Environmental Processes-An International Journal
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2024
·Vol. 11
·期 2
·1-23
·
IF 3.7
Abdel-Ghafar Hamdy Maamoun,Hamouda Hamed I.
Passive freshwater generation via photothermal membranes represents a sustainable and eco-friendly solution for the water crisis. Herein, we describe a unique method for producing organic fouling-resistant Ag-CNTs/PVDF photothermal membranes using CNTs (multi-walled Carbon Nanotubes) decorated with silver (Ag) nanoparticles deposited on the hydrophilic polyvinylidene difluoride (PVDF) substrate via vacuum filtration. CNTs were decorated with different loads of silver nanoparticles via a wet-impregnation technique. The prepared Ag-CNTs nanocomposites were fully characterized, and the fabricated anti-fouling Ag-CNTs/PVDF photothermal membranes with different loadings of Ag-CNTs nanocomposite were investigated for their surface morphology, roughness, light absorption, surface temperature, contact angle measurement, water evaporation, and antifouling performances. The optimized Ag-CNTs/PVDF photothermal membrane achieved 95% solar light absorption at a surface temperature of 82 ℃ ± 0.5 with significant hydrophobic behavior due to the plasmonic impact of silver nanoparticles. The evaporation rate reached 1.2 kg.m − 2 .h − 1 using 3.5% NaCl solution (simulated to seawater) with a solar thermal conversion efficiency of 75.6% ± 2.0. The optimized Ag-CNTs/PVDF photothermal membrane showed relative stability in the evaporation rate compared to other membranes using 100 mg.L − 1 humic acid solution for 600 min after one week under natural evaporation with the same solution. The developed membrane showed an effective water evaporation rate with organic matter resistance that makes it highly recommended for application to any water source with the capability of resisting harsh conditions of the environment and with continuous freshwater generation.
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Science Translational Medicine
·
2021
·Vol. 13
·期 579
·
IF 17.992
Fan-En Kong,Guang-Meng Li,Yun-Qiang Tang,Shao-Yan Xi,Jane Ho Chun Loong,Mei-Mei Li,Hao-Long Li,Wei Cheng,Wen-Jie Zhu,Jia-Qiang Mo,Yuan-Feng Gong,Hui Tang,Yue Zhao,Yan Zhang,Stephanie Ma,Xin-Yuan Guan,Ning-Fang Ma,Mao-Bin Xie,Ming Liu
Tumor lineage plasticity is emerging as a critical mechanism of therapeutic resistance and tumor relapse. Highly plastic tumor cells can undergo phenotypic switching to a drug-tolerant state to avoid drug toxicity. Here, we investigate the transmembrane tight junction protein Claudin6 (CLDN6) as a therapeutic target related to lineage plasticity for hepatocellular carcinoma (HCC). CLDN6 was highly expressed in embryonic stem cells but markedly decreased in normal tissues. Reactivation of CLDN6 was frequently observed in HCC tumor tissues as well as in premalignant lesions. Functional assays indicated that CLDN6 is not only a tumor-associated antigen but also conferred strong oncogenic effects in HCC. Overexpression of CLDN6 induced phenotypic shift of HCC cells from hepatic lineage to biliary lineage, which was more refractory to sorafenib treatment. The enhanced tumor lineage plasticity and cellular identity change were potentially induced by the CLDN6/TJP2 (tight junction protein 2)/YAP1 (Yes-associated protein 1) interacting axis and further activation of the Hippo signaling pathway. A de novo anti-CLDN6 monoclonal antibody conjugated with cytotoxic agent (Mertansine) DM1 (CLDN6-DM1) was developed. Preclinical data on both HCC cell lines and primary tumors showed the potent antitumor efficiency of CLDN6-DM1 as a single agent or in combination with sorafenib in HCC treatment.
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Small
·
2025
·
IF 12.1
Qi-Sheng Huang,Ruohan Yang,Zhi-Dong Yang,Pei-Chen Zhao,Xiaoliang Wang,Cheng-Hui Li
Stretchable electronic skins with multifunctional sensing capabilities are of great importance in smart healthcare, wearable display electronics, intelligent robots, and human-machine interfaces. Thermoplastic elastomers play a pivotal role as soft substrate in the field of stretchable electronics. However, the dynamic interactions of common thermoplastic elastomers often result in high hysteresis and fatigue damage, limiting their performance and durability. In this study, a highly resilient and fatigue-resistant elastomer is developed by employing La 3+ -complexes as crosslinkers. The woven structure formed between the prepolymer ligands and lanthanum (III) metal ions establishes stable coordination interactions and introduces additional entanglements around the coordination crosslinkers. Furthermore, this woven structure self-assembles into hierarchical nanoarchitectures, which serve as physical crosslinks, significantly enhancing the mechanical strength. As a result, the new elastomers exhibit exceptional mechanical strength (Young's modulus ≈3.47 MPa; maximum stress ≈16.52 MPa), resilience (residual strain during cyclic stretching at 100% strain ≈8%), fatigue resistance (strength retention rate ≈90% after 2000 cycles stretching), and stable thermomechanical properties (creep strain ≈14.43% and residual strain ≈0.22% at 80 °C 0.1 MPa). Leveraging this high-performance polyurethane elastomer, ultra-thin flexible electrodes are fabricated, which can achieve stable and long-term monitoring of the physiological signals of human body.
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PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 31
·期 2
·2001867
·
IF 16.836
Ruirui Zhao,Ying Yang,Ganxiong Liu,Renjie Zhu,Jingbo Huang,Zhiyuan Chen,Zhonghui Gao,Xiao Chen,Long Qie
With advantages such as high theoretical capacity, low cost, and nontoxicity, Zn metal has been widely investigated as an anode for aqueous batteries. However, the problems of dendrite formation and sustained corrosion originating from severe interfacial side reactions and uncontrolled Zn electrodeposition in aqueous electrolytes significantly slows down the practical application of Zn metal anodes. To address these issues, herein, an anti-corrosion elastic constraint (AEC) is introduced that is built with nanosized TiO 2 and polyvinylidene fluoride (PVDF) matrix to Zn anode, where the PVDF layer serves as an elastic H 2 O/O 2 -blocking layer and the decorated TiO 2 nanoparticles assist uniform Zn electrodeposition. With this corrosion-inhibition and electrodeposition-redirection coating, the electrodeposition consistency and thermodynamic stability of the Zn anode are significantly improved, enabling a long-term stable plating/stripping performance for 2000 h with an ultralow overpotential (<50 mV) and a high average Coulombic efficiency (>99.4%) for 1000 cycles without obvious dendrite formation. Even at a high current density of 8.85 mA cm −2 with limited Zn supply (DOD Zn = 60%), stable Zn deposition is achieved over 250 h. When coupled with a MnO 2 cathode, the AEC-Zn anode shows a remarkably enhanced full-cell cycling stability, indicative of high reliability of aqueous Zn batteries for practical application.
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高影响因子
INTERNATIONAL IMMUNOPHARMACOLOGY
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2025
·
IF 4.7
Tianying Bian,Hu li,Haohao Liu,Mudi Guo,Yiding Zhang,Pinli Hu,Meihua Chen
Objectives To explore the effects and biological mechanism of apabetalone on periodontal inflammation by regulating glycolysis and metabolites. Methods A ligature-induced periodontitis model was established in mice and apabetalone was administered on the ligation silk for two weeks. Inflammation levels and alveolar bone absorption were explored using micro-computed tomography and histopathological analysis. To observe the role of apabetalone in macrophage polarization and the macrophage-mediated immune microenvironment, a Luminex assay, quantitative real-time polymerase chain reaction, a conditioned medium experiment, a Seahorse extracellular flux assay and quantitative metabolomics were used for molecular biological analysis. Results Apabetalone-treated mice exhibited ameliorated alveolar bone loss and inflammatory infiltration in the periodontium. Furthermore, apabetalone significantly inhibited the production of proinflammatory cytokines and suppressed the levels of M1-specific biomarkers both in vivo and in vitro . Apabetalone also promoted the osteogenic potential of mouse periodontal ligament cells in a macrophage-mediated microenvironment. Apabetalone restrained LPS-induced glucose uptake and lactic acid production. Apabetalone inhibited glycolysis by suppressing the transcription and protein expression of hexokinase 2, glucose transporter 1 and phosphofructokinase-2/fructose-2,6- bisphosphatase 3 (PFKFB3) in a dose-dependent manner. Quantitative analysis of certain carbohydrates involved in energy metabolism revealed that apabetalone reserved the disruption of the tricarboxylic acid (TCA) cycle and inhibited glycolysis and the pentose phosphate pathway. In addition, apabetalone increased the oxygen consumption rate. Conclusion Collectively, these findings indicate that apabetalone improves the periodontal immune microenvironment by regulating metabolites in macrophages. Apabetalone exerts anti-inflammatory and osteo-protective effects by replenishing the broken TCA cycle and suppressing glycolysis. Apabetalone is a potential candidate for the treatment of periodontitis.
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JOURNAL OF PHARMACEUTICAL SCIENCES
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2015
·
IF 2.59
Ruixin Li,Chang Shu,Wei Wang,Xiaoliang Wang,Hui Li,Danke Xu,Wenying Zhong
ABSTRACT 10-Hydroxy camptothecin (HCPT) has been proven to be a cell cycle-specific chemotherapeutic agent, which is a necessary choice to inhibit tumor residue growth and prevent tumor metastasis after surgery. But it suffers from light decomposition, poor solubility, relatively low bioavailability, and some side effects, which are the major obstacles toward its clinical use. Integration of hydrophobic HCPT with hydrophilic hydrogel is a facile approach to change the disadvantageous situation of HCPT. In this study, a novel supramolecular hydrogelator with improved synthetic strategy was triggered by chemical hydrolysis, and then self-assembled to hydrogel. Taking advantage of the high-equilibrium solubility of HCPT in hydrogelator solution, this hydrogel was utilized to load HCPT via encapsulation as an effective carrier. HCPT hydrogels were characterized by several techniques including transmission electronic microscopy , rheology, and UV spectroscopy. In vitro release experiment indicated HCPT hydrogel could maintain long term and sustained release of HCPT at high accumulated rate. 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay showed that HCPT hydrogel had an optimized anticancer efficacy. Besides, with prominent physical properties of carrier, HCPT hydrogel possessed satisfactory stability, syringeability, and recoverability, demonstrating itself as a potential localized injectable drug delivery system . © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:2266–2275, 2015
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Materials Today Nano
·
2024
·
IF 8.2
Hao Wang,Siyu Hou,Weihao Feng,Dongliang Li,Jialin Liu,Weisong Yang,Suichu Huang,Feiran Li,Xuezeng Zhao,Fang Chen,Cong Huang,Yunlu Pan
Biosensors based on field-effect transistor (FET) are extensively utilized in biomedical engineering for their capability to achieve rapid and label-free detection of targets. However, the extremely low concentration level of biomarkers, crucial for human health, put forward higher requirements for biosensors. Developing stable and reliable biosensors with high sensitivity for biomarker detection remains challenging. In this study, we report a highly sensitive MoS 2 -FET biosensor for the cytokine IFN-γ. Surface etching of the MoS 2 channel using a reactive ion etching system increases reactive sites for biological molecules on the channel surface, thereby enhancing the detection performance of the biosensor. The MoS 2 -FET biosensor functionalized with aptamer demonstrates high sensitivity and selectivity for IFN-γ detection (limit of detection is 5.98×10 -5 nM). Notably, the signal responses of the MoS 2 -FET biosensor are higher than that of the MoS 2 -FET biosensor without Ar etching and graphene-FET biosensor. Additionally, this paper analyzes the relationship between the modification density of probe molecules and the biosensor's detection signal, establishing a theoretical foundation for further enhancing the sensor's detection performance. Experimental results confirm that the highly sensitive MoS 2 -FET biosensor provides an effective testing platform for the biomarkers with low concentrations, crucial for disease prevention and early diagnosis.
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高影响因子
Water
·
2024
·Vol. 16
·期 17
·2368
·
IF 3
Ruina Zhang,Kexin Li,Longqiang Yi,Xin Su,Changyuan Liu,Xinyu Rong,Haoxin Ran,Yingjie Wei,Li Wan,Rui Han,Yinghai Wu
An integrated constructed wetland-microbial electrolysis cell (ICW-MEC) system was investigated for nitrogen removal under different pollution loads, hydraulic loads (HLRs), and aeration conditions. The treatment performance of each unit and the microbial community characteristics for nitrogen removal were elucidated. The results showed that, on average, 80% of NH4+-N, around 70% of nitrate nitrogen (NO3−-N), and 70% of total nitrogen (TN) were removed by the system under three pollution loads, with less influence by pollution loads. The high removal efficiencies of NH4+-N (81.8%), NO3−-N (71.4%), and TN (72.8%) indicated tolerable to high HLRs. The intermittent aeration negatively affected NH4+-N removal, while increasing NO3−-N and TN removals by 3.2–13.0% and 3.7–16.7%. The contribution efficiencies of the secondary unit to the removal of NH4+-N, NO3−-N, TN, and total organic carbon (TOC) reached 47.4%, 55.0%, 45.9%, and 38.8%, respectively. The distinct microbial communities existed in various units of the ICW-MEC system, which were strongly affected by environmental factors and shaped by diverse fillers and structures of the system. The dominant bacteria contributed to the efficient nitrogen removal performance of the ICW-MEC system. The three units exerted their advantages to ensure efficient and stable system operation.
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高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2025
·
IF 4.7
Hailong Liu,Furong Tao,Hairui Ji,Hailong Zhang,Libin Liu
Developing the coating with superior waterproofing and heat dissipation abilities can prevent electronics from contamination and heat damage. However, most of these coatings show poor transparency and antifouling ability. In this study, a multifunctional ultra-slippery transparent coating (STC) has been developed by simply spraying suspensions consisting of poly(perfluorodecyl acrylate-co-isobornyl acrylate) followed by the curing treatment at room temperature. The thickness of the coating is only 1.5 μm measured by scanning electron microscope. A high transparency of 90 % is observed by UV–vis–NIR. X-ray photoelectron spectroscopy and fourier transform infrared spectroscopy demonstrate successful formation of STC and explain low surface energy. The slippery surface makes the rapid sliding of water and oil droplets when tilted at only 8°. The surface of the coating can be cleaned by water and oil-based liquids due to its excellent slippery property. In addition, the heat dissipation of electronic devices was improved after coating STC. High transparency makes it easier to observe the working condition of precision equipment. Also, the STC protects the electronic components from short circuit destroying during for underwater operation. Therefore, the prepared STC shows great promise for various electronic devices due to its easy fabrication and versatile performance.
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Regenerative Biomaterials
·
2025
·
IF 8.1
Liang Min-Hao,Zhou Lei,Li Juan,Liang Bin,Zhou Liang-Yun,Xue Feng-Feng,Jiang Li-Bo,Hong Wei
Postmenopausal osteoporosis (PMOP) is a predominant form of clinical osteoporosis. It has led to significant health and social burdens for older patients. Reestablishing the balance between osteogenic and osteoclastic is a crucial strategy for treating PMOP. Curcumin (Cur), a naturally derived polyphenolic substance, has gained recognition as a viable option for treating osteoporosis. Despite its potential, the clinical use of Cur is hindered by its limited bioavailability and the presence of side effects. Nanoparticles modified with aspartic acid octapeptide (ASP8) exhibit a strong affinity for bone tissue, facilitating targeted delivery. This study presents novel acid-responsive zeolite imidazolate framework-8 (ZIF) nanoparticles modified with ASP8 and loaded with Cur (Cur@ZIF@ASP8, CZA). Upon delivery by this nanoparticle drug delivery system, Cur can effectively regulate bone homeostasis, offering a potential therapeutic strategy for osteoporosis. This study demonstrated that CZA nanoparticles could successfully transport Cur to bone tissue without significant toxicity. Furthermore, nanoparticles promote bone formation and inhibit osteoclast activity. They also modify the expression of related genes and proteins, such as OCN, ALP, CTSK, and MMP9. Significant evaluations utilizing microcomputed tomography, Masson’s staining, hematoxylin and eosin staining, and immunofluorescence staining demonstrated that intravenous CZA administration in ovariectomized mice resulted in bone destruction while simultaneously reducing overall bone loss. In conclusion, CZA nanoparticles hold promise as a therapeutic option for osteoporosis.
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高影响因子
LAB ON A CHIP
·
2025
·
IF 5.4
Yu-Xin Zhang,Ming Wang,Li-Li Xu,Yijing Chen,Shu-Ting Zhong,Ying Feng,Hai-Bo Zhang,Shi-Bo Cheng,Min Xie,Wei-Hua Huang
Exosomes have gained increasing attention as robust, biocompatible carriers for targeted therapy. However, current techniques for exosome drug loading suffer from low drug loading efficiency, substantial exosome loss during repeated purification and quantification processes. Here, we present an integrated microfluidic chip (IMC) that streamlines drug loading, separation, and electrochemical detection of exosomes from plasma in a single device. In this design, the three-dimensional (3D) macroporous scaffold and the magnetoresponsive electrode are successfully assembled into the modeling microchip, playing the functions of “3D chaotic flow mixer”, “magnetic separator” and “electrochemical detector”. When plasma, doxorubicin (DOX), boron clusters and immunomagnetic nanoprobes (IMP) are simultaneously injected into the IMC, the exosomes are loaded with DOX-boron cluster (EDB) complexes and synchronously recognized by IMP in the “3D chaotic flow mixer”. Our strategy exhibits high DOX loading efficiency owing to the superchaotropic effect of boron cluster and enhanced immunolabeling efficiency by the thorough mixing of 3D scaffold. Meanwhile, the novel magnetoresponsive electrode enables magnetic separation and real-time, enzyme-linked immunoelectrochemical quantification of exosomes, thereby simplifying the workflow from drug loading to quantification. The resulting EDB in combination with magnetic hyperthermia achieves up to 90% cell-killing efficiency against DOX-resistant breast cancer cells. Overall, our system could simultaneously realize the enhanced DOX loading into exosomes, efficient magnetic immunoseparation of exosomes, and sensitive electrochemical quantification of exosomes, offering a promising approach for autologous exosome-based drug delivery for cancer treatment.
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高影响因子
TALANTA
·
2025
·
IF 6.1
Yue Zhang,Rongyan Shen,Yuting Huang,Zhihong Wang,Liangfu Tang,Zhijin Fan
Plant elicitors with distinctive benefits including low toxicity, small application dosages and an innovative mode of action are considered as green agrochemicals by stimulating the host plant immunity. Several new plant elicitors have been developed for tobacco protection against virus attack. Among them, as a milestone in Chinese plant elicitor development, methiadinil (IUPAC: 4-methyl- N -(5-methylthiazol-2-yl)-1,2,3-thiadiazole-5-carboxamide) shows broad application prospects. Because of its low application dosage, its residue determination requires diverse highly sensitive method. Here we developed an indirect enzyme-linked immunosorbent assay (ELISA) method for methiadinil residue determination with the lowest detection limit of 10.69 ng/mL and a linear detection range between 21.84 ng/mL of IC 20 and 1513.81 ng/mL of IC 80 by a rational hapten designation. Meanwhile, this indirect ELISA method showed good specificity with low cross-reactivity for methiadinil analogue determination and a good correlation with the HPLC method for tobacco sample measurement. This sensitive, rapid and accurate methiadinil residue determination method in tobacco leaves is of great significance for the monitoring of methiadinil in tobacco and guidance for other environmental sample determination and the rational application of methidadinil.
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高影响因子
危险品化学品经营许可证（带存储）