INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Hongwei Jiang,Lei Zhou,Yue Wang,Guangxian Liu,Shengfeng Peng,Wenzhi Yu,Yuqing Tian,Junping Liu,Wei Liu
Phenolic acids are promising inhibitors of polyphenol oxidase (PPO), but the effects of carboxyl group and pH on their inhibition effects are still unclear. In this study, methyl cinnamate, cinnamic acid and 4-carboxycinnamic acid were investigated by their inhibitory effects with pH varied from 6.8 to 5.0. Results showed that 4-carboxycinnamic acid had the strongest inhibitory effect on PPO, followed by cinnamic acid and methyl cinnamate. Acidic pH enhanced the inhibitory effects of cinnamic acid and its derivatives on PPO, and the enhancement degree, IC 50 and K i declining degree were followed as 4-carboxycinnamic acid > cinnamic acid > methyl cinnamate. Methyl cinnamate exhibited competitive inhibition on PPO, while cinnamic acid and 4-carboxycinnamic acid exhibited mixed-type inhibition. Inhibitors induced slight changes in the secondary and tertiary structures of PPO, which were enhanced by acidic pH. Molecular docking results showed that 4-carboxycinnamic acid exhibited the strongest binding ability, and the main interaction forces were around carboxyl groups, and acidic pH enhanced the binding effect through more interactions and lower binding energy. This study could provide new insights into industrial application of cinnamic acid and its derivatives for the control of enzymatic browning of fruits and vegetables.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Lihua Huang,Ying Luo,Yiyang Cong,Jia Liu,Caiyan Xu,Zhaoxiang Zeng,Yihua Yin,Hao Hong,Wenjin Xu
Metal–organic frameworks (MOFs) are unique coordination polymers that have emerged as important candidates for drug delivery in recent years. Herein, we designed a drug delivery system for multi-modal combination therapy (IR-820/DOX@MIL-101-PDA-PEG-F3, simplified as ID@MIL-PPF3). In this study, pH-sensitive nanocarriers MIL-101(Fe) were prepared and loaded with the effective chemotherapy agent doxorubicin (DOX) and the phototherapeutic reagent new indocyanine green (IR-820) using a physical adsorption method. Dopamine was spontaneously polymerized in alkaline solutions to form a hybrid coating on MIL-101(Fe) (denoted as ID@MIL-101-PDA). The surface of ID@MIL-101-PDA was functionalized by the synthesized polymer NH2-PEG-OCH3/F3 to obtain ID@MIL-PPF3. Characterization results show that ID@MIL-PPF3 has a good drug loading rate (27.7%) and photothermal conversion efficiency (28.89%). In addition, Fe3+ released from MIL-101(Fe) can engage in a Fenton-like reaction to generate hydroxyl radicals (˙OH) to realize chemodynamic therapy (CDT). ID@MIL-PPF3 not only demonstrates the ability to intelligently release drugs, but also realizes chemotherapy combined with PDT/PTT/CDT therapy for tumor cells, which was proved by in vitro evaluation. In conclusion, ID@MIL-PPF3 provides a new idea and method for building a multi-modal combination therapy targeted drug delivery platform.
✓ 已验证
产品关联
DOI
高影响因子
Surfaces and Interfaces
·
2025
·
IF 6.3
Yajie Cheng,Zichen Xu,Qiang Wang,Kexin Zhang,Lin Wang,Yongbo Deng,Teng Ma,Hao Wei,Zengxian Guo
To address the issues of high filler content and poor wave absorption performance in single-component absorbers, we constructed tubular high-dielectric polypyrrole (PPy) through morphology control and doping, achieving high-performance microwave absorption at ultra-low filler content. This study utilized various surfactants for the oxidative polymerization of high-dielectric PPy (PPy-S X ) and its micromorphology was further optimized via pH regulation to further obtain excellent impedance matching of PPy (PPy-S 5 -X). Experimental results reveal that non-ionic surfactants, particularly methyl orange (MO), significantly improve the dielectric properties of tubular PPy (PPy-S 5 ). pH-regulation (from pH 1 to 11) markedly influences micromorphology. PPy-S 5 –5 (pH=5.0) possesses the most remarkable nanoparticle-nanotube morphology for impedance matching at ultralow filling content. With a thickness of 2 mm, PPy-S 5 –5 (5 wt% filling amount) exhibits an RL min of –40.88 dB with an effective absorption bandwidth of 5.04 GHz (10.24–15.28 GHz). By contrast, the RL min of PPy-S 5 –5 is over six times better than that of PPy-S 1 synthesized using cetyltrimethyl ammonium bromide (CTAB). This superior microwave absorption performance is due to enhanced electromagnetic wave loss for two main reasons: First, MO as a soft template promotes tubular PPy formation, allowing charges to continuously move and transfer between molecules to enhance conduction loss. Additionally, pH regulation optimizes particle distribution on PPy nanotubes, improving multi-interface interactions and interfacial polarization. This micromorphology regulation strategy of PPy unlocks its potential as a lightweight, efficient absorbent material, achieving superior absorption performance at low filling volumes in wave-absorbing applications.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Guiqiang Qi,Kang Chen,Wenhua Guan,Junyu Xie,Xiangyan Chen,Guanhua Zhang,Ran Yan,Geng Yang
Photothermal therapy (PTT) and photodynamic therapy (PDT) provide targeted approaches to cancer treatment, but each therapy has inherent limitations such as insufficient tissue penetration, uneven heat distribution, extreme hypoxia, and overexpressed HSP90 in tumor cells. To address these issues, herein, by encapsulating the IR780 dye and glucose oxidase (GOx) enzyme within ZIF-8 nanoparticles, we created a versatile system capable of combining photodynamic and enhanced photothermal therapy. The integration of the IR780 dye facilitated the generation of reactive oxygen species and hyperthermia upon light activation, enabling dual-mode cancer cell ablation. Moreover, GOx catalyzes the decomposition of glucose into gluconic acid and hydrogen peroxide, leading to the inhibition of ATP production and downregulation of heat shock protein 90 (HSP90) expression, sensitizing cancer cells to heat-induced cytotoxicity. This synergistic combination resulted in significantly improved therapeutic outcomes. Both in vitro and in vivo results validated that the nanoplatform demonstrated superior specificity and favorable therapeutic responses. Our innovative approach represents a promising strategy for overcoming current limitations in cancer treatments and offers the potential for clinical translation in the future.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 26
·期 4
·1-18
·
IF 2.1
Lu Zhimeng,Yan Kun,Liu Chunlei,Wang Jiapeng,Yu Guiping,Zhang Hao
Tripterygium wilfordii Hook F, a traditional medicine in China has bioactive but toxic triptolide (TP, a diterpenoid triepoxide) as its main active constituents. The applications of TP are hampered by its prominent toxicity and low solubility in water. In this study, a safe pH-sensitive material [methoxy polyethylene glycol (mPEG)- adipic dihydrazide (ADH)] was synthesized and loaded with TP to form pH-sensitive polymeric micelles, thereby improving the safety and solubility of TP, as well as providing a theoretical basis for the wide application of TP. The mPEG-ADH/TP micelles were characterized by a series of indicators [namely entrapment efficiency (EE), critical micellar concentration (CMC), electrokinetic potential, stability, polydispersed index (PDI), and particle size]. Also, we ascertained the in vitro release of TP from mPEG-ADH/TP micelles along with pharmacokinetic investigations in vivo. Besides, we evaluated the cytotoxicity of mPEG-ADH/TP micelles against A549 cells, HCT116 cells, and HaCat cells and further conducted in vivo toxicity studies in rats. The TP-loaded mPEG-ADH micelles had smaller sized particles (48.3 nm), excellent PDI (0.142), stable property and higher EE (89.87%). Importantly, the TP in the mPEG-ADH/TP micelles was almost completely released at acidic pH (pH 5.0), while the drug was released slowly and sparingly at physiological pH (pH 7.4). The results suggest the release of TP from mPEG-ADH/TP micelles was sensitive to pH, which could facilitate targeting of the drug into intra-cellularly low pH endosomes and lysosomes as well as enhance cytotoxicity in cancer tissues. Moreover, mPEG-ADH/TP micelles exhibited excellent proliferation inhibition on tumor cells. In addition, the liver injury of rats in the 1 mg/kg dose of mPEG-ADH/TP micelles group was significantly reduced by Hematoxylin–eosin (HE) staining. Taken together, mPEG-ADH/TP micelles could act as a promising alternative to enhance the efficacy of oncologic treatments.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Lan Ding,Jing Xu,Zeyu Zhang,Kezhen Qi,Ge Jin
Electrocatalytic hydrogen evolution reaction (HER) via water splitting is a prospective technology for achieving the sustainable production of hydrogen. So, ruthenium-based electrocatalysts have been extensively studied. However, metallic ruthenium tends to agglomerate due to the high cohesive energy, resulting in decreased HER performance in practical usage. Introducing sufficient support for dispersing and immobilizing ruthenium-based species is a viable way to enhance the utilization efficiency. MXene-based materials with unique surface termination groups, superior chemical stability, high specific surface area and favorable electrical conductivity have received significant attention as low-cost carriers for the development of active catalysts in HER. Herein, nitrogen (N) and sulfur (S) atom-doped titanium carbide (Ti 3 C 2 ) quantum dots (QDs) were successfully synthesized as efficient carriers for anchoring ultra-small ruthenium nanoparticles (NPs) toward electrocatalytic HER. Electrochemical tests reveal that the resultant N,S-Ti 3 C 2 QDs/Ru displays superior HER performance with low overpotentials of 28, 25 and 56 mV at 10 mA cm −2 current density in 0.5 M H 2 SO 4 , 1 M KOH and 1 M PBS solutions, respectively. Such a low overpotential is comparable to most previously reported non-metallic catalysts, Ru-based electrocatalysts and commercial Pt/C. In addition, N,S-Ti 3 C 2 QDs/Ru displays extraordinarily long-term stability over a relatively wide pH range and is indeed a kind of pH-universal catalyst for hydrogen evolution. Furthermore, density functional theory (DFT) calculations demonstrate that the interactions between metal Ru and N,S-Ti 3 C 2 MXene QDs effectively regulate the electronic structure of the active site Ru, lowering the energy barrier of the electrocatalytic HER intermediate, thus dramatically enhancing the activity for N,S-Ti 3 C 2 QDs/Ru. This work proposes a novel approach to functionalize MXene quantum dots for use as low-cost electrocatalysts with promising practical applications in renewable energy conversion.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
·
IF 11.3
Yuetong Luo,Kaixing Fu,Dawei Wang,Jinming Luo
Nanobubbles (NBs) have been utilized to enhance the removal of perfluoroalkyl and polyfluoroalkyl substances (PFAS) from water. However, the effectiveness of NBs under various operational conditions, including varying PFAS concentrations, pH levels, and the presence of coexisting ions, has remained insufficiently explored. A deeper understanding of these interfacial interactions is crucial to optimizing and maximizing the efficiency of NBs in PFAS removal. This study aims to bridge these knowledge gaps by systematically exploring the role of NBs in augmenting the adsorption of legacy PFAS on various carbon-based adsorbents, including granular activated carbon (GAC), carbon nanotubes (CNTs), and graphene. Our experimental results demonstrated a significant improvement in PFAS adsorption on carbon-based adsorbents in the presence of NBs, with the enhancement effect particularly pronounced at a high initial PFAS concentration (50 mg L–1). Acidic conditions notably facilitated PFAS removal in the NB-assisted carbon adsorption system, aligning well with the predictions from the Derjaguin–Landau–Verwey–Overbeek (DLVO) theory. Furthermore, ionic strength was found to play a critical role, with lower levels stabilizing NBs and promoting interactions with adsorbent surfaces, while higher levels reduced the effectiveness of NBs. Additionally, multivalent cations (particularly Fe3+) showed a substantially greater enhancement in PFAS removal efficiency compared to Na+ and Ca2+. This study deepens the understanding of NB-assisted PFAS removal using carbon-based adsorbents and provides practical insights into optimizing treatment processes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POWDER TECHNOLOGY
·
2025
·
IF 4.6
Menglu An,Weiying Wang,Jingguo Li,Shaokui Cao,Yingliang Liu,Jun Shi
MnO 2 nanosheets have attracted extensive attention in the field of photothermal therapy due to their excellent pH/glutathione (GSH) responsiveness. In this study, MoS 2 @gold nanorods (AuNRs)/polydopamine (PDA)@MnO 2 (400–500 nm) nanocomposites with controllable drug release property were prepared by covering MnO 2 nanosheets around near-infrared (NIR) responsive MoS 2 @AuNRs (100–200 nm) via in-situ redox reaction. The large surface area and strong negative charge of MnO 2 nanosheets ensured that MoS 2 @AuNRs/PDA@MnO 2 had a high loading efficiency of 92.44 % for doxorubicin hydrochloride (DOX). MoS 2 @AuNRs/PDA@MnO 2 revealed significant NIR/pH/GSH triple-responsive drug release properties owing to the synergistically enhanced NIR photothermal-response of MoS 2 @AuNRs (61.10 % of photothermal conversion efficiency) and the reaction between MnO 2 and GSH in weakly acidic media. In addition, in vitro cell viability results confirmed that MoS 2 @AuNRs/PDA@MnO 2 could efficiently kill tumor cells under the dual action of acidic media and NIR laser. This study develops a novel nanocarrier with NIR/pH/GSH triple-responsive drug delivery capability, which has broad applications in photothermal therapy and intelligent drug delivery.
✓ 已验证
产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2017
·
IF 3.386
Yue Wang,Ning Yang,Dandan Wang,Yang He,Li Chen,Yiping Zhao
The lack of identified binding sites for drugs and the undegradability limited the development of the thermo-sensitive hydrogels based on N-isopropylacrylamide (NIPAAm) in the intelligent drug delivery system (DDS). Therefore, the poly (Maleic anhydride-β-cyclodextrin- co -NIPAAm) (poly (MAH-β-CD- co -NIPAAm)) hydrogels were obtained to overcome these disadvantages. β-cyclodextrin (β-CD) with the drug inclusion properties and degradation capacity was modified by maleic anhydride (MAH) and the resultant monomer was fixed in the gel network by a series of polymerization reactions . The physical and chemical properties of the monomer and the poly (MAH-β-CD- co -NIPAAm) hydrogels were systemically investigated. The swelling/deswelling kinetics at different temperature and pH indicated that the gels exhibit dual responsiveness. The model drug naproxen sodium was identified by MAH-β-CD, so it was efficiently loaded on the hydrogels. The drug released in a controlled manner from the copolymerization hydrogels, especially displayed slower release efficiency in simulates stomach conditions. And these hydrogels also showed biodegradability in the presence of α-amylase. The above facts demonstrated that the poly (MAH-β-CD- co -NIPAAm) hydrogels was an effective oral drug system.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 89
·56519-56527
·
IF 3.108
Aihua Yao,Qingge Fu,Ling Xu,Yan Xu,Wenqi Jiang,Deping Wang
Poly(4-vinylpyridine) (P4VP), a pH-sensitive polymer, was employed to non-covalently functionalize graphene oxides (GOs) through π–π stacking interactions. Citrate-capped Au nanoparticles (Au NPs) were then immobilized onto the P4VP-grafted GO, yielding pH-responsive Au NPs–GO nanocomposites. Such Au NPs–GO nanocomposites displayed pH-responsive localized surface plasmon resonance (LSPR) changes and assembly behavior due to protonation and deprotonation of the pyridine units of P4VP molecules. The catalytic activity of the Au NPs–GO nanocomposites was evaluated using the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) as a model reaction, and demonstrated significantly high catalytic activity and stability at low pH (2.0), which was 4-fold higher than that at high pH (5.0). Furthermore, our results indicated that the Au NPs–GO nanocomposites induced active adsorption and selective SERS detection of negatively charged analytes under low pH conditions, and are therefore highly attractive for real-world chemical detection.
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2017
·
IF 3.833
Tingting Zhou,Jiagen Li,Xu Jia,Xubo Zhao,Peng Liu
Novel biocompatible and biodegradable pH/reduction dual-responsive oxidized alginate-doxorubicin (mPEG-OAL-DOX/Cys) prodrug nanohydrogels were designed for tumor-specific intracellular triggered release of anticancer drug DOX by conjugating DOX via acid-labile Schiff base linkage into the PEGylated oxidized alginate (mPEG-OAL) cross-linked with bioreducible disulfide bond. The effect of the complexation with cyclodextrins (α-CD and β-CD) before or after the cross-linking of the mPEG-OAL on the DOX content and controlled release performance was investigated. It was found that the cyclodextrin inclusion complex prodrug nanohydrogels mPEG(CD)-OAL-DOX/Cys, prepared by cross-linking of the mPEG-OAL after complexation with cyclodextrins, exhibited better pH/reduction dual-responsive controlled release performance than the mPEG-OAL-DOX/Cys(CD) ones prepared by cross-linking of the mPEG-OAL before complexation with cyclodextrins, owing to the supramolecular cross-linking of the adjacent pseudopolyrotaxanes. Especially for the cyclodextrin inclusion complex prodrug nanohydrogels mPEG(α-CD)-OAL-DOX/Cys, DOX was released rapidly under lower pH media mimicking the tumor microenvironment and completely released within 48 h, while the premature leakage under the simulated physiological condition was ∼40%, without burst release in both cases. The cellular toxicity and uptake results demonstrated that the mPEG(α-CD)-OAL-DOX/Cys prodrug nanohydrogels possessed similar inhibition against cancer cell growth in comparison with the free DOX and enhanced drug intracellular accumulation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
GREEN CHEMISTRY
·
2018
·Vol. 20
·期 7
·1538-1550
·
IF 8.586
Liang Qi,Zhigang Luo,Xuanxuan Lu
In this work, a pH-responsive [2-(dimethylamine)ethyl methacrylate] (DMAEMA) grafted maize starch composite was synthesized via free radical polymerization in the presence of the crosslinker N,N′-methylenebisacrylamide (BIS). Combined with the gelatinization–ethanol precipitation process, this starch-based composite in an optimized component ratio showed a nanometer size and regular spherical shape, along with a high freedom of the molecular chain, which was not only a breakthrough in terms of structure, but also brought about an outstanding performance in pH-responsiveness. Its superiority was proved by the formation of a Pickering emulsion that underwent pH-induced reversible emulsification/demulsification for at least 8 cycles without obvious performance decay or even morphology changes. Dynamic light scattering, zeta potential measurement and interfacial tension measurement, as well as contact angle measurement, confirmed synergistically that the reversible emulsification/demulsification cycle was the result of the tunable wettability and size of these novel starch-based nanoparticles under pH variation. More importantly, benefitting from DMAEMA as the stabilizer and growth point for Au nanoparticles and the large interfacial area of the emulsion droplets together with the pH-responsive reversible emulsification/demulsification cycle, the generated Pickering emulsion could be readily applied as catalytic microreactors for the hydrogenation of p-nitroanisole at the oil–water interface. This catalysis exhibited both high catalytic activity and good recyclability. The excellent performance makes us believe that this system is promising for meeting the requirements of green and sustainable chemistry.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）