Sustainable Chemistry and Pharmacy
·
2025
·
IF 5.8
Qingfen Zhang,Dan Ge,Shengcheng Mi,Qi Lu
The bioactive properties of essential oil are strongly associated with their chemical composition. In this work, a novel method of salt-enhanced homogenization pretreatment coupled with solvent-free microwave extraction (HP-SSFME) was developed for extracting essential oil (KGEO) from fresh Kaempferia galanga rhizomes, which significantly improved the extraction efficiency. Gas chromatography was employed to measure the contents of the main active components, ethyl p -methoxycinnamate (EPMC) and ethyl cinnamate (EC) in the essential oil. The extraction process was optimized by the Box-Behnken Design using the comprehensive scores of the yields of EPMC, EC, and KGEO obtained by the entropy weight method. The optimal parameters were determined as follows: amount of sodium chloride was 1.60 %, homogenization speed of 15000 r/min, homogenization time of 4 min, microwave irradiation power of 300 W, microwave irradiation time of 23 min. Under these conditions, the KGEO yield was 5.10 %, EPMC yield was 3.81 %, EC yield was 0.89 %. Compared with the conventional methods, the HP-SSFME method not only significantly increased the extraction yield of KGEO but also remarkably enhanced the yields of EPMC and EC. Additionally, the HP-SSFME method has low CO 2 emission and energy consumption, highlighting its environmental friendliness. Moreover, in terms of antibacterial activity, the HP-SSFME outperformed other methods, demonstrating a more powerful and extensive inhibitory effect against a range of bacteria. This study provides a valuable reference for the efficient extraction and quality control of essential oils from Kaempferia galanga rhizomes.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Chao Zhang,Chunhe Gu,Fan Su,Mengrui Wang,Junxia Chen,Ziqing Chang,Junping Zhou,Mingzhe Yue,Fei Liu,Zhen Feng
Iridoid glycosides (IGs) are secondary metabolites found in plants such as the noni plant ( Morinda citrifolia L.), known for their diverse biological activities and potential health benefits. Herein, we screened fifteen natural deep eutectic solvents (NADES) and two conventional solvents (CS, 70% (V/V) methanol and 70% (V/V) ethanol) for extraction of IGs from noni fruit pomace. Our findings indicate that non-acidic NADES promote IG extraction. Glycerol/glycine combined with β-cyclodextrin was selected, and a molecular simulation was performed to elucidate the interaction between NADES components and IGs. Further, the structure-activity relationship and interaction mechanisms of IGs with α-glucosidase were investigated using multispectral and molecular docking tools. The results demonstrated that deacetylation of the B-ring's C-10 improved the inhibitory potential of IGs. Deacetylation produces hydrophobic contacts, which enhance the inhibitory effect of deacetylasperulosidic acid on α-glucosides. Additionally, hydrogen bonds and van der Waals forces drive the formation of non-covalent complexes between IGs and enzymes.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2023
·Vol. 32
·期 2
·536-547
·
IF 5.3
Chen Weishuo,Zhong Channa,Li Shuangcheng,Wen Die,Zhou Dongdong,Shao Jun,Chen Shuiliang,Hou Haoqing,Xiang Sheng
The blends of poly(D-lactic acid) and poly(L-lactic acid) (PDLA/PLLA) produce the stereocomplex crystals (SC) with a melting temperature of ~ 250 °C, which exhibits higher crystallization rate and mechanical strength than PDLA or PLLA. The SC was also reported as an effective nucleator for PLA homochiral crystals (HC). In the PDLA/PLLA blends, the SC would develop at first in most of cases. However, the morphology of SC in the asymmetric blends were rarely reported, and the effect of the SC morphology on the subsequently crystallization of HC was not clear yet. In this study, the PDLA/PLLA blends with dissimilar weight ratios were prepared by three methods, i.e. , electrostatic spinning, solution casting, and melted-cooling, and the SC with different morphologies were achieved. Then, the crystallization behavior of HC under the existence of SC was studied. Results indicated that the SC morphology exerted diverse effects on the formation of HC. The SC with fibrous and banded morphology produced by electrostatic spinning presented great limitation for the formation of HC. The SC with spherical morphology developed in the solution casting films enhanced the formation of HC. The SC with network structure produced in the melted-cooling specimens accelerated the crystallization rate of HC significantly. This investigation indicated that not only the content of SC, but also the morphology of SC would influence the crystallization behavior of HC, which would make a deep understanding for the crystallization behavior of PDLA/PLLA specimens.
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ULTRASONICS SONOCHEMISTRY
·
2024
·
IF 8.7
Junping Wang,Hongyi Zhao,Xuexue Xue,Yutong Han,Xin Wang,Zunlai Sheng
Lycopene-rich guava ( Psidium guajava L.) exhibits significant economic potential as a functional food ingredient, making it highly valuable for the pharmaceutical and agro-food industries. However, there is a need to enhance the extraction methods of lycopene to fully exploit its beneficial uses. In this study, we evaluated various ionic liquids to identify the most effective one for extracting lycopene from guava. Among thirteen ionic liquids with varying carbon chains or anions, 1-butyl-3-methylimidazolium chloride demonstrated the highest productivity. Subsequently, a single-factor experiment was employed to test the impact of several parameters on the efficiency of lycopene extraction using this selected ionic liquid. These parameters included extraction time, ultrasonic power, liquid-solid ratio, concentration of the ionic liquid, as well as material particle size. Moreover, models of artificial neural networks using genetic algorithms (ANN-GA) and response surface methodology (RSM) were employed to comprehensively assess the first four key parameters. The optimized conditions for ionic liquid ultrasound-assisted extraction (IL-UAE) were determined as follows: 33 min of extraction time, 225 W of ultrasonic power, 22 mL/g of liquid-solid ratio, 3.0 mol/L of IL concentration, and extraction cycles of three. Under these conditions, lycopene production reached an impressive yield of 9.35 ± 0.36 mg/g while offering advantages such as high efficiency, time savings, preservation benefits, and most importantly environmental friendliness.
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Food & Function
·
2019
·Vol. 10
·期 5
·2906-2913
·
IF 3.241
Yanlong Li,Xudong Tian,Shengcai Li,Lijun Chang,Ping Sun,Yubei Lu,Xiaoyan Yu,Shiwang Chen,Zhengquan Wu,Zhong Xu,Wanrong Kang
Dysfunction of the intestinal epithelial barrier plays an important role in the pathogenesis of several intestinal diseases, including celiac disease, inflammatory bowel disease, and irritable bowel syndrome. The present research was carried out to investigate the protective effect of total polysaccharides of adlay bran (TPA) on TNF-α-evoked epithelial barrier dysfunction in Caco-2 cells. Caco-2 cells were treated with or without TPA in the absence or presence of TNF-α, and transepithelial electrical resistance (TEER) and Phenol Red flux were assayed to evaluate the intestinal epithelial barrier function. The results indicated that TPA suppressed the TNF-α-induced release of pro-inflammatory factors. Furthermore, TPA obviously assuaged both the increased paracellular permeability and the decrease of TEER in TNF-α-challenged Caco-2 cells. Furthermore, TPA obviously assuaged TNF-α-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-κB p65. Our results indicated that TPA assuages the TNF-α-evoked dysfunction of the intestinal epithelial barrier by inhibiting the NF-κB p65-mediated inflammatory response.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Yu Liu,Di Zhu,Liangyi Zhao,Zhengguo Wu,Yonghua Zheng,Peng Jin
Although the impact of postharvest trans-2-hexenal (E2H) application in maintaining the quality of horticultural products has been widely studied, its effect on fresh common beans and the preservation mechanism remain unexplored. In this study, the impacts of E2H on reactive oxygen species (ROS) and cell wall metabolisms, and lignin biosynthesis in common beans were investigated. Fresh common beans fumigated with E2H (0, 0.5, 1.0, 1.5, and 2.0 μL L −1 ) were stored at 20 ± 1 °C for 12 days. Results showed that 1.0 μL L −1 E2H remarkedly repressed the decline of chlorophyll content to delay the yellowing, maintained ROS homeostasis, modulated cell wall metabolism-related enzyme activities to regulate cell wall components, and inhibited lignin biosynthesis-related enzyme activities to reduce lignin accumulation, thereby alleviating softening and lignification in common beans. These findings indicated that E2H could improve antioxidant activity, delay softening, and attenuate lignification to mitigate the quality deterioration in common beans.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Bingyao Zhou,Hong Wang,Shui Hu,Qi Yan,Pudun Zhang
Effects of montmorillonite (MMT) on the crystallization behavior of poly(L-lactic acid) (PLLA) were investigated by variable-temperature FTIR spectroscopy. The variations of carbonyl band (1800–1720 cm −1 ) of different PLLA/MMT nanocomposites were focused due to its strong intensity and the involved abundant structure information. Difference spectrometry was used to evaluate the structural variations of PLLA after introducing MMT, and perturbation correlation moving window two-dimensional analysis (PCMW2D) split the temperature range into two sub-regions, i.e., 32–116 ℃ and 116–152 ℃, on the basis of the spectral variation. Two-dimensional correlation spectroscopy (2DCOS) was further applied to such sub-regions in order to find the change order between varied PLLA polymorphs. The results showed that less addition of MMT (≤3%) would lead to a well-exfoliated structure, which not only had no nucleation effect for PLLA, but also delayed the cold crystallization to a higher temperature compared with the one of pure PLLA. However, a higher addition of MMT (≥5%) would lead to an intercalated structure, which acted as a nucleating agent and thus advanced the cold crystallization to a lower temperature. Nevertheless, the introduction of MMT cannot affect the phase transition order between the amorphous, the intermediate, the α′- and the α′-PLLAs based on 2DCOS results.
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MOLECULES
·
2026
·Vol. 31
·期 20
·3615
·
IF 5.1
Haoyu Jia,Tong Yan,Luran Wang,Lingling Song
Icariside I is a pharmacologically important prenylated flavonoid glycoside, yet its efficient biocatalytic production from icariin is hindered by the limited stability and recyclability of the enzymes involved. In this study, an α-L-rhamnosidase mutant R783A (Rha R783A) was heterologously expressed, purified, and immobilized within a Cu-based metal–organic framework (MOF) via a one-pot co-precipitation strategy. The resulting Rha R783A@MOF biocomposite exhibited enhanced stability compared to the free enzyme, retaining >90% residual activity after incubation at 60 °C for 2 h and 86.4% after 30 days of storage. It also demonstrated broad pH adaptability. In the biotransformation of icariin, Rha R783A@MOF achieved a 99.8% conversion rate and a 97.8% yield of icariside I. Furthermore, the biocomposite maintained an 88.9% yield after eight consecutive reuse cycles under high-temperature conditions (60 °C), demonstrating excellent operational stability. This work presents a robust and sustainable strategy for icariside I production, highlighting the potential of MOF microparticles as an effective platform for the biocatalytic synthesis of high-value flavonoid compounds.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 14
·1082
·
IF 3.2
Pang Bo,Cui Yanqun,Yin Jing
As a fundamental element in integrated photonic systems, the functionality of polymer-based waveguide amplifiers is primarily determined by the optical properties of the active material. More precisely, the amplification bandwidth establishes the working spectral region of the photonic circuit. Consequently, developing gain media that feature both broad bandwidth and high gain has emerged as a critical challenge in the field. The performance of this gain medium is fundamentally determined by rare-earth-ion-doped crystals, as the emission spectrum of these crystals ultimately dictates the achievable gain bandwidth. In this study, Y 2 O 3 : Yb, Er, Ce crystals with emission peaks covering the entire S + C + L band were prepared. In Y₂O₃ crystals with low crystal field symmetry, the 4 I₁₃/₂ and 4 I₁₅/₂ levels of Er 3+ ions were observed to undergo severe splitting, which in turn allows for effective broadening of the operational bandwidth. Fluorescence analysis reveals that the broadband emission from Er 3+ ions stems from the pronounced energy level splitting caused by the crystal field effect. When irradiated with a 980 nm laser, the emitted peak coverage from these Y 2 O 3 : Yb, Er, Ce crystals spans the complete S + C + L spectral range, demonstrating broadband optical amplification properties. Incorporation of Ce 3+ substantially improved the emission strength within these crystals across the S + C + L spectral region. Given their remarkable broadband luminescence characteristics across the S + C + L spectral range, Y 2 O 3 : Yb, Er, Ce materials represent promising candidates for gain media in next-generation polymer-based optical amplifiers.
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Frontiers in Nutrition
·
2023
·
IF 5
Tang Xinjing,Wang Zhirong,Zheng Jiong,Kan Jianquan,Chen Guangjing,Du Muying
To enhance the content of adlay bran soluble dietary fiber (SDF) and improve its functionality, we investigated the influences of steam explosion (SE) on the physicochemical, structural properties, and in vitro hypoglycemic activities of adlay bran SDF. The cellulose, hemicellulose, and lignin contents of adlay bran decreased significantly after SE treatment. When the SE strength was 0.8 MPa for 3 min, the SDF content was 9.37%, which was a significant increase of 27.48% compared to the control. Under these conditions, SDF showed the highest oil-holding capacity (OHC) (2.18 g/g), cholesterol adsorption capacity (CAC) (27.29 mg/g), glucose adsorption capacity (GAC) (15.54 mg/g), glucose dialysis retardation index (GDRI) (36.57%), and α-Amylase activity inhibition ratio (α-AAIR) (74.14%). Compared with SDF from untreated adlay bran, SDF from SE-treated adlay bran showed lower weight molecular. In addition, differential scanning calorimetry (DSC) measurement showed that the peak temperature of SDF from adlay bran treated by SE increased by 4.19°C compared to the untreated SDF sample. The structure of SDF from adlay bran treated by SE showed that the SDF surface was rough and poriferous and the specific surface areas increased. In conclusion, SE pretreatment increases the content of SDF in adlay bran and improves its physicochemical, structural properties, and biological activities, which will be beneficial for the further exploitation of adlay bran.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Yuhang Hu,Xuhui Kan,Tingting Yang,Xia Fan,Wangting Zhou,Guijie Chen,Yamei Yan,Lu Lu,Jia Mi,Xiaoxiong Zeng,Youlong Cao
Chlorogenic acids are important phenolics in the fruits of wolfberry, but little attention has been paid on their glucosylated forms. In the present study, a glucosylated form of chlorogenic acid was isolated from the fruits of Lycium barbarum L. var. auranticarpum K. F. Ching (also called yellow wolfberry) and identified to be (-)-5- O -(3- O -β- d -glucopyranosylcaffeoyl)-quinic acid (5-CQA-3′βG) by high resolution mass spectrometry and nuclear magnetic resonance spectrometry. The content of 5-CQA-3′βG in the dried fruit was determined as 0.0293 ± 0.0015% by HPLC. In addition, 5-CQA-3′βG showed a good scavenging capacity for 2,2′-azino-bis-(3-ethylben-zothiazoline-6-sulphonate) free radicals but had a relatively low reducing power and scavenging capacity for 2,2-diphenyl-1-picrylhydrazyl free radical. Moreover, the secretion of nitric oxide, tumor necrosis factor-α and interleukin-6 as well as related mRNA expression were reduced in lipopolysaccharide-stimulated RAW264.7 macrophage cells treated with 5-CQA-3′βG. This is the first report describing purification, identification and bioactivity of glucosylated CQA from yellow wolfberry.
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PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Shuai Wang,Yunxiao Wang,Shunxin Wang,Shuang Guo,Dongyu Gu,Jifeng Wang,Yi Yang
In this study, R. pseudoacacia flowers exhibited potential lipase ( Aspergillus niger ) inhibitory activity. To quickly explore the active compound, ligand fishing was adopted for screening the ligand from R. pseudoacacia flowers by lipase immobilized on magnetic polyamidoamine dendrimer-coated multi-walled carbon nanotubes . After ligand fishing, the target compound was separated purposefully by optimizing the separation conditions of high-speed counter-current chromatography (HSCCC). As results, kaempferol with the IC 50 of 327.64 ± 15.33 μg/mL was separated and identified. The further molecular docking results indicated that kaempferol was interacted with amino acid residue in the active site of lipase through van der Waals force, hydrogen bonds and Pi-Pi T-shaped interactions, yielding the binding energy of − 6.43 kcal/mol. The present method not only revealed the lipase inhibitory substances in R. pseudoacacia , but also provided an effective means for the screening of other natural substances.
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