ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Xinyue Zhou,Yu Zhang,Tongxin Sun,Xu Xu,Lei Zhang
Therapeutic drug monitoring of isoniazid (INH), a first-line antitubercular agent, is critical due to its narrow therapeutic window and risk of toxicity or resistance at nonoptimal concentrations. Current methods lack the simplicity and accessibility required for point-of-care testing (POCT), especially in resource-limited settings. Herein, we report a paper-based colorimetric biosensing platform that integrates hollow-structured Fe-NC (Iron-Nitrogen-Carbon) nanozymes with smartphone-assisted readout for rapid, sensitive, and selective detection of INH in human biofluids. The nanozyme is synthesized via controlled pyrolysis of a dual-linker zeolitic imidazolate/tetrazolate framework (ZTF), where 2-methylimidazole (2-MIM) and thermally labile 5-aminotetrazole (5-AT) direct the formation of a hollow architecture that maximizes accessible Fe-N 4 active sites and enhances mass transport. This design confers superior peroxidase-like activity, enabling catalytic oxidation of chromogenic substrates in the presence of H 2 O 2 with high specificity toward INH. The resulting sensor achieves a detection limit of 0.24 μM and maintains high accuracy in human serum and urine, with minimal matrix interference. The entire assay is completed using a portable, low-cost device and a smartphone application for colorimetric analysis. Validated on human urine and serum, the platform demonstrates excellent reproducibility, stability, and field adaptability. This work presents a rational nanozyme design strategy through ligand-mediated structural control and establishes a scalable, equipment-free sensing framework for real-time therapeutic drug monitoring in POCT.
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Miaojia Du,Yaopeng Zhang,Shubin Zhang,Chunyan Ma,Fang Li,Chensi Shen
Antimony contamination in industrial wastewater requires effective simultaneous removal of both Sb(III) and Sb( V ) species, yet their contrasting chemical characteristics pose significant challenges for conventional adsorbents. Here, we demonstrate that amorphous chitosan-Fe coordination polymer sheets (CS-Fe aCPs) achieve exceptional Sb(III/ V ) capture through a dual-mode synergistic mechanism. For Sb(III), ligand exchange dominates the adsorption process, wherein Sb(OH) 3 directly coordinates with Fe 3+ centers by displacing weakly-bound NO 3 − ligands, as evidenced by stoichiometric NO 3 − release and significant Fe 2p binding energy shifts in XPS analysis. This process further triggers sequential Sb bridging interactions, producing an S-shaped isotherm and enabling a maximum capacity of 626.97 mg/g. For Sb( V ), the persistently high positive surface charge (+15 to +30 mV across pH 2–10) facilitates electrostatic capture of [Sb(OH) 6 ] − anions, supplemented by partial ligand displacement, achieving 574.55 mg/g capacity. The amorphous coordination framework provides abundant coordinatively unsaturated Fe 3+ sites and structural adaptability essential for accommodating both Sb species without steric hindrance. This dual-mode synergy ensures pH-insensitive performance, exceptional resistance to competing ions, and stable operation in fixed-bed column and membrane filtration systems, establishing CS-Fe aCPs as a cost-effective platform for mixed Sb speciation remediation.
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DOI
高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Kavya Adot Veetil,Senthil Kannan,Eun Kyu Sun,Md. Homayun Kabir,Ook Choi,Tae-Hyun Kim
Integrating nanomaterials with tunable surface functionalities into polymer matrices offers a promising route for developing high-performance mixed matrix membranes (MMMs). Among these, graphitic carbon nitride (g-C3N4) facilitates gas transport and enhances membrane permeability due to its intrinsic nanopores. However, while improving the CO2 permeability, pristine g-C3N4 often compromises the CO2/CH4 selectivity. To address this trade-off, iron-doped g-C3N4 (Fe-g-C3N4) was incorporated into a polymer of intrinsic microporosity (PIM-1), possessing a high free volume and excellent gas diffusion characteristics. Iron doping served to increase the CO2-philicity of g-C3N4 and strengthen its interaction with the CO2 molecules, thereby improving both permeability and selectivity. The resulting Fe-g-C3N4/PIM-1 MMMs demonstrated enhanced CO2 permeability and CO2/CH4 selectivity, indicating their potential for use in CO2 separation applications. Incorporating 0.5 wt % Fe-doped g-C3N4 into the PIM-1 matrix led to a 38.5% increase in CO2 permeability compared to pristine PIM-1 and a 12.7% improvement over the undoped g-C3N4-based MMM. While undoped g-C3N4 reduced the CO2/CH4 selectivity, Fe doping had the reverse effect, enhancing the selectivity by 7.2% relative to the undoped system. Notably, the Fe-g-C3N4/PIM-1 MMMs approach the 2008 Robeson upper bound for the CO2/CH4 separation. In addition, the membrane exhibited improved mechanical strength and antiaging and antiplasticization characteristics, collectively outperforming pristine PIM-1.
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2026
·
IF 4
Ke-Rong Wang,Yu-Fei Bai,Xiao-Ye Chang,Yun-Kai Lv,Li-Qing Yu
A one-pot PEG-modified MIL-88B(Fe) coating was developed for breath aldehydes. • The 10% PEG/Fe³⁺ ratio gave the highest responses for all five aldehydes. • Detection limits were 0.018–0.030 ng mL⁻¹ with precision below 10%. • The coating retained 87.9–93.9% response after 110 extraction cycles. A polyethylene glycol (PEG)-modified MIL-88B(Fe) composite was synthesized by a one-pot route and evaluated as a coating for headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography–mass spectrometry (GC–MS) for the determination of five C6–C10 aldehydes. Among the materials prepared at PEG/Fe 3+ molar ratios of 0, 5, 10, and 15%, PEG 10 @MIL-88B(Fe) produced the highest peak areas for all five aldehydes. Characterization by powder X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy, and N 2 adsorption–desorption analysis supported PEG modification while retaining the structural characteristics of MIL-88B(Fe). Under the optimized conditions, the developed method provided enrichment factors of 2563–15,562. Calibration curves were linear over 0.1–500 ng mL –1 (R 2 = 0.9911–0.9988), with LODs of 0.018–0.030 and LOQs of 0.059–0.099 ng mL –1 of calibration solution (liquid-standard-equivalent). Intra-day, inter-day, fiber-to-fiber, and batch-to-batch RSDs were 3.9–5.9%, 4.2–8.2%, 4.0–9.8%, and 5.3–10.1%, respectively. The method showed limited interference from representative breath volatile organic compounds, with relative responses of 89.30–92.02%, while matrix effects ranged from 94.7% to 104.1%. After 110 extraction/desorption cycles, the coating retained 87.9–93.9% of its initial response. The PEG 10 @MIL-88B(Fe)-coated SPME fiber was applied to exhaled-breath samples, with spike recoveries of 87.2–105.5%, supporting its applicability to the trace determination of C6–C10 aldehydes in exhaled breath. Download: Download high-res image (309KB) Download: Download full-size image
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高影响因子
Small
·
2026
·
IF 11.8
Peng Wang,Chenyu Gao,Zhaoying Li,Dianming Chu,Wenjuan Bai,Yan He
Solid-solution catalysts hold great promise as low-cost catalysts for the growth of small-diameter single-walled carbon nanotubes (SWCNTs); however, their catalytic performance is limited by low metal-site utilization and unfavorable interfacial structures in conventional architectures. Here, we report a facile design strategy for FeMgAlOx solid-solution catalysts featuring abundant active sites and enhanced interfacial structures that suppress nanocluster agglomeration. The successful synthesis of this catalyst relies on a high-temperature-induced two-step strategy: high-temperature oxidation enhances crystallinity, while high-temperature air/CO 2 treatment facilitates the formation of strong metal-support interactions (SMSI) on inert metal oxide supports. In this architecture, the ultrathin two-dimensional morphology and ordered atomic arrangement promote active-metal spillover, yielding abundant active sites; meanwhile, CO 2 induction significantly enhances the SMSI-mediated confinement capability for Fe nanoclusters. Crystalline evolution and SMSI regulation synergistically facilitate the exsolution of active Fe species from the bulk solid solution, thereby forming thermally stable Fe nanoclusters. Furthermore, optimized single-walled carbon nanotube (SWCNT) growth kinetics confirm that the modified solid solution possesses both a higher density of active sites and enhanced intrinsic catalytic activity. Ultimately, our catalyst enables the growth of SWCNTs with diameters ranging from 0.96 to 3.33 nm, offering a simple and low-cost route for SWCNT synthesis with broad application prospects.
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高影响因子
CHEMICAL PAPERS
·
2026
·
IF 2.7
Chen Yifei,Sheng Shuqi,Liu Yuqi,Li Qiaoxia,Sun Jiazhe,Zhong Mingqiang,Qu Baiyou,Hu Caixia,Zhao Zhengping
Salen-type Schiff bases, formed by the condensation of salicylaldehyde with diamines, serve as versatile tetradentate N 2 O 2 chelating ligands owing to their tunable electronic and steric structures. Their corresponding metal complexes have been extensively applied as highly efficient and stable catalysts in diverse transformations, particularly in ring-opening polymerization (ROP) reactions. In this study, two structurally related propanediamine-derived bis-Schiff base ligands were synthesized from 3,5-di-tert-butylsalicylaldehyde and corresponding diamines, along with a series of Ce-, Fe-, and Co-Salen complexes. A thorough investigation was conducted on their catalytic performances and influencing factors in the ROP of rac-lactide. The results indicate that the catalytic performance of these Salen-metal complexes is dual-influenced by both the ligand structure and the nature of the metal center. Among the investigated catalysts, the Ce-Salen complex exhibited higher catalytic activity and comparatively favorable M n and dispersity values compared to its Fe- and Co-based counterparts under identical conditions. This comparative study provides valuable insights into the metal-center effects in Salen-type catalysts and offers rational guidance for designing efficient catalysts for PLA synthesis.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Lili Liu,Yi Yuan,Haibo He,Junping Dong,Xitian Peng,Xiaoxia Yan,Liqiang Luo
Cu/Fe-N-C SAzymes with dual enzyme activities are rapidly synthesized via microwave. • A four-channel sensor array enables pesticide-specific fingerprint-like responses. • The array discriminates three types of pesticides (5–500 ng/mL) and their mixtures. • LDA and LOOCV confirm robust broad-spectrum screening capability toward pesticides. • High-throughput screening of multi-pesticide residues in fruits is validated. Background The widespread and excessive use of pesticides poses significant risks to both human health and ecological integrity. Inspired by the mammalian olfactory cross-response mechanisms, colorimetric sensor arrays provide a rapid, cost-effective and visual platform for multi-residue pesticide monitoring. Results Herein, we report a four-channel response array constructed from Cu-N-C and Fe-N-C single-atom nanozymes rapidly synthesized via microwave assistance. These nanozymes exhibit intrinsic laccase-like (LAC) and peroxidase-like (POD) dual enzymatic activities, which are differentially modulated by distinct pesticide classes to generate characteristic fingerprint-like responses. Integrating with linear discriminant analysis (LDA) for dimensionality reduction and visualization, this array successfully discriminates three major pesticide categories―sulfonylureas, organophosphates, and carbamates, comprising nine typical pesticides within the discrimination concentration range of 5–500 ng/mL, and further distinguishes pesticide mixtures of varying compositional ratios. Significance Leave-one-out cross-validation (LOOCV) confirms the robust broad-spectrum classification capability of the system. The practical utility of this array is demonstrated through high-throughput screening of multi-pesticide residues in fruit samples. The synergistic integration of microwave-accelerated nanozyme synthesis and multichannel colorimetric sensing establishes a versatile and reliable paradigm for universal pesticide detection in complex matrices. Two single-atom nanozymes, Cu-N-C and Fe-N-C, exhibiting both laccase-and peroxidase-like activities, are rapidly prepared by microwave-assisted synthesis. A four-channel colorimetric array is then established, in which the nanozyme activities are differentially modulated by distinct pesticide categories (sulfonylureas, organophosphates, and carbamates), producing characteristic fingerprint responses. Linear discriminant analysis (LDA) enables precise discrimination of nine pesticides and their mixtures over a concentration range of 5–500 ng/mL, with robust classification confirmed by leave-one-out cross-validation (LOOCV). This platform represents a reliable and efficient strategy for high-throughput screening of multi-pesticide residues in fruits. Download: Download high-res image (303KB) Download: Download full-size image
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高影响因子
MOLECULES
·
2026
·Vol. 31
·期 19
·3412
·
IF 5.1
Xinyao Su,Wen Guo,Qunming Zhou,Tingting Xie,Lingyan Wu,Shangyang Wang,You Fu,Shurong Li,Wei Peng,Peijun Meng
Cancer theranostics urgently demands multifunctional nanomaterials capable of simultaneously enabling high-sensitivity imaging and multimodal synergistic therapy. In this study, a three-layer core–shell nanocomposite, NaYF4:Yb,Tm@NaGdF4:Eu@NH2-MIL-53(Fe), was designed and synthesized. The NaYF4:Yb,Tm nanoparticle core provides upconversion luminescence upon near-infrared (NIR) excitation and can serve as an excitation source for photodynamic therapy. An epitaxially grown NaGdF4:Eu intermediate shell was introduced to enhance luminescence and provide T1-weighted magnetic resonance imaging (MRI) capability. The outermost NH2-MIL-53(Fe) metal–organic framework shell was subsequently coated to provide potential chemodynamic therapy (CDT) capability. The effects of the Eu3+doping concentration, reaction temperature, reaction time, and oleic acid (OA)/1-octadecene (ODE) ratio on the anisotropic growth into a dumbbell-like morphology were examined to determine the optimal conditions. Under the optimal conditions (10 mol% Eu3+, 300 °C, 60 min, OA/ODE = 4:16), core–shell nanocrystals with regular morphology, uniform size, and the strongest upconversion luminescence were obtained. Polyvinylpyrrolidone (PVP)-mediated surface functionalization successfully induced the in situ growth of the NH2-MIL-53(Fe) outer shell, thereby constructing a three-layer core–shell nanocomposite as a potential theranostic platform. Various characterizations confirmed that the resulting composite integrates upconversion luminescence, paramagnetism, and hydroxyl radical generation capability, suggesting potential for NIR-driven dual-modal imaging-guided synergistic therapy.
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高影响因子
CATALYSIS LETTERS
·
2026
·Vol. 156
·期 6
·150
·
IF 2.5
An Bote,Song Xinran,Wang Shu,Yang Lu,Qu Peifan,Zhang Yubin,Liu Yan,Nan Yanli
Non-noble metal single-atom catalysts (SACs) have emerged as promising alternatives to Pt-based catalysts for the oxygen reduction reaction (ORR) due to their high atomic utilization and low cost. Nevertheless, the facile aggregation of metal atoms during synthesis severely reduces the density of active sites, thereby restricting their practical application in metal-air batteries. Herein, we fabricated a highly dispersed Fe single-atom catalyst (Fe-N-C) anchored on honeycomb-structured carbon (HCC). The synergistic effect of low iron content, physical confinement of honeycomb carbon, and chemical anchoring of nitrogen sites effectively inhibits metal atom aggregation and maximizes the atomic dispersion of Fe active sites. Benefiting from the ordered honeycomb porous structure and high atomic utilization, the as-synthesized Fe-N-C exhibits an outstanding half-wave potential of 0.875 V even at a low Fe loading. Notably, when applied as the air cathode in a flexible solid-state zinc-air battery, this catalyst delivers a peak power density of 160.7 mW cm − 2 , outperforming most reported non-noble metal ORR catalysts to date. This work provides a feasible strategy for the fabrication of highly dispersed single-atom catalysts for high-performance flexible energy conversion devices. Graphical The alternative text for this image may have been generated using AI.
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高影响因子
WATER RESEARCH
·
2026
·
IF 12.8
Ping Zhang,Chenchen Zhao,Fei Jiang,Chuyang Wu,Tianqi Wang,Xing Xu,Mengjie Wu,Zhanli Chen,Youqin Zou
Green Fenton-like reactions based on monometallic single-atom dual-reaction-center systems have emerged as promising strategies for sustainable water purification owing to their oxidant-free operation and low energy demand. However, their practical deployment is often hindered by limited degradation kinetics and unresolved mechanisms. Here, we report a carbon nitride-supported Fe/Mn bimetallic catalyst composed of Fe nanoclusters and adjacent Mn single atoms (FeMn-CN) that enables ultrafast and self-sustaining pollutant degradation under oxidant-free conditions. The catalyst achieves 99.5% removal of bisphenol A (BPA) within 3 min, setting an ultrahigh rate to date among self-sustaining water purification systems. Combined experimental investigations and density functional theory calculations reveal that the reaction proceeds predominantly via a direct electron-transfer pathway. Fe nanoclusters serve as primary electron acceptors, extracting electrons from BPA without external oxidants, while adjacent Mn single atoms coordinated in Mn-N 4 sites synergistically enhance the electron-accepting capacity of Fe and substantially lower the charge-transfer energy barrier. This atomic-level cooperation endows FeMn-CN with exceptional activity across a broad pH range (pH 2-10), strong tolerance to complex water matrices, high selectivity toward electron-rich contaminants and facile regeneration. Furthermore, continuous-flow reactor tests and life-cycle assessment collectively verify the scalability and superior environmental sustainability of the FeMn-CN process. This work establishes an atomic-level design principle for electron-transfer-dominated self-sustaining remediation materials, advancing the development of next-generation oxidant-free water purification technologies.
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DOI
高影响因子
Journal of Energy Storage
·
2026
·
IF 10.7
Xueli Chen,Lu Han,Litao Zhao,Guangzhen Zhao,Guoliang Gao,Lianghao Yu,Xiuyang Shan,Quan Lin,Guang Zhu,Hailong Huang
The key challenge impeding the advancement of aqueous MHS lies the fabrication of structurally stable electrode materials with exceptional reaction kinetics and superior cycling performance. In this study, we employed elemental doping strategies to synthesize MnFe-6, which has wide interlayer spacing and an abundance of oxygen vacancies, by modulating its morphology and optimizing its structure. The MnFe-6 demonstrated superior electrochemical performance (199.4 F g −1 at 1 A g −1 ) in three-electrode tests. Systematic ex-situ XRD and XPS analysis reveal that the material's exceptional electrochemical properties originate from the pseudo capacitance generated by the reactions involving Mn 2+ and Mn 3+ /Mn 4+ , combined with the charge compensation facilitated by oxygen vacancies. An asymmetric MHS with MnFe-6 as the cathode material exhibits a specific capacitance of 171.2 F g −1 at 1 A g −1 .The MHS attained an excellent energy density of 160.7 Wh kg −1 at power density of 1299.8 W kg −1 . Moreover, it exhibited exceptional cyclability, retaining 96.5% of primary capacitance after 60,000 cycles tests at 10 A g −1 . This study establishes elemental doping as a viable and efficient strategy for the development of advanced MHS electrode materials.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Hangyuan Xing,Xinshuang Lin,Depeng Zhang,Xinyu Lu,Xinyang Liu,Rong Gao,Yuqing Zhang,Sen Zhang,Chao Deng
Dual single-atom catalysts (DACs) represent a promising frontier in the field of electrocatalysis. However, the precise construction of DACs with modulated microenvironment to enhance oxygen electrocatalytic activities remains a formidable challenge. In present work, we report a chlorine-mediated strategy to manipulate the microenvironment of dual atomic iron sites, which are anchored on carbon nanocages with surface curvature (Fe-DSA-Cl/SCNC). Theoretical calculation results reveal that the chlorine atom modulates the local microenvironment of iron dual atom sites, decreases the energy barrier, and adjusts the oxygen adsorption/desorption capability, resulting in the enhanced electrocatalytic activities. Finite element analysis (FEA) modeling results demonstrate the hollow carbon nanocage with surface curvature regulates the local electric field, improves the mass transfer, and accelerates oxygen reaction kinetics. Benefitting from both aspects of advantages, the Fe-DSA-Cl/SCNC catalyst exhibits the excellent oxygen catalytic properties with a high half-wave (E 1/2 ) potential of 0.926 V in alkaline condition and a peak power density of 289 mW cm −2 in full Zn-air battery (ZABs). Furthermore, the quasi-solid-state Zn-air batteries operates smoothly over a wide range of temperature and achieves a high stability during long-term and low-temperature cycling. Therefore, this work gives a new insight into the local microenvironment modulation and spatial configuration engineering in dual atomic sites for enhanced catalytic properties. Moreover, it also gives a new clue to design and fabrication of oxygen electrocatalysts for different working conditions. Download: Download high-res image (107KB) Download: Download full-size image
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PubMed
高影响因子
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