查找使用阿拉丁产品的科研文献

The hemocompatibility of the modified polysulfone membrane with 4-(chloromethyl)benzoic acid and sulfonated hydroxypropyl chitosan

Sheng Yan,Ming-Ming Tu,Yun-Ren Qiu

Polysulfone (PSf) membrane is widely employed in blood purification fields, but the blood compatibility of PSf membrane is not adequate. To improve the hemocompatibility of PSf membrane, 4-(chloromethyl)benzoic acid (CMBA) and sulfonated hydroxypropyl chitosan (SHPCS) were grafted onto PSf membrane surface. In our strategy, CMBA was firstly grafted on the PSf membrane surface through the Friedel-Crafts alkylation reaction, and the product was named BAPSf membrane. Then, SHPCS was grafted onto the BAPSf membrane surface by esterification , and the product was named SHPCS-BAPSf membrane. The effects of temperature and reaction time on the productivity of BAPSf and the grafting density of carboxyl and the effects of reaction time on the grafting density of SHPCS grafted onto the BAPSf membrane surface were studied. The SHPCS-BAPSf membranes are investigated by ATR-FTIR, XPS , contact angle measurements and evaluated by blood compatibility in vitro. The results reveal that the hydrophilicity of SHPCS-BAPSf membranes were grealy improved and the evaluation of protein adsorption , hemolysis test, platelet adhesion plasma recalcification time(PRT), activated partial thromboplastin time(APTT), prothrombin time(PT) and thrombin time(TT) confirmed that the SHPCS-BAPSf membranes have remarkable blood compatibility.

Oral colon-targeted responsive chitosan/pectin-based nanoparticles propels the application of tofacitinib in colitis therapy

Wu Chunfei,Bi Chuanlin,Kim Geun-soo,Yang Zizhen,Li Shuao,Dai Tong,Wu Xiaoyu,Tan Jiaojiao,He Ningning,Li Shangyong

Tofacitinib (Tof), a commercially available pan-Janus kinases inhibitor, is approved for the treatment of moderate to severe ulcerative colitis. However, its clinical application is limited due to dose-dependent systemic side effects. The present study aims to develop an efficient oral colon-targeted drug delivery systems using prebiotic pectin (Pcn) and chitosan (Csn) polysaccharides as a shell, with Tof loaded into a Bovine Serum Albumin (BSA) core, and improving it with chondroitin sulfate (Chs), thu s constructing Tof@BSA-Chs-CP nanoparticles (NPs). Our results suggest that th e pH-sensitive characteristics of the Pcn/Csn shell contribute to its capacity for attenuating absorption and systemic diffusion in the gastrointestinal tract, and exhibiting targeted localization at inflamed colonic sites in mice. Additionally, the gut microbiota-secreted polysaccharide-degrading enzyme acts as the triggering agent for Pcn/Csn shell degradation. In mice colitis models, we demonstrated that oral administration of Tof@BSA-Chs-CP NPs effectively ameliorated colitis and expedited its resolution by modulating the expression of pro-inflammatory cytokines and immune regulatory factors. Collectively, our synthetic NPs demonstrate the promising potential of Tof for the therapy of UC.

Antibacterial reuterin as a multifunctional crosslinker for constructing chitosan-based hydrogels to promote infected wound healing

Yuwei Gao,Panpan Wang,Shunfen Huang,Qizhe Zheng,Shipeng Wu,Jun Huang,Zhiyu Chen,Botao Gao

Compared to traditional antibiotics, which often contribute to antibiotic resistance, probiotics and their metabolites have garnered increasing attention for their potential to improve the wound microenvironment. Among these, reuterin, a metabolite produced by Limosilactobacillus reuteri , exhibits notable antioxidant and antimicrobial activities, making it particularly advantageous for medical applications. Inspired by the structural similarity of reuterin to conventional chemical crosslinkers, we explored its dual role for the first time—as both a bioactive component and a crosslinking agent—by combining it with chitosan to develop a novel therapeutic hydrogel, eliminating the need for additional drug loading. At an optimal reuterin-to-chitosan molar ratio of 1:2, the hydrogel demonstrated outstanding performance. Cytotoxicity assays confirmed its safety, with a hemolysis rate below 2 %, indicating excellent biocompatibility. Remarkably, the hydrogel achieved an impressive 99 % antibacterial efficacy and over 60 % DPPH radical scavenging capacity in vitro. In a rat model of infected wounds, the hydrogel exhibited acid-responsive release of reuterin, effectively suppressing bacterial proliferation. These combined effects significantly accelerated wound healing, demonstrating an approximately 10 % improvement in healing rates compared to commercial controls. In conclusion, the reuterin-crosslinked chitosan hydrogel represents a promising, safer and more effective alternative to traditional chemical crosslinked hydrogels for clinical wound management.

Preparation and Characterization of Novel Acylated Chitosan/Carboxymethyl Konjac Glucomannan Nanogels for the Encapsulation of Polyphenols

Mingxiu Long,Hui Wang,Yongfu Li,Zhaojun Chen,Zhilong Zeng,Jingwen Luo,Xizhu Tian,Fang Zhang,Xiong Liu

This research explores the development of a polysaccharide-based nanogel by modifying chitosan (Cs) and konjac glucomannan (KGM). By introducing acyl groups, the water solubility of Cs was improved, while irradiation treatment and carboxymethylation modified the molecular weight distribution and viscosity of KGM, enhancing their suitability in nanogel formulations. The nanogel synthesis was optimized, the L ACs/CKGM8 nanogel (1:1) exhibited a positive surface charge, smaller and more uniform particle size, low aggregation, and high yield. Moreover, the inclusion of Rosa roxburghii Tratt polyphenols (RP) reduced the particle size and improved the structural integrity of nanogel (NG). The RP-loaded NG exhibited excellent encapsulation efficiency (EE) of 76.64% and a loading capacity (LC) of 56.99% for RP. The controlled RP release in simulated gastrointestinal conditions suggests these nanogels may improve oral polyphenol delivery system performance.

Synergistic adsorption and corrosion inhibition of nano carbon dots and random chitosan chains in 15 % HCl

Zhikun Wang,Wentao Qu,Yunchao Peng,Jianqiang Zhang,Songqing Hu

The synergistic adsorption of carbon dot and chitosan on metal-corrosive solution interface remains complex and elusive due to their distinct architecture and chemistry. Here, copper-doped carbon dot (CuCD) and pyridine-grafted chitosan (CS-4PCA) are designed as a synergistic corrosion inhibition duo in 15 % HCl. Weight loss tests showed that the optimal CuCD (200 mg/L) and CS-4PCA (200 mg/L) individually achieved inhibition efficiencies of 67.66 % and 73.27 %, respectively. Remarkably, their binary mixture (150 mg/L CuCD + 50 mg/L CS-4PCA) exhibited a synergistic efficiency of 83.27 %, surpassing the performance of either component at the same total concentration. The addition of benzotriazole (200 mg/L) further enhanced the efficiency to 92 %. Surface characterization revealed that the CuCD/CS-4PCA composite film reduced the surface roughness of N80 steel from 32.27 μm (blank) to 8.01 μm, forming a compact protective layer. Molecular dynamics simulations demonstrated that CuCD adsorbed parallel to the Fe surface, while CS-4PCA chains filled the gaps, synergistically inhibiting corrosive particle penetration. This work provides insights into the design of high-performance compound inhibitors for harsh acidic environments.

A chitosan-based interconnected porous ionic gel constructed via cryo-polymerization for uranium extraction from seawater

Fengqi Zhang,Dagang Li,Dongxiang Zhang,Jinzheng Hou,Zilei Zhang,Runchao Tan,Haocun Tan,Xiyan Xu

Uranium extraction from seawater faces several challenges, such as extremely low uranium concentration, hydrogel adsorbents’ structural collapse under seawater pressure, and reduced adsorption efficiency in weakly alkaline conditions. To address these issues, a dual-crosslinked hydrogel matrix (CS/PAA) was developed via a one-step cryo-polymerization strategy. By integrating chemically crosslinked polyacrylic acid (PAA) and ionically crosslinked chitosan (CS), the hydrogel achieved a robust 3D interconnected porous structure with a compressive strength of 134.71 kPa. The introduction of amidoxime (AO) groups into CS/PAA further enhanced uranium adsorption, resulting in the CS/P(AA- co -AO) ionic gel. Notably, this hydrogel retained its porous architecture after ambient drying, offering a low-energy alternative to freeze-drying. The presence of chitosan not only imparts antibacterial properties but also stabilizes the gel structure under seawater conditions. The interconnected macroporous network facilitates rapid mass transfer, enabling an adsorption capacity of 11.92 mg·g −1 after 30 days in natural seawater. This innovative ionic gel, combining enhanced structural stability, environmental adaptability, and low-energy preparation, provides a promising strategy for efficient uranium recovery, addressing key limitations of conventional adsorbents.

Chitosan/oxidized cellulose composite nanofiber sponges: a rapid and effective hemostasis strategy for non-compressible hemorrhage

Zhan Zhang,Zhiyuan Lin,Chenglong Yu,San Ieng Lei,Lu Wang,Fujun Wang,Jing Gao,Wenbo Meng

Non-compressible hemorrhagic wounds, prevalent in combat and mass trauma scenarios, are characterized by arterial injury-induced exsanguination and geometrically complex wound morphology that challenges conventional hemostatic interventions. This paper presents a novel nanofiber hemostatic sponge (CT@GP-HAc), made from 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO) oxidized cellulose nanofibers (TOCN) and chitosan nanofibers (CSNF), crosslinked with genipin (GP) in an acetic acid atmosphere. The sponge features excellent shape memory and rapid hemostatic capabilities, specifically designed for deep, irregular wounds. Its unique micro-nano composite porous structure enhances blood absorption, blood cell capture, and coagulation factor recruitment. In vitro experiments show that CT@GP-HAc outperforms traditional iRegene® GEL sponges in whole blood coagulation index, coagulation time, and red blood cell and platelet adhesion. Prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) tests reveal that CT@GP-HAc's hemostatic action is independent of the human coagulation mechanism, making it suitable for patients with coagulation disorders. Biocompatibility tests indicate an extremely low hemolysis rate and non-cytotoxicity, supporting its clinical application. In vivo studies confirm CT@GP-HAc's effectiveness in reducing blood loss and shortening hemostasis time. These findings highlight the potential of CT@GP-HAc as a next-generation hemostatic material for managing non-compressible hemorrhagic wounds.

Fully bio-based grease resistant composite coating: chitosan-Genipin-microfibrillated cellulose for sustainable paper food packaging

Baoying Shi,Siqi Xie,Dengyu Huang,Yufeng Wang

As awareness of health concerns continues to rise, the development of new generations of sustainable food packaging materials has emerged as a focal point of significant attention. This study presents the development of a fully bio-based grease resistant composite coating composed of chitosan (CS), genipin (GP), and microfibrillated cellulose (MFC) for sustainable paper food packaging. The synergistic effects of crosslinking between CS and GP, combined with electrostatic interactions between CS and MFC, enabled the formation of a dense, interconnected coating layer on paper substrates. Systematic optimization of coating formulations revealed that a 2 wt% CS, 0.1 wt% GP, and 15 wt% MFC composition achieved maximum grease resistance (kit rating: 12/12) at a remarkably low coating weight of 4 g/m 2 , outperforming existing chitosan-based coatings requiring higher application weights for medium performance. The composite coating significantly enhanced mechanical properties, with two kinds of food wrapping paper after coating exhibiting tensile strength improvements of 25 % and 13 %, and burst strength increases of 25 % and 41 %, respectively. Additionally, water vapor transmission rates decreased by 22 % and 28 %, demonstrating enhanced moisture barrier functionality. Practical evaluations have confirmed the coating's robust resistance to various organic solvents, as well as its stability in hot oil. Simulated food contact tests using fried chicken and sausages revealed no detectable grease penetration or structural compromise in coated papers. This study establishes the CS/GP/MFC coating as a high-performance, environmentally sustainable alternative to fluorinated and non-biodegradable materials, with broad applicability in grease resistant food packaging systems.

Low molecular weight chitosan-coated silver nanoparticles are effective for the treatment of MRSA-infected wounds

Yinbo Peng,Chenlu Song,Chuanfeng Yang,Qige Guo,Min Yao

Carboxylated graphene oxide-chitosan spheres immobilize Cu2+ in soil and reduce its bioaccumulation in wheat plants

Lianqin Zhao,Xin Guan,Baowei Yu,Na Ding,Xinmei Liu,Qiang Ma,Shengnan Yang,Ailimire Yilihamu,Sheng-Tao Yang

Due to the strong interaction with pollutants and the huge adsorption capacity, graphene adsorbents are widely applied in water decontamination. However, graphene adsorbents are seldom used in soil remediation, because the adsorptive sites on graphene would be occupied by soil components. In this study, we prepared carboxylated graphene oxide-chitosan (GO-COOH/CS) spheres for the immobilization of Cu 2+ from water and soil. The pores in GO-COOH/CS allowed the internal diffusion of Cu 2+ solution, while they blocked the direct contact between the solid soil and the adsorptive sites on graphene sheets. Therefore, the high adsorption capacity of GO-COOH/CS spheres (78 mg/g) was largely retained for the soil Cu 2+ fixation. The partition coefficient (PC) for Cu 2+ adsorption onto GO-COOH/CS spheres was 4.2 mg/g/μM at C e of 0.48 mg/L and q e of 31 mg/g, while the PC value decreased to 0.096 mg/g/μM at C e of 91.4 mg/L and q e of 78 mg/g. At initial Cu 2+ concentrations of 120 mg/L and lower, the fixation efficiencies were all higher than 99% and the corresponding free Cu 2+ concentrations in leachates were lower than 1.0 mg/L. The Cu 2+ fixation on GO-COOH/CS spheres largely reduced its bioaccumulation in wheat roots from 127.8 μg/g to 51.2 μg/g. The toxicity evaluations suggested that GO-COOH/CS spheres were of low toxicity to wheat seedlings and did not amplify the toxicity of Cu 2+ . The implications to the design of graphene adsorbents for soil remediation are discussed. Overall, our results collectively indicated that porous GO-COOH/CS spheres were high-performance adsorbents for the immobilization of Cu 2+ to reduce Cu 2+ bioaccumulation in plants.

Amperometric cholesterol biosensor based on reduction graphene oxide-chitosan-ferrocene/platinum nanoparticles modified screen-printed electrode

Li Guiyin,Zeng Junxiang,Zhao Le,Wang Zhihong,Dong Chenyang,Liang Jintao,Zhou Zhide,Huang Yong

Cholesterol is a waxy steroid metabolite substance and plays an important role in the brain, nervous, and immune systems of humans. The level of cholesterol in human serum has become an important index for clinical diagnosis and prevention of cardiovascular disease. In this study, a highly sensitive electrochemical biosensor for cholesterol measurement has been developed based on reduced graphene oxide-chitosan-ferrocene carboxylic acid/platinum nanoparticle (RGO-CS-Fc/Pt NPs) modified screen-printed carbon electrode (SPCE). Under the effect of cholesterol oxidase (CHOD) and cholesterol esterase (CHER), the cholesterol was oxidized to generate hydrogen peroxide (H 2 O 2 ), which can be disintegrated into H 2 O with the synergistic catalysis of RGO-CS-Fc/Pt NPs and produce the redox response current of H 2 O 2 that could be determined by electrochemical amperometric (i-t) method. The prepared cholesterol biosensor was achieved by integrating of the high electrocatalytic efficiency of Pt NPs, high electronic conductivity and large surface area of RGO, the reversible electrochemical behavior of Fc, and good biocompatibility of CS. The measured of redox response current and cholesterol concentration have a good linearity in the range of 0.5–4.0 mg/mL, low detection limit of 5.70 μg/mL (S/N = 3), and good sensitivity of 0.871 nA/mM/cm 2 . Moreover, the RGO-CS-Fc/Pt NPs cholesterol biosensor exhibited excellent specificity, acceptable reproducibility, and higher recoveries in the detection of clinical serum samples, showing great potential for clinical diagnosis. Schematic presentation of an electrochemical biosensor based on RGO-CS-Fc/Pt NPs for cholesterol detection.

Immobilized and photocatalytic performances of PDMS-SiO2-chitosan@TiO2 composites on pumice under simulated sunlight irradiation

Li Shao,Heng Liu,Weiping Zeng,Caiyun Zhou,Dan Li,Liang Wang,Yeqian Lan,Feigao Xu,Gousheng Liu

It was found that, among these chitosan@TiO 2 (Cs@TiO 2 ) composites calcined at different temperatures (200, 300, 400, 500 and 600 °C), the composite calcined at 300 °C (Cs@TiO 2 -300) showed the best adsorption and photocatalytic activity . To eliminate the limitation of recycling catalyst nanoparticles , the PDMS-SiO 2 -Cs@TiO 2 composites with hydrophobic surfaces were prepared for dye degradation by embedding Cs@TiO 2 -300 nanoparticles into a PDMS-SiO 2 sol-gel system. More concretely, with pumice stone as the support of composites, the experiment was carried out in a reaction bed. When pumice stones were used as supports for PDMS-SiO 2 -Cs@TiO 2 composites, compared with its initial concentration, the concentration of dye solution decreased by 36% after 30 h of simulated sunlight irradiation. Additionally, the degradation efficiency of dyes hardly decreased after five cycles. The optical property and surface structure of PDMS-SiO 2 -Cs@TiO 2 were characterized by UV–Vis DRS and XPS , respectively. It is noteworthy that the UV–Vis DRS results indicated that the light absorption range of both Cs@TiO 2 -300 composites and PDMS-SiO 2 -Cs@TiO 2 composites had been broadened to the visible light region. Moreover, the XPS results indicated the existence of nitrogen (N) doped titanium on the surface of PDMS-SiO 2 -Cs@TiO 2 composites.