qizhi
Developing multifunctional composites has received widespread attention for cancer treatment. Herein, a metal–phenolic network (MPN)-based composite loading with chemotherapy agents (TAFP) exhibits high anti-tumor therapeutic efficacy via photothermal therapy (PTT), chemo-dynamic therapy (CDT), and chemotherapy. The nanocomposite was formed by mixing the chemotherapeutic drugs (cisplatin, DDP) into the tannic acid (TA) and Fe 3+ network (TAFe) to integrate the synergistic effect of PTT, CDT, and chemotherapy. Due to the acidic tumor microenvironment, the active substances could be released with the degradation of the metal–phenolic network, and the released DDP would induce the chemotherapy. More importantly, the released TA under the acidic environment could increase iron bioavailability by converting Fe 3+ to Fe 2+ , which converts hydrogen peroxide (H 2 O 2 ) to highly toxic hydroxyl radical via the Fenton reaction. Meanwhile, the heat generated from TAFP after near-infrared (NIR) laser irradiation could enhance the therapeutic effect of CDT and chemotherapy. Furthermore, the composite exhibited unique anticancer efficacy in vivo with low toxicity. Collectively, this work may facilitate the development of metal–phenolic network-based photothermal agents for clinic anti-tumor applications.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-19
·
IF 10.2
Zhu Ting-ting,Wang He,Gu Han-wen,Ju Ling-sha,Wu Xin-miao,Pan Wei-tong,Zhao Ming-ming,Yang Jian-jun,Liu Pan-miao
Inflammatory depression is closely related to neuroinflammation. However, current anti-inflammatory drugs have low permeability to cross blood–brain barrier with difficulties reaching the central nervous system to provide therapeutic effectiveness. To overcome this limitation, the nano-based drug delivery technology was used to synthesize melanin-like polydopamine nanoparticles (PDA NPs) (~ 250 nm) which can cross the blood–brain barrier. Importantly, PDA NPs with abundant phenolic hydroxyl groups function as excellent free radical scavengers to attenuate cell damage caused by reactive oxygen species or acute inflammation. In vitro experiments revealed that PDA NPs exhibited excellent antioxidative properties. Next, we aimed to investigate the therapeutic effect of PDA NPs on inflammatory depression through intraperitoneal injection to the lipopolysaccharide-induced inflammatory depression model in mice. PDA NPs significantly reversed the depression-like behavior. PDA NPs was also found to reduce the peripheral and central inflammation induced by LPS, showing that alleviated splenomegaly, reduced serum inflammatory cytokines, inhibited microglial activation and restored synaptic loss. Various experiments also showed that PDA NPs had good biocompatibility both in vivo and in vitro. Our work suggested that PDA NPs may be biocompatible nano-drugs in treating inflammatory depression but their clinical application requires further study. Graphical Abstract
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CATALYSIS LETTERS
·
2023
·
IF 2.8
Zhang Chao,Zhang Zhengping,Niu Jin,Li Zhilin,Wang Feng
Platinum catalysts with {111} surface has obvious advantages, but the control of {111} exposure usually requires surfactants which cover the surface and decrease the catalytic performance. In this paper, tetrahedral platinum nanoparticle catalysts were successfully prepared with a simple one-step hydrothermal method and their size were successfully controlled under sub-5 nm. The tetrahedral morphology was controlled through the decomposition of dimethylamine by DMF and the small size was determined by alcohol acid radical. Because of the profitable effect of the amines for the tetrahedral morphology, no surfactant was need during the preparation. The catalysis activity was assured by the tetrahedral morphology with Pt {111} exposure without the surfactant covering, and the small size further increased the number of activity sites. For HOR, the catalyst showed higher activity, stronger anti-CO poisoning performance and longer stability than those of commercial catalyst with the same platinum load. For ORR, the catalyst also showed better performances which further promoted the four-electron reaction. Our simple preparation method successfully achieved the aims of the morphology control, size control and the elimination of surfactant, which effectively assured the good catalyst performances. The simple preparation path of such good catalysts shows a great application potential. Graphical Abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 6
·1-9
·
IF 2.8
Chen Wei,Sun Hui,Jin Yingrong,Yang Hualin,He Yi,Zhu Xinghua
Cs 3 Bi 2 I 6 Br 3 perovskite is one of the bismuth iodide family compounds. Because it contains no toxic lead, and has high stability in air and humidity, endowing a potential application prospects in photoelectric and radiation detectors. Herein, the Cs 3 Bi 2 I 6 Br 3 single crystal (Φ13 × 65 mm 3 ) with a (001) preferred direction was grown by using the melt method with solvent-synthesized polycrystalline particles, and the thin single wafer with a thickness up to 0.95 mm was obtained. The as-grown single crystal possesses high infrared transmittance of up to 70% in the range from 400 to 4000 cm −1 and an optical band gap of about 2.03 eV estimated from the visible absorption curve. A highly intrinsic resistivity 2.3 × 10 10 Ω·cm and a dielectric constant about 10 were obtained from the electrical performance parameter measurements. The X-ray sensitivity of the X-ray detector is 55.62 µC/Gy air /cm 2 (incident dose rate 0.24 mGy/s), as well as the signal-to-noise ratio, is up to 301. These results indicate Cs 3 Bi 2 I 6 Br 3 single crystals are a potential material for X-ray detection.
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ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
·
2023
·Vol. 84
·期 3
·413-425
·
IF 4
Wang Zhuang,Yu Le,Wang De-Gao
Advanced nanomaterials can be released into the environment and can coexist with natural organic matter (NOM). However, evidence on the impacts of NOM on the environmental behavior and toxicity of advanced nanomaterials is still scarce. Here, we investigated the behavior and toxic effects of two layered double hydroxides (LDHs) nanomaterials with different metallic constituents (Mg-Al-LDH and Zn-Al-LDH) at relatively low exposure concentrations on a freshwater green alga ( Chlorella pyrenoidosa ) in the absence and presence of two types of NOM, namely dissolved organic matter (DOM) and dealkaline lignin (DL). The DOM or DL interaction with the LDHs at different mixture levels was shown to be an antagonistic effect on the growth inhibition toxicity to C. pyrenoidosa mainly. The estimation of the index of Integrated Biological Responses version 2 indicated that the joint interaction of the LDHs with DOM or DL occurred in the following order of frequency synergism > antagonism > additivity. Furthermore, the physicochemical characteristics of LDHs were crucial for illuminating the mechanism by which the DOM or DL modified the LDH-induced oxidative stress response. These findings highlighted the important role of NOM in the behavior and effect of LDHs as a representative of a new class of multifunctional nanomaterials in the freshwater environment.
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Lipids in Health and Disease
·
2023
·Vol. 22
·期 1
·1-14
·
IF 4.5
Tan Lunbo,Ouyang Zijun,Chen Zhilong,Sun Fen,Guo Haichun,Wang Feng,Mulder Monique,Sun Yuan,Lu Xifeng,Zhang Jian V.,Danser A. H. Jan,Verdonk Koen,Fan Xiujun,Yang Qing
Background The adipokine chemerin regulates adipogenesis and the metabolic function of both adipocytes and liver. Chemerin is elevated in preeclamptic women, and overexpression of chemerin in placental trophoblasts induces preeclampsia-like symptoms in mice. Preeclampsia is known to be accompanied by dyslipidemia, albeit via unknown mechanisms. Here, we hypothesized that chemerin might be a contributor to dyslipidemia. Methods Serum lipid fractions as well as lipid-related genes and proteins were determined in pregnant mice with chemerin overexpression in placental trophoblasts and chemerin-overexpressing human trophoblasts. In addition, a phospholipidomics analysis was performed in chemerin-overexpressing trophoblasts. Results Overexpression of chemerin in trophoblasts increased the circulating and placental levels of cholesterol rather than triglycerides. It also increased the serum levels of lysophosphatidic acid, high-density lipoprotein cholesterol (HDL-C), and and low-density lipoprotein cholesterol (LDL-C), and induced placental lipid accumulation. Mechanistically, chemerin upregulated the levels of peroxisome proliferator-activated receptor g, fatty acid-binding protein 4, adiponectin, sterol regulatory element-binding protein 1 and 2, and the ratio of phosphorylated extracellular signal-regulated protein kinase (ERK)1/2 / total ERK1/2 in the placenta of mice and human trophoblasts. Furthermore, chemerin overexpression in human trophoblasts increased the production of lysophospholipids and phospholipids, particularly lysophosphatidylethanolamine. Conclusions Overexpression of placental chemerin production disrupts trophoblast lipid metabolism, thereby potentially contributing to dyslipidemia in preeclampsia.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-18
·
IF 16.6
Deng Tuo,Gao Dongxiu,Song Xuemei,Zhou Zhipeng,Zhou Lixiao,Tao Maixian,Jiang Zexiu,Yang Lian,Luo Lan,Zhou Ankun,Hu Lin,Qin Hongbo,Wu Mingyi
The discovery of natural adhesion phenomena and mechanisms has advanced the development of a new generation of tissue adhesives in recent decades. In this study, we develop a natural biological adhesive from snail mucus gel, which consists a network of positively charged protein and polyanionic glycosaminoglycan. The malleable bulk adhesive matrix can adhere to wet tissue through multiple interactions. The biomaterial exhibits excellent haemostatic activity, biocompatibility and biodegradability, and it is effective in accelerating the healing of full-thickness skin wounds in both normal and diabetic male rats. Further mechanistic study shows it effectively promotes the polarization of macrophages towards the anti-inflammatory phenotype, alleviates inflammation in chronic wounds, and significantly improves epithelial regeneration and angiogenesis. Its abundant heparin-like glycosaminoglycan component is the main active ingredient. These findings provide theoretical and material insights into bio-inspired tissue adhesives and bioengineered scaffold designs.
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Microbial Cell Factories
·
2023
·Vol. 22
·期 1
·1-12
·
IF 6.4
Yang Haiquan,Zhang Kunjie,Shen Wei,Chen Lei,Xia Yuanyuan,Zou Wei,Cao Yu,Chen Xianzhong
Background The tobacco leaf–derived cembratriene-ol exhibits anti-insect effects, but its content in plants is scarce. Cembratriene-ol is difficult and inefficiently chemically synthesised due to its complex structure. Moreover, the titer of reported recombinant hosts producing cembratriene-ol was low and cannot be applied to industrial production. Results In this study, Pantoea ananatis geranylgeranyl diphosphate synthase (CrtE) and Nicotiana tabacum cembratriene-ol synthase (CBTS) were heterologously expressed to synthsize the cembratriene-ol in Escherichia coli . Overexpression of cbts* , the 1-deoxy- d -xylulose 5-phosphate synthase gene dxs , and isopentenyl diphosphate isomerase gene idi promoted the production of cembratriene-ol. The cembratriene-ol titer was 1.53-folds higher than that of E . coli Z17 due to the systematic regulation of ggpps , cbts* , dxs , and idi expression. The production of cembratriene-ol was boosted via the overexpression of genes ispA , ispD , and ispF . The production level of cembratriene-ol in the optimal medium at 72 h was 8.55-folds higher than that before fermentation optimisation. The cembratriene-ol titer in the 15-L fermenter reached 371.2 mg L − 1 , which was the highest titer reported. Conclusion In this study, the production of cembratriene-ol in E . coli was significantly enhanced via systematic optimization. It was suggested that the recombinant E . coli producing cembratriene-ol constructed in this study has potential for industrial production and applications.
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International Journal of Minerals Metallurgy and Materials
·
2023
·Vol. 30
·期 5
·813-823
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IF 4.8
Xu Ruijing,Zou Wenjie,Rao Bo,Zhao Wei,Wang Ting,Zhang Zhijun
This study presents a comparative study of the flocculation behavior of kaolinite induced by chitosan-graft-poly(acrylamide-dimethyl diallyl ammonium chloride) (Chi-g-CPAM) and a commercial cationic polyacrylamide (CPAM). The flocculation behaviour was characterised in terms of both flocculation kinetics and the corresponding morphology changes during flocculation. Both Chi-g-CPAM and CPAM were grafted from silica wafers by means of atom transfer radical polymerization (ATRP). The quartz crystal microbalance with dissipation (QCM-D) tests were conducted. The equilibrium time flocculated by Chi-g-CPAM was found to be 0.46 times as that of CPAM, together with a larger total mass of kaolinite layer. The flocculation behaviour by Chi-g-CPAM can be well captured by a pseudo-first-order model. In contrast, the presence of CPAM leads to a more complex kinetics. A relatively larger fitting slope (0.4663) was obtained at the initial stage but the fitting slope droped to 0.2026 after 800 min, indicating a densification process caused by CPAM. The flocculation kinetics of CPAM can be captured by the Elovich model for the inital stage but the combination of pseudo-first-order and pseudo-second-order models for the latter stages, which can be attributed to the long chain of CPAM. With a dosage of 75 g/t, the settling test with Chi-g-CPAM exhibits the same turbidity in the supernatant but a smaller layer thickness of the settlement compared to CPAM. The study enables a better understanding of the flocculation behavior and contributes to the development of efficient flocculants in mineral processing and tailings treatment.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2022
·Vol. 49
·期 1
·241-252
·
IF 3.134
Xing Qianqian,Zhao Jiancheng,Zhu Yulei,Hou Xianglin,Wang Yingxiong
5-Chloro-2-pentanone (5C2P) and its derivatives are widely utilized in the pharmaceutical and agrochemical industry. A new catalytic approach was proposed to convert 3-acetyl-1-propanol to 5C2P using bis(trichloromethyl)carbonate (triphosgene, BTC) as the efficient chlorine source. Various qualitative and quantitative nuclear magnetic resonance techniques ( 1 H, 13 C NMR), especially 1D selective gradient total correlation spectroscopy (Sel-TOCSY) and 2D heteronuclear single quantum correlation ( 1 H- 13 C HSQC) were used in the process. The reaction conditions, such as temperature, time, mole ratio, solvent as well as initiator were optimized. Experiment results showed that the yield of 5C2P reached a maximum of 97.93% in 1,2-dichloroethane at 80 °C after 2 h under the initiation of N,N-dimethylacetamide, and the optimal molar ratio of 3-acetyl-1-propanol to BTC was 1:0.4. The reaction mechanism was proposed and confirmed accordingly. Interestingly, an intermediate product of 1-(dimethylamino)ethyl carbonochloridate was observed, and its chemical structure was characterized by both Sel-TOCSY and 1 H- 13 C HSQC. This study enriched the catalytic reaction ways for the preparation of 5C2P.
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Nano-Micro Letters
·
2022
·Vol. 15
·期 1
·1-13
·
IF 23.655
Xue Pan,Chen Yuanhao,Xu Yiyi,Valenzuela Cristian,Zhang Xuan,Bisoyi Hari Krishna,Yang Xiao,Wang Ling,Xu Xinhua,Li Quan
Design and fabrication of MXene-based soft actuators with angle-independent structural color.
The nanostructured MXene can not only facilitate the formation of short-range ordered 3D amorphous photonic crystals, but also help significantly improve structural color saturation.
The soft actuators exhibit brilliant angle-independent structural color, ultrafast actuation and recovery speeds in response to vapor.
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JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
·
2022
·Vol. 149
·期 2
·683-699
·
IF 4.322
Shen Chongxing,Yue Xiaofeng,Dai Linyong,Wang Jianwu,Li Jinjin,Fang Qiang,Zhi Yi,Shi Chunmeng,Li Weibing
Background Bladder cancer has a high rate of recurrence and drug resistance due to the lack of effective therapies. IR-780 iodide, a near-infrared (NIR) mitochondria-targeting fluorescent agent, has been demonstrated to achieve higher selectivity than other drugs in different tumor types and exhibited tumor-killing effects in some cancers. However, this therapeutic strategy is rarely studied in bladder cancer. Material and methods The accumulation of IR-780 in bladder cancer was measured by NIR imaging. Human bladder cell lines (T24, 5637, and TCCSUP) were treated with IR-780 or combined IR-780 and hyperbaric oxygen (HBO). Cell viability, cell apoptosis, cellular ATP production, mitochondrial reactive oxygen species (ROS), and plasma membrane potential were detected. Mitochondrial complex I protein NDUFS1 was measured by western blot. To confirm the anti-tumor efficacy of IR-780 + HBO, mouse bladder cell line (MB49) tumor-bearing mice were established and tumor size and weight were recorded. Besides, cell apoptosis and tumor size were assessed in drug-resistant bladder cancer cells (T24/DDP) and xenografts to evaluate the effect of IR-780 + HBO on drug-resistant bladder cancer. Results IR-780 selectively accumulated in bladder cancer (bladder cancer cells, transplanted tumors, and bladder cancer tissue from patients) and could induce cancer cell apoptosis by targeting the mitochondrial complex I protein NDUFS1. The combination with HBO could significantly enhance the anti-tumor effect of IR-780 in vitro by promoting cancer cell uptake and inducing excessive mitochondrial ROS production, while suppressing tumor growth and recurrence in animal models without causing apparent toxicity. Moreover, this combination antitumor strategy was also demonstrated in drug-resistant bladder cancer cells (T24/DDP) and xenografts. Conclusion We identified for the first time a combination of IR-780 and HBO (IR-780 + HBO), which exhibits mitochondria-targeting and therapeutic capabilities, as a novel treatment paradigm for bladder cancer.
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