JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Ziyu Huo,Luoxin Zhuang,Ge Shi,Yanjie He,Zhe Cui,Peng Fu,Minying Liu,Xiaoguang Qiao,Xinchang Pang
Multi-stimuli responsive fluorescence probe could pave the way for monitoring more complex environmental changes. Here we prepared multifunctional nanoparticle Fe 3 O 4 @SiO 2 @P(DMAEMA- co -TPEE), which displayed yolk-shell morphology with well-defined polymer brush. With superparamagnetic Fe 3 O 4 component and pH/temperature dual sensitive PDMAEMA polymer brush, the as prepared nanoparticles (YS-NPs) exhibited as multi-stimuli responsive fluorescence probe for real-time visual monitoring of environmental changes such as magnetic field, temperature and pH. Such YS-NPs could also be applied as a sensitive detector for CO 2 in aqueous solution. Notably, the solution of YS-NPs showed high colloidal stability during the environmental changes, and surface aggregation-induced emission (S-AIE) was proposed for the aggregation of TPE residue on the surface of YS-NPs.
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高影响因子
Animals
·
2023
·Vol. 13
·期 24
·3832
·
IF 3
Hongmei Xu,Yueyue Li,Qiao Li,Zifeng Ma,Shi Yin,Honghong He,Yan Xiong,Xianrong Xiong,Daoliang Lan,Jian Li,Wei Fu
Simple SummaryIn recent years, authoritative journals have consistently reported DHODH’s critical role in resistance to ferroptosis, significantly advancing the research on related mechanisms. Nevertheless, the nucleotide sequence of the yakDHODHgene remains unknown, and its involvements in ferroptosis processes in yak cells remain elusive. Therefore, in the present study, we cloned the coding region of the yakDHODHgene, and revealed its high conservation in mammals. Furthermore, by using a bisphenol S (BPS)-induced ferroptosis model, we confirmed the role of theDHODHgene in mitigating ferroptosis in yak skin fibroblasts (YSFs) derived from a three-mouth-old fetus. This study offers theoretical support for further exploring the functions of the yakDHODHgene and partially elucidating the molecular mechanisms underlying ferroptosis.AbstractDihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme ofde novobiosynthesis of pyrimidine. Although the involvement of DHODH in resisting ferroptosis has been successively reported in recent years, which greatly advanced the understanding of the mechanism of programmed cell death (PCD), the genetic sequence of the yakDHODHgene and its roles in ferroptosis are still unknown. For this purpose, we firstly cloned the coding region sequence ofDHODH(1188 bp) from yak liver and conducted a characterization analysis of its predictive protein that consists of 395 amino acids. We found that the coding region of the yakDHODHgene presented high conservation among species. Second, the expression profile of theDHODHgene in various yak tissues was investigated using RT-qPCR. The results demonstrated thatDHODHwas widely expressed in different yak tissues, with particularly high levels in the spleen, heart, and liver. Third, to investigate the involvement ofDHODHin regulating ferroptosis in cells, yak skin fibroblasts (YSFs) were isolated from fetuses. And then, bisphenol S (BPS) was used to induce thein vitroferroptosis model of YSFs. We observed that BPS decreased the cell viability (CCK8) and membrane potential (JC-1) of YSFs in a dose-dependent manner and induced oxidative stress by elevating reactive oxygen species (ROS). Simultaneously, it was evident that BPS effectively augmented the indicators associated with ferroptosis (MDA and BODIPY staining) and reduced GSH levels. Importantly, the co-administration of Ferrostatin-1 (Fer), a potent inhibitor of ferroptosis, significantly alleviated the aforementioned markers, thereby confirming the successful induction of ferroptosis in YSFs by BPS. Finally, overexpression plasmids and siRNAs of the yakDHODHgene were designed and transfected respectively into BPS-cultured YSFs to modulateDHODHexpression. The findings revealed thatDHODHoverexpression alleviated the occurrence of BPS-induced ferroptosis, while interference ofDHODHintensified the ferroptosis process in YSFs. In summary, we successfully cloned the coding region of the yakDHODHgene, demonstrating its remarkable conservation across species. Moreover, using BPS-induced ferroptosis in YSFs as the model, the study confirmed the role of theDHODHgene in resisting ferroptosis in yaks. These results offer valuable theoretical foundations for future investigations into the functionality of the yakDHODHgene and the underlying mechanisms of ferroptosis in this species.Keywords:yak;DHODHgene;fetal fibroblasts;ferroptosis;Bisphenol S
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高影响因子
FUEL PROCESSING TECHNOLOGY
·
2021
·
IF 7.033
Jianan Chen,Jun Zhu,Wentao Xu,Yi Chen,Jicheng Zhou
Highly efficient H 2 and S production from copious waste H 2 S is beneficial from both environmental and energy. Whereas, the highly effective direct decomposition of H 2 S reaction faces a gigantic obstacle, that is, there is the severe thermal equilibrium limitation. Herein, a family of TiO 2 modified Mo x C as novel microwave catalysts have been developed. This work demonstrates that Mo 2 C, Mo 2 C-TiO 2 and MoC@TiO 2 microwave catalysts display excellent catalytic performance to recover both valuable H 2 and elemental S from the direct decomposition of H 2 S under microwave irradiation . The optimal H 2 S conversion of MoC@TiO 2 can be as high as 99.9% (almost complete conversion) at 700 °C, which greatly outpaces the corresponding H 2 S equilibrium conversion under microwave irradiation . This result of the chemical equilibrium limitation being broken shows an interesting phenomenon, namely a significant microwave selective catalytic effect by microwave catalysis in H 2 S decomposition reaction . In addition, the apparent activation energy of the Mo 2 C, Mo 2 C-TiO 2 and MoC@TiO 2 microwave catalysts reduced to 18.2 kJ/mol, 16.8 kJ/mol and 15.6 kJ/mol under microwave irradiation. The work supplies a strategy for highly effective valuable H 2 and S production from H 2 S decomposition reaction , and paves a path to high-value utilization of hazardous waste H 2 S resources with energy-saving heating method.
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JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Pengfei Wang,Yao Liu,Ning Jiang,Ruisen Jing,Shutao Li,Qian Zhang,Huiqiang Liu,Junshan Xiu,Zhao Li,Yunyan Liu
A ternary heterojunction composite photocatalyst g-C 3 N 4 /AgBr/black phosphorus was constructed by co-modifying AgBr with g-C 3 N 4 (CN) and black phosphorus nanosheets (BPNs). The photoluminescence (PL), photocurrent intensity and electrochemical impedance spectroscopy (EIS) results proved that, compared with bare AgBr and binary CN/AgBr and AgBr/BPNs, ternary CN/AgBr/BPNs effectively promoted the separation and suppresses the recombination of electron-hole pair. The photocatalytic experiment proved that the CN/AgBr/BPNs photocatalyst exhibited almost 8 times for degradation rate of MO，and well above those of binary CN/AgBr and AgBr/BPNs. According to trapping experiments of the active species, the analysis of the energy band , we proposed the double S-scheme to explain the charge transfer and the boosting of photocatalytic activity in ternary CN/AgBr/BPNs. Impressively, this double S-scheme facilitated the transmittance of electrons at the CB position of AgBr to the VB of CN and BPNs, and greatly overcome the light corrosion and enhance the stability of AgBr. This work designed a novel S-scheme mechanism heterojunction photocatalytic material, which provides a convenient way for efficient wastewater treatment.
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高影响因子
LANGMUIR
·
2020
·
IF 3.557
Ziyi Shui,Xiangbiao Liao,Yuan Lei,Jia Ni,Yilun Liu,Yong Dan,Wei Zhao,Xi Chen
Aluminum–air batteries possess high theoretical specific capacities and energy densities. However, the desired application performance in the field of flexible electronics is limited by the rigid battery structure and slow kinetics of the oxygen reduction reaction (ORR). To address these issues, flexible, stretchable, and customizable aluminum–air batteries with a reference to honeycomb shape are composed of multilayer single battery units to achieve large scalability and start–stop control. The single aluminum–air battery combines MnO2 with N/S codoped graphene to improve the electrocatalytic activity. Benefiting from an efficient electrocatalyst and reasonable structural design, the single aluminum–air battery exhibits excellent electrochemical characteristics under deformation conditions with a high specific capacity and energy density (1203.2 mAh g–1 Al and 1630.1 mWh g–1 Al). Furthermore, the obtained honeycomb-shaped stretchable aluminum–air batteries maintain a stable output voltage over the 2500% stretching. More interestingly, the stretchable honeycomb structure not only can solve the start–stop control problem but also has the potential to reduce the self-corrosion in disposable metal–air batteries. In addition, owing to the customizable shapes and sizes, the honeycomb-shaped stretchable aluminum–air batteries facilitate the integrated application of flexible batteries in wearables.
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高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Hongju Zeng,Wang Wang,Jun Li,Jin Luo,Shengli Chen
Heteroatoms doping is able to produce catalytic sites in carbon materials for oxygen reduction reaction (ORR); while hierarchically porous structure is necessary for efficient exposure and accessibility of the usually limited catalytic sites in such activated carbon catalysts. This work reports an in situ generated dual-template method to synthesize the Fe/N/S co-doped hierarchically porous carbon (FeNS/HPC), with NaCl crystallites formed during the precursor lyophilization process as the primary template to generate ∼500 nm macropores with ultrathin graphene-like carbon-layer walls, and Fe3O4 nanoparticles formed during the high-temperature carbonization process as the secondary template to produce mesopores on the walls of macropores. As well as the coexistence of graphitic-N, pyridinic-N, and thiophene-S which are beneficial to ORR, the as prepared FeNS/HPC possesses a highly graphitized and interconnected hierarchical porous structure, giving a specific surface area as high as 938 m2 g–1. As a consequence, it exhibits excellent four-electron oxygen reduction performance in both alkaline and acid electrolytes. The in situ generation and facile solution removal make the present template method a promising way for scale-up preparation of active porous carbon materials for various applications.
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高影响因子
CRYSTAL GROWTH & DESIGN
·
2019
·
IF 4.153
Fanfan Fan,Haikuan Yuan,Yonghao Feng,Fengjiao Liu,Lijuan Zhang,Xijian Liu,Xueyan Zhu,Wei An,Sohrab Rohani,Jie Lu
In this work, the solubilities of (R)- and (R,S)-crizotinib in six solvents including methanol, ethanol, 1-propanol, 1-butanol, ethyl acetate, and n-hexane were first measured by a static method in the temperature range from 273.15 to 323.15 K at atmospheric pressure. Then, molecular simulations were performed to predict the crystal structures of (R)-crizotinib and (R,S)-crizotinib from their powder X-ray diffractograms and the solubilities in the above organic solvents using the Gibbs free energy calculation approach via the sublimation cycle. The results showed that the solubilities of (R)- and (R,S)-crizotinib in the selected solvents generally increased with the increasing temperature, and at room temperature the molar fraction solubility order was methanol > 1-butanol > 1-propanol > ethanol > ethyl acetate > n-hexane. The (R)-crizotinib crystal had a monoclinic unit cell, while the (R,S)-crizotinib crystal had a triclinic one. In particular, though it was first applied to the solubility estimation for water-insoluble drug compounds in organic solvents, the Gibbs energy calculation approach developed gave a desirable solubility prediction performance with a root-mean-square error (RMSE) of 0.7638 log S units for (R)-crizotinib and 1.1577 log S units for (R,S)-crizotinib in the selected solvents, respectively. Furthermore, the difference in the solubilities of (R)-crizotinib in different solvents mainly resulted from the different Gibbs free energies for solvation between solute and solvent other than those for sublimation. However, as to the difference in the solubilities of (R)- and (R,S)-crizotinib in the same solvent, the Gibbs free energy for sublimation made more of a contribution than that for solvation. Finally, on the basis of the solid-state characterization, the nature of crystalline (R,S)-crizotinib was confirmed to be a racemic compound. All these results shall provide pharmaceutical industry with a better understanding of this chiral system for crystallization resolution.
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 8
·6029-6037
·
IF 3.289
Di Lu,Lele Wen,Feng Nie,Lixin Xue
A serials of imidazolium functionalized poly(arylene ether sulfone) as anion exchange membranes (AEMs) for all-vanadium redox flow battery (VRB) application are synthesized successfully in this study. The AEMs obtained with different ionization levels, Im-PAES-0.5/0.7/1.1 (0.5/0.7/1.1 represents the different degrees of bromination, respectively) membranes are intensively characterized. Compared with commercial Nafion 117 membrane, the vanadium ion permeation values of AEMs are lower while their chemical stability in VO2+ are comparable. The ionic conductivities, vanadium ion permeability, stability of the membranes and their performance in VRB cells are greatly affected by ionic exchange capacity (IEC). In order to balance these important performance factors, the Im-PAES-0.7 membrane with a moderate IEC of 2.01 meq g−1 exhibits good stability, high ionic conductivity and low vanadium ion permeation, resulting in high voltage efficiencies (up to 87.5%), high coulombic efficiencies (up to 96.1%), as well as high energy efficiency. The VRB cell with the Im-PAES-0.7 membrane achieves comparable to or even slightly higher energy efficiency values (up to 81.7%) than those of Nafion 117 membranes (up to 78.9%) in the current density range of 60–120 mA cm−2. During 40 charge–discharge cycles at different current densities, the Im-PAES-0.7 anion exchange membrane exhibits a comparable short-term stability to Nafion 117 membrane.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
·
IF 9.965
Dawei Liu,Katam Srinivas,Xin Chen,Fei Ma,Xiaojuan Zhang,Xinqiang Wang,Bin Wang,Yuanfu Chen
It is still challengeable but significant to rationally develop dual-metal single-atom catalysts with rich accessible active sites and excellent intrinsic catalytic activity towards oxygen reduction reaction (ORR). Herein, we present a novel dual-metal single-atom catalyst, Fe and Zn single atoms homogenously anchored on carbon nanotubes inlaid N, S-doped hollow carbon polyhedrons (FeZn-NSC), synthesized by facile iron-salt impregnation and high-temperature pyrolysis for zeolitic imidazolate framework-8. Due to the synergistic effects of the hierarchical porous nanoarchitecture with high specific surface area (795.48 m 2 g −1 ), N, S co-doped hollow carbon polyhedrons, in-situ grown highly conductive carbon nanotubes, and high loading of dual-metal single-atoms of Fe (3.12 wt%) and Zn (3.71 wt%), the optimized FeZn-NSC delivers outstanding ORR performance with high half-wave potential of 0.87 V, low Tafel slope of 44.7 mV dec −1 , long-term durability, and strong tolerance of methanol crossover. This work provides a strategy to rationally design and facilely synthesize dual-metal single-atom catalysts with high ORR activity.
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高影响因子
MACROMOLECULES
·
2020
·
IF 5.918
Dalong Zhai,Mingjing Zhu,Shuwen Chen,Yue Yin,Xin Shang,Lixin Li,Gang Zhou,Juan Peng
Despite recent impressive advances in synthesis of all-conjugated diblock copolymers via facile quasi-living Grignard metathesis (GRIM) polymerization, it remains challenging to achieve well-defined all-conjugated triblock copolymers of interest. Herein, we report the judicious design and synthesis of a series of all-conjugated triblock copoly(3-alkylthiophene)s consisting of poly(3-butylthiophene) (P3BT), poly(3-hexylthiophene) (P3HT), poly(3-octylthiophene) (P3OT), or poly(3-dodecylthiophene) (P3DDT) in all 12 possible combinations. The effects of block sequences and the length of alkyl side chains on their cocrystallization and microphase-separated structures are investigated. Moreover, the correlation between different crystalline structures and charge mobilities in organic field-effect transistors (OFETs) is scrutinized. These rationally synthesized triblock copoly(3-alkylthiophene)s self-assemble into cocrystals with an edge-on orientation in as-cast and 150 °C-annealed samples. Remarkably, the combinations with the shortest alkyl side chains placed as the central block (i.e., P3HT-b-P3BT-b-P3OT, P3HT-b-P3BT-b-P3DDT, P3OT-b-P3BT-b-P3DDT, and P3OT-b-P3HT-b-P3DDT) exhibit higher film crystallinity and charge mobilities than the other two combinations where the blocks with shortest alkyl side chains are located at two terminals. Intriguingly, upon thermal annealing near the melting temperature of these combinations, P3BT-b-P3OT-b-P3HT, P3BT-b-P3DDT-b-P3OT, and P3HT-b-P3DDT-b-P3OT can retain their cocrystalline structure while the other combinations are found to microphase separate. Finally, the all-conjugated triblock copoly(3-alkylthiophene)s with proper block sequence demonstrate stable charge mobilities at high temperatures and good flexibility in OFET devices. Taken together, this study elucidates that the block sequence is of key importance on control of the crystallization and charge transport behavior of poly(3-alkylthiophene)-based triblock copolymers.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Qian Zhu,Xun Sun,Hong Zhao,Dan Xu,Zhengping Dong
The N, S co-doped carbon nanotube-encapsulated Co nanoparticle (NP) material was prepared by one-pot pyrolysis of cheap precursor materials. As-prepared Co@NSC-800 exhibited excellent catalytic activity in transfer hydrogenation and N-formylation of nitroarenes, and the solvent and hydrogen source were the critical factors affecting the selectivity of aniline and benzamide. Moreover, the synergistic effect between Co NPs and N, S atoms was beneficial to improve the catalytic efficiency of Co@NSC-800; especially, the incorporation of S atoms greatly boosted the selectivity of N-formylation. Despite the use of HCOONH4 (HCOOH) as a hydrogen donor for hydrogenation and formylation of nitroarenes, the special nanotube structure of the Co@NSC-800 catalyst effectively prevented the corrosion of Co NPs and showed excellent durability under harsh reaction conditions. In addition, the catalyst maintained excellent catalytic activity after six cycles and was easily separated using an external magnet. Thus, this study can provide an effective method for the transfer hydrogenation and formylation of nitroarenes.
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高影响因子
Polymer Chemistry
·
2017
·Vol. 8
·期 9
·1573-1578
·
IF 5.375
Ze Li,Chunyong Wu,Lifeng Liu,Meijiang Li,Xiongfa Yang,Chaowei Hao,Qiu Chen,Ziqiang Hu,Mengxian Luo,Guoqiao Lai,Tien-Yau Luh
Macrocyclic polysiloxanes are useful materials for the development of interpenetrating polymer networks and thermally stable materials. The main drawbacks of reported methods for the preparation of macrocyclic polysiloxanes are that mixtures of linear and cyclic polysiloxanes are commonly obtained, and complex and time-consuming separation processes are needed. Moreover, the preparation of macrocyclic polysiloxanes occasionally needs harsh conditions, and in general has low efficiency. In this research, we find that highly pure macrocyclic poly(methylvinylsiloxane)s (cPMVSs) can be chemoselectively prepared from 1,3,5,7-tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane with water catalyzed by anhydrous iron(III) chloride in high efficiency. The structure of cPMVSs is characterized by gel permeation chromatography, infrared spectroscopy, 1H- and 29Si-nuclear magnetic resonance (NMR), and viscosity. Thermogravimetric analysis shows that cPMVSs have excellent thermal stability. A metathetical ring-expanding polymerization mechanism is proposed.
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高影响因子
危险品化学品经营许可证（带存储）