JOURNAL OF NANOBIOTECHNOLOGY
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2025
·
IF 12.6
Hu Jiayao,Liu Hao,Wu Yizhou,Dong Xiaoyan,Tang Dongying,Yan Wei,Liu Bin,Zhou Hongyan
The active ingredients of Traditional Chinese Medicine with diverse structures exhibited anti-inflammatory and lipid lowering functions, demonstrating significant therapeutic effects in inflammatory diseases of atherosclerosis. We incorporate Astaxanthin (AST) and Dihydroartemisinin (DHA) into PLGA NPs to synthesized HA@PLGA@AST/DHA NPs (HPAD NPs) for alleviating atherosclerosis. In vitro assay indicated that the designed HPAD NPs promoted cholesterol efflux of macrophages by enhancing selective lipophagy, which is benefit to lipid antigen degradation. Meanwhile, HPAD NPs regulated T-cell differentiation and crucially induced macrophages from pro-inflammatory M1 type to anti-inflammatory M2 type. In vivo study demonstrated that HPAD NPs decreased the necrotic core dimension and improved plaque stability in ApoE -/- mice with atherosclerosis. Overall, this research indicated the promise of HPAD NPs for the targeted therapy of atherosclerosis. Graphical abstract Schematic illustration of HPAD NPs preparation and therapeutic strategy for AS. (A) Preparation of HPAD NPs. (B) HPAD NPs reduce inflammation and prevent AS by restoring lipophagy of macrophages and promote the polarization from M1 type to M2 type to modulate the AIM.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2025
·
IF 4
Zhong Qi-Ying,Ou-Yang Xue-Ping,Li Fang,Chen Si-Chong,Wu Gang,Wang Yu-Zhong
Polymers that exhibit both biodegradability and chemical recyclability offer a promising solution to environmental pollution and resource scarcity. Poly(glycolic acid) (PGA) is a promising chemically recyclable polymer, characterized by its seawater degradability and high mechanical strength. In this study, aliphatic polycarbonates were synthesized through melt polycondensation and subsequently copolymerized with glycolide (GL) to produce chemically recyclable PGA based triblock copolymers with well-defined structures. The properties of these copolymers, including their thermal properties, crystallization behavior, and mechanical performance, can be effectively adjusted by modifying the structure and content of the middle block. Furthermore, an in-depth investigation reveals that the pyrolysis process involves ester exchange, radical, and back-biting reactions. In addition, the high-efficiency “Monomer↔Copolymer” chemical recycling loop has been established, achieving a remarkable yield exceeding 88% along with a purity greater than 99%.
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AAPS PHARMSCITECH
·
2025
·Vol. 26
·期 2
·60
·
IF 4
Zhang Zhaoyang,Wang Sheng,Wang Qianlei,Ye Qian,Wang Wenjuan
Ion pairs represent a robust molecular force arising from the union of oppositely charged ions, held together by Coulomb attraction. Daidzein (Dai), categorized as a BCS IV drug, faces limitations in clinical application due to its relatively low solubility. To enhance the drug’s solubility, a Dai ion pair was prepared, and the mechanism underlying ion-pair formation was investigated. A comprehensive approach, combining experimental techniques and theoretical calculations, such as scanning electron microscopy, powder X-ray diffraction, differential scanning calorimetry, Fourier-transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, X-ray Photoelectron Spectroscopy, and computational simulation was employed to explore the ion-pair formation mechanism. The findings indicate a significant improvement in Dai solubility through the preparation of Arg and Lys ion-pair compounds. The results revealed that the Dai–Lys ion pair exhibited more short hydrogen bonds and fewer long hydrogen bonds than did the Dai–Arg ion pair, strengthening the intermolecular interactions and improving crystal structure stability. This study effectively enhanced the solubility of Dai and offers valuable insights into the mechanisms underlying ion pair formation in ionizable drugs. Graphical
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Nature Communications
·
2025
·
IF 15.7
Yang Jiahui,Wei Wei,Zhou Chengxi,Tan Xinyi,Wu Tai-Sing,Zhang Yi,Soo Yun-Liang,Li Molly Meng-Jung,Robertson Alex W.,Tang Ao,Sun Zhenyu
The development of a safe and affordable redox flow battery technology is important for storing intermittent renewable energy. Here, we design a stable aqueous organic iron-cerium redox flow battery based on the inexpensive metal iron and the abundant rare earth metal cerium, enabled by the universal complexing agent diethylenetriamine pentaacetic acid. Molecular dynamics simulations are employed to screen for carboxyl-containing ligands with different electron donating capacities, revealing that diethylenetriamine pentaacetic acid is an effective candidate to chelate iron and cerium in the negolyte and posolyte, respectively, as verified by experimental characterization. The complexing agent enhances the redox characteristics of iron and cerium and reduces osmotic water migration between the negative and positive chambers by allowing the same ligand in both electrolytes. Our iron-cerium redox flow battery achieves an energy efficiency of 87.7% at 40 mA cm −2 and 80.6% at 100 mA cm −2 , while retaining 95.3% of its initial capacity and maintaining around 86.3% energy efficiency after 500 cycles under neutral environments (100% of state-of-charge). The capacity is still preserved after 1779 cycles even when cycled at high-rates (80 mA·cm −2 , 70% of state-of-charge).
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Nature Communications
·
2025
·
IF 15.7
Wang Haiyan,Dang Jie,Wang Ying,Liu Feng,Lin Jinguo,He Tiancheng,Liao Qihua,Zhang Qi,Cheng Huhu,Qu Liangti
Iontronic power source harnesses ion-electron coupling effect for energy conversion, offering great potential in wearable electronics and bioelectronics. However, its limited power density and insufficient current hinder the progress toward commercialization. Here we report an iontronic electricity generator based on intrinsic asymmetric interfaces and controllable energy-release, which reaches a maximum volumetric power density of up to 3680 W m -3 , area power density of 18.4 W m -2 , and peak current of more than 5 A. Cycling power generation is ascribed to reversible electron-coupled ion-oscillation at interface. Synergistically, the intrinsic asymmetric interfaces facilitate ion-electron coupling interaction, and the energy-release gate optimizes the energy conversion pathway, thus ensuring giant power output. The developed generator shows large-scale manufacturability and good flexibility. These exceptional performances in iontronic power source not only offer useful paradigms for wearable electronics, but also indicate a strategy and direction into high-power energy conversion from low-grade environmental source.
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POLYMER BULLETIN
·
2017
·Vol. 75
·期 3
·1149-1169
·
IF 1.43
Zhang Zhen,He Changyu,Tan Lianjiang,Liu Bingya,Zhu Zhenggang,Gong Bing,Shen Yu-Mei
Block copolymer CSO 2500 -β-CD-PLA 3000 and CSO 2500 -β-CD-PLA 5000 were synthesized via H-bonding-instructed double disulfide linkage and host–guest recognition between adamantane and β-cyclodextrin. Transmission electron microscopy and dynamic light scattering results further confirmed the formation of self-assembled micelles with an average size of 45 and 96 nm, and a polydispersity index of 0.178 and 0.161 for blank micelles, respectively. The copolymers CSO 2500 -β-CD-PLA 3000 and CSO 2500 -β-CD-PLA 5000 exhibited a low critical micellization concentration of 0.041 and 0.027 mg/mL, respectively, suggesting that the micelles are highly stable in dilute solution. Doxorubicin (DOX), a hydrophobic model anticancer drug, was loaded in the micelles, and the drug release can be triggered and significantly accelerated in reductive environment. The blank micelles had fairly low cytotoxicity, but the DOX-loaded micelles exhibited great proliferation inhibition against HeLa cells, which was confirmed by MTT assay. The experimental results demonstrated that these copolymeric micelles are promising carriers for the redox-responsive intracellular delivery of hydrophobic anticancer drugs. Due to the noncovalent interactions between the host and guest, which endowed supramolecular block copolymer with the ability of reversible assembling and disassembling, dual stimuli responsiveness can be expected for this novel supramolecular block copolymer CSO 2500 -β-CD-PLA 5000 favorable in efficient anticancer drug delivery.
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Journal of Food Measurement and Characterization
·
2019
·Vol. 14
·期 1
·272-282
·
IF 1.415
Chen Xiaoyu,Ji Haiyu,Zhang Chaofeng,Yu Juan,Liu Anjun
In this study, a novel GFP-A polysaccharide was extracted from Grifola frondosa , and its structural characteristics and in vivo anti-tumor activities were investigated. The contents of total sugar, uronic acid and protein in GFP-A were 90.18% ± 0.15%, 1.43% ± 0.08% and 0.46% ± 0.03%, respectively. By gas chromatography (GC), Monosaccharide analysis showed that GFP-A (about 2484 kDa) was composed of Rha, Xyl, Man, Glc and Gal with molar percentages of 25.98, 9.32, 11.73, 4.74, and 48.22%. FT-IR and NMR analysis also revealed that GFP-A was a neutral polysaccharide mainly composed of α-type rhamnopyranose, β-type mannopyranose and α-type galactopyranose. Besides, GFP-A could enhance the immunostimulatory, and obviously increase the spleen and thymus indices, spleen lymphocyte proliferation, phagocytic index and NK cells killing activity in tumor-mice. By Flow cytometry (FACS), GFP-A treatment could increase cytotoxic activity of CD4+ and CD8+ T cells, and activate helper T cells to play central roles in immunomodulation of tumor-bearing mice. These results suggest that GFP-A has antitumor activity, which could be explored as a novel natural immunomodulatory agent and as a therapeutic compound to lessen chemotherapy.
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Journal of Ocean University of China
·
2025
·
IF 1.2
Jing Qianqian,Cheng Yajie,Wang Wenhui,Yin Junna,Wei Meiyan,Xu Tongyi,Shao Changlun
Mycobacterium marinum can cause disease in both human beings and fishes. Infected fish exhibits symptoms commonly referred to as fish tuberculosis. In this research, we screened a 14-Membered Resorcylic Acid Lactones (RALs) library constructed in the laboratory for in vitro anti- Mycobacterium marinum activity and found that several compounds, including compounds 3 , 4 , 6 , 10 , and 17 – 26 , showed good activity. Notably, the trace natural product cochilimycin B (compound 3 ) possesses significant long-lasting inhibitory function to Mycobacterium marinum . It also shows synergistic effects with drugs like isoniazid, ethambutol, and bedaquiline ( FICI ≤0.5). In addition, cochilimycin B showed a significant inhibitory effect on the biofilm produced by Mycobacterium marinum , with an inhibition rate of 65.9%. To solve the bottleneck problem of natural product drug sources, we realized an efficient one-step semi-synthetic method to obtain compound 3 with a yield of 32.1%. In vivo , inflammatory changes in BALB/c mice infected with Mycobacterium marinum were characterized. After 12 h of infection, IL-1 β was 20%–30% lower in the spleen and tail of the 3 -treated group compared to the control group. In the thymus and tail of the treated group, TNF- α levels were 30%–60% lower than in the control group. This is the first time that the significant anti- Mycobacterium marinum effect of cochilimycin B from 14-Membered Resorcylic Acid Lactones (14-RALs) was reported, offering a new chemical molecule for anti- Mycobacterium marinum drug research.
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Nature Communications
·
2025
·Vol. 16
·期 1
·10980
·
IF 15.7
Wu Honghui,Liu Wen-Che,Wu Xuanyu,Li Zhuoting,Zhang Jialu,Wang Jiawen,Zhu Qing,Zhang Jinsong,Dong Kairu,Lin Ruyi,Hu Huihui,Zeng Junjie,Wu Jiaying,Li Kan,Nan Kewang,Zhang Tianyuan,Gao Jianqing
Electrofusion is a widely used technique for inducing membrane merging in biological systems, with applications ranging from hybrid lipid architectures to therapeutic delivery. However, the direct application of conventional electrofusion to advanced nanoscale drug carriers, such as cell membrane hybrid LNPs (cLNPs), faces challenges due to diminished dielectric response and uncontrolled particle dynamics. To address these limitations, we report a periodic asymmetric field (PAF) strategy that combines microfluidic flow with periodic electric fields to enhance nanoscale electrofusion. We systemically investigate the underlying mechanisms using computational fluid dynamics simulations, and subsequently fabricate and optimize a PAF-guided microfluidic electrofusion device (PAF-MED) for the controlled synthesis of cLNPs. These PAF-MED-synthesized cLNPs demonstrate improved fusion efficiency, augmented targeting capability, and superior therapeutic efficacy in bleomycin-induced pulmonary fibrosis murine models. This approach represents a unique advancement in the nanoscale manipulation of drug carriers towards better bio-functionality and reproducibility beyond conventional capability of electrofusion.
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MICROCHIMICA ACTA
·
2025
·Vol. 193
·期 1
·43
·
IF 5.3
Chen Guo-Ying,Luo Mao-Ling,Chai Tong-Qing,Dai Jing-Jing,Yang Feng-Qing
The composite materials of Mn oxide nanowires and ZIF-8 (Mn x O y NWs@ZIF-8-NF and ZIF-8@Mn x O y NWs-TH) with controllable sizes and morphologies (nanoflower and Tanghulu-like) were successfully synthesized using different solvents (water and dimethylformamide (DMF) under mild reaction conditions. The systematic investigation was conducted to evaluate the effects of key synthesis parameters, including precursor concentration, metal-to-ligand ratio, temperature, and time, on the microstructure and crystalline morphology of the materials. Furthermore, the synthesis mechanisms of the materials in different solvents (water and DMF) were explored, revealing the influence of solvent molecules on their crystal growth processes. The prepared materials serve as “tandem enzymes” (a single nanozyme composite can perform multiple or sequential catalytic reactions), possessing multiple enzyme-like activities (hydrolase- and oxidase (OXD)-like activities). Kinetic studies indicate that the Mn x O y NWs@ZIF-8-NF composite exhibits excellent hydrolase-like catalytic activity, characterized by the high substrate affinity and maximum reaction rate ( K m : 0.01493 mM, V max : 161.42 × 10 –8 M/s). Moreover, Mn x O y NWs@ZIF-8-NF exhibits high specificity and interference-resistance in fluorescent detection of glucose oxidase (GOX) based on its hydrolase and OXD-like activities. In short, this work investigates the role of solvents as one aspect of tailoring material properties, contributing to the development of advanced functional materials and offering a methodological reference for GOX detection. Graphical
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JOURNAL OF MOLECULAR HISTOLOGY
·
2021
·Vol. 53
·期 1
·119-131
·
IF 2.611
Lin Wei,Chen Zhipeng,Mo Xiaoyi,Zhao Shengli,Wen Zhenxing,Cheung Wing Hoi,Fu Dan,Chen Bailing
The imbalance between osteogenic and adipogenic differentiation of Bone marrow-derived mesenchymal stem cells (BMSCs) is involved in the occurrence and development of osteoporosis (OP). Previous studies have indicated the potential of phosphatase and actin regulator 1 (Phactr1) in regulating osteogenic and adipogenic differentiation of BMSCs. The present study aims to investigate the function and mechanism of Phactr1 in regulating osteogenic and adipogenic differentiation of BMSCs. Herein, the expression of Phactr1 in bone and adipose tissue of OP rats was determined by immunohistochemical. BMSCs were subjected to osteogenic and adipogenic differentiation, and transfected with Phactr1 overexpression lentivirus, small interference RNA (siRNA) and KD025 (selective ROCK2 inhibitor). The relationship between Phactr1 and ROCK2 was detected by Co-IP experiment. The expression of Phactr1, Runx2, C/EBPα, RhoA and ROCK2 was detected by Western blot. Calcium nodule and lipid droplets were determined by alizarin red and Oil red O staining. Interestingly, Phactr1 increased in both bone and adipose tissue of OP rats. During osteogenic differentiation, Phactr1 decreased and active RhoA, ROCK2 increased, while overexpression Phactr1 inhibits the increase of Runx2. Phactr1 increased and active RhoA decreased, ROCK2 did not changed during adipogenic differentiation. While, Knockdown Phactr1 inhibits the increase of C/EBPα. Phactr1 and ROCK2 were combined in osteogenic differentiation, but not in adipogenic differentiation. By using KD025, the decrease of Phactr1 and increase of Runx2 were inhibited respectively in osteogenic differentiation. Meanwhile, when ROCK2 was inhibited, Phactr1, C/EBPα were significantly increased in adipogenic differentiation. These findings indicated that Phactr1 negatively regulates bone mass by inhibiting osteogenesis and promoting adipogenesis of BMSCs by activating RhoA/ROCK2.
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Nature Communications
·
2018
·Vol. 9
·期 1
·1-21
·
IF 12.353
He Bing,Shi Yujie,Liang Yanqin,Yang Anpu,Fan Zhipu,Yuan Lan,Zou Xiajuan,Chang Xin,Zhang Hua,Wang Xueqing,Dai Wenbin,Wang Yiguang,Zhang Qiang
Single-walled carbon-nanohorns (SNH) exhibit huge application prospects. Notably, spherical SNH possess different morphology from conventional carbon nanotubes (CNT). However, there is a tremendous lack of studies on the nanotoxicity and mechanism of SNH, and their comparison with nanotubes. Here, the dissimilarity between SNH and CNT is found in many aspects including necrosis, pyroptosis, apoptosis, protein expression, hydrolases leakage, lysosome stress, membrane disturbance and the interaction with membrane proteins. The improved biocompatibility of SNH over four types of established CNT is clearly demonstrated in macrophages. Importantly, a key transmembrane protein, glycoprotein nonmetastatic melanoma protein B (GPNMB) is discovered to initiate the nanotoxicity. Compared to CNT, the weaker nano-GPNMB interaction in SNH group induces lower degree of cascade actions from nano/membrane interplay to final cell hypotoxicity. In conclusion, the geometry of single-construct unit, but not that of dispersive forms or intracellular levels of nanocarbons make the most difference.
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