CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yuxuan Dai,Shenghan Gao,Zhi Zhang,Wan-Jie Du,Xinyu Bao,Yun Xu
Alzheimer's disease (AD) has displayed complex pathological features, in which oxidative stress and ferroptosis play important roles. The development of collaborative treatment methods aimed at multiple pathological factors is particularly important for effective alleviation of AD. In our research, a multifunctional delivery system (CART-CeO 2 )@HA was developed for the co-delivery of neuroprotective Cocaine- and amphetamine-regulated transcript (CART) peptides and antioxidant CeO 2 nanozymes encapsulated within an ROS-responsive nanogel. Under the stimulation of Aβ, (CART-CeO 2 )@HA exhibited effective relief for cell apoptosis, mitochondrial dysfunction and synaptic loss on account of ROS removal and ferrous ions chelation. With sufficient accumulation and sustained drug release in the brain of APP/PS1 mice, (CART-CeO 2 )@HA significantly reduced the levels of oxidative stress and ferroptosis, which facilitate the reduction of Aβ deposition and the repair of neuronal damage, jointly rescuing the cognitive impairment in APP/PS1 mice. These results verified the clinical potential of the multi-target delivery system in AD synergistic therapy.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Wanlong Li,Yuqing Ren,Quan Feng,Xianhong Zheng,Xiangyun Zhou,Jianghui Zhao,Zhi Liu
Flexibility is critical to the dimensional stability of photothermal materials during sustainable solar water evaporation. Herein, a flexible Cu 2 O-Cu co-doped carbon (Cu 2 O-Cu@C) nanofibrous membrane was fabricated by carbonization of polyacrylonitrile (PAN)/Cu(CH 3 COO) 2 nanofiber membrane at 400 °C. This process transformed Cu(CH 3 COO) 2 into a mixture of Cu 2 O and Cu. The Cu 2 O-Cu@C membrane achieved a significantly enhanced stress at break of 3.95 MPa—a 14.6-fold enhancement over pure carbon membranes (0.27 MPa). Moreover, the membrane exhibited excellent flexibility, as it recovered its original shape within 40 ms after folding and maintained its dimensional integrity throughout 1000 bending cycles. Raman spectroscopy and molecular dynamics simulations demonstrated that Cu 2 O-Cu co-doping dramatically improves mechanical properties by (1) increasing density, which enhances structural densification, (2) introducing new interatomic energy contributions that strengthen interfacial interactions, and (3) improving stress transfer and crack inhibition to promote external force dissipation. Under one sun illumination, the Cu 2 O-Cu@C nanofibrous membrane achieved evaporation rates of 1.57 kg·m −2 ·h −1 for 3.5 % saline water and 1.61 kg·m −2 ·h −1 for actual dye wastewater. In addition, following hydrophilic hydrogel modification, the Cu 2 O-Cu@C membrane maintained a stable evaporation rate exceeding 1.76 kg·m −2 ·h −1 during 10-h indoor tests. It also showed no salt crystallization in outdoor testing, confirming its salt resistance and long-term stability for practical applications. These findings will encourage research aimed at enhancing the mechanical properties of PAN-based carbon nanofibers, which are intended for applications in flexible photothermal evaporators, wearable electronics, and related devices.
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TALANTA
·
2025
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IF 6.1
Mengxi Chen,Fang Xu,Shenyue Zhou,Yuanyuan Yu,Jiayu Xu,Lei Gan,Mengmeng Wang,Yuxia Sun,Haiyang Zhang,Weipeng Wang
Extracellular vesicles (EVs) and their cargos are increasingly being recognized as noninvasive diagnostic markers. The isolation of EVs from complex biological samples is crucial for subsequent analysis. Herein, a distearoyl phospholipid ethanolamine-functionalized zeolitic imidazolate framework (ZIF-8-DSPE) was developed, which combines the surface charge interaction of ZIF-8 with the synergistic effect of DSPE insertion into the phospholipid membrane of EVs to improve the EV isolating selectivity. Benefitting from this feature, it could be well compatible with the analysis of RNA and proteins in EVs. Furthermore, the ZIF-8-DSPE was utilized to isolate EVs from clinical plasma of primary colorectal cancer (CRC) patients, CRC patients with liver metastases (CRCLM) and healthy donors (HD). Proteomics results illustrated that 11 proteins were up-regulated in the CRCLM group compared to the CRC group, and 59 proteins were upregulated in the CRC group compared to the HD group. Furthermore, some proteins such as PRDX2, TFP1, FGG and F13A1 were found to be closely related to CRC progression and metastasis, and have the potential to be biomarkers for CRC. These findings proposed that it is a promising strategy to identify biomarkers from plasma EVs for early detection and disease monitoring of CRC.
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PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Xining Guo,Huiying Li,Leshi Zhang,Rui Hao,Fei Ye,Jianmin Gu,Kaihang Sun,Guozhu Li,Ji−Jun Zou,Zhourong Xiao,Desong Wang
The photothermal catalytic conversion of CO2 into value-added chemicals is of great significance for realizing the goal of carbon neutralization. However, these catalysts have problems such as an insignificant photothermal effect and high recombination of photogenerated carriers. Here, porous TiO2 was prepared by hydrothermal crystallization and topological conversion of metal–organic frameworks (MOFs), and loaded with highly dispersed Pt catalysts to realize an efficient photothermal catalytic reverse water-gas shift (RWGS) reaction. N2-adsorption results showed that the as-prepared Pt/TiO2 catalysts had an abundant mesoporous structure, thus contributing to the rapid diffusion of reactants and light transport. X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HRTEM) results showed that Pt was uniformly dispersed on the catalyst surface with an average particle size of 2.06 nm. H2-TPR profiles showed that the Pt/TiO2 catalyst had strong metal–support interactions, CO2-TPD showed its strong CO2 adsorption capacity, and CO-TPD showed its weak CO adsorption strength. In situ X-ray photoelectron spectroscopy (XPS) showed that the electron cloud density on the Pt surface further increased under light illumination, which contributed to the activation and dissociation of H2. In addition, the Pt/TiO2 catalyst had a narrow band gap width and sufficiently low reduction potential, and its excellent photothermal and photovoltaic properties ensured efficient performance in the photothermal RWGS reaction. The Pt/TiO2 catalysts showed a high CO2 conversion of 29.8%, a product CO selectivity higher than 99.6%, and a stability of more than 3000 min at 350 °C, with a light intensity of 1.2 W cm–2 and a GHSV of 36,000 mL gcat–1 h–1.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
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IF 9
Yuzhe Zhou,Yanmei Ma,Xiangyun Li,Wentao Yan,Yong Zhou,Congjie Gao
The co-solvent-assisted interfacial polymerization (CAIP) strategy has proven to be an effective method for fabricating high-performance forward osmosis (FO) membranes. However, current research primarily focuses on the role of co-solvents in conventional interfacial polymerization (IP) technology, with relatively limited studies on unconventional IP technologies. This study explores support-free interfacial polymerization (SFIP) by incorporating dimethyl sulfoxide (DMSO) as a co-solvent. The impact of DMSO on polyamide (PA) structure and membrane performance is systematically investigated throughout the SFIP process. At a DMSO concentration of 1.5 w/v%, SFIP-D1.5 membrane exhibited a high water flux of 29 LMH without a significant increase in reverse salt flux. This phenomenon can be attributed to the dual role of DMSO in promoting monomer diffusion and inducing swelling of the SFIP-PA film. Furthermore, the SFIP-D1.5 membrane exhibited stable performance over 24 h operation and maintained comparable anti-fouling properties during multi-cycle fouling tests. This study reveals the distinct behavior of DMSO in the SFIP process compared to conventional IP, and demonstrates the potential of the CAIP strategy within unconventional IP techniques. This provides a promising approach to enhance both the selectivity and permeability of TFC FO membranes fabricated using strong solvents as co-solvents.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
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IF 9
Jinshan Chen,Qiao Zeng,Shuangyou Bao,Fei Wang,Chi Wang,Kai Li,Yi Mei
Designing efficient and selective photocatalysts for CO 2 conversion under mild and practical conditions remains a significant challenge. This study aims to establish a sustainable strategy for constructing MOF-derived TiO 2 @TPA hybrids that enable efficient charge separation and selective CO 2 -to-CO conversion under low CO 2 concentrations without sacrificial agents. To achieve this, a TiO 2 @TPA hybrid material was synthesized via in-situ hydrothermal transformation of MIL-125(Ti) in water at 100 °C, without the use of organic solvents or high-temperature calcination. The resulting composite integrates TiO 2 nanocrystals with polymeric terephthalic acid (TPA) through Ti–O–C bonds, forming a stable interface that promotes ligand-to-metal charge transfer (LMCT). This interfacial structure enhances visible-light absorption and facilitates efficient charge separation. When applied to photocatalytic CO 2 reduction under low CO 2 concentrations (∼10 %), the TiO 2 @TPA hybrid achieved highly selective CO generation without the need for sacrificial agents or photosensitizers. In situ infrared spectroscopy and surface photovoltage analysis revealed the formation and stabilization of *COOH intermediates, elucidating the enhanced reaction pathway. This study demonstrates a scalable strategy for constructing MOF-derived hybrid photocatalysts and provides insights into interfacial design for selective CO 2 separation and conversion.
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高影响因子
Materials
·
2025
·Vol. 18
·期 15
·3633
·
IF 3.2
Hengfen Shen,Hao Du,Peng Li,Mei Wang
As an efficient clean energy technology, water electrolysis for hydrogen production has its efficiency limited by the sluggish oxygen evolution reaction (OER) kinetics, which drives the demand for the development of high-performance anode OER catalysts. This work constructs bimetallic (Al, Mn) co-doped nanoporous spinel CoFe 2 O 4 (np-CFO) with a tunable structure and composition as an OER catalyst through a simple two-step dealloying strategy. The as-formed np-CFO (Al and Mn) features a hierarchical flaky configuration; that is, there are a large number of fine nanosheets attached to the surface of a regular micron-sized flake, which not only increases the number of active sites but also enhances mass transport efficiency. Consequently, the optimized catalyst exhibits a low OER overpotential of only 320 mV at a current density of 10 mA cm −2 , a minimal Tafel slope of 45.09 mV dec −1 , and exceptional durability. Even under industrial conditions (6 M KOH, 60 °C), it only needs 1.83 V to achieve a current density of 500 mA cm −2 and can maintain good stability for approximately 100 h at this high current density. Theoretical simulations indicate that Al and Mn co-doping could indeed optimize the electronic structure of CFO and thus decrease the energy barrier of OER to 1.35 eV. This work offers a practical approach towards synthesizing efficient and stable OER catalysts.
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PubMed
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MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Ziwei Guo,Jingce Bi,Yi Wang,Xiaoguang Sang,Xia Zhang,Zhuopeng Wang,Yide Han
Metal-organic framework materials (MOFs) have shown great promise in electrochemical sensing applications due to their high specific surface area, excellent thermal and chemical stability. However, the practical application of MOFs in non-enzymatic electrochemical glucose sensing is limited by their inherent drawbacks, such as poor electrical conductivity and low mass transfer efficiency. To overcome these challenges, we successfully synthesized a Co@UiO-66-NH 2 /acetylene black (Co@UiO-66-NH 2 /AB) nanocomposite through a dual-solvent method followed by mechanical grinding method and applied it as an efficient electrochemical glucose sensor. Experimental results demonstrate that the Co@UiO-66-NH 2 /AB nanocomposite exhibits significantly enhanced electrochemical sensing performance for glucose detection, compared to pure Co@UiO-66-NH 2 . Specifically, 0.5Co@UiO-66-NH 2 /AB nanocomposite achieves sensitivities of 89.60 μA·mM −1 ·cm −2 and 37.65 μA·mM −1 ·cm −2 in the linear ranges of 0–800 μM and 800–6000 μM, respectively, with a low detection limit of 2.31 μM and a rapid response time of approximately 3.6 s. Additionally, 0.5Co@UiO-66-NH 2 /AB nanocomposite demonstrates remarkable stability, with the current signal remaining nearly constant over an extended period of 3000 s. This enhanced performance can be attributed to the abundant active sites provided by Co@UiO-66-NH 2 , coupled with the enhanced electrical conductivity imparted by acetylene black. Moreover, the sensor exhibits minimal interference from common interfering substances, such as uric acid, dopamine hydrochloride, and ascorbic acid, was observed during glucose detection. Meanwhile, the 0.5Co@UiO-66-NH 2 /AB nanocomposite was also applied for the rapid determination of glucose in bovine serum albumin. Consequently, the Co@UiO-66-NH 2 /AB nanocomposite holds great potential for application in electrochemical biosensors.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
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IF 4.9
Qingfeng Luo,Yuyi Deng,Qiyuan Yang,Nanxin Zhao,Can Wang,Xingsheng Li
Osteopontin (OPN), highly expressed in foam cells, serves as a hallmark of atherosclerotic plaques and a potential target for site-specific drug delivery. In this study, we developed OPN-targeted liposomes (OPN LIP) co-loaded with curcumin and perfluoro-n-pentane (PFP) to enhance therapeutic efficacy against atherosclerosis. The liposomes exhibited uniform particle size, colloidal stability, favorable biocompatibility, and minimal cytotoxicity. In vitro experiments demonstrated efficient and time-dependent cellular uptake by ox-LDL–stimulated RAW264.7 foam cells. Upon exposure to low-intensity focused ultrasound (LIFU), the nanocarriers underwent acoustic cavitation-induced rupture, leading to rapid curcumin release and significant induction of apoptosis. OPN LIP treatment notably reduced IL-1α and TNF-α levels and aggravated apoptosis in foam cells. Transcriptomic analysis revealed modulation of inflammatory and apoptotic pathways, including TLR, NF-κB, and Mapk3 signaling. These findings highlight the potential of OPN LIP as an ultrasound-responsive, targeted nanoplatform capable of suppressing inflammation and foam cell viability, providing a promising approach for the treatment of atherosclerosis through combined physical and pharmacological strategies.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Xinlei Jia,Donghui Guo,Zelong Wang,Ning Zhou,Runze Jin,Baosheng Xu
Regulating the composition and microstructure of nanomaterials is a major challenge in the development of high-performance materials for electromagnetic wave (EMW) absorption. This paper introduces a new lightweight EMW-absorbing material Co@N/C with a yolk–shell structure and compositions of ferromagnetic metal and carbon materials. The minimum reflection loss (RL min ) of the as-designed Co@N/C nanospheres with a filler loading of 25 wt% reaches −67.68 dB and the effective absorption bandwidth of a 1.9 mm thickness is 5.3 GHz. The exceptional absorption performance of the EMW absorption is primarily achieved through the synergistic effect between the Co–carbonaceous material and the yolk–shell structure, which optimizes the impedance matching. The polarization loss, conductivity loss, magnetic loss, and multiple scattering mainly contribute to the excellent EMW-absorption ability of the materials. The proposed method for regulating the structure and morphology of Co@N/C can efficiently construct high-performance EMW absorbers.
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FERROELECTRICS
·
2024
·
IF 0.6
Zhao Hong,Xu Dan,Yu Taolin,Duan Xiaoyang,Zhou Xinyuan,Zhao Wenjie,He Jun
The effects of Li/Er and Li/Bi co-substitution on the structure, dielectric, and ferroelectric properties of BaTiO3 (BT) ceramics were investigated and analyzed. X-ray diffraction measurements show that the doped samples have a single tetragonal structure without secondary phases. Rietveld refinement results show that the Li/Er and Li/Bi ions tend to replace A-sites of BT lattices at low doping content. As the doping content increases, the Curie temperature moves to the high-temperature region due to the increased tetragonality and internal stress. Compared with the undoped ceramics, the ferroelectric properties of the doped ceramics are improved. The enhanced remnant polarization is attributed to the combined effects of large grain modulation and defect dipole arrangement.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Yiting Ye,Jiaqi Liu,Tingzi Yan,Yujia Yan,Jiangkai Fan,Xiao Zhang,Li Gan,Hui Chai,Guoying Zhou
Due to the huge waste caused by fruit mildew during transportation and storage, there is an urgent need to develop novel packing materials with antibacterial and degradable properties. Herein, poly(lactic-co-caprolactone)/Gelatin/Tannic acid (PLCL/GEL/TA) membranes were fabricated by electrospinning of PLCL and GEL to obtain PLCL/GEL membranes, followed by cross-linking with TA. The microstructures of PLCL/GEL/TA membranes were characterized by scanning electron microscope (SEM). The mechanical and wetting properties were evaluated by Instron universal material testing and Drop shape analysis system, respectively. The antibacterial and antioxidant properties were determined. The preservation properties of the membranes were evaluated using blueberry as a model fruit. The results showed that smooth and uniform microstructure was formed on all electrospun membranes. The PLCL/GEL/TA membranes exhibited enhanced mechanical property, wettability, biodegradability, antioxidant and antibacterial properties, when compared to PLCL/GEL membranes without TA treatment. In addition, these increased properties showed positive correlation with TA content. Besides, TA was slowly released from the PLCL/GEL/TA membranes, in a controlled and sustained manner. Moreover, the cytotoxicity assays confirmed the non-toxic nature of these membranes. Finally, the PLCL/GEL/TA membranes effectively inhibited decay degree, weight loss, and extended the shelf life of blueberries. Overall, the antioxidant, antibacterial, biodegradable and biocompatible PLCL/GEL/TA membranes exhibited remarkable preservation performance, demonstrating significant potential as novel packing materials.
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