Nature Communications
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2026
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IF 18.1
Peng Xiaoyan,Han Liwei,Wu Xuanhao,Keok Hong Ling,Zhang Wanglin,Mao Min,Zhu Haiyun,Liu Lingmei,Yang Hao,Yang Aijun,Chu Jifeng,Li Yi,Xiao Song,Buenconsejo Pio John S.,Zhang Mingming,Zhao Dan,Yuan Hongye
Precise control over the stacking of two-dimensional (2D) metal-organic framework (MOF) nanosheets enables the fabrication of MOF films or membranes with adjustable interlayer spacing and/or pore size, offering great potential for numerous applications, yet remains highly challenging. We herein propose a postsynthetic modification strategy to functionalize solution-processable NUS-8 nanosheets with photo-responsive monodentate carboxylic acids undergoing a “trans-cis” conformational change upon irradiation or with non-responsive counterparts. This yields azobenzene-functionalized NUS-8 (designated as NUS-8-Azobenzene) and/or tetra-phenylethylene-functionalized NUS-8 (NUS-8-TPE). The 2D nature and excellent solution processability of resultant NUS-8-Azobenzene and NUS-8-TPE facilitate the fabrication of large-area, highly homogeneous films/membranes with (00l) preferential orientation. Responsive interlayer spacing was observed in the NUS-8-Azobenzene stacked membranes, confirmed by multiple characterizations. Subtle variations in interlayer spacing of NUS-8-Azobenzene stacked membranes under irradiation enable a certain control over the ubiquitous trade-off between membrane selectivity and permeability. This study presents a strategy for fabricating 2D MOF membranes with scalable production and new functionalities, even for rigid and non-responsive MOFs, holding significant potential for practical applications in separation.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2026
·Vol. 37
·期 1
·42
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IF 4.7
Xiaomei Ye,Shuzhen Lu,Hao Peng,Zhirong Huang,Chunyu Pan,Yayan Huang,Kangrui Yuan,Youfa Qin
Mesoporous metal-organic frameworks (MOFs) have the advantages of high specific surface area, tunable pore size, and favorable biocompatibility, making them promising candidates for drug delivery in cancer therapy. In this study, a series of mesoporous zinc-based MOF, constructed using cyclopentane dicarboxylic acid as the organic linker, was successfully synthesized via a surfactant-assisted solvothermal method. Surface characterization revealed that MOF-2 exhibited high surface area (1325 m 2 /g), pore volume (0.273 cm 3 /g), and average pore diameter (5.69 nm). UV-Vis analysis showed that MOF-2 demonstrated improved drug loading (18% w/w), encapsulation efficiency (86%), and cumulative release (96%), along with both pH-responsive degradation and drug release properties. Furthermore, cisplatin-loaded MOF-2 exhibited potent antitumor activity against A549 cells and effectively inhibited cell migration and invasion, while maintaining minimal cytotoxicity toward LO2 normal hepatic cells. These findings suggest MOF-2 as a promising nanocarrier for pH-responsive anticancer drug delivery.
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Microbiome
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2026
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IF 14.9
Guanjing Cai,Yingying Wu,Ziming Chen,Xiaoyu Yang,Xue Jiang,Qingshuang Wang,Runlin Cai,Hui Wang
Background Marine algae represent major producers of complex polysaccharides and serve as hosts for diverse microbial communities in the phycosphere. Flavobacteriaceae are among the key bacterial taxa involved in polysaccharide degradation and carbon remineralization in this environment. However, the extent to which algal hosts drive the divergence of polysaccharide utilization profiles in these bacteria remains unclear. Results We conducted a genome-resolved analysis of 103 cultured Flavobacteriaceae strains isolated from red, green, and brown macroalgae, as well as from diatoms and dinoflagellates. We found that macroalga-associated strains generally harbored more abundant and diverse CAZyme-encoding genes than their microalga-associated counterparts. Moreover, strains associated with different algal phyla showed distinct metabolic specializations that aligned with the typical polysaccharides of their respective hosts, strongly supporting host-specific adaptation. In four widely distributed genera ( Maribacter , Flagellimonas , Polaribacter , Winogradskyella ), CAZyme profile dissimilarity and key glycoside hydrolase gene divergence exhibited phylogenetic congruence with algal host phylogeny (Mantel r up to 0.76 and 0.85, respectively), indicative of host-associated functional adaptation. Using Maribacter as a model, cultivation experiments and transcriptome characterization demonstrated that polysaccharide utilization efficiency is not solely linked to the organization of genes into polysaccharide utilization loci (PULs), but also associated with the expression dynamics of key transcription factors (TFs), particularly those from AraC and DeoR families, whose expression patterns were coordinated with laminarin degradation. Notably, these two TF families also exhibited host-associated divergence patterns similar to those of CAZyme-encoding genes. Furthermore, analysis of the Tara Oceans metagenomic data indicated that, within the AraC and DeoR families, a higher proportion of genes were positively correlated with chlorophyll a content compared to other TF families, reinforcing their specialized roles in alga-associated bacterial lifestyles. Conclusions Our integrative genomic and transcriptomic analyses reveal evolutionary and regulatory adaptation of marine Flavobacteriaceae to distinct algal hosts. These findings highlight algae-derived habitats as specialized niches that shape microbial metabolic potential, and suggest that carbohydrate metabolism plays a key role in host-driven bacterial evolution across global oceans. Your browser is not supporting the HTML5
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INFLAMMATION
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2026
·Vol. 49
·期 1
·92
·
IF 5.4
Shiying Lin,Xin Liu,Jian Jiang,Wenqiang Ge,Qingxiao Tao,Suwen Liu,Ouyang Zhanmu,Yang Yang,Man Li,Hongxiang Chen
The endogenous cannabinoid system, comprising endocannabinoids, cannabinoid receptors, and enzymes responsible for synthesis and degradation of endocannabinoids, is integral to the regulation of skin inflammation. However, the precise contributions of cannabinoid-metabolizing enzymes including fatty acid amide hydrolase and monoacylglycerol lipase (MAGL) remain poorly defined in psoriatic pathogenesis. In this study, we demonstrated the significant MAGL upregulation in psoriatic lesions and established that pharmacological inhibition of MAGL markedly reduced psoriasiform inflammation and pruritus in imiquimod-challenged C57BL/6 mice. Mechanically, inhibition of MAGL decreased the expression of 12-lipoxygenase (ALOX12), subsequently reducing the synthesis of 12-hydroxyeicosatetraenoic acid (12-HETE), which is the principal metabolite of ALOX12. Importantly, these effects were reversed by cannabinoid receptor 2 (CB2R) antagonism or knockout, establishing a signaling axis in which MAGL inhibition activates CB2R to suppress ALOX12. Collectively, our findings identified MAGL as a potentially targetable nexus in psoriasiform inflammation and itch.
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Nature Communications
·
2026
·
IF 18.1
Xu Yinhan,Tian Meirong,Zhang Mengmeng,Hu Dengwen,Han Guoqiang,Zhu Jintao,Xu Jiangping,Kim Shin-Hyun
Responsive optical materials offer real-time visual feedback to external stimuli by converting them into visible light signals, holding great promise in display, sensing, and information encryption. Typically, heterogeneous Janus droplets can exhibit vivid coloration induced by total internal reflection and interference (TIRI) at concave liquid–liquid interfaces. Yet, achieving stimuli-responsive TIRI-based structural colors remains a challenge due to the difficulty in controlling interface curvature and reflective behavior under external stimuli. Here, we report the fabrication of Janus droplets with tunable TIRI structural colors that respond to both surfactant composition and temperature. By tailoring surfactant formulation, the droplet morphology and interface curvature can be adjusted, enabling reversible modulation of structural color appearance, including both iridescent and non-iridescent modes depending on incident light conditions. Furthermore, the structural color can be reversibly or irreversibly switched on/off in response to temperature changes, due to phase transitions that alter light reflection at the concave interface. Owing to their temperature-dependent optical response and real-time visual signaling, these droplets can serve as single-use security labels for monitoring freeze history of freeze-sensitive pharmaceuticals, providing reliable indication of product integrity.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Yu Jiang,Yaowu Zhang,Jingqi Hou,Heng Liu,Xianyu Dai,Yuchuan Hou
Characterizing the tumor immune microenvironment (TIME) to explore potential therapeutic targets is fundamental to advancing precision tumor immunotherapy. However, the immunosuppressive nature of “cold” tumors, notably prostate cancer, poses a significant barrier to immunotherapy, demanding new approaches to simultaneously reinvigorate anti-tumor immunity and modulate the molecular drivers of immune evasion. Here, we identified VSIG4 as a key regulator of prostate tumor-resident macrophage fate through single-cell sequencing analysis. Meanwhile, a shikonin (Shik)-mediated downregulation of VSIG4 in macrophages is verified, potentially attenuating its immunosuppressive effects. Building on these findings, cytosine guanine dinucleotide (CpG) oligodeoxynucleotide (ODN)-modified manganese (Mn)-Shik metal-polyphenol network nanodrugs (Mn/Shik@CpG NDs) are designed to reverse the “cold” immune environment of prostate tumor. In this scenario, Mn/Shik@CpG NDs release monomeric components under the stimulation of acidic and glutathione-rich tumor microenvironment (TME), thus exerting their immunomodulatory effects synergistically. Since the released Shik can induce DNA damage by necroptosis promoting reactive oxygen species production, cGAS-STING signaling pathway is initiated, which further activates interferon production in the TME. In addition, the necroptosis of Shik initiates immunogenic cell death, further activating innate immunity and promoting adaptive immune responses. Mn 2+ is a cGAS-STING sensitizer, which amplifies the intratumoral interferon response. As an immune adjuvant, CpG ODN effectively promotes the maturation of dendritic cells, as well as the helper T cell differentiation and pro-inflammatory cytokine secretion, thus activating both innate and adaptive immunity. In vivo studies suggest that Shik-mediated VSIG4 downregulation, combined with innate and adaptive immune activation, remodels the TIME to evoke a significant anti-tumor response. Furthermore, transcriptomic analysis of rechallenged tumors indicated this durable protection was driven by a genuine immune memory response, revealing a gene signature of T cell activation and immune reprogramming. Collectively, beyond presenting a novel therapeutic candidate for converting immunologically “cold” tumors into “hot” ones, our work validates a data-guided design pipeline, offering a conceptual blueprint to inform the precise engineering of future nanodrugs.
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Nature Communications
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2026
·
IF 18.1
Wang Zhenhao,Yang Zhaoxiang,Ma Yingchao,Lyu Shanzhi,Hu Xiaohua,Wang Yapei
Phototherapy, valued for its non-toxicity, selectivity, and minimal trauma, is predominantly applied to treat superficial diseases due to the limited penetration of light through tissues. While optical-fiber-assisted interventional phototherapy addresses this limitation, it lacks an immediate mechanism to mitigate overheating of surrounding healthy tissues. To improve the biosafety of interventional phototherapy, we develop an adaptive optical waveguide system (AOWS) based on a negative feedback modulation mechanism. The AOWS employs a thermally responsive liquid as the waveguide gating material, characterized by a precisely tunable low critical solution temperature (LCST). When the temperature surpasses the LCST, one-dimensional light propagation is scattered, providing effective thermal regulation. Furthermore, the design supports adjustable optical fiber outlets, with convex or concave configurations and varied curvatures, enabling precise control of the divergence angle. Superior to conventional optical fibers with smaller divergence angles, the AOWS facilitates closer placement to the lesion site, delivering a larger illumination area while significantly reducing the light pathway through normal tissue. More importantly, it provides thermal protection almost like an “on-off” switch without relying on irradiation power, ensuring enhanced safety and efficacy.
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Nature Communications
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2026
·
IF 18.1
Tang Yixiang,Wan Yuchi,Yan Wei,Zhang Jiujun,Lv Ruitao
Electrochemical nitrate upgrading presents a sustainable route for repairing unbalanced nitrogen cycle. However, the low energy efficiency caused by high overpotential impedes the industrialization progress. Herein, Ru clusters supported on metal hydroxide are constructed by a universal self-corrosion strategy, and the metal-support interaction is modulated to simultaneously optimize NO 3 − adsorption and water dissociation for achieving high energy efficiency at positive potentials. The Co(OH) 2 -supported Ru with moderate metal-support interaction exhibits a high energy efficiency of 49.5% and a high NH 3 Faradaic efficiency of ~100% at positive potentials. Furthermore, a long-term stability over 1200 h is achieved at an industrial-scale current density of 200 mA cm −2 . Moreover, the assembled rechargeable hybrid battery system shows a great potential in waste upcycling and energy conversion. This work underscores the significance of metal-support interaction for promoting nitrate electroreduction at positive potentials.
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JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 7
·274
·
IF 3.5
Liu Yan,Yu Yali,Zhu Yongfeng F.,Mu Bin,Zong Li,Wang Aiqin Q.
To achieve the synergistic utilization of water and fertilizer in arid saline-alkali regions, this study developed a composite superabsorbent of carboxymethyl cellulose-grafted-polyacrylic acid (CMC- g -PAA/HA/CGFS) using coal gasification slag (CGFS) and humic acid (HA) as functional components. Structural characterization confirmed that PAA was successfully grafted onto the CMC backbone, and CGFS was uniformly dispersed within the polymer matrix, which not only enhanced the thermal stability of the composite but also significantly improved its pore connectivity and surface roughness. Benefiting from this structural advantage, the material achieved a water absorption capacity of 550 g/g in distilled water and 71 g/g in 0.9 wt% NaCl solution within 30 min. When incorporated into saline-alkali soil at a 2 wt% application rate, the composite extended the soil water retention period from 23 to 36 days, increasing water retention efficiency by 56.5%. More importantly, the interaction between CGFS and the polymer matrix enabled a two-stage release pattern of HA, which was characterized by an initial fast release followed by a sustained slow release, thereby achieving phased nutrient supply. This synergistic effect of water retention and controlled release not only improved the efficiency of water and fertilizer management but also significantly promoted the growth of cabbage seedlings, with a 37.5% increase in total biomass. In summary, this study not only achieves the high-value utilization of CGFS but also provides a low-cost and efficient solution for the synergistic utilization of water and fertilizer in arid saline-alkali regions.
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Nature Protocols
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2026
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IF 18.4
Wei Siyuan,Zhang Xuchun,Guo Yishan,Liu Fa,Yao Zhu-Jun
The incorporation of N -methylated or α,α-disubstituted amino acids into peptides can markedly enhance their drug-like properties by improving proteolytic stability and membrane permeability. However, the solid-phase synthesis of such sterically hindered peptides remains a persistent challenge. Here we present a detailed protocol based on our recently developed ribosome-mimicking molecular reactor (RMMR) strategy, which substantially improves the synthetic efficiency of these difficult sequences via solid phase peptide synthesis (SPPS). This protocol provides a comprehensive, step-by-step procedure to facilitate a quick startup by the users, including the synthesis of Oxyma-C as the key activating unit precursor in the RMMR structure, the preparation of RMMR resin through modification of conventional SPPS resin and implementation of RMMR-SPPS in both manual and automated synthesizer formats. Peptides containing N -methylated and/or α,α-disubstituted amino acid(s) are synthesized efficiently using our strategy, with crude purities of up to 98% and respectable isolated yields, greatly surpassing existing methods. It is anticipated that this approach will facilitate broader adoption of RMMR-SPPS, addressing critical technical gaps and accelerating the discovery of orally bioavailable or intracellularly targeted macrocyclic peptide drug candidates.
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Scientific Reports
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2026
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IF 4.9
Zhu Lei,Xu Honghua,Chen Rui,Zhang Can,Wang He,Li Yong,Xu Li,Wang Biao,Xu Ziqiang
Cellulose paper plays the key role in the oil-paper insulation system ensuring safe and reliable operation of power systems, which faces challenges related to its inherent low thermal conductivity, high dielectric constant and hydrophilicity. Herein, polymerization reactions are induced on the surface and within the bulk of the cellulose insulating paper via atmospheric-pressure low-temperature plasma with a precursor formed by incorporating BN powders into octamethylcyclotetrasiloxane (OMCTS). As indicated by SEM, EDS, FTIR, and XPS results, a low-polarity cross-linking network is constructed within intrinsic porous structures of the paper, comprehensively improving thermal, electrical and waterproof performances. The thermal conductivity is increased by 15.9%, thereby enabling a significant enhancement in the heat dissipation capability. The relative dielectric constant of the insulating paper is decreased by 27.3%, maintaining effective dielectric adaptation with insulating oil. The surface and bulk insulation performance of the oil-impregnated paper is reinforced, with a 9.4% increase in the flashover voltage and a 17.5% improvement in bulk breakdown strength. The wetting property is changed from hydrophilic to hydrophobic, reducing water absorption by 32.6%, inhibiting the transport of water molecules. This work provides a promising approach for developing high-performance insulating paper for safe and stable power transmission.
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Nature Communications
·
2026
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IF 18.1
Liu Feihu,Dou Jie,Li Ying,Zhang Wei,Li Jiale,Li Yuchen,Guo Qiyao,Zhao Yuanyuan,He Benlin,Duan Jialong,Chen Qi,Tang Qunwei
Flexible perovskite solar cells (F-PSCs) offer a compelling solution to the intrinsic rigidity of silicon-based photovoltaics, enabling power generation on irregular surfaces. However, their practical application hinges on the perovskite layer’s ability to concurrent thermal cycling, so as to match the deformability of polymer substrates. Different from the conventional lattice solidification strategy for rigid devices, we incorporate a fluorinated misplaced-dipole engineered repairable elastomer into the perovskite film, which enhances perovskite intergranular toughness and mitigates thermal stress fatigue cracks. The resultant perovskite film exhibits suppressed lattice thermal fluctuation, thereby boosting enhanced environmental resilience. Consequently, the optimized F-PSCs deliver a champion efficiency of 25.54%, versus 26.83% for their rigid counterparts. More importantly, the F-PSC demonstrates exceptional durability under harsh operational stresses, retaining over 90% of the initial PCE after 11,000 bending cycles and maintaining a comparable retention rate following 500 thermal cycles, paving the way towards for the long-lasting flexible photovoltaic devices.
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